KEGG   PATHWAY: adr04141
Entry
adr04141                    Pathway                                
Name
Protein processing in endoplasmic reticulum - Apis dorsata (giant honeybee)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
adr04141  Protein processing in endoplasmic reticulum
adr04141

Other DBs
GO: 0030433 0034976
Organism
Apis dorsata (giant honeybee) [GN:adr]
Gene
102672829  protein transport protein Sec61 subunit alpha [KO:K10956]
102671753  protein transport protein Sec61 subunit beta [KO:K09481]
102675508  protein transport protein Sec61 subunit gamma [KO:K07342]
102680719  translocation protein SEC62 isoform X1 [KO:K12275]
102676192  translocation protein SEC63 homolog [KO:K09540]
102681053  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 [KO:K12666]
102677197  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [KO:K12667]
102672822  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
102676707  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [KO:K12670]
102672493  LOW QUALITY PROTEIN: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151] [EC:2.4.99.18]
102680016  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
102675211  tumor suppressor candidate 3 isoform X1 [KO:K19478]
102681187  oligosaccharyltransferase complex subunit ostc-A [KO:K26501]
116185619  transmembrane protein 258 [KO:K26502]
102677647  mannosyl-oligosaccharide glucosidase GCS1 [KO:K01228] [EC:3.2.1.106]
102671081  nucleotide exchange factor SIL1 [KO:K14001]
102677164  hypoxia up-regulated protein 1 isoform X1 [KO:K09486]
102680505  endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
102680219  dnaJ homolog shv [KO:K09517]
102672559  dnaJ homolog subfamily C member 1-like [KO:K09521]
102675891  dnaJ homolog subfamily C member 3 [KO:K09523]
102671904  endoplasmin [KO:K09487]
102679023  neutral alpha-glucosidase AB isoform X2 [KO:K05546] [EC:3.2.1.207]
102675638  glucosidase 2 subunit beta [KO:K08288]
102673179  calnexin-like isoform X1 [KO:K08054]
102675746  protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
102677868  calreticulin [KO:K08057]
102673139  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA-like [KO:K01230] [EC:3.2.1.113]
102674268  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase [KO:K23741] [EC:3.2.1.209]
102680328  vesicular integral-membrane protein VIP36 isoform X1 [KO:K10082]
102679213  protein ERGIC-53 [KO:K10080]
102677616  prolactin regulatory element-binding protein [KO:K14003]
102673718  GTP-binding protein SAR1 [KO:K07953] [EC:3.6.5.-]
102680562  protein SEC13 homolog [KO:K14004]
102674965  protein transport protein Sec31A [KO:K14005]
102675275  protein transport protein Sec23A isoform X1 [KO:K14006]
102681923  protein transport protein Sec24B [KO:K14007]
102681268  LOW QUALITY PROTEIN: protein transport protein Sec24C [KO:K14007]
102678777  UDP-glucose:glycoprotein glucosyltransferase isoform X1 [KO:K11718] [EC:2.4.1.-]
102672502  ER degradation-enhancing alpha-mannosidase-like protein 2 [KO:K10085]
102675132  ER degradation-enhancing alpha-mannosidase-like protein 3 [KO:K10086]
102675386  protein disulfide-isomerase [KO:K09580] [EC:5.3.4.1]
102672749  protein disulfide-isomerase A6 homolog [KO:K09584] [EC:5.3.4.1]
102671458  endoplasmic reticulum resident protein 29 [KO:K09586]
102671741  thioredoxin domain-containing protein 5 [KO:K13984] [EC:5.3.4.1]
102672213  ero1-like protein [KO:K10950] [EC:1.8.4.-]
102674050  endoplasmic reticulum lectin 1 isoform X1 [KO:K14008]
102671319  translocon-associated protein subunit alpha [KO:K13249]
102671552  translocon-associated protein subunit beta [KO:K13250]
102675056  translocon-associated protein subunit gamma [KO:K13251]
102676018  translocon-associated protein subunit delta [KO:K04571]
102676132  B-cell receptor-associated protein 31-like [KO:K14009]
102676506  B-cell receptor-associated protein 31-like [KO:K14009]
102681519  translocating chain-associated membrane protein 1-like 1 [KO:K14010]
102671174  derlin-1 [KO:K11519]
102673339  derlin-2 [KO:K13989]
102673974  UBX domain-containing protein 4 [KO:K24348]
102677328  UBX domain-containing protein 1 [KO:K24348]
102681794  UBX domain-containing protein 6 [KO:K14011]
102674338  NSFL1 cofactor p47 isoform X1 [KO:K14012]
102680939  small VCP/p97-interacting protein [KO:K14014]
102671765  transitional endoplasmic reticulum ATPase TER94 [KO:K13525]
102671772  nuclear protein localization protein 4 homolog [KO:K14015]
102677620  ubiquitin recognition factor in ER-associated degradation protein 1 isoform X2 [KO:K14016]
102674310  heat shock 70 kDa protein cognate 4-like [KO:K03283]
102676033  heat shock 70 kDa protein cognate 4 [KO:K03283]
102681295  dnaJ homolog subfamily A member 1 [KO:K09502]
102677477  dnaJ protein homolog 1 [KO:K09507]
102676876  dnaJ homolog subfamily B member 12 [KO:K09518]
102671187  dnaJ homolog subfamily C member 5-like isoform X1 [KO:K09525]
102673994  heat shock protein 83 [KO:K04079]
102675325  heat shock protein 83-like [KO:K04079]
102680519  heat shock 70 kDa protein 4 isoform X1 [KO:K09485]
102678625  BAG family molecular chaperone regulator 2 [KO:K09556]
102681403  hsp70-binding protein 1 [KO:K09562]
102671076  protein lethal(2)essential for life-like isoform X2 [KO:K09542]
102670824  protein lethal(2)essential for life-like [KO:K09542]
102676666  protein lethal(2)essential for life-like [KO:K09542]
102676805  protein lethal(2)essential for life-like [KO:K09542]
102676941  protein lethal(2)essential for life-like [KO:K09542]
102677083  protein lethal(2)essential for life-like [KO:K09542]
102677234  protein lethal(2)essential for life-like [KO:K09542]
102677366  protein lethal(2)essential for life-like [KO:K09542]
102677505  protein lethal(2)essential for life-like [KO:K09542]
102673206  ubiquitin thioesterase OTU1 [KO:K13719] [EC:3.1.2.-]
102676845  phospholipase A-2-activating protein [KO:K14018]
102670617  UV excision repair protein RAD23 homolog B-like isoform X1 [KO:K10839]
102672959  ubiquilin-4 [KO:K04523]
102673833  peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase isoform X1 [KO:K01456] [EC:3.5.1.52]
102675100  ataxin-3-like isoform X1 [KO:K11863] [EC:3.4.22.-]
102675055  ubiquitin conjugation factor E4 B isoform X1 [KO:K10597] [EC:2.3.2.27]
102681832  eukaryotic translation initiation factor 2-alpha kinase [KO:K08860] [EC:2.7.11.1]
102673115  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
102676469  activating transcription factor of chaperone isoform X1 [KO:K04374]
102681848  cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
102680031  wolframin isoform X1 [KO:K14020]
102674817  membrane-bound transcription factor site-1 protease [KO:K08653] [EC:3.4.21.112]
102675167  membrane-bound transcription factor site-2 protease [KO:K07765] [EC:3.4.24.85]
102671643  X-box-binding protein 1 isoform X1 [KO:K09027]
102680634  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
102671856  mitogen-activated protein kinase kinase kinase 15 isoform X1 [KO:K04426] [EC:2.7.11.25]
102675503  dual specificity mitogen-activated protein kinase kinase hemipterous-like [KO:K04431] [EC:2.7.12.2]
102673534  stress-activated protein kinase JNK isoform X1 [KO:K04440] [EC:2.7.11.24]
102676486  E3 ubiquitin-protein ligase MARCH6 [KO:K10661] [EC:2.3.2.27]
102680885  ubiquitin-conjugating enzyme E2 J1-like isoform X1 [KO:K10578] [EC:2.3.2.23]
102675202  ubiquitin-conjugating enzyme E2 J2-like [KO:K04554] [EC:2.3.2.23]
102677381  ubiquitin-conjugating enzyme E2 G1 isoform X1 [KO:K10575] [EC:2.3.2.23]
102677411  ubiquitin-conjugating enzyme E2 G2 isoform X1 [KO:K04555] [EC:2.3.2.23]
102674093  E3 ubiquitin-protein ligase synoviolin A isoform X1 [KO:K10601] [EC:2.3.2.27]
102671299  E3 ubiquitin-protein ligase RNF185-like [KO:K10666] [EC:2.3.2.27]
102672681  uncharacterized protein LOC102672681 [KO:K14025]
102681658  protein sel-1 homolog 1 [KO:K14026]
102673227  E3 ubiquitin-protein ligase AMFR-like [KO:K10636] [EC:2.3.2.36]
102671207  E3 ubiquitin-protein ligase CHIP isoform X2 [KO:K09561] [EC:2.3.2.27]
102671611  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
102675252  E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
102681185  RING-box protein 1A isoform X1 [KO:K03868] [EC:2.3.2.32]
102676121  cullin-1 [KO:K03347]
102676796  S-phase kinase-associated protein 1 [KO:K03094]
102674981  F-box only protein 6-like isoform X1 [KO:K10100]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
adr00510  N-Glycan biosynthesis
adr03050  Proteasome
adr03060  Protein export
KO pathway
ko04141   
LinkDB

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