KEGG   PATHWAY: aara04148
Entry
aara04148                   Pathway                                
Name
Efferocytosis - Anopheles arabiensis
Class
Cellular Processes; Transport and catabolism
Pathway map
aara04148  Efferocytosis
aara04148

Organism
Anopheles arabiensis [GN:aara]
Gene
120900924  caspase-1-like [KO:K02187] [EC:3.4.22.56]
120905765  caspase-like [KO:K04397] [EC:3.4.22.60]
120900367  caspase-like [KO:K04397] [EC:3.4.22.60]
120900925  caspase-1-like isoform X1 [KO:K04397] [EC:3.4.22.60]
120901230  caspase-3-like [KO:K04397] [EC:3.4.22.60]
120903002  caspase-1-like [KO:K04397] [EC:3.4.22.60]
120895331  caspase-like [KO:K04397] [EC:3.4.22.60]
120895342  caspase-like [KO:K04397] [EC:3.4.22.60]
120895798  caspase-like [KO:K04397] [EC:3.4.22.60]
120896274  caspase-1-like [KO:K04397] [EC:3.4.22.60]
120896275  caspase-like [KO:K04397] [EC:3.4.22.60]
120896277  caspase-like [KO:K04397] [EC:3.4.22.60]
120908823  85/88 kDa calcium-independent phospholipase A2 [KO:K16343] [EC:3.1.1.4]
120894455  ADAM 17-like protease [KO:K06059] [EC:3.4.24.86]
120899748  disintegrin and metalloproteinase domain-containing protein 10 isoform X1 [KO:K06704] [EC:3.4.24.81]
120898114  uncharacterized protein LOC120898114 [KO:K06704] [EC:3.4.24.81]
120894372  protein similar isoform X1 [KO:K08268]
120899903  aryl hydrocarbon receptor nuclear translocator homolog isoform X1 [KO:K09097]
120900074  tyrosine-protein kinase hopscotch [KO:K04447] [EC:2.7.10.2]
120902746  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
120902005  dual specificity mitogen-activated protein kinase kinase dSOR1 [KO:K04368] [EC:2.7.12.2]
120896880  prostaglandin E2 receptor EP4 subtype [KO:K04261]
120905982  cyclic AMP response element-binding protein B isoform X1 [KO:K05870]
120893943  calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type isoform X1 [KO:K05853] [EC:7.2.2.10]
120906742  calcium/calmodulin-dependent protein kinase type II alpha chain [KO:K04515] [EC:2.7.11.17]
120905032  mitogen-activated protein kinase p38b-like isoform X1 [KO:K04441] [EC:2.7.11.24]
120900163  MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
120901665  dual specificity protein phosphatase Mpk3 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
120902984  anoctamin-4 [KO:K19499]
120906072  XK-related protein 6 [KO:K26811]
120904870  probable phospholipid-transporting ATPase IA isoform X1 [KO:K14802] [EC:7.6.2.1]
120906279  probable phospholipid-transporting ATPase IF isoform X1 [KO:K26934] [EC:7.6.2.1]
120906372  cell cycle control protein 50A [KO:K26935]
120900086  adapter molecule Crk [KO:K04438]
120902892  engulfment and cell motility protein 1 [KO:K12366]
120898410  dedicator of cytokinesis protein 2 isoform X1 [KO:K13708]
120908650  ras-like GTP-binding protein RhoL [KO:K04392]
120902458  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
120902480  ras-related protein Rac1 isoform X1 [KO:K04392]
120895467  ras-like GTP-binding protein RhoL [KO:K04392]
120894576  calreticulin [KO:K08057]
120902523  low-density lipoprotein receptor-related protein 1 isoform X1 [KO:K04550]
120895202  protein draper isoform X1 [KO:K24068]
120908535  PTB domain-containing adapter protein ced-6 isoform X1 [KO:K23285]
120901904  ras-related protein Rab-5B [KO:K07889]
120906581  vacuolar protein sorting-associated protein 8 homolog [KO:K20178]
120893934  vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
120906119  vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
120906260  vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
120893848  vacuolar protein sorting-associated protein 33A [KO:K20182]
120899988  ras-related protein Rab-14 isoform X1 [KO:K07881]
120893796  vam6/Vps39-like protein [KO:K20183]
120899581  vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
120896024  ras-related protein Rab-7a [KO:K07897]
120904320  arginase, hepatic [KO:K01476] [EC:3.5.3.1]
120901909  ornithine decarboxylase 2-like [KO:K01581] [EC:4.1.1.17]
120902383  ornithine decarboxylase 1-like [KO:K01581] [EC:4.1.1.17]
120903950  ornithine decarboxylase 2-like [KO:K01581] [EC:4.1.1.17]
120904111  ornithine decarboxylase 1-like [KO:K01581] [EC:4.1.1.17]
120904112  ornithine decarboxylase 2-like [KO:K01581] [EC:4.1.1.17]
120904237  ornithine decarboxylase 1-like [KO:K01581] [EC:4.1.1.17]
120900530  carnitine O-palmitoyltransferase 1, liver isoform isoform X1 [KO:K08765] [EC:2.3.1.21]
120901828  cytochrome b-c1 complex subunit Rieske, mitochondrial isoform X1 [KO:K00411] [EC:7.1.1.8]
120897848  homeobox protein extradenticle isoform X1 [KO:K09355]
120906136  lipase 3-like [KO:K01052] [EC:3.1.1.13]
120897952  lipase 1-like [KO:K01052] [EC:3.1.1.13]
120893830  lipase 3-like [KO:K01052] [EC:3.1.1.13]
120894139  lipase 3-like [KO:K01052] [EC:3.1.1.13]
120894381  lipase 3-like [KO:K01052] [EC:3.1.1.13]
120903742  lipase 3-like [KO:K01052] [EC:3.1.1.13]
120906127  lipase 3-like [KO:K01052] [EC:3.1.1.13]
120903035  phospholipase A2 group XV-like [KO:K06129] [EC:3.1.1.5]
120898101  glucose transporter type 1 isoform X1 [KO:K07299]
120895943  tyrosine-protein phosphatase corkscrew isoform X1 [KO:K07293] [EC:3.1.3.48]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
aara00010  Glycolysis / Gluconeogenesis
aara04140  Autophagy - animal
aara04145  Phagosome
KO pathway
ko04148   
LinkDB

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