KEGG   PATHWAY: acar04142
Entry
acar04142                   Pathway                                
Name
Lysosome - Antrostomus carolinensis (chuck-will's-widow)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
acar04142  Lysosome
acar04142

Other DBs
GO: 0005764
Organism
Antrostomus carolinensis (chuck-will's-widow) [GN:acar]
Gene
104521333  ATP6V0A2; V-type proton ATPase 116 kDa subunit a [KO:K02154]
104522211  ATP6V0A1; V-type proton ATPase 116 kDa subunit a [KO:K02154]
104522230  ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
104524908  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
104527808  ATP6V1H; V-type proton ATPase subunit H [KO:K02144]
104522963  V-type proton ATPase subunit S1 [KO:K03662]
104520022  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
104519270  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
104530935  DMXL1; dmX-like protein 1 isoform X1 [KO:K24155]
104520491  DMXL2; dmX-like protein 2 isoform X1 [KO:K24155]
104528518  WDR7; WD repeat-containing protein 7 [KO:K24738]
104530725  LOW QUALITY PROTEIN: nuclear receptor coactivator 7 [KO:K25442]
104524292  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
104522986  CTSC; dipeptidyl peptidase 1 [KO:K01275] [EC:3.4.14.1]
104528979  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
104532132  cathepsin E [KO:K01382] [EC:3.4.23.34]
104528006  CTSE; cathepsin E [KO:K01382] [EC:3.4.23.34]
104531565  mast cell protease 1A [KO:K01319] [EC:3.4.21.20]
104528744  pro-cathepsin H [KO:K01366] [EC:3.4.22.16]
104527988  LOW QUALITY PROTEIN: cathepsin K-like [KO:K01371] [EC:3.4.22.38]
104530945  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
104519086  cathepsin L1 [KO:K01365] [EC:3.4.22.15]
104524885  CTSO; cathepsin O [KO:K01374] [EC:3.4.22.42]
104518069  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
104519116  CTSZ; cathepsin Z [KO:K08568] [EC:3.4.18.1]
104520729  LGMN; legumain isoform X1 [KO:K01369] [EC:3.4.22.34]
104531235  GLA; alpha-galactosidase A [KO:K01189] [EC:3.2.1.22]
104531167  beta-galactosidase [KO:K12309] [EC:3.2.1.23]
104531195  GAA; lysosomal alpha-glucosidase [KO:K12316] [EC:3.2.1.20]
104528727  LOW QUALITY PROTEIN: lysosomal acid glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]
104528573  IDUA; alpha-L-iduronidase [KO:K01217] [EC:3.2.1.76]
104524204  alpha-N-acetylgalactosaminidase [KO:K01204] [EC:3.2.1.49]
104525364  GALC; galactocerebrosidase [KO:K01202] [EC:3.2.1.46]
104522467  GUSB; beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
104524719  FUCA2; plasma alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
104517617  FUCA1; tissue alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
104520696  beta-hexosaminidase subunit alpha [KO:K12373] [EC:3.2.1.52]
104526474  HEXB; beta-hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
104524290  MANBA; beta-mannosidase [KO:K01192] [EC:3.2.1.25]
104518906  hyaluronidase-1 [KO:K01197] [EC:3.2.1.35]
104531149  hyaluronidase-1-like [KO:K01197] [EC:3.2.1.35]
104531564  LOW QUALITY PROTEIN: hyaluronidase-2-like [KO:K01197] [EC:3.2.1.35]
104527433  LOW QUALITY PROTEIN: hyaluronidase PH-20 [KO:K01197] [EC:3.2.1.35]
104527434  LOW QUALITY PROTEIN: hyaluronidase-4 [KO:K01197] [EC:3.2.1.35]
104530574  ARSB; arylsulfatase B [KO:K01135] [EC:3.1.6.12]
104521413  ARSG; arylsulfatase G [KO:K12381] [EC:3.1.6.-]
104517665  GALNS; N-acetylgalactosamine-6-sulfatase [KO:K01132] [EC:3.1.6.4]
104518915  GNS; N-acetylglucosamine-6-sulfatase [KO:K01137] [EC:3.1.6.14]
104529358  IDS; iduronate 2-sulfatase [KO:K01136] [EC:3.1.6.13]
104530284  lysosomal acid lipase/cholesteryl ester hydrolase [KO:K01052] [EC:3.1.1.13]
104521992  putative lysosomal acid lipase/cholesteryl ester hydrolase [KO:K01052] [EC:3.1.1.13]
104532067  PLA2G15; group XV phospholipase A2 [KO:K06129] [EC:3.1.1.5]
104524349  DNASE2B; deoxyribonuclease-2-beta [KO:K01158] [EC:3.1.22.1]
104519114  ACP2; lysosomal acid phosphatase [KO:K14410] [EC:3.1.3.2]
104528140  ASAH1; acid ceramidase [KO:K12348] [EC:3.5.1.23]
104518435  AGA; N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase [KO:K01444] [EC:3.5.1.26]
104531953  LOW QUALITY PROTEIN: prosaposin-like [KO:K12382]
104531952  prosaposin [KO:K12382]
104523071  GM2A; ganglioside GM2 activator [KO:K12383]
104532141  PPT1; palmitoyl-protein thioesterase 1 [KO:K01074] [EC:3.1.2.22]
104529101  LAMP2; lysosome-associated membrane glycoprotein 2 [KO:K06528]
104529654  LAMP1; LOW QUALITY PROTEIN: lysosome-associated membrane glycoprotein 1 [KO:K06528]
104526500  LAMP3; LOW QUALITY PROTEIN: lysosome-associated membrane glycoprotein 3 [KO:K06562]
104531801  SCARB2; lysosome membrane protein 2 [KO:K12384]
104520974  NPC1; NPC intracellular cholesterol transporter 1 [KO:K12385]
104519841  NPC2; NPC intracellular cholesterol transporter 2 [KO:K13443]
104523464  CTNS; cystinosin [KO:K12386]
104529022  SLC17A5; sialin [KO:K12301]
104529077  LAPTM4A; lysosomal-associated transmembrane protein 4A [KO:K12387]
104528618  LAPTM5; lysosomal-associated transmembrane protein 5 [KO:K12387]
104528916  LAPTM4B; lysosomal-associated transmembrane protein 4B [KO:K12387]
104529025  ABCA2; LOW QUALITY PROTEIN: ATP-binding cassette sub-family A member 2 [KO:K05642]
104524810  ABCB9; ATP-binding cassette sub-family B member 9 [KO:K05656]
104530981  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 [KO:K12305] [EC:3.6.1.6]
104522737  CLN5; ceroid-lipofuscinosis neuronal protein 5 [KO:K12390]
104523301  MFSD8; major facilitator superfamily domain-containing protein 8 [KO:K12307]
104527410  HGSNAT; heparan-alpha-glucosaminide N-acetyltransferase [KO:K10532] [EC:2.3.1.78]
104531956  SUMF1; formylglycine-generating enzyme [KO:K13444] [EC:1.8.3.7]
104532149  GNPTAB; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta [KO:K08239] [EC:2.7.8.17]
104522860  GNPTG; N-acetylglucosamine-1-phosphotransferase subunit gamma [KO:K10087]
104528724  NAGPA; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [KO:K01125] [EC:3.1.4.45]
104520734  IGF2R; cation-independent mannose-6-phosphate receptor [KO:K06564]
104531483  M6PR; LOW QUALITY PROTEIN: cation-dependent mannose-6-phosphate receptor [KO:K10089]
104525697  CLTA; clathrin light chain A [KO:K04644]
104521261  CLTB; clathrin light chain B [KO:K04645]
104524844  LOW QUALITY PROTEIN: clathrin heavy chain 1 [KO:K04646]
104522401  CLTC; clathrin heavy chain 1 [KO:K04646]
104518357  AP1G1; AP-1 complex subunit gamma-1 isoform X1 [KO:K12391]
104523282  AP1M1; AP-1 complex subunit mu-1 [KO:K12393]
104520042  AP1S2; AP-1 complex subunit sigma-2 isoform X1 [KO:K12394]
104517541  AP-1 complex subunit sigma-1A [KO:K12394]
104530527  AP1S3; AP-1 complex subunit sigma-3 [KO:K12395]
104518288  AP3D1; AP-3 complex subunit delta-1 [KO:K12396]
104529822  AP-3 complex subunit beta-2 [KO:K12397]
104526110  AP-3 complex subunit beta-1-like [KO:K12397]
104531364  AP3M2; AP-3 complex subunit mu-2 [KO:K12398]
104519897  AP-3 complex subunit mu-1 [KO:K12398]
104519651  AP-3 complex subunit sigma-1 [KO:K12399]
104518433  AP4E1; AP-4 complex subunit epsilon-1 [KO:K12400]
104524090  AP4B1; LOW QUALITY PROTEIN: AP-4 complex subunit beta-1 [KO:K12401]
104518737  AP4S1; AP-4 complex subunit sigma-1 [KO:K12403]
104521308  GGA1; ADP-ribosylation factor-binding protein GGA1 isoform X1 [KO:K12404]
104527695  GGA3; ADP-ribosylation factor-binding protein GGA3 [KO:K12404]
104522751  GGA2; ADP-ribosylation factor-binding protein GGA2 [KO:K12404]
104518501  MCOLN1; mucolipin-1 [KO:K04992]
104519320  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 10.1038/s41577-021-00626-8 (2021)
DOI:10.1038/s41577-021-00626-8
Related
pathway
acar00511  Other glycan degradation
acar00531  Glycosaminoglycan degradation
acar04130  SNARE interactions in vesicular transport
acar04140  Autophagy - animal
acar04144  Endocytosis
KO pathway
ko04142   
LinkDB

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