KEGG   PATHWAY: arow04145
Entry
arow04145                   Pathway                                
Name
Phagosome - Apteryx rowi (Okarito brown kiwi)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
arow04145  Phagosome
arow04145

Other DBs
GO: 0045335
Organism
Apteryx rowi (Okarito brown kiwi) [GN:arow]
Gene
112975416  VAMP3; vesicle-associated membrane protein 3 [KO:K13505]
112971184  STX12; syntaxin-12 isoform X1 [KO:K13813]
112969466  STX7; syntaxin-7 isoform X1 [KO:K08488]
112966901  ACTG1; actin, cytoplasmic 2 [KO:K05692]
112967343  actin, cytoplasmic type 5 [KO:K05692]
112974241  ACTB; actin, cytoplasmic 1 [KO:K05692]
112971904  STX18; syntaxin-18 isoform X1 [KO:K08492]
112977148  SEC22B; vesicle-trafficking protein SEC22b [KO:K08517]
112962885  LOW QUALITY PROTEIN: class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
112966136  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
112962344  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
112963225  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
112963733  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
112963734  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
112963740  HLA class II histocompatibility antigen, DR alpha chain-like isoform X1 [KO:K06752]
112963806  class II histocompatibility antigen, B-L beta chain-like [KO:K06752]
112963807  HLA class II histocompatibility antigen, DQ alpha 1 chain-like [KO:K06752]
112965201  rano class II histocompatibility antigen, A beta chain-like [KO:K06752]
112966631  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
112966632  LOW QUALITY PROTEIN: class II histocompatibility antigen, B-L beta chain-like [KO:K06752]
112961735  class II histocompatibility antigen, B-L beta chain-like [KO:K06752]
112961741  class II histocompatibility antigen, B-L beta chain-like isoform X1 [KO:K06752]
112961742  class II histocompatibility antigen, M beta 1 chain-like [KO:K06752]
112962247  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
112962249  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
112972069  RAB5A; ras-related protein Rab-5A [KO:K07887]
112961075  RAB5B; ras-related protein Rab-5B [KO:K07888]
112968726  RAB5C; ras-related protein Rab-5C [KO:K07889]
112962381  EEA1; early endosome antigen 1 isoform X1 [KO:K12478]
112977860  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
112968501  TFRC; transferrin receptor protein 1 isoform X1 [KO:K06503]
112974782  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
112965950  ATP6V1A; V-type proton ATPase catalytic subunit A isoform X1 [KO:K02145] [EC:7.1.2.2]
112974578  V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
112973642  ATP6V1B2; V-type proton ATPase subunit B, brain isoform isoform X1 [KO:K02147]
112968385  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
112976410  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
112966525  ATP6V1C1; V-type proton ATPase subunit C 1 isoform X1 [KO:K02148]
112975004  ATP6V1D; V-type proton ATPase subunit D isoform X1 [KO:K02149]
112968313  ATP6V1E1; V-type proton ATPase subunit E 1 isoform X1 [KO:K02150]
112976537  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
112962967  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
112964180  V-type proton ATPase subunit e 2 [KO:K02153]
112964688  ATP6V0E1; V-type proton ATPase subunit e 1 isoform X1 [KO:K02153]
112971632  TCIRG1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
112962530  ATP6V0A2; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
112968718  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
112974678  ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
112973027  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
112973284  ATP6V0D1; V-type proton ATPase subunit d 1 isoform X1 [KO:K02146]
112973437  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
112968881  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
112975987  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit isoform X1 [KO:K03661]
112960471  V-type proton ATPase subunit S1-like [KO:K03662]
112961046  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
112970756  RAB7A; ras-related protein Rab-7a isoform X1 [KO:K07897]
112971659  RAB7B; ras-related protein Rab-7b isoform X1 [KO:K07898]
112960679  RILP; rab-interacting lysosomal protein [KO:K13883]
112972748  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 isoform X1 [KO:K10413]
112971947  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 [KO:K10414]
112963904  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
112969387  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 [KO:K10415]
112977508  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 isoform X1 [KO:K10416]
112962296  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]
112965087  tubulin alpha-8 chain [KO:K07374]
112965777  tubulin alpha-3 chain isoform X1 [KO:K07374]
112971981  tubulin alpha chain-like [KO:K07374]
112971982  tubulin alpha-5 chain-like [KO:K07374]
112972001  tubulin alpha-5 chain [KO:K07374]
112978102  tubulin alpha-3 chain isoform X1 [KO:K07374]
112978103  tubulin alpha-3 chain-like [KO:K07374]
112960845  tubulin alpha-1A chain [KO:K07374]
112968315  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
112964161  tubulin beta chain-like [KO:K07375]
112964656  TUBB6; tubulin beta-6 chain [KO:K07375]
112960956  TUBB1; tubulin beta-1 chain [KO:K07375]
112967918  tubulin beta chain isoform X1 [KO:K07375]
112962975  TUBB4B; tubulin beta-4B chain [KO:K07375]
112975147  TUBB3; tubulin beta-3 chain [KO:K07375]
112963728  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
112960865  LAMP1; lysosome-associated membrane glycoprotein 1 isoform X1 [KO:K06528]
112977045  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
112973990  M6PR; cation-dependent mannose-6-phosphate receptor isoform X1 [KO:K10089]
112976786  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
112964994  myeloperoxidase-like [KO:K10789] [EC:1.11.2.2]
112965020  MPO; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
112976832  CTSL; cathepsin L1 [KO:K01365] [EC:3.4.22.15]
112966767  cathepsin L1-like isoform X1 [KO:K01365] [EC:3.4.22.15]
112972481  cathepsin S-like [KO:K01368] [EC:3.4.22.27]
112972517  cathepsin S-like [KO:K01368] [EC:3.4.22.27]
112970766  SEC61A1; protein transport protein Sec61 subunit alpha [KO:K10956]
112978062  SEC61A2; protein transport protein Sec61 subunit alpha isoform X1 [KO:K10956]
112960652  SEC61B; protein transport protein Sec61 subunit beta isoform X1 [KO:K09481]
112976414  SEC61G; protein transport protein Sec61 subunit gamma [KO:K07342]
112961738  LOW QUALITY PROTEIN: antigen peptide transporter 2-like [KO:K05654] [EC:7.4.2.14]
112961787  LOW QUALITY PROTEIN: antigen peptide transporter 2-like [KO:K05654] [EC:7.4.2.14]
112963223  antigen peptide transporter 2-like [KO:K05654] [EC:7.4.2.14]
112965958  calreticulin-like [KO:K08057]
112964753  CANX; calnexin [KO:K08054]
112973021  C1R; complement C1r subcomponent [KO:K01330] [EC:3.4.21.41]
112975117  ITGB2; integrin beta-2 isoform X1 [KO:K06464]
112960884  C3; complement C3 [KO:K03990]
112974053  COLEC11; collectin-11 isoform X1 [KO:K10066]
112962465  COLEC12; collectin-12 [KO:K10062]
112973049  pulmonary surfactant-associated protein A-like [KO:K10067]
112973063  pulmonary surfactant-associated protein A-like [KO:K10067]
112960635  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
112964516  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
112963211  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
112962770  ITGB3; integrin beta-3 [KO:K06493]
112973848  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
112977838  THBS1; thrombospondin-1 [KO:K16857]
112975250  THBS2; thrombospondin-2 [KO:K04659]
112969920  THBS4; thrombospondin-4 [KO:K04659]
112965584  COMP; cartilage oligomeric matrix protein [KO:K04659]
112978247  THBS3; thrombospondin-3 [KO:K04659]
112976729  toll-like receptor 2 type-2 isoform X1 [KO:K10159]
112976730  toll-like receptor 2 type-2 isoform X1 [KO:K10159]
112967647  toll-like receptor 2 type-2 [KO:K10159]
112975355  toll-like receptor 10 [KO:K10169]
112963054  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
112972000  PLA2R1; secretory phospholipase A2 receptor [KO:K06560]
112962775  MRC2; C-type mannose receptor 2 [KO:K06560]
112969080  LOW QUALITY PROTEIN: macrophage mannose receptor 1-like [KO:K06560]
112969087  macrophage mannose receptor 1-like [KO:K06560]
112969089  macrophage mannose receptor 1-like [KO:K06560]
112969090  LOW QUALITY PROTEIN: macrophage mannose receptor 1-like [KO:K06560]
112976965  hepatic lectin-like [KO:K06563]
112971249  MARCO; macrophage receptor MARCO [KO:K13884]
112962575  SCARB1; scavenger receptor class B member 1 [KO:K13885]
112967582  CD36; platelet glycoprotein 4 [KO:K06259]
112978482  cytochrome b-245 light chain [KO:K08009]
112969450  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
112974255  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
112965029  NCF1; neutrophil cytosol factor 1 [KO:K08011]
112964485  NCF2; neutrophil cytosol factor 2 [KO:K08010]
112971476  NCF4; neutrophil cytosol factor 4 [KO:K08012]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:15894272
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
PMID:10684585
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
Reference
PMID:18492791
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
PMID:15036145
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
PMID:17245426
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
PMID:17637737
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
PMID:18513324
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
arow04142  Lysosome
arow04144  Endocytosis
arow04620  Toll-like receptor signaling pathway
KO pathway
ko04145   
LinkDB

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