KEGG   PATHWAY: ebu00230
Entry
ebu00230                    Pathway                                
Name
Purine metabolism - Enterobacteriaceae bacterium S05
Class
Metabolism; Nucleotide metabolism
Pathway map
ebu00230  Purine metabolism
ebu00230

Module
ebu_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:ebu00230]
ebu_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:ebu00230]
ebu_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:ebu00230]
ebu_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:ebu00230]
ebu_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:ebu00230]
Other DBs
GO: 0006163 0042278
Organism
Enterobacteriaceae bacterium S05 [GN:ebu]
Gene
CUC76_19065  ADP-ribose diphosphatase [KO:K01515] [EC:3.6.1.13 3.6.1.-]
CUC76_16005  NUDIX hydrolase [KO:K01515] [EC:3.6.1.13 3.6.1.-]
CUC76_17420  ADP compounds hydrolase NudE [KO:K08312] [EC:3.6.1.-]
CUC76_11785  deoB; phosphopentomutase [KO:K01839] [EC:5.4.2.7]
CUC76_07805  alpha-D-glucose phosphate-specific phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
CUC76_25275  ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
CUC76_22855  amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
CUC76_14160  phosphoribosylamine--glycine ligase [KO:K01945] [EC:6.3.4.13]
CUC76_22235  phosphoribosylglycinamide formyltransferase [KO:K11175] [EC:2.1.2.2]
CUC76_24710  formate-dependent phosphoribosylglycinamide formyltransferase [KO:K08289] [EC:6.3.1.21]
CUC76_21980  phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
CUC76_22240  phosphoribosylformylglycinamidine cyclo-ligase [KO:K01933] [EC:6.3.3.1]
CUC76_09080  5-(carboxyamino)imidazole ribonucleotide synthase [KO:K01589] [EC:6.3.4.18]
CUC76_09075  purE; 5-(carboxyamino)imidazole ribonucleotide mutase [KO:K01588] [EC:5.4.99.18]
CUC76_22315  phosphoribosylaminoimidazolesuccinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
CUC76_05560  adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
CUC76_14155  purH; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
CUC76_09315  adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
CUC76_09265  ushA; bifunctional UDP-sugar hydrolase/5'-nucleotidase [KO:K11751] [EC:3.1.3.5 3.6.1.45]
CUC76_20730  5'/3'-nucleotidase SurE [KO:K03787] [EC:3.1.3.5 3.1.3.6]
CUC76_07900  UMP phosphatase [KO:K02566] [EC:3.1.3.5]
CUC76_17410  GMP/IMP nucleotidase [KO:K20881] [EC:3.1.3.-]
CUC76_09280  inosine/guanosine kinase [KO:K00892] [EC:2.7.1.73]
CUC76_11780  deoD; purine-nucleoside phosphorylase [KO:K03784] [EC:2.4.2.1]
CUC76_09915  pyrimidine/purine nucleoside phosphorylase [KO:K09913] [EC:2.4.2.1 2.4.2.2]
CUC76_00415  hypothetical protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
CUC76_21795  laccase domain-containing protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
CUC76_10965  hypoxanthine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
CUC76_22195  IMP dehydrogenase [KO:K00088] [EC:1.1.1.205]
CUC76_22135  nucleoside-diphosphate kinase [KO:K00940] [EC:2.7.4.6]
CUC76_11725  yjjX; non-canonical purine NTP phosphatase [KO:K01529] [EC:3.6.1.73]
CUC76_19325  XTP/dITP diphosphatase [KO:K01519] [EC:3.6.1.66]
CUC76_10345  xanthine phosphoribosyltransferase [KO:K00769] [EC:2.4.2.22]
CUC76_22200  GMP synthase (glutamine-hydrolyzing) [KO:K01951] [EC:6.3.5.2]
CUC76_02040  GMP synthase [KO:K01951] [EC:6.3.5.2]
CUC76_11100  GMP reductase [KO:K00364] [EC:1.7.1.7]
CUC76_02175  guaD; guanine deaminase [KO:K01487] [EC:3.5.4.3]
CUC76_22640  nucleoside deaminase [KO:K01487] [EC:3.5.4.3]
CUC76_16160  guanylate kinase [KO:K00942] [EC:2.7.4.8]
CUC76_23200  ribonucleoside-diphosphate reductase subunit alpha [KO:K00525] [EC:1.17.4.1]
CUC76_21275  ribonucleotide-diphosphate reductase subunit alpha [KO:K00525] [EC:1.17.4.1]
CUC76_23195  ribonucleotide-diphosphate reductase subunit beta [KO:K00526] [EC:1.17.4.1]
CUC76_21270  nrdF; class 1b ribonucleoside-diphosphate reductase subunit beta [KO:K00526] [EC:1.17.4.1]
CUC76_12830  anaerobic ribonucleoside-triphosphate reductase [KO:K21636] [EC:1.1.98.6]
CUC76_10740  dGTPase [KO:K01129] [EC:3.1.5.1]
CUC76_22960  5'-deoxynucleotidase [KO:K08722] [EC:3.1.3.89]
CUC76_16150  bifunctional GTP diphosphokinase/guanosine-3',5'-bis(diphosphate) 3'-diphosphatase [KO:K01139] [EC:2.7.6.5 3.1.7.2]
CUC76_22225  exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
CUC76_14720  guanosine-5'-triphosphate,3'-diphosphate diphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
CUC76_20625  GTP diphosphokinase [KO:K00951] [EC:2.7.6.5]
CUC76_14585  class I adenylate cyclase [KO:K05851] [EC:4.6.1.1]
CUC76_13175  adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
CUC76_01315  adenosine deaminase [KO:K01488] [EC:3.5.4.4]
CUC76_24235  AMP nucleosidase [KO:K01241] [EC:3.2.2.4]
CUC76_20565  LOG family protein [KO:K06966] [EC:3.2.2.10 3.2.2.-]
CUC76_23695  adenine deaminase [KO:K01486] [EC:3.5.4.2]
CUC76_13020  cpdB; 2',3'-cyclic-nucleotide 2'-phosphodiesterase [KO:K01119] [EC:3.1.4.16 3.1.3.6]
CUC76_09290  adenylate kinase [KO:K00939] [EC:2.7.4.3]
CUC76_20630  nucleoside triphosphate pyrophosphohydrolase [KO:K04765] [EC:3.6.1.9]
CUC76_12645  phosphodiesterase [KO:K03651] [EC:3.1.4.53]
CUC76_19075  3',5'-cyclic-AMP phosphodiesterase [KO:K03651] [EC:3.1.4.53]
CUC76_11430  apaH; bis(5'-nucleosyl)-tetraphosphatase (symmetrical) [KO:K01525] [EC:3.6.1.41]
CUC76_20700  cysC; adenylyl-sulfate kinase [KO:K00860] [EC:2.7.1.25]
CUC76_20695  sulfate adenylyltransferase subunit CysN [KO:K00956] [EC:2.7.7.4]
CUC76_20690  sulfate adenylyltransferase subunit 2 [KO:K00957] [EC:2.7.7.4]
CUC76_02665  monooxygenase [KO:K16839] [EC:1.14.13.113]
CUC76_09020  uraH; hydroxyisourate hydrolase [KO:K07127] [EC:3.5.2.17]
CUC76_02650  uraH; hydroxyisourate hydrolase [KO:K07127] [EC:3.5.2.17]
CUC76_02655  uraD; OHCU decarboxylase [KO:K16840] [EC:4.1.1.97]
CUC76_02190  Asp/Glu racemase [KO:K16841] [EC:5.1.99.3]
CUC76_09135  allantoinase AllB [KO:K01466] [EC:3.5.2.5]
CUC76_02195  allantoinase PuuE [KO:K16842] [EC:3.5.2.5]
CUC76_09110  allantoate amidohydrolase [KO:K02083] [EC:3.5.3.9]
CUC76_02330  allantoate amidohydrolase [KO:K02083] [EC:3.5.3.9]
CUC76_02325  aminotransferase [KO:K00839] [EC:2.6.1.112]
CUC76_09115  (S)-ureidoglycine aminohydrolase [KO:K14977] [EC:3.5.3.26]
CUC76_09170  ureidoglycolate lyase [KO:K01483] [EC:4.3.2.3]
CUC76_18955  ureC; urease subunit alpha [KO:K01428] [EC:3.5.1.5]
CUC76_18960  urease subunit beta [KO:K01429] [EC:3.5.1.5]
CUC76_18965  urease subunit gamma [KO:K01430] [EC:3.5.1.5]
CUC76_09105  ureidoglycolate dehydrogenase [KO:K00073] [EC:1.1.1.350]
CUC76_02285  Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase GatCAB subunit A [KO:K22601] [EC:2.1.3.5]
CUC76_02295  gamma-glutamyltransferase [KO:K22602] [EC:3.5.1.126]
CUC76_09085  carbamate kinase [KO:K00926] [EC:2.7.2.2]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
ebu00030  Pentose phosphate pathway
ebu00220  Arginine biosynthesis
ebu00250  Alanine, aspartate and glutamate metabolism
ebu00260  Glycine, serine and threonine metabolism
ebu00340  Histidine metabolism
ebu00630  Glyoxylate and dicarboxylate metabolism
ebu00730  Thiamine metabolism
ebu00740  Riboflavin metabolism
ebu00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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