Entry Name Porphyrin metabolism - Bradyrhizobium sp. BF49
Description Porphyrins are a group of chemical compounds with the backbone ring structure consisting of four linked pyrrole units. Metal complexes of porphyrins, as well as those of corrinoids with the one-carbon shorter ring structure, play important biological roles. They include iron-containing heme, magnesium-containing chlorophyll, nickel-containing coenzyme F430 and cobalt-containing cobamide (such as vitamin B12 coenzyme) as shown in this map.
Class Metabolism; Metabolism of cofactors and vitaminsBRITE hierarchy
Pathway map Ortholog table Module brad_M00925 Cobalamin biosynthesis, aerobic, uroporphyrinogen III => precorrin 2 => cobyrinate a,c-diamide [PATH:brad00860 ]
Other DBs Organism Bradyrhizobium sp. BF49 [GN:
brad ]
Gene BF49_5690 UroporphyrinogenIII methyltransferase EC 211107 UroporphyrinogenIII synthase EC 42175 [KO:K01719 ] [EC:4.2.1.75 ]
BF49_0208 Protoporphyrinogen IX oxidase novel form HemJ EC 13 [KO:K08973 ] [EC:1.3.99.-]
BF49_2828 4hydroxyphenylacetate 3monooxygenase reductase component EC 168 [KO:K13786 ] [EC:1.16.8.-]
Compound C03373 Aminoimidazole ribotide
C03516 Magnesium protoporphyrin
C03741 (S)-4-Amino-5-oxopentanoate
C04122 D-1-Aminopropan-2-ol O-phosphate
C04536 Magnesium protoporphyrin monomethyl ester
C04778 N1-(5-Phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole
C05787 Bilirubin beta-diglucuronide
C06503 Hydrogenobyrinate a,c diamide
C06504 Cob(II)yrinate a,c diamide
C06505 Cob(I)yrinate a,c diamide
C06506 Adenosyl cobyrinate a,c diamide
C06507 Adenosyl cobyrinate hexaamide
C06509 Adenosyl cobinamide phosphate
C06510 Adenosine-GDP-cobinamide
C11538 Cobalt-sirohydrochlorin
C11543 Cobalt-dihydro-precorrin 6
C11630 15,16-Dihydrobiliverdin
C11829 13(1)-Hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester
C11830 13(1)-Oxo-magnesium-protoporphyrin IX 13-monomethyl ester
C11831 Divinylprotochlorophyllide
C11832 Divinyl chlorophyllide a
C11851 Zn-Bacteriochlorophyll a
C12147 L-Threonine O-3-phosphate
C16540 7(1)-Hydroxychlorophyllide a
C18022 Red chlorophyll catabolite
C18098 Primary fluorescent chlorophyll catabolite
C18151 7(1)-Hydroxychlorophyll a
C18152 3-Vinylbacteriochlorophyllide a
C18153 3-Hydroxyethylbacteriochlorophyllide a
C18154 3-Hydroxyethylchlorophyllide a
C18155 Bacteriochlorophyllide a
C18156 Bacteriochlorophyllide b
C18157 8-Ethyl-12-methyl-3-vinylbacteriochlorophyllide d
C18160 Bacteriochlorophyllide d
C18161 Bacteriochlorophyllide c
C21217 Geranylgeranyl bacteriochlorophyllide a
C21427 8,12-Diethyl-3-vinylbacteriochlorophyllide d
C21428 12-Ethyl-8-propyl-3-vinylbacteriochlorophyllide d
C21429 12-Ethyl-8-isobutyl-3-vinylbacteriochlorophyllide d
C21431 8-Ethyl-12-methylbacteriochlorophyllide d
C21432 8,12-Diethylbacteriochlorophyllide d
C21433 12-Ethyl-8-propylbacteriochlorophyllide d
C21434 12-Ethyl-8-isobutylbacteriochlorophyllide d
C21435 Geranylgeranyl bacteriochlorophyllide b
C21510 Nickel-sirohydrochlorin
C21511 Nickel-sirohydrochlorin a,c-diamide
C21512 15,17(3)-Seco-F430-17(3)-acid
C21582 Bacteriochlorophyllide e
C21835 12,18-Didecarboxysiroheme
C22451 5-Methoxy-6-methylbenzimidazole
Reference Authors Woodcock SC, Raux E, Levillayer F, Thermes C, Rambach A, Warren MJ.
Title Effect of mutations in the transmethylase and dehydrogenase/chelatase domains of sirohaem synthase (CysG) on sirohaem and cobalamin biosynthesis.
Journal Reference Authors Johansson P, Hederstedt L
Title Organization of genes for tetrapyrrole biosynthesis in gram--positive bacteria.
Journal Reference Authors Maggio-Hall LA, Escalante-Semerena JC.
Title In vitro synthesis of the nucleotide loop of cobalamin by Salmonella typhimurium enzymes.
Journal Reference Authors Roper JM, Raux E, Brindley AA, Schubert HL, Gharbia SE, Shah HN, Warren MJ.
Title The enigma of cobalamin (Vitamin B12) biosynthesis in Porphyromonas gingivalis. Identification and characterization of a functional corrin pathway.
Journal Reference Authors Scott AI, Roessner CA.
Title Biosynthesis of cobalamin (vitamin B(12)).
Journal Reference Authors Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC.
Title The biosynthesis of adenosylcobalamin (vitamin B12).
Journal Reference Authors Roessner CA, Huang KX, Warren MJ, Raux E, Scott AI.
Title Isolation and characterization of 14 additional genes specifying the anaerobic biosynthesis of cobalamin (vitamin B12) in Propionibacterium freudenreichii (P. shermanii).
Journal Reference Authors Frankenberg N, Mukougawa K, Kohchi T, Lagarias JC.
Title Functional genomic analysis of the HY2 family of ferredoxin-dependent bilin reductases from oxygenic photosynthetic organisms.
Journal Reference Authors Chew AG, Bryant DA
Title Chlorophyll biosynthesis in bacteria: the origins of structural and functional diversity.
Journal Reference Authors Frigaard NU, Chew AG, Li H, Maresca JA, Bryant DA
Title Chlorobium tepidum: insights into the structure, physiology, and metabolism of a green sulfur bacterium derived from the complete genome sequence.
Journal Reference Authors Deery E, Schroeder S, Lawrence AD, Taylor SL, Seyedarabi A, Waterman J, Wilson KS, Brown D, Geeves MA, Howard MJ, Pickersgill RW, Warren MJ
Title An enzyme-trap approach allows isolation of intermediates in cobalamin biosynthesis.
Journal Reference Authors Moore SJ, Lawrence AD, Biedendieck R, Deery E, Frank S, Howard MJ, Rigby SE, Warren MJ
Title Elucidation of the anaerobic pathway for the corrin component of cobalamin (vitamin B12).
Journal Related brad00250 Alanine, aspartate and glutamate metabolism
brad00260 Glycine, serine and threonine metabolism
KO pathway LinkDB All DBs
