KEGG   PATHWAY: dme00600
Entry
dme00600                    Pathway                                
Name
Sphingolipid metabolism - Drosophila melanogaster (fruit fly)
Class
Metabolism; Lipid metabolism
Pathway map
dme00600  Sphingolipid metabolism
dme00600

Module
dme_M00094  Ceramide biosynthesis [PATH:dme00600]
dme_M00099  Sphingosine biosynthesis [PATH:dme00600]
dme_M00100  Sphingosine degradation [PATH:dme00600]
Other DBs
GO: 0006665
Organism
Drosophila melanogaster (fruit fly) [GN:dme]
Gene
Dmel_CG4016  Spt-I; serine palmitoyltransferase subunit I, isoform A [KO:K00654] [EC:2.3.1.50]
Dmel_CG4162  lace; lace, isoform B [KO:K00654] [EC:2.3.1.50]
Dmel_CG10425  Kdsr; 3-ketodihydrosphingosine reductase [KO:K04708] [EC:1.1.1.102]
Dmel_CG3576  schlank; schlank, isoform B [KO:K23727] [EC:2.3.1.291]
Dmel_CG1471  CDase; ceramidase, isoform F [KO:K12349] [EC:3.5.1.23]
Dmel_CG13969  bwa; brain washing, isoform A [KO:K01441] [EC:3.5.1.23]
Dmel_CG9078  ifc; infertile crescent, isoform A [KO:K04712] [EC:1.14.19.17 1.14.18.5]
Dmel_CG3376  CG3376; uncharacterized protein, isoform C [KO:K12350] [EC:3.1.4.12]
Dmel_CG12034  nSMase; neutral sphingomyelinase [KO:K12351] [EC:3.1.4.12]
Dmel_CG6962  CG6962; uncharacterized protein [KO:K12353] [EC:3.1.4.12]
Dmel_CG16708  Cerk; ceramide kinase, isoform B [KO:K04715] [EC:2.7.1.138]
Dmel_CG8804  wun; wunen, isoform B [KO:K01080] [EC:3.1.3.4]
Dmel_CG8805  wun2; wunen-2, isoform B [KO:K01080] [EC:3.1.3.4]
Dmel_CG11440  laza; lazaro [KO:K01080] [EC:3.1.3.4]
Dmel_CG11438  CG11438; uncharacterized protein, isoform B [KO:K01080] [EC:3.1.3.4]
Dmel_CG11437  CG11437; uncharacterized protein [KO:K01080] [EC:3.1.3.4]
Dmel_CG11426  CG11426; uncharacterized protein [KO:K01080] [EC:3.1.3.4]
Dmel_CG11425  CG11425; uncharacterized protein [KO:K01080] [EC:3.1.3.4]
Dmel_CG4585  Cpes; ceramide phosphoethanolamine synthase, isoform B [KO:K26283] [EC:2.7.8.48]
Dmel_CG1747  Sk1; sphingosine kinase 1, isoform A [KO:K04718] [EC:2.7.1.91]
Dmel_CG32484  Sk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
Dmel_CG8946  Sply; Sphingosine-1-phosphate lyase, isoform A [KO:K01634] [EC:4.1.2.27]
Dmel_CG6437  GlcT; glucosylceramide synthase [KO:K00720] [EC:2.4.1.80]
Dmel_CG31414  Gba1b; glucocerebrosidase 1b, isoform B [KO:K01201] [EC:3.2.1.45]
Dmel_CG31148  Gba1a; glucocerebrosidase 1a [KO:K01201] [EC:3.2.1.45]
Dmel_CG33090  CG33090; uncharacterized protein, isoform B [KO:K17108] [EC:3.2.1.45]
Dmel_CG3132  Ect3; Ectoderm-expressed 3 [KO:K12309] [EC:3.2.1.23]
Dmel_CG9092  Gal; beta galactosidase, isoform B [KO:K12309] [EC:3.2.1.23]
Dmel_CG1787  Hexo2; hexosaminidase 2 [KO:K12373] [EC:3.2.1.52]
Dmel_CG1318  Hexo1; hexosaminidase 1, isoform A [KO:K12373] [EC:3.2.1.52]
Dmel_CG12070  Sap-r; Saposin-related, isoform A [KO:K12382]
Compound
C00065  L-Serine
C00154  Palmitoyl-CoA
C00195  N-Acylsphingosine
C00319  Sphingosine
C00346  Ethanolamine phosphate
C00550  Sphingomyelin
C00836  Sphinganine
C01120  Sphinganine 1-phosphate
C01190  Glucosylceramide
C01290  Lactosylceramide
C01747  Psychosine
C02686  Galactosylceramide
C02934  3-Dehydrosphinganine
C02960  Ceramide 1-phosphate
C03108  D-Glucosylsphingosine
C03272  Globoside
C03405  Lactosylceramide sulfate
C03640  Sphingosyl-phosphocholine
C04730  GM3
C04737  alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
C04884  N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C04911  D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C05681  Ceramide 2-aminoethylphosphonate
C06062  Ceramide phosphoethanolamine
C06124  Sphingosine 1-phosphate
C06125  Sulfatide
C06126  Digalactosylceramide
C06127  Digalactosylceramide sulfate
C06128  GM4
C06135  GA2
C06136  GA1
C12126  Dihydroceramide
C12144  Phytosphingosine
C12145  Phytoceramide
C22467  Gangliotriaosylceramide-II3 sulfate
Reference
PMID:12011104
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
PMID:10652340
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
PMID:11305904
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
PMID:10366774
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
Related
pathway
dme00260  Glycine, serine and threonine metabolism
dme00601  Glycosphingolipid biosynthesis - lacto and neolacto series
dme00603  Glycosphingolipid biosynthesis - globo and isoglobo series
dme00604  Glycosphingolipid biosynthesis - ganglio series
KO pathway
ko00600   
LinkDB

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