KEGG   PATHWAY: aprc00270
Entry
aprc00270                   Pathway                                
Name
Cysteine and methionine metabolism - Abrus precatorius (Indian licorice)
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
Pathway map
aprc00270  Cysteine and methionine metabolism
aprc00270

Module
aprc_M00021  Cysteine biosynthesis, serine => cysteine [PATH:aprc00270]
aprc_M00034  Methionine salvage pathway [PATH:aprc00270]
aprc_M00368  Ethylene biosynthesis, methionine => ethylene [PATH:aprc00270]
Other DBs
GO: 0006534 0006555
Organism
Abrus precatorius (Indian licorice) [GN:aprc]
Gene
113847236  serine acetyltransferase 1, chloroplastic-like [KO:K00640] [EC:2.3.1.30]
113859314  serine acetyltransferase 2-like [KO:K00640] [EC:2.3.1.30]
113849619  serine acetyltransferase 5 [KO:K00640] [EC:2.3.1.30]
113854824  serine acetyltransferase 1, chloroplastic-like [KO:K00640] [EC:2.3.1.30]
113869215  serine acetyltransferase 2-like isoform X1 [KO:K00640] [EC:2.3.1.30]
113858756  cysteine synthase, chloroplastic/chromoplastic-like isoform X1 [KO:K01738] [EC:2.5.1.47]
113858757  cysteine synthase [KO:K01738] [EC:2.5.1.47]
113870494  cysteine synthase-like [KO:K01738] [EC:2.5.1.47]
113846961  cysteine synthase 2 [KO:K01738] [EC:2.5.1.47]
113861913  cysteine synthase isoform X1 [KO:K01738] [EC:2.5.1.47]
113873720  cysteine synthase-like isoform X1 [KO:K01738] [EC:2.5.1.47]
113873775  cysteine synthase-like isoform X1 [KO:K01738] [EC:2.5.1.47]
113856658  cysteine synthase-like isoform X1 [KO:K01738] [EC:2.5.1.47]
113860583  bifunctional L-3-cyanoalanine synthase/cysteine synthase 1, mitochondrial [KO:K13034] [EC:2.5.1.47 4.4.1.9]
113861844  cystathionine beta-lyase, chloroplastic isoform X1 [KO:K01760] [EC:4.4.1.13]
113872926  homocysteine S-methyltransferase 3-like [KO:K00547] [EC:2.1.1.10]
113861833  selenocysteine methyltransferase-like [KO:K00547] [EC:2.1.1.10]
113869761  homocysteine S-methyltransferase 1 [KO:K00547] [EC:2.1.1.10]
113860908  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 1 isoform X1 [KO:K00549] [EC:2.1.1.14]
113867031  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase-like [KO:K00549] [EC:2.1.1.14]
113855581  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 1-like [KO:K00549] [EC:2.1.1.14]
113870938  S-adenosylmethionine synthase 3 [KO:K00789] [EC:2.5.1.6]
113861067  S-adenosylmethionine synthase-like [KO:K00789] [EC:2.5.1.6]
113873733  S-adenosylmethionine synthase 1-like [KO:K00789] [EC:2.5.1.6]
113863044  S-adenosylmethionine synthase 3 [KO:K00789] [EC:2.5.1.6]
113863966  S-adenosylmethionine synthase [KO:K00789] [EC:2.5.1.6]
113846318  S-adenosylmethionine synthase [KO:K00789] [EC:2.5.1.6]
113869613  S-adenosylmethionine synthase [KO:K00789] [EC:2.5.1.6]
113868613  S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]
113847971  S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
113860758  S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
113874661  S-adenosylmethionine decarboxylase proenzyme 4-like [KO:K01611] [EC:4.1.1.50]
113852149  S-adenosylmethionine decarboxylase proenzyme 4-like [KO:K01611] [EC:4.1.1.50]
113874828  spermidine synthase 1-like [KO:K00797] [EC:2.5.1.16]
113851419  spermidine synthase 2-like [KO:K00797] [EC:2.5.1.16]
113868436  spermine synthase [KO:K00797] [EC:2.5.1.16]
113868857  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
113857909  spermidine synthase 2 [KO:K00797] [EC:2.5.1.16]
113861932  nicotianamine synthase [KO:K05953] [EC:2.5.1.43]
113853087  nicotianamine synthase-like [KO:K05953] [EC:2.5.1.43]
113856646  nicotianamine synthase-like [KO:K05953] [EC:2.5.1.43]
113864404  5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 1 [KO:K01244] [EC:3.2.2.16]
113872671  methylthioribose kinase [KO:K00899] [EC:2.7.1.100]
113849020  methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]
113865012  probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1 isoform X1 [KO:K16054] [EC:4.2.1.109 3.1.3.77]
113853943  probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1 isoform X1 [KO:K16054] [EC:4.2.1.109 3.1.3.77]
113871000  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 2 [KO:K08967] [EC:1.13.11.53 1.13.11.54]
113871332  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1 isoform X1 [KO:K08967] [EC:1.13.11.53 1.13.11.54]
113846281  uncharacterized protein LOC113846281 [KO:K23977] [EC:2.6.1.117]
113865993  probable aminotransferase TAT2 isoform X1 [KO:K00815] [EC:2.6.1.5]
113853632  aromatic aminotransferase ISS1-like isoform X1 [KO:K00837] [EC:2.6.1.-]
113857126  aromatic aminotransferase ISS1-like isoform X1 [KO:K00837] [EC:2.6.1.-]
113873241  methionine gamma-lyase-like [KO:K01761] [EC:4.4.1.11]
113857874  methionine gamma-lyase-like [KO:K01761] [EC:4.4.1.11]
113858168  DNA (cytosine-5)-methyltransferase CMT2 [KO:K00558] [EC:2.1.1.37]
113870312  DNA (cytosine-5)-methyltransferase CMT3 [KO:K00558] [EC:2.1.1.37]
113866806  DNA (cytosine-5)-methyltransferase CMT3 [KO:K00558] [EC:2.1.1.37]
113867535  DNA (cytosine-5)-methyltransferase 1-like [KO:K00558] [EC:2.1.1.37]
113863427  uncharacterized protein LOC113863427 [KO:K17398] [EC:2.1.1.37]
113849119  adenosylhomocysteinase-like [KO:K01251] [EC:3.13.2.1]
113853972  adenosylhomocysteinase isoform X1 [KO:K01251] [EC:3.13.2.1]
113862976  1-aminocyclopropane-1-carboxylate synthase 1-like [KO:K20772] [EC:4.4.1.14]
113850216  1-aminocyclopropane-1-carboxylate synthase-like [KO:K20772] [EC:4.4.1.14]
113854068  1-aminocyclopropane-1-carboxylate synthase [KO:K20772] [EC:4.4.1.14]
113869425  1-aminocyclopropane-1-carboxylate synthase-like [KO:K20772] [EC:4.4.1.14]
113859086  1-aminocyclopropane-1-carboxylate synthase 3-like [KO:K01762] [EC:4.4.1.14]
113866254  1-aminocyclopropane-1-carboxylate synthase 3-like [KO:K01762] [EC:4.4.1.14]
113855769  1-aminocyclopropane-1-carboxylate synthase 7-like [KO:K01762] [EC:4.4.1.14]
113867669  1-aminocyclopropane-1-carboxylate synthase 7-like [KO:K01762] [EC:4.4.1.14]
113869663  1-aminocyclopropane-1-carboxylate synthase 3-like [KO:K01762] [EC:4.4.1.14]
113848032  1-aminocyclopropane-1-carboxylate oxidase isoform X1 [KO:K05933] [EC:1.14.17.4]
113848101  1-aminocyclopropane-1-carboxylate oxidase-like [KO:K05933] [EC:1.14.17.4]
113848132  1-aminocyclopropane-1-carboxylate oxidase-like [KO:K05933] [EC:1.14.17.4]
113874873  1-aminocyclopropane-1-carboxylate oxidase [KO:K05933] [EC:1.14.17.4]
113852871  1-aminocyclopropane-1-carboxylate oxidase 5 isoform X1 [KO:K05933] [EC:1.14.17.4]
113855602  1-aminocyclopropane-1-carboxylate oxidase-like [KO:K05933] [EC:1.14.17.4]
113867580  1-aminocyclopropane-1-carboxylate oxidase [KO:K05933] [EC:1.14.17.4]
113867978  1-aminocyclopropane-1-carboxylate oxidase 1 [KO:K05933] [EC:1.14.17.4]
113861905  aspartokinase 2, chloroplastic-like isoform X1 [KO:K00928] [EC:2.7.2.4]
113867259  aspartokinase 2, chloroplastic-like isoform X1 [KO:K00928] [EC:2.7.2.4]
113849607  bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplastic-like isoform X1 [KO:K12524] [EC:2.7.2.4 1.1.1.3]
113856677  bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic-like isoform X1 [KO:K12524] [EC:2.7.2.4 1.1.1.3]
113853988  uncharacterized protein LOC113853988 [KO:K00133] [EC:1.2.1.11]
113863926  cystathionine gamma-synthase 1, chloroplastic [KO:K01739] [EC:2.5.1.48]
113858401  branched-chain amino acid aminotransferase 2, chloroplastic-like [KO:K00826] [EC:2.6.1.42]
113858581  branched-chain-amino-acid aminotransferase 6-like [KO:K00826] [EC:2.6.1.42]
113859927  branched-chain amino acid aminotransferase 1, mitochondrial-like [KO:K00826] [EC:2.6.1.42]
113865197  branched-chain-amino-acid aminotransferase 2, chloroplastic-like isoform X1 [KO:K00826] [EC:2.6.1.42]
113868885  branched-chain amino acid aminotransferase 2, chloroplastic-like isoform X1 [KO:K00826] [EC:2.6.1.42]
113849699  alanine--glyoxylate aminotransferase 2 homolog 2, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
113849938  alanine--glyoxylate aminotransferase 2 homolog 2, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
113873831  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
113863270  alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
113851640  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
113854610  glutamate--cysteine ligase, chloroplastic [KO:K01919] [EC:6.3.2.2]
113863435  glutathione synthetase, chloroplastic-like [KO:K21456] [EC:6.3.2.3]
113863436  glutathione synthetase, chloroplastic-like [KO:K21456] [EC:6.3.2.3]
113864525  aspartate aminotransferase 1 [KO:K14454] [EC:2.6.1.1]
113850968  aspartate aminotransferase, mitochondrial-like [KO:K14455] [EC:2.6.1.1]
113857951  aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
113845856  aspartate aminotransferase P2, mitochondrial isoform X1 [KO:K00811] [EC:2.6.1.1]
113855253  thiosulfate/3-mercaptopyruvate sulfurtransferase 2-like isoform X1 [KO:K01011] [EC:2.8.1.1 2.8.1.2]
113849921  L-lactate dehydrogenase A-like [KO:K00016] [EC:1.1.1.27]
113869903  L-lactate dehydrogenase A-like [KO:K00016] [EC:1.1.1.27]
113850487  D-cysteine desulfhydrase 2, mitochondrial [KO:K05396] [EC:4.4.1.15]
113854827  bifunctional D-cysteine desulfhydrase/1-aminocyclopropane-1-carboxylate deaminase, mitochondrial [KO:K05396] [EC:4.4.1.15]
113872820  L-cysteine desulfhydrase-like [KO:K22207] [EC:4.4.1.28]
113862943  probable L-cysteine desulfhydrase, chloroplastic [KO:K22207] [EC:4.4.1.28]
113871160  malate dehydrogenase, cytoplasmic isoform X1 [KO:K00025] [EC:1.1.1.37]
113871346  malate dehydrogenase-like [KO:K00025] [EC:1.1.1.37]
113850251  LOW QUALITY PROTEIN: malate dehydrogenase, cytoplasmic-like [KO:K00025] [EC:1.1.1.37]
113846473  malate dehydrogenase, chloroplastic [KO:K00026] [EC:1.1.1.37]
113859114  malate dehydrogenase 2, peroxisomal isoform X1 [KO:K00026] [EC:1.1.1.37]
113864439  malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]
113868377  malate dehydrogenase, glyoxysomal isoform X1 [KO:K00026] [EC:1.1.1.37]
113860942  probable S-sulfocysteine synthase, chloroplastic [KO:K22846] [EC:2.5.1.144]
113862220  probable arabinosyltransferase ARAD1 [KO:K22846] [EC:2.5.1.144]
113870748  D-3-phosphoglycerate dehydrogenase 1, chloroplastic [KO:K00058] [EC:1.1.1.95 1.1.1.399]
113857133  D-3-phosphoglycerate dehydrogenase 1, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
113859186  phosphoserine aminotransferase 1, chloroplastic-like [KO:K00831] [EC:2.6.1.52]
113869202  phosphoserine aminotransferase 2, chloroplastic-like [KO:K00831] [EC:2.6.1.52]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03431  S-Inosyl-L-homocysteine
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05324  Nicotianamine
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11437  1-Deoxy-D-xylulose 5-phosphate
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
C22359  S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
PMID:15102328
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
PMID:14551435
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
PMID:12022921
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
PMID:12670965
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
PMID:17169919
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
PMID:17030798
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
PMID:18625006
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
PMID:18391471
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
PMID:10613873
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
PMID:12644499
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
PMID:18520135
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:19270684
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
aprc00010  Glycolysis / Gluconeogenesis
aprc00250  Alanine, aspartate and glutamate metabolism
aprc00260  Glycine, serine and threonine metabolism
aprc00290  Valine, leucine and isoleucine biosynthesis
aprc00430  Taurine and hypotaurine metabolism
aprc00480  Glutathione metabolism
aprc00620  Pyruvate metabolism
aprc00640  Propanoate metabolism
aprc00770  Pantothenate and CoA biosynthesis
aprc00900  Terpenoid backbone biosynthesis
aprc00920  Sulfur metabolism
KO pathway
ko00270   
LinkDB

DBGET integrated database retrieval system