KEGG   ORTHOLOGY: K02187
Entry
K02187                      KO                                     

Symbol
CASP3
Name
caspase 3 [EC:3.4.22.56]
Pathway
map01524  Platinum drug resistance
map04010  MAPK signaling pathway
map04115  p53 signaling pathway
map04210  Apoptosis
map04215  Apoptosis - multiple species
map04650  Natural killer cell mediated cytotoxicity
map04657  IL-17 signaling pathway
map04668  TNF signaling pathway
map04726  Serotonergic synapse
map04932  Non-alcoholic fatty liver disease
map04933  AGE-RAGE signaling pathway in diabetic complications
map04936  Alcoholic liver disease
map05010  Alzheimer disease
map05012  Parkinson disease
map05014  Amyotrophic lateral sclerosis
map05016  Huntington disease
map05020  Prion disease
map05022  Pathways of neurodegeneration - multiple diseases
map05120  Epithelial cell signaling in Helicobacter pylori infection
map05130  Pathogenic Escherichia coli infection
map05132  Salmonella infection
map05133  Pertussis
map05134  Legionellosis
map05145  Toxoplasmosis
map05146  Amoebiasis
map05152  Tuberculosis
map05160  Hepatitis C
map05161  Hepatitis B
map05162  Measles
map05163  Human cytomegalovirus infection
map05164  Influenza A
map05165  Human papillomavirus infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05168  Herpes simplex virus 1 infection
map05169  Epstein-Barr virus infection
map05170  Human immunodeficiency virus 1 infection
map05200  Pathways in cancer
map05203  Viral carcinogenesis
map05205  Proteoglycans in cancer
map05206  MicroRNAs in cancer
map05210  Colorectal cancer
map05222  Small cell lung cancer
map05416  Viral myocarditis
map05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K02187  CASP3; caspase 3
   04668 TNF signaling pathway
    K02187  CASP3; caspase 3
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K02187  CASP3; caspase 3
   04215 Apoptosis - multiple species
    K02187  CASP3; caspase 3
   04115 p53 signaling pathway
    K02187  CASP3; caspase 3
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K02187  CASP3; caspase 3
   04657 IL-17 signaling pathway
    K02187  CASP3; caspase 3
  09156 Nervous system
   04726 Serotonergic synapse
    K02187  CASP3; caspase 3
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K02187  CASP3; caspase 3
   05206 MicroRNAs in cancer
    K02187  CASP3; caspase 3
   05205 Proteoglycans in cancer
    K02187  CASP3; caspase 3
   05203 Viral carcinogenesis
    K02187  CASP3; caspase 3
  09162 Cancer: specific types
   05210 Colorectal cancer
    K02187  CASP3; caspase 3
   05222 Small cell lung cancer
    K02187  CASP3; caspase 3
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K02187  CASP3; caspase 3
   05161 Hepatitis B
    K02187  CASP3; caspase 3
   05160 Hepatitis C
    K02187  CASP3; caspase 3
   05164 Influenza A
    K02187  CASP3; caspase 3
   05162 Measles
    K02187  CASP3; caspase 3
   05168 Herpes simplex virus 1 infection
    K02187  CASP3; caspase 3
   05163 Human cytomegalovirus infection
    K02187  CASP3; caspase 3
   05167 Kaposi sarcoma-associated herpesvirus infection
    K02187  CASP3; caspase 3
   05169 Epstein-Barr virus infection
    K02187  CASP3; caspase 3
   05165 Human papillomavirus infection
    K02187  CASP3; caspase 3
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K02187  CASP3; caspase 3
   05130 Pathogenic Escherichia coli infection
    K02187  CASP3; caspase 3
   05132 Salmonella infection
    K02187  CASP3; caspase 3
   05133 Pertussis
    K02187  CASP3; caspase 3
   05134 Legionellosis
    K02187  CASP3; caspase 3
   05152 Tuberculosis
    K02187  CASP3; caspase 3
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K02187  CASP3; caspase 3
   05145 Toxoplasmosis
    K02187  CASP3; caspase 3
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K02187  CASP3; caspase 3
   05012 Parkinson disease
    K02187  CASP3; caspase 3
   05014 Amyotrophic lateral sclerosis
    K02187  CASP3; caspase 3
   05016 Huntington disease
    K02187  CASP3; caspase 3
   05020 Prion disease
    K02187  CASP3; caspase 3
   05022 Pathways of neurodegeneration - multiple diseases
    K02187  CASP3; caspase 3
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K02187  CASP3; caspase 3
   05416 Viral myocarditis
    K02187  CASP3; caspase 3
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K02187  CASP3; caspase 3
   04932 Non-alcoholic fatty liver disease
    K02187  CASP3; caspase 3
   04933 AGE-RAGE signaling pathway in diabetic complications
    K02187  CASP3; caspase 3
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    K02187  CASP3; caspase 3
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K02187  CASP3; caspase 3
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.56  caspase-3
     K02187  CASP3; caspase 3
Peptidases and inhibitors [BR:ko01002]
 Cysteine peptidases
  Family C14: caspase family
   K02187  CASP3; caspase 3
Other DBs
GO: 0097200
Genes
HSA: 836(CASP3)
PTR: 461669(CASP3)
PPS: 100974934(CASP3)
GGO: 101126742(CASP3)
PON: 100435491(CASP3)
NLE: 100585064(CASP3)
MCC: 694473(CASP3)
MCF: 102144182(CASP3)
CSAB: 103236614(CASP3)
CATY: 105593734 105597738(CASP3)
PANU: 101023728(CASP3)
RRO: 104666783 104673791(CASP3)
RBB: 108512689
PTEH: 111548479(CASP3) 111551382
CJC: 100387570(CASP3)
SBQ: 101029697(CASP3)
MMUR: 105880624 105882502(CASP3)
MMU: 12367(Casp3)
MCAL: 110299851(Casp3)
MPAH: 110336608(Casp3)
RNO: 25402(Casp3)
MCOC: 116069240(Casp3)
CGE: 100689061(Casp3)
PLEU: 114693817(Casp3)
NGI: 103744668 103750475(Casp3)
OCU: 100008840(CASP3)
TUP: 102472926(CASP3) 102487119
CFA: 403567(CASP3)
VVP: 112934766(CASP3)
VLG: 121489913(CASP3)
AML: 100469056(CASP3)
UMR: 103680991(CASP3)
UAH: 113262259(CASP3)
ORO: 101371336(CASP3)
ELK: 111144607
MPUF: 101690858(CASP3)
EJU: 114206181(CASP3)
MLX: 118010074(CASP3)
FCA: 493932(CASP3)
PYU: 121039672(CASP3)
PTG: 102954729(CASP3)
PPAD: 109251018(CASP3)
AJU: 106979326(CASP3)
HHV: 120246375(CASP3)
BTA: 408016(CASP3)
BOM: 102287348(CASP3)
BIU: 109553316(CASP3)
BBUB: 102415768(CASP3)
CHX: 102177031(CASP3)
OAS: 114116869 443031(CASP3)
ODA: 120865721(CASP3)
CCAD: 122432443(CASP3)
SSC: 397244(CASP3)
CFR: 102520133(CASP3)
CBAI: 105067685(CASP3)
CDK: 105084433(CASP3)
BACU: 103019939(CASP3)
LVE: 103073819(CASP3)
OOR: 101289847(CASP3)
DLE: 111173401(CASP3)
PCAD: 102975528 102977692(CASP3)
ECB: 100034083(CASP3)
EPZ: 103549132(CASP3)
EAI: 106830081(CASP3)
MYB: 102258599(CASP3)
MYD: 102760961(CASP3)
MMYO: 118650210(CASP3)
MNA: 107535740(CASP3)
HAI: 109395706(CASP3)
DRO: 112306749(CASP3)
SHON: 118993073(CASP3)
AJM: 119036917(CASP3)
MMF: 118622705(CASP3)
PALE: 102897289(CASP3)
PGIG: 120618435(CASP3)
RAY: 107510456(CASP3)
MJV: 108389793(CASP3)
TOD: 119257947(CASP3)
LAV: 100672256(CASP3)
TMU: 101354307
MDO: 654273(CASP3) 654275
SHR: 100922500(CASP3) 100922757
PCW: 110222594(CASP3)
OAA: 100087105(CASP3)
GGA: 395476(CASP3)
PCOC: 116238124(CASP3)
MGP: 100548182(CASP3)
CJO: 107313280(CASP3)
NMEL: 110397291(CASP3)
APLA: 101805296(CASP3)
ACYG: 106035172(CASP3)
TGU: 100230799(CASP3)
LSR: 110477516(CASP3)
SCAN: 103825669(CASP3)
PMOA: 120497893(CASP3)
GFR: 102035830(CASP3)
FAB: 101808212(CASP3)
PHI: 102104322(CASP3)
PMAJ: 107203069(CASP3)
CCAE: 111945572(CASP3)
CCW: 104690575(CASP3)
ETL: 114055579(CASP3)
FPG: 101913355(CASP3) 101922533
FCH: 102050683 102056397(CASP3)
CLV: 102089427(CASP3)
EGZ: 104129473(CASP3)
NNI: 104021286(CASP3)
ACUN: 113479376(CASP3)
PADL: 103922530(CASP3) 103926227
AAM: 106484082(CASP3)
NPD: 112942609(CASP3)
ASN: 102369935 102383553(CASP3)
AMJ: 102572621(CASP3) 102576234(CASP14)
CPOO: 109309794(CASP3)
GGN: 109301036(CASP3)
PSS: 102463409
CMY: 102942062(CASP3)
CPIC: 101948246(CASP3)
TST: 117877835(CASP3)
CABI: 116836650(CASP3)
ACS: 100563931(casp3)
PVT: 110083865(CASP3)
PBI: 103049711(CASP3)
PMUR: 107302670(CASP3)
TSR: 106539846(CASP3)
PGUT: 117654566(CASP3)
PMUA: 114585959 114604250(CASP3)
ZVI: 118083396(CASP3)
GJA: 107115654(CASP3)
XLA: 100036910(casp3.2.L) 397720(casp3.2.S)
XTR: 100151728(casp3.2) 100486222(casp3.1)
DRE: 140621(casp3a) 566604(casp3b)
IPU: 100528811(casp3) 108260860
EEE: 113581517(casp3) 113586537
TRU: 446083(casp3)
LCO: 104928227 104936945(caspase-3)
NCC: 104959742 104967108(casp3)
CGOB: 115010976(casp3) 115014922
ELY: 117254954(casp3a) 117261186(casp3b)
PLEP: 121942065(casp3a) 121948074(casp3b) 121963193
ECRA: 117951380 117960699(casp3a)
MSAM: 119888653 119898808(casp3a)
CUD: 121506610 121508374(casp3a)
OLA: 100049215(casp3) 100049265
OML: 112137236(casp3a) 112153020
XCO: 114139499 114144355(casp3)
CVG: 107090480 107094160(casp3)
CTUL: 119774386(casp3a) 119794097
NFU: 107390752(casp3) 107397381
KMR: 108234461(casp3a) 108240012
CSEM: 103383467 103391460(casp3)
XGL: 120785392 120800586(casp3a)
MALB: 109957512(casp3) 109972113
SASA: 100194892(casp3) 106602722(CASP3) 106612018
OMY: 100653443(casp3b) 110497496 110525880 110534285(casp3a)
SNH: 120035095 120040359 120052764(casp3a) 120062476(casp3b)
ELS: 105006735(casp3) 105029385(casp3)
SFM: 108924572(casp3) 114912449
PKI: 111853593(casp3)
AANG: 118228056(casp3a) 118231090
LOC: 102691196
LCM: 106705928(CASP3)
CMK: 103187405(casp3) 103190313
APLC: 110975794
DPE: 113565090
DMN: 108158700
DHE: 111592184
MDE: 101899570
LCQ: 111676405
AARA: 120900924
AAG: 5567300
PPYR: 116180848
PXU: 106127530
DMK: 116936557
PVM: 113829172
HAZT: 108673778
VDE: 111249074
VJA: 111272320
MYI: 110452312
LAK: 106173180
EGL: EGR_04745
NVE: 5502486
EPA: 110247107
 » show all
Reference
PMID:7983002
  Authors
Fernandes-Alnemri T, Litwack G, Alnemri ES
  Title
CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.
  Journal
J Biol Chem 269:30761-4 (1994)
  Sequence
[hsa:836]
Reference
  Authors
Brentnall M, Rodriguez-Menocal L, De Guevara RL, Cepero E, Boise LH
  Title
Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis.
  Journal
BMC Cell Biol 14:32 (2013)
DOI:10.1186/1471-2121-14-32
  Sequence
[mmu:12367]
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