KEGG   PATHWAY: caua00590
Entry
caua00590                   Pathway                                
Name
Arachidonic acid metabolism - Carassius auratus (goldfish)
Class
Metabolism; Lipid metabolism
Pathway map
caua00590  Arachidonic acid metabolism
caua00590

Other DBs
GO: 0019369
Organism
Carassius auratus (goldfish) [GN:caua]
Gene
113113022  group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
113093781  phospholipase A2, minor isoenzyme-like [KO:K01047] [EC:3.1.1.4]
113107479  phospholipase A2, minor isoenzyme-like [KO:K01047] [EC:3.1.1.4]
113107480  phospholipase A2, minor isoenzyme-like [KO:K01047] [EC:3.1.1.4]
113115231  uncharacterized protein LOC113115231 [KO:K01047] [EC:3.1.1.4]
113044334  pla2g12a; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
113051308  group XIIA secretory phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
113057286  group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
113058280  uncharacterized protein LOC113058280 [KO:K01047] [EC:3.1.1.4]
113071531  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
113099910  group 3 secretory phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
113102212  group 3 secretory phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
113094578  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
113062352  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
113062962  cytosolic phospholipase A2-like [KO:K16342] [EC:3.1.1.4]
113069794  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
113115927  cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
113070145  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
113070146  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
113070147  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
113070154  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
113070174  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
113070191  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
113070198  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
113070215  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
113070798  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
113045808  cytosolic phospholipase A2-like [KO:K16342] [EC:3.1.1.4]
113117207  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
113086959  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
113086991  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
113087107  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
113087123  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
113087139  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
113087155  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
113117853  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
113065020  85/88 kDa calcium-independent phospholipase A2-like [KO:K16343] [EC:3.1.1.4]
113039858  85/88 kDa calcium-independent phospholipase A2-like isoform X1 [KO:K16343] [EC:3.1.1.4]
113075672  phospholipase B1, membrane-associated-like [KO:K14621] [EC:3.1.1.4 3.1.1.5]
113075673  phospholipase B1, membrane-associated-like [KO:K14621] [EC:3.1.1.4 3.1.1.5]
113095747  phospholipase B1, membrane-associated-like [KO:K14621] [EC:3.1.1.4 3.1.1.5]
113062909  phospholipase B1, membrane-associated-like [KO:K14621] [EC:3.1.1.4 3.1.1.5]
113062910  phospholipase B1, membrane-associated-like [KO:K14621] [EC:3.1.1.4 3.1.1.5]
113037832  phospholipase B1, membrane-associated-like [KO:K14621] [EC:3.1.1.4 3.1.1.5]
113037921  phospholipase B1, membrane-associated-like [KO:K14621] [EC:3.1.1.4 3.1.1.5]
113072504  phospholipase B1, membrane-associated-like [KO:K14621] [EC:3.1.1.4 3.1.1.5]
113117435  phospholipase B1, membrane-associated-like [KO:K14621] [EC:3.1.1.4 3.1.1.5]
113120199  HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
113120278  HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
113114074  HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
113114515  HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
113091102  HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
113091109  HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
113091133  HRAS-like suppressor 3 isoform X1 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
113049679  prostaglandin G/H synthase 1-like [KO:K00509] [EC:1.14.99.1]
113079489  prostaglandin G/H synthase 1-like [KO:K00509] [EC:1.14.99.1]
113120750  prostaglandin G/H synthase 2-like isoform X1 [KO:K11987] [EC:1.14.99.1]
113062963  prostaglandin G/H synthase 2-like [KO:K11987] [EC:1.14.99.1]
113115972  prostaglandin G/H synthase 2-like [KO:K11987] [EC:1.14.99.1]
113045805  prostaglandin G/H synthase 2-like [KO:K11987] [EC:1.14.99.1]
113072624  prostaglandin G/H synthase 2-like [KO:K11987] [EC:1.14.99.1]
113075803  prostaglandin E synthase-like [KO:K15729] [EC:5.3.99.3]
113049387  prostaglandin E synthase-like [KO:K15729] [EC:5.3.99.3]
113107674  prostaglandin E synthase 2 [KO:K05309] [EC:5.3.99.3]
113071972  prostaglandin E synthase 2-like [KO:K05309] [EC:5.3.99.3]
113041049  prostaglandin E synthase 3-like isoform X1 [KO:K15730] [EC:5.3.99.3]
113070279  prostaglandin E synthase 3-like isoform X1 [KO:K15730] [EC:5.3.99.3]
113070530  prostaglandin E synthase 3-like [KO:K15730] [EC:5.3.99.3]
113065460  prostaglandin E synthase 3-like [KO:K15730] [EC:5.3.99.3]
113075683  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
113068667  carbonyl reductase [NADPH] 1-like isoform X1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
113098224  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
113038637  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
113038652  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
113055415  prxl2b; prostamide/prostaglandin F synthase [KO:K15717] [EC:1.11.1.20]
113113563  15-hydroxyprostaglandin dehydrogenase [NAD(+)]-like [KO:K00069] [EC:1.1.1.141]
113095004  15-hydroxyprostaglandin dehydrogenase [NAD(+)]-like [KO:K00069] [EC:1.1.1.141]
113038215  15-hydroxyprostaglandin dehydrogenase [NAD(+)]-like [KO:K00069] [EC:1.1.1.141]
113038216  15-hydroxyprostaglandin dehydrogenase [NAD(+)]-like [KO:K00069] [EC:1.1.1.141]
113038217  15-hydroxyprostaglandin dehydrogenase [NAD(+)]-like [KO:K00069] [EC:1.1.1.141]
113063802  15-hydroxyprostaglandin dehydrogenase [NAD(+)]-like [KO:K00069] [EC:1.1.1.141]
113061548  thromboxane-A synthase-like [KO:K01832] [EC:5.3.99.5]
113070573  thromboxane-A synthase-like [KO:K01832] [EC:5.3.99.5]
113118226  thromboxane-A synthase-like isoform X1 [KO:K01832] [EC:5.3.99.5]
113054068  prostaglandin-H2 D-isomerase-like isoform X1 [KO:K01830] [EC:5.3.99.2]
113042283  lipocalin-like [KO:K01830] [EC:5.3.99.2]
113068038  lipocalin-like [KO:K01830] [EC:5.3.99.2]
113049663  lipocalin-like isoform X1 [KO:K01830] [EC:5.3.99.2]
113079611  prostaglandin-H2 D-isomerase-like isoform X1 [KO:K01830] [EC:5.3.99.2]
113069928  lipocalin-like [KO:K01830] [EC:5.3.99.2]
113109443  prostaglandin-H2 D-isomerase-like [KO:K01830] [EC:5.3.99.2]
113109647  prostaglandin-H2 D-isomerase-like [KO:K01830] [EC:5.3.99.2]
113083296  lipocalin-like [KO:K01830] [EC:5.3.99.2]
113117913  lipocalin-like [KO:K01830] [EC:5.3.99.2]
113066012  lipocalin-like isoform X1 [KO:K01830] [EC:5.3.99.2]
113050312  prostacyclin synthase-like [KO:K01831] [EC:5.3.99.4]
113097085  prostacyclin synthase-like [KO:K01831] [EC:5.3.99.4]
113066049  arachidonate 5-lipoxygenase-like [KO:K00461] [EC:1.13.11.34]
113066078  arachidonate 5-lipoxygenase-like [KO:K00461] [EC:1.13.11.34]
113112941  arachidonate 5-lipoxygenase-like [KO:K00461] [EC:1.13.11.34]
113048375  arachidonate 5-lipoxygenase-like isoform X1 [KO:K00461] [EC:1.13.11.34]
113048377  arachidonate 5-lipoxygenase-like [KO:K00461] [EC:1.13.11.34]
113057166  arachidonate 5-lipoxygenase-like [KO:K00461] [EC:1.13.11.34]
113047946  leukotriene A-4 hydrolase-like [KO:K01254] [EC:3.3.2.6]
113058671  leukotriene A-4 hydrolase-like [KO:K01254] [EC:3.3.2.6]
113117858  ptgr2; LOW QUALITY PROTEIN: prostaglandin reductase 2 [KO:K13949] [EC:1.3.1.48]
113052114  ptgr1; prostaglandin reductase 1 [KO:K13948] [EC:1.3.1.74 1.3.1.48]
113105698  prostaglandin reductase 1-like [KO:K13948] [EC:1.3.1.74 1.3.1.48]
113113366  leukotriene C4 synthase-like [KO:K00807] [EC:4.4.1.20]
113113488  leukotriene C4 synthase-like [KO:K00807] [EC:4.4.1.20]
113106837  glutathione hydrolase 5 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
113054553  glutathione hydrolase 5 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
113107736  glutathione hydrolase 1 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
113070774  LOW QUALITY PROTEIN: glutathione hydrolase 1 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
113070776  glutathione hydrolase 5 proenzyme-like isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
113110267  glutathione hydrolase 1 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
113110268  glutathione hydrolase 5 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
113085437  glutathione hydrolase 1 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
113073155  glutathione hydrolase 1 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
113077208  cytochrome P450 2J3-like isoform X1 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
113062932  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
113062933  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
113062936  LOW QUALITY PROTEIN: cytochrome P450 2J3-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
113059714  cytochrome P450 2J3-like isoform X1 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
113044022  cytochrome P450 2U1-like [KO:K07422] [EC:1.14.14.80]
113044056  cytochrome P450 2U1-like [KO:K07422] [EC:1.14.14.80]
113052069  arachidonate 5-lipoxygenase-like [KO:K00458] [EC:1.13.11.31]
113052070  arachidonate 12-lipoxygenase, 12S-type-like [KO:K00458] [EC:1.13.11.31]
113052072  arachidonate 5-lipoxygenase-like [KO:K00458] [EC:1.13.11.31]
113105799  arachidonate 5-lipoxygenase-like [KO:K00458] [EC:1.13.11.31]
113038569  hydroperoxide isomerase ALOXE3-like [KO:K18684] [EC:4.2.1.152 5.4.4.7]
113038431  arachidonate 15-lipoxygenase B-like [KO:K08022] [EC:1.13.11.33 1.13.11.-]
113043657  hydroperoxide isomerase ALOXE3-like [KO:K08022] [EC:1.13.11.33 1.13.11.-]
113072679  hydroperoxide isomerase ALOXE3-like [KO:K08022] [EC:1.13.11.33 1.13.11.-]
113060837  bifunctional epoxide hydrolase 2-like [KO:K08726] [EC:3.3.2.10 3.1.3.76]
113117731  bifunctional epoxide hydrolase 2-like [KO:K08726] [EC:3.3.2.10 3.1.3.76]
Compound
C00157  Phosphatidylcholine
C00219  Arachidonate
C00427  Prostaglandin H2
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00696  Prostaglandin D2
C00909  Leukotriene A4
C01312  Prostaglandin I2
C02165  Leukotriene B4
C02166  Leukotriene C4
C02198  Thromboxane A2
C03577  20-Hydroxyleukotriene E4
C04577  15-OxoETE
C04671  (5Z)-11alpha-Hydroxy-9,15-dioxoprostanoate
C04707  (5Z,13E)-11alpha-Hydroxy-9,15-dioxoprost-5,13-dienoate
C04742  (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
C04758  (5Z,13E)-9alpha-Hydroxy-11,15-dioxoprosta-5,13-dienoate
C04805  5(S)-HETE
C04822  8(R)-HPETE
C04835  (5Z,13E)-6,9alpha-Epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate
C04853  20-OH-Leukotriene B4
C05356  5(S)-HPETE
C05949  12-Keto-leukotriene B4
C05950  20-COOH-Leukotriene B4
C05951  Leukotriene D4
C05952  Leukotriene E4
C05953  Prostaglandin A2
C05954  Prostaglandin B2
C05955  Prostaglandin C2
C05956  Prostaglandin G2
C05957  Prostaglandin J2
C05958  Delta-12-Prostaglandin J2
C05959  11-epi-Prostaglandin F2alpha
C05960  15-Keto-prostaglandin F2alpha
C05961  6-Keto-prostaglandin F1alpha
C05962  6-Keto-prostaglandin E1
C05963  Thromboxane B2
C05964  11-Dehydro-thromboxane B2
C05965  12(S)-HPETE
C05966  15(S)-HPETE
C06314  Lipoxin A4
C06315  Lipoxin B4
C06462  Leukotriene F4
C13809  9,11,15-Trihydroxy-prosta-5,13-dien-1-oic acid
C14717  15-Deoxy-Delta12,14-PGJ2
C14732  5-OxoETE
C14748  20-HETE
C14749  19(S)-HETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
C14772  5,6-DHET
C14773  8,9-DHET
C14774  11,12-DHET
C14775  14,15-DHET
C14776  8(S)-HETE
C14777  12(S)-HETE
C14778  16(R)-HETE
C14779  9(S)-HETE
C14780  11(R)-HETE
C14781  15H-11,12-EETA
C14782  11,12,15-THETA
C14794  2,3-Dinor-8-iso prostaglandin F2alpha
C14795  2,3-Dinor-8-iso prostaglandin F1alpha
C14807  12-OxoETE
C14808  Hepoxilin A3
C14809  Trioxilin A3
C14810  Hepoxilin B3
C14811  Trioxilin B3
C14812  12(R)-HPETE
C14813  11H-14,15-EETA
C14814  11,14,15-THETA
C14815  5,6-Epoxytetraene
C14820  11(R)-HPETE
C14821  9(S)-HPETE
C14822  12(R)-HETE
C14823  8(S)-HPETE
C14824  8(R)-HETE
Reference
PMID:14636671
  Authors
Spector AA, Fang X, Snyder GD, Weintraub NL.
  Title
Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function.
  Journal
Prog Lipid Res 43:55-90 (2004)
DOI:10.1016/S0163-7827(03)00049-3
Reference
PMID:15292194
  Authors
Harman CA, Rieke CJ, Garavito RM, Smith WL.
  Title
Crystal structure of arachidonic acid bound to a mutant of prostaglandin endoperoxide H synthase-1 that forms predominantly 11-hydroperoxyeicosatetraenoic acid.
  Journal
J Biol Chem 279:42929-35 (2004)
DOI:10.1074/jbc.M403013200
Reference
PMID:15205388
  Authors
Poloyac SM, Tortorici MA, Przychodzin DI, Reynolds RB, Xie W, Frye RF, Zemaitis MA.
  Title
The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney.
  Journal
Drug Metab Dispos 32:727-33 (2004)
DOI:10.1124/dmd.32.7.727
Reference
PMID:14660610
  Authors
Chuang SS, Helvig C, Taimi M, Ramshaw HA, Collop AH, Amad M, White JA, Petkovich M, Jones G, Korczak B.
  Title
CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids.
  Journal
J Biol Chem 279:6305-14 (2004)
DOI:10.1074/jbc.M311830200
Reference
PMID:14626496
  Authors
Sacerdoti D, Gatta A, McGiff JC.
  Title
Role of cytochrome P450-dependent arachidonic acid metabolites in liver physiology and pathophysiology.
  Journal
Prostaglandins Other Lipid Mediat 72:51-71 (2003)
DOI:10.1016/S1098-8823(03)00077-7
Reference
PMID:14622984
  Authors
Pfister SL, Spitzbarth N, Zeldin DC, Lafite P, Mansuy D, Campbell WB.
  Title
Rabbit aorta converts 15-HPETE to trihydroxyeicosatrienoic acids: potential role of cytochrome P450.
  Journal
Arch Biochem Biophys 420:142-52 (2003)
DOI:10.1016/j.abb.2003.09.026
Reference
PMID:11679404
  Authors
Fleming I.
  Title
Cytochrome p450 and vascular homeostasis.
  Journal
Circ Res 89:753-62 (2001)
DOI:10.1161/hh2101.099268
Reference
PMID:11328810
  Authors
Qu W, Bradbury JA, Tsao CC, Maronpot R, Harry GJ, Parker CE, Davis LS, Breyer MD, Waalkes MP, Falck JR, Chen J, Rosenberg RL, Zeldin DC.
  Title
Cytochrome P450 CYP2J9, a new mouse arachidonic acid omega-1 hydroxylase predominantly expressed in brain.
  Journal
J Biol Chem 276:25467-79 (2001)
DOI:10.1074/jbc.M100545200
Reference
PMID:10908295
  Authors
Tsao CC, Foley J, Coulter SJ, Maronpot R, Zeldin DC, Goldstein JA.
  Title
CYP2C40, a unique arachidonic acid 16-hydroxylase, is the major CYP2C in murine intestinal tract.
  Journal
Mol Pharmacol 58:279-87 (2000)
DOI:10.1124/mol.58.2.279
Reference
PMID:9812980
  Authors
Pfister SL, Spitzbarth N, Nithipatikom K, Edgemond WS, Falck JR, Campbell WB.
  Title
Identification of the 11,14,15- and 11,12, 15-trihydroxyeicosatrienoic acids as endothelium-derived relaxing factors of rabbit aorta.
  Journal
J Biol Chem 273:30879-87 (1998)
DOI:10.1074/jbc.273.47.30879
Related
pathway
caua00591  Linoleic acid metabolism
KO pathway
ko00590   
LinkDB

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