KEGG PATHWAY: bmoj00270

PATHWAY: bmoj00270

Entry

bmoj00270                   Pathway

Name

Cysteine and methionine metabolism - Bacillus mojavensis

Description

Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].

Class

Metabolism; Amino acid metabolism

Pathway map

bmoj00270

Cysteine and methionine metabolism

Module

bmoj_M00017

Methionine biosynthesis, aspartate => homoserine => methionine [PATH:bmoj00270]

bmoj_M00021

Cysteine biosynthesis, serine => cysteine [PATH:bmoj00270]

bmoj_M00034

Methionine salvage pathway [PATH:bmoj00270]

bmoj_M00609

Cysteine biosynthesis, methionine => cysteine [PATH:bmoj00270]

Other DBs

GO:	0006534 0006555

Organism

Bacillus mojavensis [GN:bmoj]

Gene

HC660_01200

cysE; Serine O-acetyltransferase [KO:K00640] [EC:2.3.1.30]

HC660_00860

cysK; Cysteine synthase [KO:K01738] [EC:2.5.1.47]

HC660_28630

ytkP; Cysteine synthase [KO:K01738] [EC:2.5.1.47]

HC660_25280

mccB; Cystathionine gamma-lyase and homocysteine gamma-lyase for reverse transsulfuration pathway [KO:K17217] [EC:4.4.1.1 4.4.1.2]

HC660_12470

metC; Cystathionine beta-lyase [KO:K01760] [EC:4.4.1.13]

HC660_30300

patB; Promiscuous cystathionine / cystine beta-lyase / cysteine desulfhydrase [KO:K14155] [EC:4.4.1.13]

HC660_25290

mccA; Cystathionine beta-synthase for the reverse transsulfuration pathway [KO:K17216] [EC:2.5.1.134]

HC660_02760

ybgG; Homocysteine S-methyltransferase [KO:K00547] [EC:2.1.1.10]

HC660_11560

samT; 5,10-methylenetetrahydrofolate reductase SamT [KO:K24042] [EC:2.1.1.13 1.5.1.54]

HC660_13870

metE; 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase [KO:K00549] [EC:2.1.1.14]

HC660_29190

metK; S-adenosylmethionine synthetase [KO:K00789] [EC:2.5.1.6]

HC660_27790

speD; S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]

HC660_36560

speE; Spermidine synthase [KO:K00797] [EC:2.5.1.16]

HC660_25300

mtnN; 5'-methylthioadenosine nucleosidase / S-adenosylhomocysteine nucleosidase [KO:K01243] [EC:3.2.2.9]

HC660_14250

mtnK; 5-methylthioribose kinase (methionine salvage pathway) [KO:K00899] [EC:2.7.1.100]

HC660_16020

ylmD; Multicopper polyphenol oxidase [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]

HC660_14240

mtnA; Methylthioribose-1-phosphate isomerase (methionine salvage pathway) [KO:K08963] [EC:5.3.1.23]

HC660_14300

mtnB; Methylthioribulose-1-phosphate dehydratase [KO:K08964] [EC:4.2.1.109]

HC660_14280

mtnW; 2,3-diketo-5-methylthiopentyl-1-phosphate enolase [KO:K08965] [EC:5.3.2.5]

HC660_14290

mtnX; 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase [KO:K08966] [EC:3.1.3.87]

HC660_14310

mtnD; 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase [KO:K08967] [EC:1.13.11.53 1.13.11.54]

HC660_14270

mtnE; Glutamine-dependent 2-keto-4-methylthiobutyrate transaminase [KO:K08969] [EC:2.6.1.117]

HC660_28300

msrC; Free methionine-(R)-sulfoxide reductase, contains GAF domain [KO:K08968] [EC:1.8.4.14]

HC660_05560

mtbP; DNA-cytosine methyltransferase [KO:K00558] [EC:2.1.1.37]

HC660_26750

bsuMB; DNA-cytosine methyltransferase subunit B [KO:K00558] [EC:2.1.1.37]

HC660_25310

yrrT; SAM-dependent methyltransferase YrrT [KO:K17462] [EC:2.1.1.-]

HC660_29310

luxS; S-ribosylhomocysteine lyase / autoinducer-2 production protein [KO:K07173] [EC:4.4.1.21]

HC660_04210

thrD; Aspartokinase [KO:K00928] [EC:2.7.2.4]

HC660_17410

dapG; Aspartokinase I [KO:K00928] [EC:2.7.2.4]

HC660_27250

lysC; Aspartokinase II [KO:K00928] [EC:2.7.2.4]

HC660_17400

asd; Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]

HC660_31080

hom; Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]

HC660_20700

metAA; Homoserine O-succinyltransferase [KO:K00651] [EC:2.3.1.46 2.3.1.31]

HC660_12460

metI; Cystathionine gamma-synthase / O-acetylhomoserine sulfhydrylase [KO:K01739] [EC:2.5.1.48]

HC660_02740

ilvE; Isoleucine-valine aminotransferase / aromatic amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]

HC660_37670

ilvK; Branched-chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]

HC660_29940

cdoA; Cysteine dioxygenase [KO:K00456] [EC:1.13.11.20]

HC660_21170

aspB; Aspartate aminotransferase [KO:K00812] [EC:2.6.1.1]

HC660_10170

yhdR; Putative aspartate aminotransferase [KO:K11358] [EC:2.6.1.1]

HC660_03410

lctE; L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]

HC660_33300

Amino acid racemase RacX family [KO:K25316] [EC:5.1.1.10]

HC660_25000

racX; Promiscuous aminoacid racemase (prefers arginine, lysine and ornithine) [KO:K25316] [EC:5.1.1.10]

HC660_27900

mdh; Malate dehydrogenase (NAD-dependent) [KO:K00024] [EC:1.1.1.37]

HC660_16490

sdaAB; L-serine dehydratase, beta subunit [KO:K01752] [EC:4.3.1.17]

HC660_16500

sdaAA; L-serine dehydratase, alpha subunit [KO:K01752] [EC:4.3.1.17]

HC660_19190

yoaD; Hydroxypyruvate reductase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

HC660_21870

serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

HC660_10590

serC; Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]

Compound

C00019

S-Adenosyl-L-methionine

C00021

S-Adenosyl-L-homocysteine

C00022

Pyruvate

C00041

L-Alanine

C00049

L-Aspartate

C00051

Glutathione

C00059

Sulfate

C00065

L-Serine

C00073

L-Methionine

C00094

Sulfite

C00097

L-Cysteine

C00109

2-Oxobutanoate

C00155

L-Homocysteine

C00170

5'-Methylthioadenosine

C00197

3-Phospho-D-glycerate

C00263

L-Homoserine

C00283

Hydrogen sulfide

C00409

Methanethiol

C00441

L-Aspartate 4-semialdehyde

C00491

L-Cystine

C00506

L-Cysteate

C00606

3-Sulfino-L-alanine

C00793

D-Cysteine

C00957

Mercaptopyruvate

C00979

O-Acetyl-L-serine

C01005

O-Phospho-L-serine

C01077

O-Acetyl-L-homoserine

C01118

O-Succinyl-L-homoserine

C01137

S-Adenosylmethioninamine

C01180

4-Methylthio-2-oxobutanoic acid

C01234

1-Aminocyclopropane-1-carboxylate

C01817

L-Homocystine

C01962

Thiocysteine

C02218

Dehydroalanine

C02291

L-Cystathionine

C02356

(S)-2-Aminobutanoate

C02989

L-Methionine S-oxide

C03082

4-Phospho-L-aspartate

C03089

5-Methylthio-D-ribose

C03145

N-Formylmethionine

C03232

3-Phosphonooxypyruvate

C03431

S-Inosyl-L-homocysteine

C03539

S-Ribosyl-L-homocysteine

C04188

S-Methyl-5-thio-D-ribose 1-phosphate

C04582

S-Methyl-5-thio-D-ribulose 1-phosphate

C05324

Nicotianamine

C05524

Aminoacyl-L-methionine

C05526

S-Glutathionyl-L-cysteine

C05527

3-Sulfinylpyruvate

C05528

3-Sulfopyruvate

C05823

3-Mercaptolactate

C05824

S-Sulfo-L-cysteine

C06547

Ethylene

C08276

3-(Methylthio)propanoate

C09306

Sulfur dioxide

C11437

1-Deoxy-D-xylulose 5-phosphate

C11481

HSO3-

C11499

(S)-3-Sulfolactate

C11537

(2R)-3-Sulfolactate

C15606

1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one

C15650

2,3-Diketo-5-methylthiopentyl-1-phosphate

C15651

2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate

C18049

N-Acyl-L-homoserine lactone

C19787

5'-S-Methyl-5'-thioinosine

C21015

gamma-L-Glutamyl-L-2-aminobutyrate

C21016

Ophthalmate

C22359

S-Methyl-1-thio-D-xylulose 5-phosphate

Reference

PMID:15102328

Authors

Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A

Title

Bacterial variations on the methionine salvage pathway.

Journal

BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9

Reference

PMID:14551435

Authors

Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.

Title

A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.

Journal

Science 302:286-90 (2003)
DOI:10.1126/science.1086997

Reference

PMID:12022921

Authors

Sekowska A, Danchin A.

Title

The methionine salvage pathway in Bacillus subtilis.

Journal

BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8

Reference

PMID:12670965

Authors

Berger BJ, English S, Chan G, Knodel MH.

Title

Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.

Journal

J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003

Reference

PMID:17169919

Authors

Goyer A, Collakova E, Shachar-Hill Y, Hanson AD

Title

Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.

Journal

Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055

Reference

PMID:17030798

Authors

Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S

Title

Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.

Journal

Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103

Reference

PMID:18625006

Authors

Pirkov I, Norbeck J, Gustafsson L, Albers E

Title

A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.

Journal

FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x

Reference

PMID:18391471

Authors

Ashida H, Saito Y, Kojima C, Yokota A

Title

Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.

Journal

Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651

Reference

PMID:10613873

Authors

Kitabatake M, So MW, Tumbula DL, Soll D

Title

Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?

Journal

J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000

Reference

PMID:12644499

Authors

Mino K, Ishikawa K

Title

Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.

Journal

J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003

Reference

PMID:18520135

Authors

Tanabe S

Title

Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.

Journal

Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:19270684

Authors