KEGG   PATHWAY: clv04914
Entry
clv04914                    Pathway                                
Name
Progesterone-mediated oocyte maturation - Columba livia (rock pigeon)
Description
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Class
Organismal Systems; Endocrine system
Pathway map
clv04914  Progesterone-mediated oocyte maturation
clv04914

Other DBs
GO: 0001556
Organism
Columba livia (rock pigeon) [GN:clv]
Gene
102097861  PGR; progesterone receptor [KO:K08556]
102084272  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X4 [KO:K02649]
102092838  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
102084904  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102083735  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102095297  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
102084293  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102085840  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
102087983  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102085027  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
102089738  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
102090037  mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
102090861  mitogen-activated protein kinase 12 isoform X2 [KO:K04441] [EC:2.7.11.24]
102097012  mitogen-activated protein kinase 11 isoform X2 [KO:K04441] [EC:2.7.11.24]
102095096  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
102086179  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
102096204  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
102094612  ADCY1; LOW QUALITY PROTEIN: adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
102097532  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
102092425  ADCY3; LOW QUALITY PROTEIN: adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
102085466  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
102092552  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
102090470  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
102086133  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
102095574  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
102094181  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X4 [KO:K04345] [EC:2.7.11.11]
102097857  AURKA; aurora kinase A [KO:K11481] [EC:2.7.11.1]
102090088  CPEB1; cytoplasmic polyadenylation element-binding protein 1 isoform X2 [KO:K02602]
102087745  CPEB2; cytoplasmic polyadenylation element-binding protein 2 isoform X7 [KO:K02602]
102093501  CPEB3; cytoplasmic polyadenylation element-binding protein 3 [KO:K02602]
102097866  CPEB4; cytoplasmic polyadenylation element-binding protein 4 isoform X2 [KO:K02602]
102090911  SPDYA; speedy protein A [KO:K08694]
102083762  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
102089140  CCNA1; cyclin-A1 [KO:K06627]
102094005  CCNA2; cyclin-A2 [KO:K06627]
102089125  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
102086480  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
102096091  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102084879  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102097643  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X3 [KO:K04373] [EC:2.7.11.1]
102086308  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
102089715  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
102087387  RPS6KA1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
102098298  CCNB1; LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B1 [KO:K05868]
102084928  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
102088890  CCNB3; G2/mitotic-specific cyclin-B3 isoform X2 [KO:K21771]
102089833  STK10; LOW QUALITY PROTEIN: serine/threonine-protein kinase 10 [KO:K08837] [EC:2.7.11.1]
102089372  PLK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
102084553  CDC25A; M-phase inducer phosphatase 1 [KO:K06645] [EC:3.1.3.48]
102087487  CDC25B; LOW QUALITY PROTEIN: M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
102092033  INS; insulin isoform X1 [KO:K04526]
102092089  IGF1; insulin-like growth factor I [KO:K05459]
102089963  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
102095269  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102098970  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102098034  PDE3B; LOW QUALITY PROTEIN: cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
102096076  KRAS; GTPase KRas isoform X3 [KO:K07827]
102088487  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
102096788  RAF1; LOW QUALITY PROTEIN: RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
102091159  BUB1; mitotic checkpoint serine/threonine-protein kinase BUB1 isoform X1 [KO:K02178] [EC:2.7.11.1]
102089676  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 isoform X4 [KO:K06679]
102091219  MAD2L1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
102090805  MAD2L2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
102093465  FZR1; fizzy-related protein homolog [KO:K03364]
102091514  ANAPC1; anaphase-promoting complex subunit 1 [KO:K03348]
102085414  ANAPC2; anaphase-promoting complex subunit 2 [KO:K03349]
102095608  CDC27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
102084273  ANAPC4; anaphase-promoting complex subunit 4 [KO:K03351]
102085604  ANAPC5; anaphase-promoting complex subunit 5 [KO:K03352]
102092950  CDC16; cell division cycle protein 16 homolog [KO:K03353]
102088851  ANAPC7; anaphase-promoting complex subunit 7 [KO:K03354]
102096759  CDC23; cell division cycle protein 23 homolog [KO:K03355]
102098392  ANAPC10; anaphase-promoting complex subunit 10 [KO:K03357]
102093629  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
102090639  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
102097033  ANAPC15; anaphase-promoting complex subunit 15 [KO:K25228]
102086692  ANAPC16; LOW QUALITY PROTEIN: anaphase-promoting complex subunit 16 [KO:K25229]
Compound
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:12045215
  Authors
Schmitt A, Nebreda AR.
  Title
Signalling pathways in oocyte meiotic maturation.
  Journal
J Cell Sci 115:2457-9 (2002)
Reference
PMID:12084906
  Authors
Cato AC, Nestl A, Mink S.
  Title
Rapid actions of steroid receptors in cellular signaling pathways.
  Journal
Sci STKE 2002:RE9 (2002)
DOI:10.1126/stke.2002.138.re9
Reference
PMID:11730319
  Authors
Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
  Title
The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
  Journal
Biol Cell 93:27-33 (2001)
DOI:10.1016/S0248-4900(01)01127-3
Reference
PMID:11063930
  Authors
Nebreda AR, Ferby I.
  Title
Regulation of the meiotic cell cycle in oocytes.
  Journal
Curr Opin Cell Biol 12:666-75 (2000)
DOI:10.1016/S0955-0674(00)00150-2
Reference
PMID:10497333
  Authors
Ferrell JE Jr.
  Title
Xenopus oocyte maturation: new lessons from a good egg.
  Journal
Bioessays 21:833-42 (1999)
DOI:10.1002/(SICI)1521-1878(199910)21:10<833::AID-BIES5>3.0.CO;2-P
Reference
PMID:12374568
  Authors
Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
  Title
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
  Journal
Biochem J 369:227-38 (2003)
DOI:10.1042/BJ20021243
Reference
PMID:12477927
  Authors
Duckworth BC, Weaver JS, Ruderman JV.
  Title
G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
  Journal
Proc Natl Acad Sci U S A 99:16794-9 (2002)
DOI:10.1073/pnas.222661299
Reference
PMID:11148128
  Authors
Abrieu A, Doree M, Fisher D.
  Title
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
  Journal
J Cell Sci 114:257-67 (2001)
Related
pathway
clv04010  MAPK signaling pathway
clv04110  Cell cycle
KO pathway
ko04914   
LinkDB

DBGET integrated database retrieval system