KEGG   PATHWAY: cfus00270
Entry
cfus00270                   Pathway                                
Name
Cysteine and methionine metabolism - Cystobacter fuscus
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
Pathway map
cfus00270  Cysteine and methionine metabolism
cfus00270

Module
cfus_M00021  Cysteine biosynthesis, serine => cysteine [PATH:cfus00270]
cfus_M00035  Methionine degradation [PATH:cfus00270]
cfus_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:cfus00270]
Other DBs
GO: 0006534 0006555
Organism
Cystobacter fuscus [GN:cfus]
Gene
CYFUS_002535  transferase [KO:K00640] [EC:2.3.1.30]
CYFUS_005639  serine acetyltransferase [KO:K00640] [EC:2.3.1.30]
CYFUS_007386  serine acetyltransferase [KO:K00640] [EC:2.3.1.30]
CYFUS_000404  cysteine synthase [KO:K01738] [EC:2.5.1.47]
CYFUS_007387  hypothetical protein [KO:K01738] [EC:2.5.1.47]
CYFUS_007760  hypothetical protein [KO:K01758] [EC:4.4.1.1]
CYFUS_008317  cystathionine beta-lyase [KO:K01760] [EC:4.4.1.13]
CYFUS_004586  cystathionine gamma-synthase [KO:K01760] [EC:4.4.1.13]
CYFUS_007757  hypothetical protein [KO:K01697] [EC:4.2.1.22]
CYFUS_002940  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
CYFUS_009071  methionine adenosyltransferase [KO:K00789] [EC:2.5.1.6]
CYFUS_001638  S-adenosylmethionine decarboxylase [KO:K01611] [EC:4.1.1.50]
CYFUS_004432  hypothetical protein [KO:K00797] [EC:2.5.1.16]
CYFUS_001642  spermidine synthase [KO:K00797] [EC:2.5.1.16]
CYFUS_005607  hypothetical protein [KO:K00797] [EC:2.5.1.16]
CYFUS_008939  hypothetical protein [KO:K00797] [EC:2.5.1.16]
CYFUS_001122  spermine synthase [KO:K00797] [EC:2.5.1.16]
CYFUS_001123  hypothetical protein [KO:K00797] [EC:2.5.1.16]
CYFUS_009700  5'-methylthioadenosine phosphorylase [KO:K00772] [EC:2.4.2.28]
CYFUS_006455  hypothetical protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
CYFUS_001751  S-adenosylhomocysteine deaminase [KO:K12960] [EC:3.5.4.31 3.5.4.28]
CYFUS_007957  N-ethylammeline chlorohydrolase [KO:K12960] [EC:3.5.4.31 3.5.4.28]
CYFUS_008922  hypothetical protein [KO:K12960] [EC:3.5.4.31 3.5.4.28]
CYFUS_006930  amidohydrolase [KO:K12960] [EC:3.5.4.31 3.5.4.28]
CYFUS_009702  S-methyl-5-thioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]
CYFUS_000591  methylthioribulose-1-phosphate dehydratase [KO:K08964] [EC:4.2.1.109]
CYFUS_000593  2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatase [KO:K09880] [EC:3.1.3.77]
CYFUS_000592  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase [KO:K08967] [EC:1.13.11.53 1.13.11.54]
CYFUS_003942  hypothetical protein [KO:K08968] [EC:1.8.4.14]
CYFUS_007031  cytosine methyltransferase [KO:K00558] [EC:2.1.1.37]
CYFUS_004834  cytosine methyltransferase [KO:K00558] [EC:2.1.1.37]
CYFUS_006619  hypothetical protein [KO:K00558] [EC:2.1.1.37]
CYFUS_004655  adenosylhomocysteinase [KO:K01251] [EC:3.13.2.1]
CYFUS_006411  aspartokinase [KO:K00928] [EC:2.7.2.4]
CYFUS_003161  aspartokinase [KO:K00928] [EC:2.7.2.4]
CYFUS_007182  aspartokinase [KO:K00928] [EC:2.7.2.4]
CYFUS_004307  aspartokinase [KO:K00928] [EC:2.7.2.4]
CYFUS_006640  aspartokinase [KO:K00928] [EC:2.7.2.4]
CYFUS_004584  Aspartokinase / Homoserine dehydrogenase [KO:K12524] [EC:2.7.2.4 1.1.1.3]
CYFUS_003160  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
CYFUS_006313  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
CYFUS_002842  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
CYFUS_003837  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
CYFUS_002784  homoserine acetyltransferase [KO:K00641] [EC:2.3.1.31 2.3.1.46]
CYFUS_008215  aspartokinase [KO:K00641] [EC:2.3.1.31 2.3.1.46]
CYFUS_004585  hypothetical protein [KO:K01739] [EC:2.5.1.48]
CYFUS_007363  O-acetylhomoserine sulfhydrylase / O-succinylhomoserine sulfhydrylase [KO:K01739] [EC:2.5.1.48]
CYFUS_008214  O-acetylhomoserine aminocarboxypropyltransferase [KO:K01740] [EC:2.5.1.49]
CYFUS_006464  branched chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]
CYFUS_006709  branched chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]
CYFUS_009834  branched chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]
CYFUS_008063  glutamate--cysteine ligase [KO:K01919] [EC:6.3.2.2]
CYFUS_000037  glutathione synthase [KO:K01920] [EC:6.3.2.3]
CYFUS_000821  aspartate aminotransferase [KO:K00812] [EC:2.6.1.1]
CYFUS_005582  aspartate aminotransferase [KO:K00812] [EC:2.6.1.1]
CYFUS_003096  L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]
CYFUS_009033  alanine racemase [KO:K25317] [EC:5.1.1.10]
CYFUS_004557  malate dehydrogenase [KO:K00024] [EC:1.1.1.37]
CYFUS_003112  L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
CYFUS_008776  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
CYFUS_006675  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
CYFUS_006579  pyridoxal phosphate-dependent enzyme [KO:K22847] [EC:2.8.5.1]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03431  S-Inosyl-L-homocysteine
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05324  Nicotianamine
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11437  1-Deoxy-D-xylulose 5-phosphate
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
C22359  S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
PMID:15102328
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
PMID:14551435
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
PMID:12022921
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
PMID:12670965
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
PMID:17169919
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
PMID:17030798
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
PMID:18625006
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
PMID:18391471
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
PMID:10613873
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
PMID:12644499
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
PMID:18520135
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:19270684
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
cfus00010  Glycolysis / Gluconeogenesis
cfus00250  Alanine, aspartate and glutamate metabolism
cfus00260  Glycine, serine and threonine metabolism
cfus00290  Valine, leucine and isoleucine biosynthesis
cfus00430  Taurine and hypotaurine metabolism
cfus00480  Glutathione metabolism
cfus00620  Pyruvate metabolism
cfus00640  Propanoate metabolism
cfus00770  Pantothenate and CoA biosynthesis
cfus00900  Terpenoid backbone biosynthesis
cfus00920  Sulfur metabolism
KO pathway
ko00270   
LinkDB

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