KEGG PATHWAY: bchs00270

PATHWAY: bchs00270

Entry

bchs00270                   Pathway

Name

Cysteine and methionine metabolism - Brevibacillus choshinensis

Description

Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].

Class

Metabolism; Amino acid metabolism

Pathway map

bchs00270

Cysteine and methionine metabolism

Module

bchs_M00017

Methionine biosynthesis, aspartate => homoserine => methionine [PATH:bchs00270]

bchs_M00021

Cysteine biosynthesis, serine => cysteine [PATH:bchs00270]

bchs_M00034

Methionine salvage pathway [PATH:bchs00270]

Other DBs

GO:	0006534 0006555

Organism

Brevibacillus choshinensis [GN:bchs]

Gene

JNE38_01305

cysE; serine O-acetyltransferase [KO:K00640] [EC:2.3.1.30]

JNE38_01140

cysK; cysteine synthase A [KO:K01738] [EC:2.5.1.47]

JNE38_09380

cysK; cysteine synthase A [KO:K01738] [EC:2.5.1.47]

JNE38_25755

bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase [KO:K17217] [EC:4.4.1.1 4.4.1.2]

JNE38_19670

aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme [KO:K01760] [EC:4.4.1.13]

JNE38_07560

pyridoxal phosphate-dependent aminotransferase [KO:K14155] [EC:4.4.1.13]

JNE38_11745

pyridoxal phosphate-dependent aminotransferase [KO:K14155] [EC:4.4.1.13]

JNE38_25760

cysK; cysteine synthase A [KO:K17216] [EC:2.5.1.134]

JNE38_11545

metH; methionine synthase [KO:K00548] [EC:2.1.1.13]

JNE38_11550

bifunctional homocysteine S-methyltransferase/methylenetetrahydrofolate reductase [KO:K24042] [EC:2.1.1.13 1.5.1.54]

JNE38_28460

methionine adenosyltransferase [KO:K00789] [EC:2.5.1.6]

JNE38_03920

speD; adenosylmethionine decarboxylase [KO:K01611] [EC:4.1.1.50]

JNE38_19720

adenosylmethionine decarboxylase [KO:K01611] [EC:4.1.1.50]

JNE38_29045

speE; polyamine aminopropyltransferase [KO:K00797] [EC:2.5.1.16]

JNE38_00720

spermidine synthase [KO:K00797] [EC:2.5.1.16]

JNE38_02225

spermidine synthase [KO:K00797] [EC:2.5.1.16]

JNE38_02230

spermidine synthase [KO:K00797] [EC:2.5.1.16]

JNE38_05960

speD; adenosylmethionine decarboxylase [KO:K00797] [EC:2.5.1.16]

JNE38_21665

5'-methylthioadenosine/adenosylhomocysteine nucleosidase [KO:K01243] [EC:3.2.2.9]

JNE38_26570

S-methyl-5-thioribose kinase [KO:K00899] [EC:2.7.1.100]

JNE38_19400

pgeF; peptidoglycan editing factor PgeF [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]

JNE38_06475

amidohydrolase [KO:K12960] [EC:3.5.4.31 3.5.4.28]

JNE38_07140

amidohydrolase [KO:K12960] [EC:3.5.4.31 3.5.4.28]

JNE38_12980

amidohydrolase [KO:K12960] [EC:3.5.4.31 3.5.4.28]

JNE38_16010

amidohydrolase family protein [KO:K12960] [EC:3.5.4.31 3.5.4.28]

JNE38_26565

mtnA; S-methyl-5-thioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]

JNE38_26595

methylthioribulose 1-phosphate dehydratase [KO:K08964] [EC:4.2.1.109]

JNE38_26585

2,3-diketo-5-methylthiopentyl-1-phosphate enolase [KO:K08965] [EC:5.3.2.5]

JNE38_26590

2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase [KO:K08966] [EC:3.1.3.87]

JNE38_26600

cupin domain-containing protein [KO:K08967] [EC:1.13.11.53 1.13.11.54]

JNE38_21780

pyridoxal phosphate-dependent aminotransferase [KO:K08969] [EC:2.6.1.117]

JNE38_29220

aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme [KO:K01761] [EC:4.4.1.11]

JNE38_07555

aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme [KO:K01761] [EC:4.4.1.11]

JNE38_20135

megL; methionine gamma-lyase [KO:K01761] [EC:4.4.1.11]

JNE38_00270

dcm; DNA (cytosine-5-)-methyltransferase [KO:K00558] [EC:2.1.1.37]

JNE38_11805

MerR family transcriptional regulator [KO:K17462] [EC:2.1.1.-]

JNE38_19515

adenosylhomocysteinase [KO:K01251] [EC:3.13.2.1]

JNE38_09255

aspartate kinase [KO:K00928] [EC:2.7.2.4]

JNE38_17625

dapG; aspartate kinase [KO:K00928] [EC:2.7.2.4]

JNE38_24515

aspartate kinase [KO:K00928] [EC:2.7.2.4]

JNE38_26025

aspartate kinase [KO:K00928] [EC:2.7.2.4]

JNE38_17630

aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]

JNE38_09965

homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]

JNE38_15535

homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]

JNE38_19045

homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]

JNE38_04105

metA; homoserine O-succinyltransferase [KO:K00651] [EC:2.3.1.46 2.3.1.31]

JNE38_21995

alpha/beta fold hydrolase [KO:K00641] [EC:2.3.1.31 2.3.1.46]

JNE38_19675

aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme [KO:K01739] [EC:2.5.1.48]

JNE38_02585

homocysteine synthase [KO:K01740] [EC:2.5.1.49]

JNE38_08665

branched-chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]

JNE38_25945

cysteine dioxygenase family protein [KO:K00456] [EC:1.13.11.20]

JNE38_11610

sulfurtransferase [KO:K01011] [EC:2.8.1.1 2.8.1.2]

JNE38_23275

aspartate/glutamate racemase family protein [KO:K25316] [EC:5.1.1.10]

JNE38_07600

pyridoxal-phosphate dependent enzyme [KO:K05396] [EC:4.4.1.15]

JNE38_25350

D-cysteine desulfhydrase [KO:K05396] [EC:4.4.1.15]

JNE38_29405

mdh; malate dehydrogenase [KO:K00024] [EC:1.1.1.37]

JNE38_07405

mdh; malate dehydrogenase [KO:K00024] [EC:1.1.1.37]

JNE38_15805

ACT domain-containing protein [KO:K01752] [EC:4.3.1.17]

JNE38_18780

sdaAA; L-serine ammonia-lyase, iron-sulfur-dependent, subunit alpha [KO:K01752] [EC:4.3.1.17]

JNE38_18785

sdaAB; L-serine ammonia-lyase, iron-sulfur-dependent subunit beta [KO:K01752] [EC:4.3.1.17]

JNE38_12530

phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

JNE38_24920

C-terminal binding protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]

Compound

C00019

S-Adenosyl-L-methionine

C00021

S-Adenosyl-L-homocysteine

C00022

Pyruvate

C00041

L-Alanine

C00049

L-Aspartate

C00051

Glutathione

C00059

Sulfate

C00065

L-Serine

C00073

L-Methionine

C00094

Sulfite

C00097

L-Cysteine

C00109

2-Oxobutanoate

C00155

L-Homocysteine

C00170

5'-Methylthioadenosine

C00197

3-Phospho-D-glycerate

C00263

L-Homoserine

C00283

Hydrogen sulfide

C00409

Methanethiol

C00441

L-Aspartate 4-semialdehyde

C00491

L-Cystine

C00506

L-Cysteate

C00606

3-Sulfino-L-alanine

C00793

D-Cysteine

C00957

Mercaptopyruvate

C00979

O-Acetyl-L-serine

C01005

O-Phospho-L-serine

C01077

O-Acetyl-L-homoserine

C01118

O-Succinyl-L-homoserine

C01137

S-Adenosylmethioninamine

C01180

4-Methylthio-2-oxobutanoic acid

C01234

1-Aminocyclopropane-1-carboxylate

C01817

L-Homocystine

C01962

Thiocysteine

C02218

Dehydroalanine

C02291

L-Cystathionine

C02356

(S)-2-Aminobutanoate

C02989

L-Methionine S-oxide

C03082

4-Phospho-L-aspartate

C03089

5-Methylthio-D-ribose

C03145

N-Formylmethionine

C03232

3-Phosphonooxypyruvate

C03431

S-Inosyl-L-homocysteine

C03539

S-Ribosyl-L-homocysteine

C04188

S-Methyl-5-thio-D-ribose 1-phosphate

C04582

S-Methyl-5-thio-D-ribulose 1-phosphate

C05324

Nicotianamine

C05524

Aminoacyl-L-methionine

C05526

S-Glutathionyl-L-cysteine

C05527

3-Sulfinylpyruvate

C05528

3-Sulfopyruvate

C05823

3-Mercaptolactate

C05824

S-Sulfo-L-cysteine

C06547

Ethylene

C08276

3-(Methylthio)propanoate

C09306

Sulfur dioxide

C11437

1-Deoxy-D-xylulose 5-phosphate

C11481

HSO3-

C11499

(S)-3-Sulfolactate

C11537

(2R)-3-Sulfolactate

C15606

1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one

C15650

2,3-Diketo-5-methylthiopentyl-1-phosphate

C15651

2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate

C18049

N-Acyl-L-homoserine lactone

C19787

5'-S-Methyl-5'-thioinosine

C21015

gamma-L-Glutamyl-L-2-aminobutyrate

C21016

Ophthalmate

C22359

S-Methyl-1-thio-D-xylulose 5-phosphate

Reference

PMID:15102328

Authors

Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A

Title

Bacterial variations on the methionine salvage pathway.

Journal

BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9

Reference

PMID:14551435

Authors

Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.

Title

A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.

Journal

Science 302:286-90 (2003)
DOI:10.1126/science.1086997

Reference

PMID:12022921

Authors

Sekowska A, Danchin A.

Title

The methionine salvage pathway in Bacillus subtilis.

Journal

BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8

Reference

PMID:12670965

Authors

Berger BJ, English S, Chan G, Knodel MH.

Title

Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.

Journal

J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003

Reference

PMID:17169919

Authors

Goyer A, Collakova E, Shachar-Hill Y, Hanson AD

Title

Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.

Journal

Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055

Reference

PMID:17030798

Authors

Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S

Title

Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.

Journal

Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103

Reference

PMID:18625006

Authors

Pirkov I, Norbeck J, Gustafsson L, Albers E

Title

A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.

Journal

FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x

Reference

PMID:18391471

Authors

Ashida H, Saito Y, Kojima C, Yokota A

Title

Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.

Journal

Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651

Reference

PMID:10613873

Authors

Kitabatake M, So MW, Tumbula DL, Soll D

Title

Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?

Journal

J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000

Reference

PMID:12644499

Authors

Mino K, Ishikawa K

Title

Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.

Journal

J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003

Reference

PMID:18520135

Authors

Tanabe S

Title

Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.

Journal

Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:19270684

Authors