KEGG   PATHWAY: bui00260
Entry
bui00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Burkholderia sp. PAMC 28687
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bui00260  Glycine, serine and threonine metabolism
bui00260

Module
bui_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bui00260]
bui_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bui00260]
bui_M00555  Betaine biosynthesis, choline => betaine [PATH:bui00260]
bui_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:bui00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Burkholderia sp. PAMC 28687 [GN:bui]
Gene
AX768_05410  aspartate kinase [KO:K00928] [EC:2.7.2.4]
AX768_22950  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
AX768_06445  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
AX768_23190  homoserine kinase [KO:K02204] [EC:2.7.1.39]
AX768_06450  threonine synthase [KO:K01733] [EC:4.2.3.1]
AX768_26595  threonine aldolase [KO:K01620] [EC:4.1.2.48]
AX768_18010  threonine aldolase [KO:K01620] [EC:4.1.2.48]
AX768_10390  threonine aldolase [KO:K01620] [EC:4.1.2.48]
AX768_29515  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
AX768_12605  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
AX768_16520  serine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
AX768_20845  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
AX768_12705  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
AX768_10890  D-glycerate dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
AX768_07745  D-glycerate dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
AX768_06605  glycerate kinase [KO:K00865] [EC:2.7.1.165]
AX768_00500  gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
AX768_01175  phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
AX768_29185  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
AX768_11255  3-phosphoserine/phosphohydroxythreonine aminotransferase [KO:K00831] [EC:2.6.1.52]
AX768_07960  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
AX768_12610  NAD(P)-dependent oxidoreductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
AX768_26390  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
AX768_26395  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
AX768_08770  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
AX768_27255  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
AX768_05100  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
AX768_10100  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
AX768_29490  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
AX768_29495  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
AX768_29550  (Fe-S)-binding protein [KO:K00479] [EC:1.14.13.251]
AX768_29555  hybrid-cluster NAD(P)-dependent oxidoreductase [KO:K21832] [EC:1.14.13.251]
AX768_29530  N-methylproline demethylase [KO:K21833] [EC:1.5.7.3]
AX768_29535  (Fe-S)-binding protein [KO:K21834]
AX768_29540  electron transfer flavoprotein subunit alpha [KO:K25960]
AX768_29545  drug:proton antiporter [KO:K25961]
AX768_15570  methyltryptophan oxidase [KO:K00301] [EC:1.5.3.1]
AX768_29425  sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
AX768_29415  sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
AX768_29430  sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
AX768_29420  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
AX768_29410  serine dehydratase [KO:K01752] [EC:4.3.1.17]
AX768_00950  threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
AX768_06500  serine/threonine dehydratase [KO:K01754] [EC:4.3.1.19]
AX768_00920  amino acid deaminase [KO:K01753] [EC:4.3.1.18]
AX768_22980  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
AX768_22970  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
AX768_21845  hypothetical protein [KO:K15785] [EC:2.6.1.76]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bui00010  Glycolysis / Gluconeogenesis
bui00020  Citrate cycle (TCA cycle)
bui00230  Purine metabolism
bui00250  Alanine, aspartate and glutamate metabolism
bui00270  Cysteine and methionine metabolism
bui00290  Valine, leucine and isoleucine biosynthesis
bui00300  Lysine biosynthesis
bui00330  Arginine and proline metabolism
bui00460  Cyanoamino acid metabolism
bui00470  D-Amino acid metabolism
bui00564  Glycerophospholipid metabolism
bui00600  Sphingolipid metabolism
bui00620  Pyruvate metabolism
bui00630  Glyoxylate and dicarboxylate metabolism
bui00640  Propanoate metabolism
bui00680  Methane metabolism
bui00860  Porphyrin metabolism
bui00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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