KEGG   ORTHOLOGY: K00458
Entry
K00458                      KO                                     
Symbol
ALOX12
Name
arachidonate 12-lipoxygenase [EC:1.13.11.31]
Pathway
map00590  Arachidonic acid metabolism
map01100  Metabolic pathways
map01523  Antifolate resistance
map04726  Serotonergic synapse
map04750  Inflammatory mediator regulation of TRP channels
Reaction
R01596  arachidonate:oxygen 12-oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K00458  ALOX12; arachidonate 12-lipoxygenase
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K00458  ALOX12; arachidonate 12-lipoxygenase
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K00458  ALOX12; arachidonate 12-lipoxygenase
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    K00458  ALOX12; arachidonate 12-lipoxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.31  arachidonate 12-lipoxygenase
     K00458  ALOX12; arachidonate 12-lipoxygenase
Other DBs
GO: 0004052
Genes
HSA: 239(ALOX12)
PTR: 455242(ALOX12) 455243
PPS: 100992721(ALOX12)
GGO: 101140132(ALOX12)
PON: 100435170 100448016
NLE: 100605486(ALOX12)
HMH: 116458265(ALOX12)
MCC: 713748(ALOX12)
MCF: 102136652(ALOX12)
MTHB: 126939829
MNI: 105473015
CSAB: 103242265(ALOX12)
CATY: 105582822(ALOX12)
PANU: 101012932(ALOX12)
TGE: 112609056(ALOX12)
MLEU: 105549914(ALOX12)
RRO: 104673348(ALOX12)
RBB: 108514395(ALOX12)
TFN: 117067814(ALOX12)
PTEH: 111521261(ALOX12)
CANG: 105523575(ALOX12)
CJC: 100400641(ALOX12)
SBQ: 101051396(ALOX12)
CIMI: 108306615(ALOX12)
CSYR: 103263245(ALOX12) 103263247
MMUR: 105878109(ALOX12) 105879294
LCAT: 123650840(ALOX12)
PCOQ: 105819472(ALOX12)
OGA: 100951876(ALOX12) 100961111
MMU: 11684(Alox12) 11685(Alox12e)
MCAL: 110304778(Alox12)
MPAH: 110331792(Alox12)
RNO: 287454(Alox12) 303252(Alox12e)
MCOC: 116077965
MUN: 110540751
CGE: 100764620(Alox12)
PROB: 127219012 127219013(Alox12)
PLEU: 114693220(Alox12)
NGI: 103752172(Alox12)
HGL: 101702123(Alox12)
CPOC: 100719400
CCAN: 109682903(Alox12)
DORD: 105983295 105983533(Alox12)
DSP: 122100378(Alox12)
PLOP: 125365503(Alox12)
MMMA: 107158101(Alox12)
OCU: 100340525
OPI: 101518253(ALOX12)
TUP: 102493396(ALOX12) 102494779
GVR: 103587106(ALOX12)
CFA: 479476(ALOX12)
CLUD: 112647510
VVP: 112924805
VLG: 121500195
NPO: 129497890(ALOX12)
AML: 100471037(ALOX12)
UMR: 103660455(ALOX12)
UAH: 113271099(ALOX12)
UAR: 123792172(ALOX12)
ELK: 111161172
MPUF: 101684639(ALOX12)
MNP: 132003859(ALOX12)
MLK: 131815812(ALOX12)
NVS: 122906679(ALOX12)
ORO: 101379600(ALOX12)
EJU: 114225417(ALOX12)
ZCA: 113907925(ALOX12) 113939134
MLX: 117999898 117999978(ALOX12)
NSU: 110584560(ALOX12)
LWW: 102750079(ALOX12)
FCA: 101094304
PYU: 121016040(ALOX12)
PCOO: 112856976
PBG: 122484839
LRUF: 124519666
PTG: 102969788(ALOX12)
PPAD: 109245992
PUC: 125927078
AJU: 106972408
HHV: 120231410(ALOX12)
BTA: 407169(ALOX12) 787450(ALOX12E)
BOM: 102284543(ALOX12)
BIU: 109574004(ALOX12)
BBUB: 102395651(ALOX12)
BBIS: 104993944 104993949(ALOX12)
CHX: 102187263(ALOX12)
OAS: 101113685(ALOX12)
ODA: 120866088(ALOX12)
CCAD: 122446320 122446338(ALOX12)
MBEZ: 129542462(ALOX12) 129542473
SSC: 100620614(ALOX12)
CFR: 102504047(ALOX12)
CBAI: 105077467(ALOX12)
CDK: 105103060(ALOX12)
VPC: 102533742(ALOX12)
BACU: 103020542(ALOX12)
LVE: 103074060(ALOX12)
OOR: 101279538(ALOX12)
DLE: 111185974(ALOX12)
PCAD: 102977395(ALOX12)
PSIU: 116745598(ALOX12)
NASI: 112390424(ALOX12)
ECB: 100072916
EPZ: 103561430(ALOX12)
EAI: 106844160(ALOX12)
MNA: 107544244(ALOX12)
HAI: 109394599(ALOX12)
DRO: 112308919(ALOX12)
SHON: 118979425(ALOX12)
AJM: 119037160(ALOX12)
PHAS: 123809459
RFQ: 117013802(ALOX12)
PPAM: 129072205(ALOX12)
PALE: 102897481(ALOX12)
PGIG: 120612187(ALOX12)
PVP: 105291977(ALOX12)
RAY: 107509504(ALOX12)
MJV: 108401224
TOD: 119232717
SARA: 101547220(ALOX12) 101547484
LAV: 100656524
TMU: 101341400
ETF: 101643858(ALOX12)
DNM: 101444550
SHR: 100933073
AFZ: 127560919
PCW: 110194257
OAA: 100079469
MUO: 115458185(ALOX12)
GSH: 117350677(ALOX12)
DRE: 322732(alox12)
SANH: 107669199
SGH: 107593795
CCAR: 109050063
PTET: 122348592(alox12)
LROH: 127167780(alox12)
OMC: 131543981(alox12)
PPRM: 120487640
RKG: 130102666(alox12)
MAMB: 125264591(alox12)
CIDE: 127515195
TROS: 130570780(alox12)
TDW: 130422185(alox12)
MANU: 129441089(alox12)
IPU: 108267744 108267745(alox12)
PHYP: 113539915
TFD: 113635137(alox12)
TVC: 132848618(alox12)
AMEX: 103037595
EEE: 113580793
CHAR: 105889668(alox12)
TRU: 101070898
TFS: 130522950(alox12)
LCO: 104937156
NCC: 104948188
TBEN: 117497588(alox12)
CGOB: 115023433
PGEO: 117463440(alox12)
GACU: 117535413(alox12)
ELY: 117272669(alox12)
EFO: 125884070(alox12)
PLEP: 121962177(alox12)
SLUC: 116043997(alox12)
ECRA: 117934769(alox12)
ESP: 116707176
PFLV: 114545687
GAT: 120822087(alox12)
PPUG: 119222432(alox12)
AFB: 129093703(alox12)
CLUM: 117747621(alox12)
MSAM: 119912247(alox12)
SCHU: 122869982(alox12)
CUD: 121506630(alox12)
ALAT: 119026959(alox12)
MZE: 101479810
ONL: 100698983
OAU: 116321155(alox12)
OLA: 101174953
OML: 112155872(alox12)
XMA: 102224924
XCO: 114157899
XHE: 116733267
PRET: 103480141
PFOR: 103148853
PLAI: 106946955
PMEI: 106917266
GAF: 122820467(alox12)
PPRL: 129378384(alox12)
CVG: 107103814
CTUL: 119775005(alox12)
GMU: 124880055(alox12)
NFU: 107384708(alox15)
KMR: 108242243(alox12)
ALIM: 106526983
NWH: 119414629(alox12)
AOCE: 111564179
MCEP: 125000804(alox12)
POV: 109637629
SSEN: 122766699(alox12)
HHIP: 117751994(alox12)
HSP: 118102186(alox12)
LCF: 108879679 108895226(alox12)
SDU: 111223569
SLAL: 111667993
XGL: 120797417(alox12)
PEE: 133398110(alox12)
PTAO: 133473005(alox12)
BPEC: 110170766
MALB: 109957267
BSPL: 114849198(alox12)
SJO: 128383885(alox12)
SASA: 100380705(lox12) 106608934
OTW: 112214522(alox12) 112259738
OMY: 110500350(alox12) 110531448
OGO: 124008639 124013533(alox12)
OKE: 118378215 118392202(alox12)
SALP: 111952161
SNH: 120030395 120049296(alox12)
CCLU: 121554183 121571287(alox12)
ELS: 105027651
SFM: 108922837
PKI: 111846328
AANG: 118223344(alox12)
LOC: 102685586(alox12)
ARUT: 117426941
CMK: 103190915(alox12)
RTP: 109926716
HOC: 132835132(alox12) 132835215
LPIC: 129282967
MMER: 123540522
XEN: 124443531
 » show all
Reference
PMID:2244907
  Authors
Yoshimoto T, Yamamoto Y, Arakawa T, Suzuki H, Yamamoto S, Yokoyama C, Tanabe T, Toh H
  Title
Molecular cloning and expression of human arachidonate 12-lipoxygenase.
  Journal
Biochem Biophys Res Commun 172:1230-5 (1990)
DOI:10.1016/0006-291X(90)91580-L
  Sequence
[hsa:239]
Reference
  Authors
Yoshimoto T, Takahashi Y
  Title
Arachidonate 12-lipoxygenases.
  Journal
Prostaglandins Other Lipid Mediat 68-69:245-62 (2002)
DOI:10.1016/S0090-6980(02)00034-5
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