KEGG   PATHWAY: cang04142
Entry
cang04142                   Pathway                                
Name
Lysosome - Colobus angolensis palliatus (Angola colobus)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
cang04142  Lysosome
cang04142

Other DBs
GO: 0005764
Organism
Colobus angolensis palliatus (Angola colobus) [GN:cang]
Gene
105516295  V-type proton ATPase 116 kDa subunit a isoform 2 [KO:K02154]
105503007  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform 1 [KO:K02154]
105511394  ATP6V0A4; V-type proton ATPase 116 kDa subunit a isoform 4 [KO:K02154]
105512072  TCIRG1; V-type proton ATPase 116 kDa subunit a isoform 3 [KO:K02154]
105508257  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
105504569  ATP6V0D1; V-type proton ATPase subunit d 1 isoform X1 [KO:K02146]
105508692  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
105521644  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
105523662  LOW QUALITY PROTEIN: V-type proton ATPase 16 kDa proteolipid subunit-like [KO:K02155]
105524938  V-type proton ATPase 16 kDa proteolipid subunit-like [KO:K02155]
105526405  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
105514441  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit isoform X1 [KO:K03661]
105502213  DMXL2; dmX-like protein 2 isoform X1 [KO:K24155]
105527384  DMXL1; dmX-like protein 1 isoform X1 [KO:K24155]
105516881  WDR7; WD repeat-containing protein 7 isoform X1 [KO:K24738]
105513567  NCOA7; nuclear receptor coactivator 7 isoform X1 [KO:K25442]
105502413  CTSA; lysosomal protective protein isoform X1 [KO:K13289] [EC:3.4.16.5]
105512391  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
105509301  CTSC; dipeptidyl peptidase 1 isoform X1 [KO:K01275] [EC:3.4.14.1]
105503291  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
105523007  CTSE; cathepsin E isoform X1 [KO:K01382] [EC:3.4.23.34]
105512114  CTSF; cathepsin F [KO:K01373] [EC:3.4.22.41]
105503705  CTSG; cathepsin G [KO:K01319] [EC:3.4.21.20]
105509239  CTSH; pro-cathepsin H [KO:K01366] [EC:3.4.22.16]
105508848  CTSK; cathepsin K [KO:K01371] [EC:3.4.22.38]
105514486  CTSL; cathepsin L1 isoform X1 [KO:K01365] [EC:3.4.22.15]
105524452  CTSO; cathepsin O [KO:K01374] [EC:3.4.22.42]
105508849  CTSS; cathepsin S isoform X1 [KO:K01368] [EC:3.4.22.27]
105501514  CTSV; cathepsin L2 [KO:K01375] [EC:3.4.22.43]
105512145  CTSW; cathepsin W isoform X1 [KO:K08569] [EC:3.4.22.-]
105506428  CTSZ; cathepsin Z [KO:K08568] [EC:3.4.18.1]
105514743  napsin-A-like [KO:K08565] [EC:3.4.23.-]
105514744  NAPSA; napsin-A [KO:K08565] [EC:3.4.23.-]
105517032  LGMN; legumain isoform X1 [KO:K01369] [EC:3.4.22.34]
105520548  TPP1; tripeptidyl-peptidase 1 isoform X1 [KO:K01279] [EC:3.4.14.9]
105520678  GLA; alpha-galactosidase A [KO:K01189] [EC:3.2.1.22]
105525791  GLB1; LOW QUALITY PROTEIN: beta-galactosidase [KO:K12309] [EC:3.2.1.23]
105523338  GAA; lysosomal alpha-glucosidase [KO:K12316] [EC:3.2.1.20]
105502032  GBA; glucosylceramidase isoform X1 [KO:K01201] [EC:3.2.1.45]
105508056  IDUA; alpha-L-iduronidase [KO:K01217] [EC:3.2.1.76]
105514017  NAGA; alpha-N-acetylgalactosaminidase [KO:K01204] [EC:3.2.1.49]
105503004  NAGLU; alpha-N-acetylglucosaminidase [KO:K01205] [EC:3.2.1.50]
105517075  GALC; galactocerebrosidase isoform X1 [KO:K01202] [EC:3.2.1.46]
105518950  beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
105526131  FUCA2; plasma alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
105514302  FUCA1; tissue alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
105524127  HEXB; beta-hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
105520211  HEXA; beta-hexosaminidase subunit alpha isoform X1 [KO:K12373] [EC:3.2.1.52]
105512679  MANBA; beta-mannosidase isoform X1 [KO:K01192] [EC:3.2.1.25]
105520806  MAN2B1; lysosomal alpha-mannosidase isoform X1 [KO:K12311] [EC:3.2.1.24]
105513761  NEU1; sialidase-1 [KO:K01186] [EC:3.2.1.18]
105509671  HYAL2; hyaluronidase-2 [KO:K01197] [EC:3.2.1.35]
105509673  HYAL1; hyaluronidase-1 isoform X1 [KO:K01197] [EC:3.2.1.35]
105509677  HYAL3; hyaluronidase-3 isoform X1 [KO:K01197] [EC:3.2.1.35]
105518664  hyaluronidase-4-like [KO:K01197] [EC:3.2.1.35]
105518665  HYAL4; hyaluronidase-4 [KO:K01197] [EC:3.2.1.35]
105518667  SPAM1; hyaluronidase PH-20 isoform X1 [KO:K01197] [EC:3.2.1.35]
105511973  ARSA; arylsulfatase A [KO:K01134] [EC:3.1.6.8]
105524186  ARSB; arylsulfatase B [KO:K01135] [EC:3.1.6.12]
105500764  ARSG; arylsulfatase G [KO:K12381] [EC:3.1.6.-]
105501931  GALNS; N-acetylgalactosamine-6-sulfatase [KO:K01132] [EC:3.1.6.4]
105502627  GNS; N-acetylglucosamine-6-sulfatase isoform X1 [KO:K01137] [EC:3.1.6.14]
105503392  IDS; iduronate 2-sulfatase isoform X1 [KO:K01136] [EC:3.1.6.13]
105505367  SGSH; N-sulphoglucosamine sulphohydrolase [KO:K01565] [EC:3.10.1.1]
105515914  LIPA; lysosomal acid lipase/cholesteryl ester hydrolase isoform X1 [KO:K01052] [EC:3.1.1.13]
105504561  PLA2G15; group XV phospholipase A2 isoform X1 [KO:K06129] [EC:3.1.1.5]
105521803  DNASE2B; deoxyribonuclease-2-beta [KO:K01158] [EC:3.1.22.1]
105520791  DNASE2; deoxyribonuclease-2-alpha isoform X1 [KO:K01158] [EC:3.1.22.1]
105527127  ACP2; lysosomal acid phosphatase isoform X1 [KO:K14410] [EC:3.1.3.2]
105520827  ACP5; tartrate-resistant acid phosphatase type 5 [KO:K14379] [EC:3.1.3.2]
105520536  SMPD1; sphingomyelin phosphodiesterase isoform X1 [KO:K12350] [EC:3.1.4.12]
105506653  ASAH1; acid ceramidase isoform X1 [KO:K12348] [EC:3.5.1.23]
105524367  AGA; N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase isoform X1 [KO:K01444] [EC:3.5.1.26]
105501643  PSAP; prosaposin isoform X1 [KO:K12382]
105507040  PSAPL1; proactivator polypeptide-like 1 [KO:K12382]
105504249  GM2A; ganglioside GM2 activator isoform X1 [KO:K12383]
105513774  PPT2; lysosomal thioesterase PPT2 isoform X1 [KO:K01074] [EC:3.1.2.22]
105521159  PPT1; palmitoyl-protein thioesterase 1 isoform X1 [KO:K01074] [EC:3.1.2.22]
105523214  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
105505968  LAMP1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
105514442  LAMP3; lysosome-associated membrane glycoprotein 3 isoform X1 [KO:K06562]
105523622  CD68; macrosialin isoform X1 [KO:K06501]
105500574  CD63 antigen isoform X1 [KO:K06497]
105500577  CD63 antigen isoform X1 [KO:K06497]
105501324  SCARB2; lysosome membrane protein 2 isoform X1 [KO:K12384]
105509780  NPC1; Niemann-Pick C1 protein [KO:K12385]
105517157  NPC2; epididymal secretory protein E1 isoform X1 [KO:K13443]
105515647  CTNS; cystinosin isoform X1 [KO:K12386]
105512483  SLC17A5; sialin [KO:K12301]
105504730  SLC11A1; LOW QUALITY PROTEIN: natural resistance-associated macrophage protein 1 [KO:K12347]
105503641  SLC11A2; natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
105518247  LAPTM4A; lysosomal-associated transmembrane protein 4A isoform X1 [KO:K12387]
105519400  LAPTM4B; lysosomal-associated transmembrane protein 4B isoform X1 [KO:K12387]
105521310  LAPTM5; lysosomal-associated transmembrane protein 5 [KO:K12387]
105522797  ABCA2; ATP-binding cassette sub-family A member 2 [KO:K05642]
105516307  ABCB9; ATP-binding cassette sub-family B member 9 isoform X1 [KO:K05656]
105519457  CD164; sialomucin core protein 24 [KO:K06546]
105510201  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 [KO:K12305] [EC:3.6.1.6]
105516072  SORT1; sortilin [KO:K12388]
105505621  CLN3; battenin isoform X1 [KO:K12389]
105520241  CLN5; ceroid-lipofuscinosis neuronal protein 5 [KO:K12390]
105507203  MFSD8; major facilitator superfamily domain-containing protein 8 [KO:K12307]
105522559  HGSNAT; heparan-alpha-glucosaminide N-acetyltransferase [KO:K10532] [EC:2.3.1.78]
105508376  SUMF1; sulfatase-modifying factor 1 isoform X1 [KO:K13444] [EC:1.8.3.7]
105506693  GNPTAB; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta [KO:K08239] [EC:2.7.8.17]
105522881  GNPTG; N-acetylglucosamine-1-phosphotransferase subunit gamma [KO:K10087]
105525695  NAGPA; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [KO:K01125] [EC:3.1.4.45]
105506730  IGF2R; cation-independent mannose-6-phosphate receptor [KO:K06564]
105519845  M6PR; cation-dependent mannose-6-phosphate receptor isoform X1 [KO:K10089]
105509911  CLTA; clathrin light chain A isoform X1 [KO:K04644]
105515101  CLTB; clathrin light chain B isoform X1 [KO:K04645]
105523730  CLTCL1; clathrin heavy chain 2 [KO:K04646]
105520084  CLTC; clathrin heavy chain 1 isoform X1 [KO:K04646]
105503756  AP1G2; AP-1 complex subunit gamma-like 2 isoform X1 [KO:K12391]
105525992  AP1G1; AP-1 complex subunit gamma-1 isoform X1 [KO:K12391]
105506603  AP1B1; AP-1 complex subunit beta-1 [KO:K12392]
105519787  AP1M1; AP-1 complex subunit mu-1 isoform X1 [KO:K12393]
105520862  AP1M2; AP-1 complex subunit mu-2 [KO:K12393]
105510454  AP1S2; AP-1 complex subunit sigma-2 isoform X1 [KO:K12394]
105524670  AP1S1; AP-1 complex subunit sigma-1A isoform X1 [KO:K12394]
105518794  AP1S3; AP-1 complex subunit sigma-3 [KO:K12395]
105527639  AP3D1; AP-3 complex subunit delta-1 [KO:K12396]
105524096  AP3B1; AP-3 complex subunit beta-1 isoform X1 [KO:K12397]
105520271  AP3B2; AP-3 complex subunit beta-2 isoform X1 [KO:K12397]
105502057  AP3M1; AP-3 complex subunit mu-1 isoform X1 [KO:K12398]
105525127  AP3M2; AP-3 complex subunit mu-2 isoform X1 [KO:K12398]
105527370  AP3S1; AP-3 complex subunit sigma-1 isoform X1 [KO:K12399]
105502208  AP4E1; AP-4 complex subunit epsilon-1 [KO:K12400]
105505326  AP4B1; AP-4 complex subunit beta-1 isoform X1 [KO:K12401]
105513078  AP4M1; AP-4 complex subunit mu-1 isoform X1 [KO:K12402]
105511680  AP4S1; AP-4 complex subunit sigma-1 isoform X1 [KO:K12403]
105523511  GGA2; ADP-ribosylation factor-binding protein GGA2 [KO:K12404]
105513414  GGA3; ADP-ribosylation factor-binding protein GGA3 isoform X1 [KO:K12404]
105527801  GGA1; ADP-ribosylation factor-binding protein GGA1 [KO:K12404]
105512904  MCOLN1; mucolipin-1 [KO:K04992]
105525682  LITAF; lipopolysaccharide-induced tumor necrosis factor-alpha factor [KO:K19363]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 10.1038/s41577-021-00626-8 (2021)
DOI:10.1038/s41577-021-00626-8
Related
pathway
cang00511  Other glycan degradation
cang00531  Glycosaminoglycan degradation
cang04130  SNARE interactions in vesicular transport
cang04140  Autophagy - animal
cang04144  Endocytosis
KO pathway
ko04142   
LinkDB

DBGET integrated database retrieval system