KEGG   PATHWAY: cmk04514
Entry
cmk04514                    Pathway                                
Name
Cell adhesion molecules - Callorhinchus milii (elephant shark)
Description
Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
cmk04514  Cell adhesion molecules
cmk04514

Other DBs
GO: 0050839
Organism
Callorhinchus milii (elephant shark) [GN:cmk]
Gene
103180163  T-cell surface antigen CD2 isoform X1 [KO:K06449]
103181350  vsir; V-type immunoglobulin domain-containing suppressor of T-cell activation [KO:K23268]
103184833  igsf11; immunoglobulin superfamily member 11 [KO:K06791]
103177701  programmed cell death 1 ligand 1 [KO:K06745]
103180140  T-cell-specific surface glycoprotein CD28 homolog [KO:K06470]
103176829  cytotoxic T-lymphocyte protein 4 [KO:K06538]
103189724  major histocompatibility complex class I-related gene protein [KO:K06751]
103181487  cd8a; T-cell surface glycoprotein CD8 alpha chain isoform X1 [KO:K06458]
103189083  CD276 antigen [KO:K06746]
103185647  CD276 antigen-like [KO:K06746]
103191209  CD276 antigen [KO:K06746]
103180169  butyrophilin-like protein 2 [KO:K06746]
103182617  uncharacterized protein LOC103182617 [KO:K06744]
103191363  tumor necrosis factor receptor superfamily member 5 [KO:K03160]
103191371  tumor necrosis factor receptor superfamily member 5 [KO:K03160]
103191377  tumor necrosis factor receptor superfamily member 5-like [KO:K03160]
103178144  tumor necrosis factor ligand superfamily member 10 [KO:K03161]
103180129  CD166 antigen [KO:K06547]
103184826  uncharacterized protein LOC103184826 [KO:K16350]
103176852  integrin beta-2 [KO:K06464]
103174770  ptprc; receptor-type tyrosine-protein phosphatase C [KO:K06478] [EC:3.1.3.48]
103177577  nectin-3 isoform X3 [KO:K06592]
103178655  nectin-3 [KO:K06592]
103179243  cldn2; claudin-2 [KO:K06087]
103176907  claudin-10 isoform X1 [KO:K06087]
103176908  claudin-10 [KO:K06087]
103177521  putative claudin-24 isoform X1 [KO:K06087]
103177657  claudin-23-like [KO:K06087]
103179547  claudin-6-like [KO:K06087]
103179619  cldn23l; claudin-23 [KO:K06087]
103180504  claudin-4-like [KO:K06087]
103180502  claudin-4-like [KO:K06087]
103180500  claudin-4-like [KO:K06087]
103174645  cldn18; claudin-18 [KO:K06087]
103181353  cldn19; claudin-19 [KO:K06087]
103181435  claudin-16-like [KO:K06087]
103186446  claudin-20 [KO:K06087]
103188588  cldn5a; claudin 5a [KO:K06087]
103188737  claudin-14 [KO:K06087]
103189322  cldn11a; claudin-11a [KO:K06087]
103191449  claudin-1 [KO:K06087]
103191450  claudin-16-like [KO:K06087]
121850970  cldn12; claudin-12 [KO:K06087]
103182021  si:ch73-61d6.3; uncharacterized protein si:ch73-61d6.3 [KO:K06088]
103182692  oclnb; uncharacterized protein oclnb [KO:K06088]
103177716  junctional adhesion molecule A [KO:K06089]
103188603  jam2a; junctional adhesion molecule 2A isoform X1 [KO:K06735]
103180302  jam3b; junctional adhesion molecule 3B [KO:K06785]
103180275  esama; endothelial cell adhesion molecule a [KO:K06787]
103188041  cadherin-5 [KO:K06533]
103190790  cd99; CD99 molecule [KO:K06520]
103178359  CD99 antigen-like protein 2 isoform X1 [KO:K06520]
103179971  P-selectin-like [KO:K06496]
103180066  E-selectin-like [KO:K06496]
103176505  itga4; integrin alpha-4 [KO:K06483]
103188814  integrin beta-1 isoform X1 [KO:K05719]
103185506  itga9; integrin alpha-9 [KO:K06585]
103182004  Schwann cell myelin protein [KO:K06527]
103188856  vascular cell adhesion protein 1 [KO:K06527]
103171689  itgb7; integrin beta-7 [KO:K06590]
103172945  L-selectin-like isoform X1 [KO:K06495]
103185919  glg1a; Golgi apparatus protein 1 [KO:K06816]
103191041  nectin-1 isoform X1 [KO:K06081]
103190758  nectin-1-like [KO:K06081]
103179705  cadherin-2 isoform X2 [KO:K06736]
103180312  neural cell adhesion molecule 1 isoform X6 [KO:K06491]
103189793  LOW QUALITY PROTEIN: neural cell adhesion molecule 2 [KO:K06491]
103180321  cell adhesion molecule 1 [KO:K06781]
103174754  ntng1a; netrin-G1 isoform X1 [KO:K07522]
103174963  lrrc4ca; leucine rich repeat containing 4C, genome duplicate a [KO:K07523]
103184627  ntng2a; netrin-G2 isoform X1 [KO:K16359]
103188947  lrrc4.2; leucine-rich repeat-containing protein 4 [KO:K16351]
103174611  ptprfa; protein tyrosine phosphatase receptor type Fa isoform X1 [KO:K05695] [EC:3.1.3.48]
103175831  chondroadherin [KO:K16360]
103171770  leucine-rich repeat-containing protein 4B-like [KO:K16360]
103187478  syndecan-4 [KO:K06257]
103175123  sdc2; syndecan-2 precursor [KO:K16336]
103179506  syndecan-3 [KO:K16337]
103171879  sdc4; syndecan-4 [KO:K16338]
103176518  itgav; integrin alpha-V [KO:K06487]
103183810  integrin alpha-8 isoform X1 [KO:K06487]
103185062  itgb8; integrin beta-8 isoform X1 [KO:K06591]
103187062  itga8; integrin alpha-8 [KO:K06584]
103180846  nrxn1a; neurexin 1a isoform X1 [KO:K07377]
103175759  neuroligin-1 [KO:K07378]
103189363  nlgn3a; neuroligin-3a isoform X1 [KO:K07378]
121849906  neuroligin-1-like [KO:K07378]
103183552  receptor-type tyrosine-protein phosphatase delta isoform X2 [KO:K06778] [EC:3.1.3.48]
103184521  SLIT and NTRK-like protein 1 [KO:K25832]
103181117  SLIT and NTRK-like protein 5 [KO:K25836]
103184519  LOW QUALITY PROTEIN: SLIT and NTRK-like protein 6 [KO:K25837]
103185469  receptor-type tyrosine-protein phosphatase delta isoform X1 [KO:K06777] [EC:3.1.3.48]
103175545  slitrk3a; SLIT and NTRK-like protein 3 [KO:K25834]
103179377  nrcama; neuronal cell adhesion molecule a isoform X1 [KO:K06756]
103179379  cntn1b; contactin 1b isoform X1 [KO:K06759]
103181055  LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase mu [KO:K05693] [EC:3.1.3.48]
103182537  cntn2; contactin-2 [KO:K06760]
103182438  neurofascin isoform X2 [KO:K06757]
103183798  cntnap1; LOW QUALITY PROTEIN: contactin-associated protein 1 [KO:K07379]
103187001  contactin-associated protein-like 2 isoform X1 [KO:K07380]
103175998  B-cadherin [KO:K05689]
103176450  integrin alpha-6 isoform X1 [KO:K06485]
103176576  LOW QUALITY PROTEIN: integrin alpha-6 [KO:K06485]
103176577  LOW QUALITY PROTEIN: integrin alpha-6-like [KO:K06485]
103190848  cadherin-4 isoform X1 [KO:K06797]
103188086  cdh15; cadherin-15 [KO:K06809]
103188702  neo1a; neogenin 1a isoform X1 [KO:K06766]
Reference
PMID:14690046
  Authors
Barclay AN.
  Title
Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
  Journal
Semin Immunol 15:215-23 (2003)
DOI:10.1016/S1044-5323(03)00047-2
Reference
PMID:11910893
  Authors
Sharpe AH, Freeman GJ.
  Title
The B7-CD28 superfamily.
  Journal
Nat Rev Immunol 2:116-26 (2002)
DOI:10.1038/nri727
Reference
PMID:9597126
  Authors
Grewal IS, Flavell RA.
  Title
CD40 and CD154 in cell-mediated immunity.
  Journal
Annu Rev Immunol 16:111-35 (1998)
DOI:10.1146/annurev.immunol.16.1.111
Reference
PMID:16034094
  Authors
Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
  Title
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
  Journal
J Immunol 175:1558-65 (2005)
DOI:10.4049/jimmunol.175.3.1558
Reference
PMID:12234363
  Authors
Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
  Title
Cell adhesion and polarity during immune interactions.
  Journal
Immunol Rev 186:68-82 (2002)
DOI:10.1034/j.1600-065X.2002.18607.x
Reference
PMID:15071551
  Authors
Dejana E.
  Title
Endothelial cell-cell junctions: happy together.
  Journal
Nat Rev Mol Cell Biol 5:261-70 (2004)
DOI:10.1038/nrm1357
Reference
PMID:14519386
  Authors
Bazzoni G.
  Title
The JAM family of junctional adhesion molecules.
  Journal
Curr Opin Cell Biol 15:525-30 (2003)
DOI:10.1016/S0955-0674(03)00104-2
Reference
PMID:10798271
  Authors
Becker BF, Heindl B, Kupatt C, Zahler S.
  Title
Endothelial function and hemostasis.
  Journal
Z Kardiol 89:160-7 (2000)
DOI:10.1007/PL00007320
Reference
PMID:9150551
  Authors
Elangbam CS, Qualls CW Jr, Dahlgren RR.
  Title
Cell adhesion molecules--update.
  Journal
Vet Pathol 34:61-73 (1997)
DOI:10.1177/030098589703400113
Reference
PMID:12810109
  Authors
Muller WA.
  Title
Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
  Journal
Trends Immunol 24:327-34 (2003)
DOI:10.1016/S1471-4906(03)00117-0
Reference
PMID:14519398
  Authors
Yamagata M, Sanes JR, Weiner JA.
  Title
Synaptic adhesion molecules.
  Journal
Curr Opin Cell Biol 15:621-32 (2003)
DOI:10.1016/S0955-0674(03)00107-8
Reference
PMID:15882774
  Authors
Ethell IM, Pasquale EB.
  Title
Molecular mechanisms of dendritic spine development and remodeling.
  Journal
Prog Neurobiol 75:161-205 (2005)
DOI:10.1016/j.pneurobio.2005.02.003
Reference
PMID:11050419
  Authors
Benson DL, Schnapp LM, Shapiro L, Huntley GW.
  Title
Making memories stick: cell-adhesion molecules in synaptic plasticity.
  Journal
Trends Cell Biol 10:473-82 (2000)
DOI:10.1016/S0962-8924(00)01838-9
Reference
PMID:11860281
  Authors
Rosdahl JA, Mourton TL, Brady-Kalnay SM.
  Title
Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
  Journal
Mol Cell Neurosci 19:292-306 (2002)
DOI:10.1006/mcne.2001.1071
Reference
PMID:10964748
  Authors
Dunican DJ, Doherty P.
  Title
The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
  Journal
Mol Cell Biol Res Commun 3:255-63 (2000)
DOI:10.1006/mcbr.2000.0225
Reference
PMID:12367625
  Authors
Girault JA, Peles E.
  Title
Development of nodes of Ranvier.
  Journal
Curr Opin Neurobiol 12:476-85 (2002)
DOI:10.1016/S0959-4388(02)00370-7
Reference
PMID:10664064
  Authors
Arroyo EJ, Scherer SS.
  Title
On the molecular architecture of myelinated fibers.
  Journal
Histochem Cell Biol 113:1-18 (2000)
DOI:10.1007/s004180050001
Reference
PMID:14556710
  Authors
Salzer JL.
  Title
Polarized domains of myelinated axons.
  Journal
Neuron 40:297-318 (2003)
DOI:10.1016/S0896-6273(03)00628-7
Reference
PMID:15561584
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002
Reference
PMID:15551862
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116
Reference
PMID:15115723
  Authors
Siu MK, Cheng CY.
  Title
Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
  Journal
Biol Reprod 71:375-91 (2004)
DOI:10.1095/biolreprod.104.028225
Reference
PMID:15056568
  Authors
Lee NP, Cheng CY.
  Title
Adaptors, junction dynamics, and spermatogenesis.
  Journal
Biol Reprod 71:392-404 (2004)
DOI:10.1095/biolreprod.104.027268
Reference
PMID:15728677
  Authors
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
  Title
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
  Journal
Development 132:1525-37 (2005)
DOI:10.1242/dev.01697
Reference
PMID:12500939
  Authors
Marthiens V, Gavard J, Lambert M, Mege RM.
  Title
Cadherin-based cell adhesion in neuromuscular development.
  Journal
Biol Cell 94:315-26 (2002)
DOI:10.1016/S0248-4900(02)00005-9
Reference
PMID:15923648
  Authors
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
  Title
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
  Journal
J Cell Sci 118:2355-62 (2005)
DOI:10.1242/jcs.02397
Related
pathway
cmk04520  Adherens junction
cmk04530  Tight junction
KO pathway
ko04514   
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