KEGG   PATHWAY: csec04150
Entry
csec04150                   Pathway                                
Name
mTOR signaling pathway - Cryptotermes secundus (drywood termite)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
csec04150  mTOR signaling pathway
csec04150

Organism
Cryptotermes secundus (drywood termite) [GN:csec]
Gene
111866607  Y+L amino acid transporter 2 [KO:K13780]
111874624  large neutral amino acids transporter small subunit 1 [KO:K13780]
111866608  large neutral amino acids transporter small subunit 1 [KO:K13780]
111871093  sodium-coupled neutral amino acid transporter 9 isoform X1 [KO:K14995]
111861955  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
111861361  V-type proton ATPase subunit B [KO:K02147]
111875683  V-type proton ATPase subunit C [KO:K02148]
111871389  V-type proton ATPase subunit D 1 [KO:K02149]
111863919  V-type proton ATPase subunit E [KO:K02150]
111871226  V-type proton ATPase subunit F [KO:K02151]
111874525  V-type proton ATPase subunit G [KO:K02152]
111862075  V-type proton ATPase subunit H isoform X1 [KO:K02144]
111863676  ragulator complex protein LAMTOR1 [KO:K20397]
111861534  ragulator complex protein LAMTOR2 homolog [KO:K20398]
111874928  ragulator complex protein LAMTOR3-A [KO:K04370]
111872008  ragulator complex protein LAMTOR4 [KO:K20399]
111866523  uncharacterized protein LOC111866523 [KO:K16344]
111866852  folliculin isoform X1 [KO:K09594]
111862993  uncharacterized protein LOC111862993 [KO:K20401]
111868709  ras-related GTP-binding protein A isoform X1 [KO:K16185]
111861319  ras-related GTP-binding protein C isoform X2 [KO:K16186]
111864025  GATOR complex protein MIOS isoform X1 [KO:K20407]
111864044  GATOR complex protein WDR24 [KO:K20408]
111866032  GATOR complex protein WDR59 [KO:K20409]
111863379  protein SEC13 homolog [KO:K14004]
111861680  GATOR complex protein Iml1 [KO:K20404]
111866273  GATOR complex protein NPRL2 [KO:K20405]
111871095  GATOR complex protein NPRL2 [KO:K20405]
111871046  GATOR complex protein NPRL3 isoform X1 [KO:K20406]
111872935  S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
111873291  regulatory-associated protein of mTOR [KO:K07204]
111869020  serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
111864682  target of rapamycin complex subunit lst8 [KO:K08266]
111862351  TELO2-interacting protein 1 homolog [KO:K20403]
111866616  CAP-Gly domain-containing linker protein 2 isoform X1 [KO:K10421]
111862650  uncharacterized protein LOC111862650 [KO:K10421]
111865116  growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
111867931  phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
111866311  serine/threonine-protein kinase unc-51 [KO:K08269] [EC:2.7.11.1]
111869306  eukaryotic translation initiation factor 4E [KO:K03259]
111863696  eukaryotic translation initiation factor 4E type 2 [KO:K03259]
111868310  ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
111864501  eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
111875501  40S ribosomal protein S6 [KO:K02991]
111867977  STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
111865009  serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
111868422  protein Mo25 [KO:K08272]
111865905  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X3 [KO:K07198] [EC:2.7.11.31]
111868529  hamartin isoform X1 [KO:K07206]
111873276  tuberin [KO:K07207]
111872037  TBC1 domain family member 7 [KO:K20396]
111867395  GTP-binding protein Rheb homolog [KO:K07208]
111861258  protein wingless [KO:K03209]
111864514  protein Wnt-1-like [KO:K00408]
111866769  protein Wnt-5b isoform X2 [KO:K00444]
111861269  protein Wnt-6 [KO:K00445]
111868950  protein Wnt-7b [KO:K00572]
111861257  protein Wnt-4 isoform X2 [KO:K01064]
111861255  protein Wnt-10a [KO:K01357]
111866785  protein Wnt-11b-2 [KO:K01384]
111867320  protein Wnt-16 isoform X1 [KO:K01558]
111870939  frizzled-2 [KO:K02432]
111874658  frizzled-4 [KO:K02354]
111862450  frizzled-2 [KO:K02375]
111874670  frizzled-10 isoform X1 [KO:K02842]
111867713  LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 6 [KO:K03068]
111865377  segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
111863303  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
111861297  LIRP [KO:K04526]
111862713  uncharacterized protein LOC111862713 [KO:K04526]
111861959  insulin-like growth factor [KO:K05459]
111861850  insulin-like peptide receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
111863536  insulin-like receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
111861232  protein enhancer of sevenless 2B [KO:K04364]
111873103  protein son of sevenless [KO:K03099]
111875773  GTPase HRas [KO:K07827]
111870385  GTPase HRas [KO:K07827]
111872156  raf homolog serine/threonine-protein kinase Raf [KO:K04365] [EC:2.7.11.1]
111874579  dual specificity mitogen-activated protein kinase kinase dSOR1 [KO:K04368] [EC:2.7.12.2]
111868600  dual specificity mitogen-activated protein kinase kinase dSOR1 isoform X1 [KO:K04368] [EC:2.7.12.2]
111866618  mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
111865586  ribosomal protein S6 kinase 2 beta isoform X1 [KO:K04373] [EC:2.7.11.1]
111867485  insulin receptor substrate 1 isoform X1 [KO:K16172]
111865305  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
111867061  phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
111875189  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
111873335  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
111871175  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
111867624  3-phosphoinositide-dependent protein kinase 1 isoform X2 [KO:K06276] [EC:2.7.11.1]
111874177  RAC serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111866549  inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
111868886  target of rapamycin complex 2 subunit MAPKAP1 [KO:K20410]
111866543  rapamycin-insensitive companion of mTOR isoform X1 [KO:K08267]
111874961  proline-rich protein 5-like isoform X1 [KO:K20411]
111863512  ras-like GTP-binding protein Rho1 [KO:K04513]
111873155  ras-like GTP-binding protein RHO [KO:K04513]
111873160  ras-like GTP-binding protein Rho1 [KO:K04513]
111868595  protein kinase C, brain isozyme isoform X1 [KO:K02677] [EC:2.7.11.13]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
csec00561  Glycerolipid metabolism
csec04140  Autophagy - animal
KO pathway
ko04150   
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