KEGG   PATHWAY: aqu00270
Entry
aqu00270                    Pathway                                
Name
Cysteine and methionine metabolism - Amphimedon queenslandica (sponge)
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
Pathway map
aqu00270  Cysteine and methionine metabolism
aqu00270

Module
aqu_M00034  Methionine salvage pathway [PATH:aqu00270]
aqu_M00035  Methionine degradation [PATH:aqu00270]
aqu_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:aqu00270]
Other DBs
GO: 0006534 0006555
Organism
Amphimedon queenslandica (sponge) [GN:aqu]
Gene
100634700  cysteine synthase 1-like [KO:K01738] [EC:2.5.1.47]
100634445  cystathionine gamma-lyase-like [KO:K01758] [EC:4.4.1.1]
100634864  LOW QUALITY PROTEIN: putative cystathionine gamma-lyase 2 [KO:K01758] [EC:4.4.1.1]
100641141  kynurenine--oxoglutarate transaminase 3-like [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
100634898  cystathionine beta-synthase-like [KO:K01697] [EC:4.2.1.22]
100635325  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
100640174  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
100640299  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
100638323  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
100639967  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
105315720  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
100638667  uncharacterized protein LOC100638667 [KO:K00547] [EC:2.1.1.10]
100631542  LOW QUALITY PROTEIN: methionine synthase-like [KO:K00548] [EC:2.1.1.13]
100642068  methionine synthase-like [KO:K00548] [EC:2.1.1.13]
100638371  S-adenosylmethionine synthase 1-like [KO:K00789] [EC:2.5.1.6]
100634988  methionine adenosyltransferase 2 subunit beta-like [KO:K00789] [EC:2.5.1.6]
100631946  S-adenosylmethionine synthase-like [KO:K00789] [EC:2.5.1.6]
100632072  S-adenosylmethionine synthase-like [KO:K00789] [EC:2.5.1.6]
100633381  S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
100631769  spermidine synthase-like [KO:K00797] [EC:2.5.1.16]
100641892  spermidine synthase-like [KO:K00797] [EC:2.5.1.16]
100631894  spermidine synthase-like [KO:K00797] [EC:2.5.1.16]
100634413  spermidine synthase-like [KO:K00797] [EC:2.5.1.16]
109590906  spermidine synthase-like [KO:K00797] [EC:2.5.1.16]
105316470  uncharacterized protein LOC105316470 [KO:K00899] [EC:2.7.1.100]
100632709  S-methyl-5'-thioadenosine phosphorylase-like [KO:K00772] [EC:2.4.2.28]
100632807  methylthioribose-1-phosphate isomerase-like [KO:K08963] [EC:5.3.1.23]
105311926  methylthioribulose-1-phosphate dehydratase-like [KO:K08964] [EC:4.2.1.109]
100634727  enolase-phosphatase E1-like isoform X1 [KO:K09880] [EC:3.1.3.77]
100634313  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase-like [KO:K08967] [EC:1.13.11.53 1.13.11.54]
100635686  tyrosine aminotransferase-like [KO:K00815] [EC:2.6.1.5]
100636382  LOW QUALITY PROTEIN: DNA (cytosine-5)-methyltransferase 1-like [KO:K00558] [EC:2.1.1.37]
100636742  DNA (cytosine-5)-methyltransferase 1-like isoform X1 [KO:K00558] [EC:2.1.1.37]
100642138  DNA (cytosine-5)-methyltransferase 3A-like isoform X1 [KO:K17398] [EC:2.1.1.37]
100632277  adenosylhomocysteinase B-like [KO:K01251] [EC:3.13.2.1]
100640668  adenosylhomocysteinase 2-like [KO:K01251] [EC:3.13.2.1]
100641810  branched-chain-amino-acid aminotransferase, cytosolic-like [KO:K00826] [EC:2.6.1.42]
100631942  alanine--glyoxylate aminotransferase 2, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
100639866  glutamate--cysteine ligase catalytic subunit-like [KO:K11204] [EC:6.3.2.2]
100641555  glutamate--cysteine ligase catalytic subunit-like [KO:K11204] [EC:6.3.2.2]
100637460  glutamate--cysteine ligase regulatory subunit-like [KO:K11205]
100638272  glutathione synthetase-like [KO:K21456] [EC:6.3.2.3]
100637150  cysteine dioxygenase 1-like [KO:K00456] [EC:1.13.11.20]
100631884  aspartate aminotransferase, cytoplasmic-like [KO:K14454] [EC:2.6.1.1]
100631759  probable aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
100642104  aspartate aminotransferase, mitochondrial-like [KO:K14455] [EC:2.6.1.1]
100639495  aspartate aminotransferase, mitochondrial-like [KO:K14455] [EC:2.6.1.1]
100637855  aspartate aminotransferase, mitochondrial-like isoform X2 [KO:K14455] [EC:2.6.1.1]
100633040  3-mercaptopyruvate sulfurtransferase-like [KO:K01011] [EC:2.8.1.1 2.8.1.2]
105314270  thiosulfate sulfurtransferase-like [KO:K01011] [EC:2.8.1.1 2.8.1.2]
100640049  3-mercaptopyruvate sulfurtransferase-like [KO:K01011] [EC:2.8.1.1 2.8.1.2]
100641364  bifunctional D-cysteine desulfhydrase/1-aminocyclopropane-1-carboxylate deaminase, mitochondrial-like [KO:K05396] [EC:4.4.1.15]
100641112  bifunctional D-cysteine desulfhydrase/1-aminocyclopropane-1-carboxylate deaminase, mitochondrial-like [KO:K05396] [EC:4.4.1.15]
100641492  bifunctional D-cysteine desulfhydrase/1-aminocyclopropane-1-carboxylate deaminase, mitochondrial-like [KO:K05396] [EC:4.4.1.15]
100634704  putative L-cysteine desulfhydrase 1 [KO:K22207] [EC:4.4.1.28]
100642116  putative L-cysteine desulfhydrase 2 [KO:K22207] [EC:4.4.1.28]
105315073  putative L-cysteine desulfhydrase 1 [KO:K22207] [EC:4.4.1.28]
100639823  malate dehydrogenase, cytoplasmic-like [KO:K00025] [EC:1.1.1.37]
100641593  malate dehydrogenase, mitochondrial-like [KO:K00026] [EC:1.1.1.37]
100634528  serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
100635774  D-3-phosphoglycerate dehydrogenase-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
100633156  phosphoserine aminotransferase-like [KO:K00831] [EC:2.6.1.52]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03431  S-Inosyl-L-homocysteine
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05324  Nicotianamine
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11437  1-Deoxy-D-xylulose 5-phosphate
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
C22359  S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
aqu00010  Glycolysis / Gluconeogenesis
aqu00250  Alanine, aspartate and glutamate metabolism
aqu00260  Glycine, serine and threonine metabolism
aqu00290  Valine, leucine and isoleucine biosynthesis
aqu00430  Taurine and hypotaurine metabolism
aqu00480  Glutathione metabolism
aqu00620  Pyruvate metabolism
aqu00640  Propanoate metabolism
aqu00770  Pantothenate and CoA biosynthesis
aqu00900  Terpenoid backbone biosynthesis
aqu00920  Sulfur metabolism
KO pathway
ko00270   
LinkDB

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