KEGG   PATHWAY: dgt04141
Entry
dgt04141                    Pathway                                
Name
Protein processing in endoplasmic reticulum - Dendronephthya gigantea (soft corals)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
dgt04141  Protein processing in endoplasmic reticulum
dgt04141

Other DBs
GO: 0030433 0034976
Organism
Dendronephthya gigantea (soft corals) [GN:dgt]
Gene
114527080  protein transport protein Sec61 subunit alpha [KO:K10956]
114525706  protein transport protein Sec61 subunit beta-like [KO:K09481]
114518015  translocation protein SEC62-like [KO:K12275]
114538189  translocation protein SEC63 homolog [KO:K09540]
114526147  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1-like [KO:K12666]
114526897  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2-like [KO:K12667]
114518274  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit-like [KO:K12670]
114518581  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B-like [KO:K07151] [EC:2.4.99.18]
114527593  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A-like [KO:K07151] [EC:2.4.99.18]
114521439  tumor suppressor candidate 3-like [KO:K19478]
114530938  oligosaccharyltransferase complex subunit ostc-B-like [KO:K26501]
114520873  transmembrane protein 258 [KO:K26502]
114538040  LOW QUALITY PROTEIN: mannosyl-oligosaccharide glucosidase-like [KO:K01228] [EC:3.2.1.106]
114515737  nucleotide exchange factor SIL1-like [KO:K14001]
114524911  hypoxia up-regulated protein 1-like [KO:K09486]
114519155  endoplasmic reticulum chaperone BiP-like [KO:K09490] [EC:3.6.4.10]
114531653  dnaJ homolog subfamily B member 11-like [KO:K09517]
114517433  dnaJ homolog subfamily C member 1-like [KO:K09521]
114526089  dnaJ homolog subfamily C member 3-like [KO:K09523]
114517680  dnaJ homolog subfamily C member 10-like [KO:K09530] [EC:1.8.4.-]
114530508  LOW QUALITY PROTEIN: endoplasmin-like [KO:K09487]
114532487  neutral alpha-glucosidase AB-like isoform X1 [KO:K05546] [EC:3.2.1.207]
114527892  glucosidase 2 subunit beta-like [KO:K08288]
114523418  calnexin-like [KO:K08054]
114529323  protein disulfide-isomerase A3-like [KO:K08056] [EC:5.3.4.1]
114527247  calreticulin-like [KO:K08057]
114535692  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA-like [KO:K01230] [EC:3.2.1.113]
114519075  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase-like [KO:K23741] [EC:3.2.1.209]
114538053  VIP36-like protein [KO:K10082]
114522870  protein ERGIC-53-like [KO:K10080]
114528851  prolactin regulatory element-binding protein-like [KO:K14003]
114525160  GTP-binding protein SAR1b-like isoform X1 [KO:K07953] [EC:3.6.5.-]
114523358  GTP-binding protein SAR2-like [KO:K07953] [EC:3.6.5.-]
114521674  protein SEC13 homolog isoform X1 [KO:K14004]
114521095  protein transport protein Sec31A-like [KO:K14005]
114540196  LOW QUALITY PROTEIN: protein transport protein Sec23A-like [KO:K14006]
114539346  LOW QUALITY PROTEIN: protein transport protein Sec23A-like [KO:K14006]
114526473  protein transport protein Sec24C-like isoform X1 [KO:K14007]
114524791  protein transport protein Sec24A-like [KO:K14007]
114528125  UDP-glucose:glycoprotein glucosyltransferase 1-like isoform X1 [KO:K11718] [EC:2.4.1.-]
114537566  ER degradation-enhancing alpha-mannosidase-like protein 1 [KO:K10084]
114516941  ER degradation-enhancing alpha-mannosidase-like protein 2 [KO:K10085]
114530194  ER degradation-enhancing alpha-mannosidase-like protein 3 [KO:K10086]
114519469  protein disulfide-isomerase 2-like [KO:K09580] [EC:5.3.4.1]
114519527  protein disulfide-isomerase 2-like [KO:K09580] [EC:5.3.4.1]
114535016  protein disulfide-isomerase A4-like [KO:K09582] [EC:5.3.4.1]
114528557  protein disulfide-isomerase A6-like [KO:K09584] [EC:5.3.4.1]
114524571  protein disulfide-isomerase 1-like [KO:K09584] [EC:5.3.4.1]
114523711  endoplasmic reticulum resident protein 29-like [KO:K09586]
114528558  thioredoxin domain-containing protein 5-like [KO:K13984] [EC:5.3.4.1]
114525190  protein OS-9-like isoform X1 [KO:K10088]
114517521  endoplasmic reticulum lectin 1-like [KO:K14008]
114516440  translocon-associated protein subunit alpha-like [KO:K13249]
114522679  translocon-associated protein subunit beta-like [KO:K13250]
114540564  translocon-associated protein subunit beta-like [KO:K13250]
114518413  translocon-associated protein subunit gamma-like [KO:K13251]
114521898  translocon-associated protein subunit delta-like [KO:K04571]
114521775  B-cell receptor-associated protein 31-like [KO:K14009]
114528593  translocating chain-associated membrane protein 1-like 1 [KO:K14010]
114516687  derlin-1-like isoform X1 [KO:K11519]
114520523  derlin-2-like [KO:K13989]
114516294  UBX domain-containing protein 4-like [KO:K24348]
114520047  UBX domain-containing protein 1-like [KO:K24348]
114542517  UBX domain-containing protein 1-like [KO:K24348]
114522860  UBX domain-containing protein 6-like isoform X1 [KO:K14011]
114541117  UBX domain-containing protein 6-like isoform X1 [KO:K14011]
114517906  NSFL1 cofactor p47-like [KO:K14012]
114520942  small VCP/p97-interacting protein-like [KO:K14014]
114535906  transitional endoplasmic reticulum ATPase [KO:K13525]
114541716  nuclear protein localization protein 4 homolog [KO:K14015]
114524008  ubiquitin recognition factor in ER-associated degradation protein 1-like [KO:K14016]
114517503  heat shock cognate 71 kDa protein-like [KO:K03283]
114519104  dnaJ homolog subfamily A member 1-like [KO:K09502]
114532659  dnaJ homolog subfamily A member 2-like [KO:K09503]
114531167  dnaJ homolog subfamily B member 1-like [KO:K09507]
114528489  dnaJ homolog subfamily B member 14-like [KO:K09518]
114517909  dnaJ homolog subfamily C member 5-like isoform X1 [KO:K09525]
114520274  heat shock protein HSP 90-beta-like [KO:K04079]
114533975  hsp70-binding protein 1-like [KO:K09562]
114528273  ubiquitin thioesterase OTU1-like [KO:K13719] [EC:3.1.2.-]
114530239  LOW QUALITY PROTEIN: phospholipase A-2-activating protein-like [KO:K14018]
114527193  UV excision repair protein RAD23 homolog B-like [KO:K10839]
114522499  ubiquilin-1-like [KO:K04523]
114517703  peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase-like isoform X1 [KO:K01456] [EC:3.5.1.52]
114532579  ataxin-3-like isoform X1 [KO:K11863] [EC:3.4.22.-]
114518277  ubiquitin conjugation factor E4 B-like [KO:K10597] [EC:2.3.2.27]
114528791  eukaryotic translation initiation factor 2 subunit 1-like [KO:K03237]
114529187  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
114531784  apoptosis regulator Bcl-2-like [KO:K02161]
114530386  cyclic AMP-dependent transcription factor ATF-6 alpha-like isoform X1 [KO:K09054]
114516410  LOW QUALITY PROTEIN: membrane-bound transcription factor site-1 protease-like [KO:K08653] [EC:3.4.21.112]
114516428  membrane-bound transcription factor site-2 protease-like [KO:K07765] [EC:3.4.24.85]
114520595  X-box-binding protein 1-like [KO:K09027]
114516947  uncharacterized protein LOC114516947 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
114535976  serine/threonine-protein kinase/endoribonuclease IRE1-like [KO:K08852] [EC:2.7.11.1 3.1.26.-]
114530987  uncharacterized protein LOC114530987 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
114529045  serine/threonine-protein kinase/endoribonuclease IRE1-like [KO:K08852] [EC:2.7.11.1 3.1.26.-]
114529095  serine/threonine-protein kinase/endoribonuclease IRE1b-like [KO:K08852] [EC:2.7.11.1 3.1.26.-]
114522665  uncharacterized protein LOC114522665 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
114530087  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
114534740  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
114518977  dual specificity mitogen-activated protein kinase kinase 7-like [KO:K04431] [EC:2.7.12.2]
114527520  stress-activated protein kinase JNK-like isoform X1 [KO:K04440] [EC:2.7.11.24]
114529417  apoptosis regulator BAX-like [KO:K02159]
114531458  apoptosis regulator BAX-like [KO:K02159]
114529280  apoptosis regulator BAX-like [KO:K02159]
114521106  bcl-2 homologous antagonist/killer-like [KO:K14021]
114517239  E3 ubiquitin-protein ligase MARCH6-like [KO:K10661] [EC:2.3.2.27]
114532628  ubiquitin-conjugating enzyme E2 J1-like [KO:K10578] [EC:2.3.2.23]
114518295  ubiquitin-conjugating enzyme E2 J2-like [KO:K04554] [EC:2.3.2.23]
114520409  ubiquitin-conjugating enzyme E2 G1-like [KO:K10575] [EC:2.3.2.23]
114525676  ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
114522320  E3 ubiquitin-protein ligase synoviolin-like [KO:K10601] [EC:2.3.2.27]
114524061  E3 ubiquitin-protein ligase RNF185-like [KO:K10666] [EC:2.3.2.27]
114523452  uncharacterized protein LOC114523452 isoform X1 [KO:K14025]
114532437  protein sel-1 homolog 1-like isoform X1 [KO:K14026]
114532743  E3 ubiquitin-protein ligase AMFR-like [KO:K10636] [EC:2.3.2.36]
114536051  E3 ubiquitin-protein ligase CHIP-like isoform X1 [KO:K09561] [EC:2.3.2.27]
114530940  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
114541205  E3 ubiquitin-protein ligase parkin-like isoform X1 [KO:K04556] [EC:2.3.2.31]
114541208  uncharacterized protein LOC114541208 [KO:K04556] [EC:2.3.2.31]
114541209  E3 ubiquitin-protein ligase parkin-like [KO:K04556] [EC:2.3.2.31]
114530307  RING-box protein 1 [KO:K03868] [EC:2.3.2.32]
114517451  cullin-1-like [KO:K03347]
114527624  S-phase kinase-associated protein 1 [KO:K03094]
114521817  F-box only protein 44-like [KO:K10100]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
dgt00510  N-Glycan biosynthesis
dgt03050  Proteasome
dgt03060  Protein export
KO pathway
ko04141   
LinkDB

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