KEGG   PATHWAY: clv04010
Entry
clv04010                    Pathway                                
Name
MAPK signaling pathway - Columba livia (rock pigeon)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
clv04010  MAPK signaling pathway
clv04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Columba livia (rock pigeon) [GN:clv]
Gene
102083415  [KO:K16342] [EC:3.1.1.4]
102083432  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
102083591  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
102083603  [KO:K16342] [EC:3.1.1.4]
102083646  RAP1B; ras-related protein Rap-1b [KO:K07836]
102083658  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
102083695  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
102083770  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
102083779  [KO:K16342] [EC:3.1.1.4]
102083886  EGF; pro-epidermal growth factor [KO:K04357]
102083959  [KO:K16342] [EC:3.1.1.4]
102084059  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
102084092  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
102084148  [KO:K16342] [EC:3.1.1.4]
102084248  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
102084432  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
102084510  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
102084634  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
102084658  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
102084879  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102084951  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
102084988  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
102085027  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
102085051  MAP3K5; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
102085060  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
102085088  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
102085143  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
102085165  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X2 [KO:K04424] [EC:2.7.11.25]
102085196  TGFB2; transforming growth factor beta-2 [KO:K13376]
102085235  FGFR1; LOW QUALITY PROTEIN: fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
102085277  RASA2; ras GTPase-activating protein 2 [KO:K08053]
102085477  CACNB4; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit beta-4 [KO:K04865]
102085780  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
102085804  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
102085840  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
102085857  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
102085878  FGF3; fibroblast growth factor 3 isoform X1 [KO:K04358]
102085924  NF1; LOW QUALITY PROTEIN: neurofibromin [KO:K08052]
102085947  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
102085948  MYC; myc proto-oncogene protein [KO:K04377]
102085990  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
102085992  NGFR; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 16 [KO:K02583]
102086078  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
102086177  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X3 [KO:K04372] [EC:2.7.11.1]
102086308  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
102086328  CACNA1B; LOW QUALITY PROTEIN: voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
102086335  MAP3K9; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
102086356  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
102086382  TEK; LOW QUALITY PROTEIN: angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
102086447  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102086486  MAP3K4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
102086538  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X4 [KO:K08018]
102086722  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
102086745  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
102086801  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102086817  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
102086843  NLK; LOW QUALITY PROTEIN: serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
102086876  NTRK1; LOW QUALITY PROTEIN: high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
102086996  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
102087091  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
102087107  PDGFC; platelet-derived growth factor C [KO:K05450]
102087238  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
102087387  RPS6KA1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
102087399  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
102087487  CDC25B; LOW QUALITY PROTEIN: M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
102087532  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
102087545  [KO:K05096] [EC:2.7.10.1]
102087578  VEGFA; vascular endothelial growth factor A [KO:K05448]
102087625  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102087774  MYD88; LOW QUALITY PROTEIN: myeloid differentiation primary response protein MyD88 [KO:K04729]
102087779  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
102087983  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102088083  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
102088125  TGFB3; transforming growth factor beta-3 [KO:K13377]
102088127  CACNA1G; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
102088133  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 [KO:K04436]
102088147  [KO:K04421] [EC:2.7.11.25]
102088301  STK3; serine/threonine-protein kinase 3 [KO:K04412]
102088332  MAP3K14; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
102088372  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
102088437  MKNK2; LOW QUALITY PROTEIN: MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
102088487  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
102088494  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
102088608  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
102088632  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
102088763  MRAS; ras-related protein M-Ras [KO:K07831]
102088789  NRK; nik-related protein kinase isoform X2 [KO:K04407] [EC:2.7.11.1]
102088936  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
102089030  RAP1A; ras-related protein Rap-1A [KO:K04353]
102089078  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
102089179  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
102089200  MAP3K21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
102089201  SRF; serum response factor isoform X2 [KO:K04378]
102089229  RASA1; ras GTPase-activating protein 1 [KO:K04352]
102089255  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
102089263  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
102089407  MECOM; MDS1 and EVI1 complex locus protein EVI1 isoform X3 [KO:K04462] [EC:2.1.1.367]
102089427  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
102089447  PPM1A; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
102089495  SOS2; son of sevenless homolog 2 [KO:K03099]
102089586  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X5 [KO:K04863]
102089715  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
102089718  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
102089727  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
102089738  [KO:K04441] [EC:2.7.11.24]
102089752  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
102089963  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
102089966  [KO:K04853]
102090037  [KO:K04441] [EC:2.7.11.24]
102090039  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
102090045  MEF2C; myocyte-specific enhancer factor 2C isoform X5 [KO:K04454]
102090065  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
102090115  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
102090195  EFNA1; ephrin-A1 [KO:K05462]
102090209  FLT4; vascular endothelial growth factor receptor 3 isoform X2 [KO:K05097] [EC:2.7.10.1]
102090291  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
102090550  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
102090585  IL1B; interleukin 1, beta [KO:K04519]
102090612  FGF16; fibroblast growth factor 16 isoform X1 [KO:K04358]
102090861  [KO:K04441] [EC:2.7.11.24]
102091004  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
102091011  MAP3K13; mitogen-activated protein kinase kinase kinase 13 isoform X2 [KO:K04422] [EC:2.7.11.25]
102091020  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
102091094  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
102091108  CACNA1D; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
102091121  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
102091137  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
102091153  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
102091194  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
102091247  CRK; adapter molecule crk [KO:K04438]
102091363  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
102091394  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102091503  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
102091763  HRAS; GTPase HRas [KO:K02833]
102091892  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
102091992  [KO:K04388] [EC:2.7.11.30]
102092020  IL1RAP; interleukin-1 receptor accessory protein [KO:K04723]
102092033  INS; insulin isoform X1 [KO:K04526]
102092034  BDNF; brain-derived neurotrophic factor isoform X2 [KO:K04355]
102092075  RASGRF2; LOW QUALITY PROTEIN: ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
102092089  IGF1; insulin-like growth factor I [KO:K05459]
102092145  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
102092160  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
102092182  NTRK2; BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
102092209  JUN; LOW QUALITY PROTEIN: transcription factor AP-1 [KO:K04448]
102092229  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
102092362  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
102092365  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 [KO:K04864]
102092494  MAP3K2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
102092630  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
102092640  FGF6; fibroblast growth factor 6 [KO:K04358]
102092659  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
102092831  CRKL; crk-like protein [KO:K04438]
102092913  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102092940  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
102093014  FGF23; fibroblast growth factor 23 [KO:K22428]
102093053  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
102093134  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
102093546  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
102093626  NR4A1; LOW QUALITY PROTEIN: nuclear receptor subfamily 4 group A member 1 [KO:K04465]
102093657  FGF20; fibroblast growth factor 20 [KO:K04358]
102093872  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
102094006  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
102094013  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
102094103  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
102094151  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102094181  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X4 [KO:K04345] [EC:2.7.11.11]
102094261  MAPKAPK3; MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
102094265  STMN1; stathmin [KO:K04381]
102094282  AREG; amphiregulin [KO:K09782]
102094352  [KO:K16342] [EC:3.1.1.4]
102094371  KITLG; kit ligand [KO:K05461]
102094464  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
102094527  PLA2G4F; cytosolic phospholipase A2 zeta isoform X2 [KO:K16342] [EC:3.1.1.4]
102094533  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
102094546  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
102094633  EFNA3; ephrin-A3 [KO:K05462]
102094659  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
102094702  IGF2; insulin-like growth factor II [KO:K13769]
102094763  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
102094981  NTF3; neurotrophin-3 [KO:K04356]
102095010  CACNA1C; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
102095050  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
102095101  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X2 [KO:K04463] [EC:2.7.12.2]
102095269  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102095289  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
102095316  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
102095405  DUSP5; LOW QUALITY PROTEIN: dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102095465  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
102095499  KIT; LOW QUALITY PROTEIN: mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
102095564  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
102095791  FGF4; fibroblast growth factor 4 [KO:K04358]
102095838  SOS1; LOW QUALITY PROTEIN: son of sevenless homolog 1 [KO:K03099]
102095954  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
102095975  FGF19; fibroblast growth factor 19 [KO:K22603]
102096076  KRAS; GTPase KRas isoform X3 [KO:K07827]
102096091  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102096117  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102096163  MAX; protein max [KO:K04453]
102096240  HSPB1; heat shock protein beta-1 [KO:K04455]
102096453  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
102096506  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
102096751  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
102096788  RAF1; LOW QUALITY PROTEIN: RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
102096790  PDGFRB; LOW QUALITY PROTEIN: platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
102096791  FGF18; fibroblast growth factor 18 [KO:K04358]
102096932  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
102097012  [KO:K04441] [EC:2.7.11.24]
102097053  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102097060  TGFA; protransforming growth factor alpha [KO:K08774]
102097070  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X3 [KO:K04442] [EC:2.7.11.1]
102097230  EPHA2; LOW QUALITY PROTEIN: ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
102097298  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
102097428  [KO:K25414]
102097446  STK4; serine/threonine-protein kinase 4 [KO:K04411]
102097507  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
102097520  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
102097525  EFNA5; ephrin-A5 [KO:K05462]
102097643  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X3 [KO:K04373] [EC:2.7.11.1]
102097661  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
102097714  NGF; beta-nerve growth factor [KO:K02582]
102097732  [KO:K04439]
102097744  MAP3K1; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
102097819  MAP4K4; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
102097854  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
102097879  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
102097929  PGF; placenta growth factor [KO:K16859]
102098028  MAPT; microtubule-associated protein tau [KO:K04380]
102098055  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
102098077  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
102098275  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
102098285  FGF9; fibroblast growth factor 9 [KO:K04358]
102098376  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
102098388  RRAS2; ras-related protein R-Ras2 [KO:K07830]
102098523  [KO:K16342] [EC:3.1.1.4]
102098562  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
102098608  DUSP6; LOW QUALITY PROTEIN: dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
102098648  FOS; LOW QUALITY PROTEIN: proto-oncogene c-Fos [KO:K04379]
102098728  NRAS; GTPase NRas [KO:K07828]
102098952  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
102098970  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110357664  FGF10; fibroblast growth factor 10 [KO:K04358]
110364865  FGF2; fibroblast growth factor 2 [KO:K18497]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
clv04070  Phosphatidylinositol signaling system
clv04110  Cell cycle
clv04115  p53 signaling pathway
clv04210  Apoptosis
clv04310  Wnt signaling pathway
KO pathway
ko04010   

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