KEGG   PATHWAY: bspl00564
Entry
bspl00564                   Pathway                                
Name
Glycerophospholipid metabolism - Betta splendens (Siamese fighting fish)
Class
Metabolism; Lipid metabolism
Pathway map
bspl00564  Glycerophospholipid metabolism
bspl00564

Module
bspl_M00090  Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:bspl00564]
bspl_M00091  Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:bspl00564]
bspl_M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:bspl00564]
Other DBs
GO: 0006650
Organism
Betta splendens (Siamese fighting fish) [GN:bspl]
Gene
114858209  glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic [KO:K00006] [EC:1.1.1.8]
114856278  gpd1b; glycerol-3-phosphate dehydrogenase 1b [KO:K00006] [EC:1.1.1.8]
114851163  glycerol-3-phosphate dehydrogenase 1-like protein [KO:K00006] [EC:1.1.1.8]
114849776  gpd2; glycerol-3-phosphate dehydrogenase, mitochondrial isoform X1 [KO:K00111] [EC:1.1.5.3]
114846417  gpam; glycerol-3-phosphate acyltransferase 1, mitochondrial [KO:K00629] [EC:2.3.1.15]
114861553  gpat2; glycerol-3-phosphate acyltransferase 2, mitochondrial [KO:K00629] [EC:2.3.1.15]
114866874  gpat3; glycerol-3-phosphate acyltransferase 3 isoform X1 [KO:K13506] [EC:2.3.1.15]
114861519  gpat4; glycerol-3-phosphate acyltransferase 4 [KO:K13506] [EC:2.3.1.15]
114861733  agpat9l; glycerol-3-phosphate acyltransferase 3-like [KO:K13506] [EC:2.3.1.15]
114866740  agpat2; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta [KO:K13509] [EC:2.3.1.51]
114847298  agpat3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma [KO:K13523] [EC:2.3.1.51 2.3.1.-]
114870570  agpat4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X1 [KO:K13523] [EC:2.3.1.51 2.3.1.-]
114841763  agpat5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon [KO:K19007] [EC:2.3.1.51]
114848322  lclat1; lysocardiolipin acyltransferase 1 isoform X1 [KO:K13513] [EC:2.3.1.- 2.3.1.51]
114842657  mboat1; lysophospholipid acyltransferase 1 isoform X1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
114848016  mboat2a; lysophospholipid acyltransferase 2 isoform X1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
114849988  mboat2b; lysophospholipid acyltransferase 2b isoform X1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
114849156  gnpat2; dihydroxyacetone phosphate acyltransferase [KO:K00649] [EC:2.3.1.42]
114849226  gnpat; dihydroxyacetone phosphate acyltransferase [KO:K00649] [EC:2.3.1.42]
114845947  adprm; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
114851897  phospholipid phosphatase 3-like [KO:K01080] [EC:3.1.3.4]
114844874  phospholipid phosphatase 3-like isoform X1 [KO:K01080] [EC:3.1.3.4]
114866680  plpp1a; phospholipid phosphatase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
114853716  plpp3; phospholipid phosphatase 3 isoform X1 [KO:K01080] [EC:3.1.3.4]
114853760  plpp2b; phospholipid phosphatase 2b [KO:K01080] [EC:3.1.3.4]
114861096  ppap2d; phosphatidic acid phosphatase type 2D isoform X2 [KO:K01080] [EC:3.1.3.4]
114861531  phospholipid phosphatase 1-like [KO:K01080] [EC:3.1.3.4]
114848963  plpp2a; phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
114844231  lpin2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
114851977  lpin1a; phosphatidate phosphatase LPIN1 isoform X3 [KO:K15728] [EC:3.1.3.4]
114853024  phosphatidate phosphatase LPIN2-like isoform X3 [KO:K15728] [EC:3.1.3.4]
114855053  zgc:123305 [KO:K15728] [EC:3.1.3.4]
114849155  lpin1b; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
114861817  plpp5; phospholipid phosphatase 5 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
114870792  plpp4; phospholipid phosphatase 4 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
114842479  dgkb; diacylglycerol kinase beta isoform X1 [KO:K00901] [EC:2.7.1.107]
114858986  dgkaa; diacylglycerol kinase, alpha a [KO:K00901] [EC:2.7.1.107]
114846887  dgke; diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
114867564  diacylglycerol kinase delta-like isoform X2 [KO:K00901] [EC:2.7.1.107]
114847426  dgkh; diacylglycerol kinase eta isoform X1 [KO:K00901] [EC:2.7.1.107]
114847592  si:dkey-172j4.3; diacylglycerol kinase delta isoform X1 [KO:K00901] [EC:2.7.1.107]
114847711  diacylglycerol kinase beta isoform X1 [KO:K00901] [EC:2.7.1.107]
114861914  dgki; diacylglycerol kinase iota isoform X2 [KO:K00901] [EC:2.7.1.107]
114856023  dgkab; diacylglycerol kinase, alpha b isoform X1 [KO:K00901] [EC:2.7.1.107]
114864059  diacylglycerol kinase theta-like isoform X1 [KO:K00901] [EC:2.7.1.107]
114850997  dgkza; diacylglycerol kinase zeta isoform X1 [KO:K00901] [EC:2.7.1.107]
114857684  dgkzb; diacylglycerol kinase zeta [KO:K00901] [EC:2.7.1.107]
114861718  chpt1; cholinephosphotransferase 1 [KO:K00994] [EC:2.7.8.2]
114855309  cept1b; choline/ethanolaminephosphotransferase 1b isoform X1 [KO:K13644] [EC:2.7.8.1 2.7.8.2]
114841753  sphingomyelin synthase-related protein 1-like [KO:K22697] [EC:3.1.4.62]
114845679  samd8; sphingomyelin synthase-related protein 1 [KO:K22697] [EC:3.1.4.62]
114851262  sgms2b; phosphatidylcholine:ceramide cholinephosphotransferase 2 [KO:K04714] [EC:2.7.8.27 3.1.4.62]
114854937  sgms2a; phosphatidylcholine:ceramide cholinephosphotransferase 2 isoform X1 [KO:K04714] [EC:2.7.8.27 3.1.4.62]
114870404  phosphatidylcholine:ceramide cholinephosphotransferase 1-like [KO:K04714] [EC:2.7.8.27 3.1.4.62]
114852912  pld1b; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
114869510  pld2; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
114848971  pld1a; phospholipase D1a isoform X1 [KO:K01115] [EC:3.1.4.4]
114868570  pld3; 5'-3' exonuclease PLD3 [KO:K16860] [EC:3.1.4.4]
114848933  5'-3' exonuclease PLD4 [KO:K16860] [EC:3.1.4.4]
114864303  pld7; 5'-3' exonuclease PLD3 isoform X1 [KO:K16860] [EC:3.1.4.4]
114857615  lcat; phosphatidylcholine-sterol acyltransferase [KO:K00650] [EC:2.3.1.43]
114866541  phospholipase A2-like isoform X2 [KO:K01047] [EC:3.1.1.4]
114859319  pla2g12a; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
114866946  pla2g3; group 3 secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
114860591  pla2g10; group 10 secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
114854607  group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
114861990  group 3 secretory phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
114868717  proca1; uncharacterized protein proca1 [KO:K01047] [EC:3.1.1.4]
114862939  pla2g1b; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
114870578  pla2g12b; group XIIB secretory phospholipase A2-like protein isoform X2 [KO:K01047] [EC:3.1.1.4]
114853826  pla2g4ab; cytosolic phospholipase A2 isoform X2 [KO:K16342] [EC:3.1.1.4]
114861077  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
114869531  pla2g6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
114849925  plb1; phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]
114865067  phospholipase A and acyltransferase 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
114865068  phospholipase A and acyltransferase 4-like isoform X1 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
121201952  plaat1l; phospholipase A and acyltransferase 1 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
114842585  lysophosphatidylcholine acyltransferase 1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
114852190  lpcat2; lysophosphatidylcholine acyltransferase 2 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
114865936  lpcat1; lysophosphatidylcholine acyltransferase 1 isoform X1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
114847767  lpcat4; lysophospholipid acyltransferase LPCAT4 isoform X1 [KO:K13512] [EC:2.3.1.23 2.3.1.-]
114842935  lpcat3; lysophospholipid acyltransferase 5 isoform X1 [KO:K13515] [EC:2.3.1.23 2.3.1.-]
114854221  lypla1; acyl-protein thioesterase 1 isoform X1 [KO:K06128] [EC:3.1.1.5]
114856852  pla2g15; group XV phospholipase A2 [KO:K06129] [EC:3.1.1.5]
114866286  lypla2; acyl-protein thioesterase 2 [KO:K06130] [EC:3.1.1.5]
114845687  pnpla7b; patatin-like phospholipase domain-containing protein 7 isoform X1 [KO:K14676] [EC:3.1.1.5]
114853256  pnpla6; patatin-like phospholipase domain-containing protein 6 isoform X1 [KO:K14676] [EC:3.1.1.5]
114867048  patatin-like phospholipase domain-containing protein 7 isoform X1 [KO:K14676] [EC:3.1.1.5]
114849634  gpcpd1; glycerophosphocholine phosphodiesterase GPCPD1 isoform X1 [KO:K18695] [EC:3.1.4.2]
114842057  chata; choline O-acetyltransferase [KO:K00623] [EC:2.3.1.6]
114845889  choline O-acetyltransferase-like [KO:K00623] [EC:2.3.1.6]
114849238  ache; acetylcholinesterase [KO:K01049] [EC:3.1.1.7]
114857746  chkb; choline/ethanolamine kinase [KO:K14156] [EC:2.7.1.32 2.7.1.82]
114857244  chka; choline kinase alpha isoform X1 [KO:K14156] [EC:2.7.1.32 2.7.1.82]
114846363  probable phosphatase phospho1 [KO:K06124] [EC:3.1.3.75]
114860536  phospho1; probable phosphatase phospho1 isoform X1 [KO:K06124] [EC:3.1.3.75]
114843964  pcyt1aa; choline-phosphate cytidylyltransferase A isoform X2 [KO:K00968] [EC:2.7.7.15]
114853772  pcyt1ba; choline-phosphate cytidylyltransferase B isoform X1 [KO:K00968] [EC:2.7.7.15]
114870038  pcyt1bb; choline-phosphate cytidylyltransferase B [KO:K00968] [EC:2.7.7.15]
114849462  selenoi; ethanolaminephosphotransferase 1 [KO:K00993] [EC:2.7.8.1]
114855456  etnk2; ethanolamine kinase 2 [KO:K00894] [EC:2.7.1.82]
114862575  etnk1; ethanolamine kinase 1 isoform X1 [KO:K00894] [EC:2.7.1.82]
114857235  zgc:113516; ethanolamine kinase 1 isoform X1 [KO:K00894] [EC:2.7.1.82]
114859956  ethanolamine-phosphate cytidylyltransferase-like isoform X1 [KO:K00967] [EC:2.7.7.14]
114859987  pcyt2; ethanolamine-phosphate cytidylyltransferase [KO:K00967] [EC:2.7.7.14]
114864457  uncharacterized protein LOC114864457 isoform X1 [KO:K05929] [EC:2.1.1.103]
114864458  uncharacterized protein LOC114864458 isoform X1 [KO:K05929] [EC:2.1.1.103]
114868468  etnppl; ethanolamine-phosphate phospho-lyase [KO:K14286] [EC:4.2.3.2]
114845771  pemt; phosphatidylethanolamine N-methyltransferase isoform X1 [KO:K00551] [EC:2.1.1.17 2.1.1.71]
114862760  cds1; phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
114863202  cds2; phosphatidate cytidylyltransferase 2 isoform X1 [KO:K00981] [EC:2.7.7.41]
114847633  pla1a; phospholipase A1 member A [KO:K13618] [EC:3.1.1.111]
114842846  ptdss1a; phosphatidylserine synthase 1 [KO:K08729] [EC:2.7.8.-]
114865511  ptdss1b; phosphatidylserine synthase 1 [KO:K08729] [EC:2.7.8.-]
114857038  ptdss2; phosphatidylserine synthase 2 isoform X1 [KO:K08730] [EC:2.7.8.29]
114867126  pisd; phosphatidylserine decarboxylase proenzyme, mitochondrial [KO:K01613] [EC:4.1.1.65]
114845798  CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial [KO:K00995] [EC:2.7.8.5]
114842070  crls1; cardiolipin synthase (CMP-forming) [KO:K08744] [EC:2.7.8.41]
114858811  tafazzin [KO:K13511] [EC:2.3.1.-]
114849907  lpgat1; acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X1 [KO:K13514] [EC:2.3.1.-]
114860089  cdipt; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
114842628  mboat7; lysophospholipid acyltransferase 7 [KO:K13516] [EC:2.3.1.-]
Compound
C00040  Acyl-CoA
C00065  L-Serine
C00084  Acetaldehyde
C00093  sn-Glycerol 3-phosphate
C00111  Glycerone phosphate
C00114  Choline
C00157  Phosphatidylcholine
C00189  Ethanolamine
C00269  CDP-diacylglycerol
C00307  CDP-choline
C00344  Phosphatidylglycerol
C00346  Ethanolamine phosphate
C00350  Phosphatidylethanolamine
C00416  Phosphatidate
C00513  CDP-glycerol
C00570  CDP-ethanolamine
C00588  Choline phosphate
C00623  sn-Glycerol 1-phosphate
C00641  1,2-Diacyl-sn-glycerol
C00670  sn-Glycero-3-phosphocholine
C00681  1-Acyl-sn-glycerol 3-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01210  N-Methylethanolamine phosphate
C01233  sn-Glycero-3-phosphoethanolamine
C01241  Phosphatidyl-N-methylethanolamine
C01996  Acetylcholine
C02737  Phosphatidylserine
C03372  Acylglycerone phosphate
C03819  1-Acylglycerophosphoinositol
C03872  L-Serine-phosphoethanolamine
C03892  Phosphatidylglycerophosphate
C03974  2-Acyl-sn-glycerol 3-phosphate
C04230  1-Acyl-sn-glycero-3-phosphocholine
C04233  2-Acyl-sn-glycero-3-phosphocholine
C04308  Phosphatidyl-N-dimethylethanolamine
C04438  1-Acyl-sn-glycero-3-phosphoethanolamine
C04590  3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638  2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
C05973  2-Acyl-sn-glycero-3-phosphoethanolamine
C05974  2-Acyl-sn-glycero-3-phosphoserine
C05976  Aminoacyl-phosphatidylglycerol
C05980  Cardiolipin
C06771  Triethanolamine
C06772  Diethanolamine
C13482  Phosphodimethylethanolamine
C18059  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
C18125  1-Acyl-sn-glycero-3-phosphoserine
C18126  1-Acyl-sn-glycero-3-phosphoglycerol
C18129  Monolysocardiolipin
C18168  Diacylglycerylhomoserine
C18169  Diacylglyceryl-N,N,N-trimethylhomoserine
C20466  2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518  2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
C22340  Heptaprenylglyceryl phosphate
C22341  Heptaprenylglycerol
C22342  Diacetylheptaprenylglycerol
Reference
PMID:1512203
  Authors
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  Title
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  Journal
J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992
Reference
PMID:10092508
  Authors
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  Title
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  Journal
Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411
Reference
PMID:10542045
  Authors
Athenstaedt K, Daum G.
  Title
Phosphatidic acid, a key intermediate in lipid metabolism.
  Journal
Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x
Reference
PMID:12431977
  Authors
Shields DJ, Lehner R, Agellon LB, Vance DE.
  Title
Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  Journal
J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200
Reference
PMID:14663079
  Authors
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  Title
Pathways for phosphatidylcholine biosynthesis in bacteria.
  Journal
Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0
Reference
PMID:15522832
  Authors
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  Title
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007
Reference
PMID:1649829
  Authors
Hsu L, Jackowski S, Rock CO
  Title
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  Journal
J Biol Chem 266:13783-8 (1991)
Reference
PMID:10938271
  Authors
Stone SJ, Vance JE.
  Title
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  Journal
J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200
Related
pathway
bspl00010  Glycolysis / Gluconeogenesis
bspl00260  Glycine, serine and threonine metabolism
bspl00561  Glycerolipid metabolism
bspl00562  Inositol phosphate metabolism
bspl00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
bspl00565  Ether lipid metabolism
bspl00620  Pyruvate metabolism
KO pathway
ko00564   
LinkDB

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