KEGG   PATHWAY: csec04120
Entry
csec04120                   Pathway                                
Name
Ubiquitin mediated proteolysis - Cryptotermes secundus (drywood termite)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
csec04120  Ubiquitin mediated proteolysis
csec04120

Other DBs
GO: 0016567
Organism
Cryptotermes secundus (drywood termite) [GN:csec]
Gene
111872708  polyubiquitin-B [KO:K04551]
111874534  polyubiquitin isoform X1 [KO:K08770]
111872533  ubiquitin-60S ribosomal protein L40 [KO:K02927]
111872467  ubiquitin-40S ribosomal protein S27a [KO:K02977]
111868599  ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
111863296  SUMO-activating enzyme subunit 1 [KO:K10684] [EC:6.2.1.45]
111867611  SUMO-activating enzyme subunit 2 [KO:K10685] [EC:6.2.1.45]
111868238  NEDD8-activating enzyme E1 catalytic subunit [KO:K10686] [EC:6.2.1.64]
111867908  ubiquitin-conjugating enzyme E2-17 kDa isoform X1 [KO:K10573] [EC:2.3.2.23]
111872738  ubiquitin-conjugating enzyme E2 C [KO:K06688] [EC:2.3.2.23]
111862395  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
111864332  ubiquitin-conjugating enzyme E2 E1 isoform X1 [KO:K20217] [EC:2.3.2.23]
111868495  NEDD8-conjugating enzyme UBE2F isoform X1 [KO:K10687] [EC:2.3.2.34]
111874614  ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
111868364  ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
111866541  ubiquitin-conjugating enzyme E2 H [KO:K10576] [EC:2.3.2.23]
111865423  SUMO-conjugating enzyme UBC9-A [KO:K10577]
111867487  ubiquitin-conjugating enzyme E2 J1 isoform X1 [KO:K10578] [EC:2.3.2.23]
111868480  ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
111873926  ubiquitin-conjugating enzyme E2-22 kDa isoform X1 [KO:K04649] [EC:2.3.2.23]
111862855  ubiquitin-conjugating enzyme E2 L3 isoform X1 [KO:K04552] [EC:2.3.2.23]
111868076  NEDD8-conjugating enzyme Ubc12 [KO:K10579] [EC:2.3.2.34]
111863531  ubiquitin-conjugating enzyme E2 N [KO:K10580] [EC:2.3.2.23]
111864869  (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O isoform X1 [KO:K10581] [EC:2.3.2.24]
111865879  ubiquitin-conjugating enzyme E2Q-like protein CG4502 [KO:K10582] [EC:2.3.2.23]
111872216  ubiquitin-conjugating enzyme E2 Q2 isoform X1 [KO:K10582] [EC:2.3.2.23]
111866109  ubiquitin-conjugating enzyme E2 R2 isoform X1 [KO:K02207] [EC:2.3.2.23]
111868202  ubiquitin-conjugating enzyme E2 S [KO:K10583] [EC:2.3.2.23]
111874785  ubiquitin-conjugating enzyme E2 W isoform X1 [KO:K10688] [EC:2.3.2.23 2.3.2.25]
111872361  ubiquitin-conjugating enzyme E2 Z-like isoform X1 [KO:K10585] [EC:2.3.2.23]
111872355  baculoviral IAP repeat-containing protein 6 isoform X2 [KO:K10586] [EC:2.3.2.23]
111870851  ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
111875281  ubiquitin-protein ligase E3B [KO:K10588] [EC:2.3.2.26]
111872390  ubiquitin-protein ligase E3C [KO:K10589] [EC:2.3.2.26]
111870041  E3 ubiquitin-protein ligase SMURF1 [KO:K04678] [EC:2.3.2.26]
111861327  E3 ubiquitin-protein ligase Su(dx) isoform X1 [KO:K05633] [EC:2.3.2.26]
111864059  E3 ubiquitin-protein ligase TRIP12 isoform X1 [KO:K10590] [EC:2.3.2.26]
111869524  E3 ubiquitin-protein ligase Nedd-4 isoform X1 [KO:K10591] [EC:2.3.2.26]
111864023  E3 ubiquitin-protein ligase Nedd-4 [KO:K10591] [EC:2.3.2.26]
111866189  E3 ubiquitin-protein ligase HUWE1 isoform X1 [KO:K10592] [EC:2.3.2.26]
111875645  E3 ubiquitin-protein ligase UBR5 isoform X2 [KO:K10593] [EC:2.3.2.26]
111873865  probable E3 ubiquitin-protein ligase HERC1 isoform X1 [KO:K10594] [EC:2.3.2.26]
111867911  E3 ubiquitin-protein ligase HERC2 [KO:K10595] [EC:2.3.2.26]
111870592  probable E3 ubiquitin-protein ligase HERC4 isoform X1 [KO:K10615] [EC:2.3.2.26]
111866288  ubiquitin conjugation factor E4 A isoform X1 [KO:K10596] [EC:2.3.2.27]
111869021  ubiquitin conjugation factor E4 B [KO:K10597] [EC:2.3.2.27]
111873329  E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
111864331  RING-type E3 ubiquitin-protein ligase PPIL2 isoform X1 [KO:K10598] [EC:5.2.1.8]
111874745  pre-mRNA-processing factor 19 isoform X1 [KO:K10599] [EC:2.3.2.27]
111871285  RING finger protein 37 [KO:K10600]
111871043  E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
111872262  E3 ubiquitin-protein ligase CBL-B-B isoform X1 [KO:K04707] [EC:2.3.2.27]
111863783  E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
111865459  E3 ubiquitin-protein ligase sina [KO:K04506] [EC:2.3.2.27]
111865590  putative E3 ubiquitin-protein ligase SINAT1 [KO:K04506] [EC:2.3.2.27]
111865840  probable E3 ubiquitin-protein ligase sinah [KO:K04506] [EC:2.3.2.27]
111874232  E3 ubiquitin-protein ligase SIAH1A-like [KO:K04506] [EC:2.3.2.27]
111866442  E3 ubiquitin-protein ligase SIAH1B [KO:K04506] [EC:2.3.2.27]
111866447  E3 ubiquitin-protein ligase SIAH1 [KO:K04506] [EC:2.3.2.27]
111866452  uncharacterized protein LOC111866452 [KO:K04506] [EC:2.3.2.27]
111866453  E3 ubiquitin-protein ligase sina-like isoform X1 [KO:K04506] [EC:2.3.2.27]
111866454  E3 ubiquitin-protein ligase siah-1 [KO:K04506] [EC:2.3.2.27]
111866455  E3 ubiquitin-protein ligase DIS1 [KO:K04506] [EC:2.3.2.27]
111866458  E3 ubiquitin-protein ligase siah-1 [KO:K04506] [EC:2.3.2.27]
111866459  E3 ubiquitin-protein ligase siah-1-like isoform X1 [KO:K04506] [EC:2.3.2.27]
111866461  E3 ubiquitin-protein ligase SIAH1A [KO:K04506] [EC:2.3.2.27]
111866465  E3 ubiquitin-protein ligase sina [KO:K04506] [EC:2.3.2.27]
111866467  E3 ubiquitin-protein ligase SIAH1B-like [KO:K04506] [EC:2.3.2.27]
111875167  E3 ubiquitin-protein ligase SIAH1B [KO:K04506] [EC:2.3.2.27]
111866797  E3 ubiquitin-protein ligase Siah1 [KO:K04506] [EC:2.3.2.27]
117282406  E3 ubiquitin-protein ligase SIAH1B-like [KO:K04506] [EC:2.3.2.27]
111868246  E3 ubiquitin-protein ligase SIAH1A [KO:K04506] [EC:2.3.2.27]
111868256  E3 ubiquitin-protein ligase sina [KO:K04506] [EC:2.3.2.27]
117282472  E3 ubiquitin-protein ligase sina-like [KO:K04506] [EC:2.3.2.27]
117282511  E3 ubiquitin-protein ligase SIAH1A-like [KO:K04506] [EC:2.3.2.27]
111869628  E3 ubiquitin-protein ligase sina [KO:K04506] [EC:2.3.2.27]
111872760  E3 ubiquitin-protein ligase SIAH1B [KO:K04506] [EC:2.3.2.27]
111868945  E3 ubiquitin-protein ligase SIAH1A [KO:K04506] [EC:2.3.2.27]
111861540  E3 ubiquitin-protein ligase SIAH1A [KO:K04506] [EC:2.3.2.27]
111861751  E3 ubiquitin-protein ligase SIAH1A [KO:K04506] [EC:2.3.2.27]
111862225  E3 ubiquitin-protein ligase Siah1 [KO:K04506] [EC:2.3.2.27]
111862459  E3 ubiquitin-protein ligase Siah1 [KO:K04506] [EC:2.3.2.27]
111870726  E3 ubiquitin-protein ligase sina-like [KO:K04506] [EC:2.3.2.27]
111871045  E3 ubiquitin-protein ligase sina [KO:K04506] [EC:2.3.2.27]
111871557  E3 ubiquitin-protein ligase Siah1 isoform X1 [KO:K04506] [EC:2.3.2.27]
111871897  E3 ubiquitin-protein ligase SIAH1A isoform X1 [KO:K04506] [EC:2.3.2.27]
111872642  E3 ubiquitin-protein ligase SIAH1 [KO:K04506] [EC:2.3.2.27]
111873183  E3 ubiquitin-protein ligase SIAH1A [KO:K04506] [EC:2.3.2.27]
111873307  E3 ubiquitin-protein ligase Siah1 isoform X1 [KO:K04506] [EC:2.3.2.27]
111873310  E3 ubiquitin-protein ligase SIAH1B isoform X1 [KO:K04506] [EC:2.3.2.27]
111863746  TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
111865903  mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
111872868  E3 ubiquitin-protein ligase COP1 isoform X1 [KO:K10143] [EC:2.3.2.27]
111870785  RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:2.3.2.27]
111866121  baculoviral IAP repeat-containing protein 7-B isoform X1 [KO:K16060]
111866114  baculoviral IAP repeat-containing protein 2 [KO:K16061]
111867077  E3 SUMO-protein ligase PIAS2 isoform X1 [KO:K04706] [EC:2.3.2.-]
111863380  E3 ubiquitin-protein ligase synoviolin isoform X1 [KO:K10601] [EC:2.3.2.27]
111861670  uncharacterized protein LOC111861670 isoform X1 [KO:K10605] [EC:2.3.2.27]
111863217  E3 ubiquitin-protein ligase FANCL isoform X2 [KO:K10606] [EC:2.3.2.27]
111864018  E3 ubiquitin-protein ligase TRIM37 [KO:K10608] [EC:2.3.2.27]
111870542  RING-box protein 1A [KO:K03868] [EC:2.3.2.32]
111864182  cullin-1 [KO:K03347]
111870551  S-phase kinase-associated protein 1 [KO:K03094]
111861980  F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362]
111872935  S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
111862818  F-box/WD repeat-containing protein 7 [KO:K10260]
111868892  cullin-2 isoform X1 [KO:K03870]
111875067  elongin-C isoform X1 [KO:K03872]
111867527  elongin-C isoform X2 [KO:K03872]
111867529  elongin-C [KO:K03872]
111867458  elongin-B isoform X1 [KO:K03873]
111869957  von Hippel-Lindau disease tumor suppressor [KO:K03871]
111869071  cullin-3-A [KO:K03869]
111874626  kelch-like ECH-associated protein 1B [KO:K10456]
111874765  rho-related BTB domain-containing protein 2 isoform X1 [KO:K07868]
111868514  cullin-4A [KO:K10609]
111863086  DNA damage-binding protein 1 isoform X1 [KO:K10610]
111871881  DNA damage-binding protein 2-like [KO:K10140]
111873417  DNA excision repair protein ERCC-8 [KO:K10570]
111873885  DET1 homolog [KO:K10571]
111875049  cullin-5 isoform X1 [KO:K10612]
111872875  anaphase-promoting complex subunit 2 [KO:K03349]
111870774  cell division cycle protein 20 homolog [KO:K03363]
111871089  protein cortex isoform X1 [KO:K03363]
111863403  fizzy-related protein homolog [KO:K03364]
111863449  fizzy-related protein homolog [KO:K03364]
111873375  fizzy-related protein homolog [KO:K03364]
111874155  anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
111869393  cell division cycle protein 27 homolog isoform X1 [KO:K03350]
111868453  anaphase-promoting complex subunit 4 [KO:K03351]
111869236  anaphase-promoting complex subunit 5 [KO:K03352]
111873518  cell division cycle protein 16 homolog isoform X1 [KO:K03353]
111874426  anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
111868370  cell division cycle protein 23 homolog [KO:K03355]
111866961  anaphase-promoting complex subunit 10 [KO:K03357]
111875047  anaphase-promoting complex subunit 15B [KO:K25228]
Reference
PMID:16922370
  Authors
Kamura T.
  Title
[Cullin-based E3 family]
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
PMID:16922408
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
PMID:16922367
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
PMID:16816840
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
DOI:10.1038/nrd2056
Reference
PMID:16405856
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
PMID:12944364
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
DOI:10.1093/jb/mvg106
Reference
PMID:17588513
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
DOI:10.1016/j.molcel.2007.06.001
Related
pathway
csec03050  Proteasome
KO pathway
ko04120   
LinkDB

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