KEGG   PATHWAY: ecc00230
Entry
ecc00230                    Pathway                                
Name
Purine metabolism - Escherichia coli O6:K2:H1 CFT073 (UPEC)
Class
Metabolism; Nucleotide metabolism
Pathway map
ecc00230  Purine metabolism
ecc00230

Module
ecc_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:ecc00230]
ecc_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:ecc00230]
ecc_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:ecc00230]
ecc_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:ecc00230]
ecc_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:ecc00230]
ecc_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:ecc00230]
ecc_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:ecc00230]
Other DBs
GO: 0006163 0042278
Organism
Escherichia coli O6:K2:H1 CFT073 (UPEC) [GN:ecc]
Gene
c3780  yqiE; ADP-ribose pyrophosphatase [KO:K01515] [EC:3.6.1.13 3.6.1.-]
c4167  yrfE; ADP compounds hydrolase nudE [KO:K08312] [EC:3.6.1.-]
c5467  deoB; Phosphopentomutase [KO:K01839] [EC:5.4.2.7]
c4150  yhfW; Hypothetical protein yhfW [KO:K01839] [EC:5.4.2.7]
c0775  pgm; Phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
c1665  prsA; Ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
c2856  purF; Amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
c4963  purD; Phosphoribosylamine--glycine ligase [KO:K01945] [EC:6.3.4.13]
c3018  purN; Phosphoribosylglycinamide formyltransferase [KO:K11175] [EC:2.1.2.2]
c3080  purL; Phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
c3017  purM; Phosphoribosylformylglycinamidine cyclo-ligase [KO:K01933] [EC:6.3.3.1]
c0636  purK; Phosphoribosylaminoimidazole carboxylase ATPase subunit [KO:K01589] [EC:6.3.4.18]
c0637  purE; Phosphoribosylaminoimidazole carboxylase catalytic subunit [KO:K01588] [EC:5.4.99.18]
c3004  purC; Phosphoribosylaminoimidazole-succinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
c1510  purB; Adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
c4964  purH; Purine biosynthesis protein PurH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
c0588  apt; Adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
c0600  ushA; Protein ushA precursor [KO:K11751] [EC:3.1.3.5 3.6.1.45]
c3311  surE; Acid phosphatase surE [KO:K03787] [EC:3.1.3.5 3.1.3.6]
c0750  nagD; NagD protein [KO:K02566] [EC:3.1.3.5]
c4170  yrfG; Hypothetical protein yrfG [KO:K20881] [EC:3.1.3.-]
c0597  gsk; Inosine-guanosine kinase [KO:K00892] [EC:2.7.1.73]
c2940  xapA; Xanthosine phosphorylase [KO:K03783] [EC:2.4.2.1]
c5468  deoD; Purine nucleoside phosphorylase [KO:K03784] [EC:2.4.2.1]
c0499  yaiE; Hypothetical protein yaiE [KO:K09913] [EC:2.4.2.1 2.4.2.2]
c3115  yfiH; Hypothetical protein yfiH [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
c0154  hpt; Hypoxanthine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
c3027  guaB; Inosine-5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
c3041  ndk; Nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
c5481  yjjX; Hypothetical protein yjjX [KO:K01529] [EC:3.6.1.73]
c3540  yggV; HAM1 protein homolog [KO:K01519] [EC:3.6.1.66]
c0384  gpt; Xanthine-guanine phosphoribosyltransferase [KO:K00769] [EC:2.4.2.22]
c3444  Xanthine dehydrogenase, molybdenum binding subunit [KO:K00087] [EC:1.17.1.4]
c3445  ygeT; Xanthine dehydrogenase, FAD binding subunit [KO:K13479] [EC:1.17.1.4]
c3446  Xanthine dehydrogenase iron-sulfur binding subunit [KO:K13480]
c3026  guaA; GMP synthase (glutamine-hydrolyzing) [KO:K01951] [EC:6.3.5.2]
c0124  guaC; GMP reductase [KO:K00364] [EC:1.7.1.7]
c3461  ygfP; Guanine deaminase [KO:K01487] [EC:3.5.4.3]
c4473  gmk; Guanylate kinase [KO:K00942] [EC:2.7.4.8]
c3228  nrdE; Ribonucleoside-diphosphate reductase 2 alpha chain [KO:K00525] [EC:1.17.4.1]
c2776  nrdA; Ribonucleoside-diphosphate reductase 1 alpha chain [KO:K00525] [EC:1.17.4.1]
c3229  nrdF; Ribonucleoside-diphosphate reductase 2 beta chain [KO:K00526] [EC:1.17.4.1]
c2777  nrdB; Ribonucleoside-diphosphate reductase 1 beta chain [KO:K00526] [EC:1.17.4.1]
c5337  nrdD; Anaerobic ribonucleoside-triphosphate reductase [KO:K21636] [EC:1.1.98.6]
c0196  dgt; Deoxyguanosinetriphosphate triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
c2832  yfbR; Hypothetical protein yfbR [KO:K08722] [EC:3.1.3.89]
c3202  yfdR; Hypothetical protein yfdR [KO:K06952] [EC:3.1.3.89]
c4475  spoT; Guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase [KO:K01139] [EC:2.7.6.5 3.1.7.2]
c4699  gppA; Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
c3020  ppx; Exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
c3347  relA; GTP pyrophosphokinase [KO:K00951] [EC:2.7.6.5]
c4725  cyaA; Adenylate cyclase [KO:K05851] [EC:4.6.1.1]
c5261  purA; Adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
c2015  add; Adenosine deaminase [KO:K01488] [EC:3.5.4.4]
c2444  amn; AMP nucleosidase [KO:K01241] [EC:3.2.2.4]
c3361  ygdH; Hypothetical protein ygdH [KO:K06966] [EC:3.2.2.10 3.2.2.-]
c4589  yicP; Probable adenine deaminase [KO:K01486] [EC:3.5.4.2]
c0594  adk; Adenylate kinase [KO:K00939] [EC:2.7.4.3]
c3346  mazG; MazG protein [KO:K04765] [EC:3.6.1.9]
c3778  icc; Icc protein [KO:K03651] [EC:3.1.4.53]
c0061  apaH; Bis(5'-nucleosyl)-tetraphosphatase, symmetrical [KO:K01525] [EC:3.6.1.41]
c3317  cysC; Adenylylsulfate kinase [KO:K00860] [EC:2.7.1.25]
c3318  cysN; Sulfate adenylyltransferase subunit 1 [KO:K00956] [EC:2.7.7.4]
c3319  cysD; Sulfate adenylyltransferase subunit 2 [KO:K00957] [EC:2.7.7.4]
c2388  Transthyretin-like protein precursor [KO:K07127] [EC:3.5.2.17]
c0626  ybbX; Allantoinase [KO:K01466] [EC:3.5.2.5]
c0630  ylbB; Allantoate amidohydrolase [KO:K02083] [EC:3.5.3.9]
c0629  ylbA; Hypothetical protein ylbA [KO:K14977] [EC:3.5.3.26]
c0620  ybbT; Ureidoglycolate hydrolase [KO:K01483] [EC:4.3.2.3]
c0631  Ureidoglycolate dehydrogenase [KO:K00073] [EC:1.1.1.350]
c3452  yqeA; Carbamate kinase-like protein yqeA [KO:K00926] [EC:2.7.2.2]
c0444  Carbamate kinase-like protein yahI [KO:K00926] [EC:2.7.2.2]
c0635  arcC; Carbamate kinase [KO:K00926] [EC:2.7.2.2]
c4764  Carbamate kinase-like protein yahI [KO:K00926] [EC:2.7.2.2]
c5349  Carbamate kinase [KO:K00926] [EC:2.7.2.2]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
ecc00030  Pentose phosphate pathway
ecc00220  Arginine biosynthesis
ecc00250  Alanine, aspartate and glutamate metabolism
ecc00260  Glycine, serine and threonine metabolism
ecc00340  Histidine metabolism
ecc00630  Glyoxylate and dicarboxylate metabolism
ecc00730  Thiamine metabolism
ecc00740  Riboflavin metabolism
ecc00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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