KEGG   PATHWAY: ecoh00630
Entry
ecoh00630                   Pathway                                
Name
Glyoxylate and dicarboxylate metabolism - Escherichia coli O145:H28 RM13516 (EHEC)
Class
Metabolism; Carbohydrate metabolism
Pathway map
ecoh00630  Glyoxylate and dicarboxylate metabolism
ecoh00630

Module
ecoh_M00012  Glyoxylate cycle [PATH:ecoh00630]
ecoh_M00621  Glycine cleavage system [PATH:ecoh00630]
Other DBs
GO: 0046487 0043648
Organism
Escherichia coli O145:H28 RM13516 (EHEC) [GN:ecoh]
Gene
ECRM13516_4874  aceA; Isocitrate lyase [KO:K01637] [EC:4.1.3.1 4.1.3.30]
ECRM13516_4946  acs; Acetyl-coenzyme A synthetase [KO:K01895] [EC:6.2.1.1]
ECRM13516_3739  glcB; Malate synthase G [KO:K01638] [EC:2.3.3.9]
ECRM13516_4873  aceB; Malate synthase [KO:K01638] [EC:2.3.3.9]
ECRM13516_3993  mdh; Malate dehydrogenase [KO:K00024] [EC:1.1.1.37]
ECRM13516_0678  gltA; Citrate synthase (si) [KO:K01647] [EC:2.3.3.1]
ECRM13516_0310  prpC; 2-methylcitrate synthase [KO:K01659] [EC:2.3.3.5]
ECRM13516_1662  acnA; Aconitase A [KO:K27802] [EC:4.2.1.3 4.2.1.99]
ECRM13516_0123  acnB; Aconitate hydratase 2 / 2-methylisocitrate dehydratase [KO:K01682] [EC:4.2.1.3 4.2.1.99]
ECRM13516_1843  Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
ECRM13516_3573  yqeF; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
ECRM13516_3638  sbm; Methylmalonyl-CoA mutase [KO:K01847] [EC:5.4.99.2]
ECRM13516_0698  Methylaspartate mutase, E subunit [KO:K19268] [EC:5.4.99.1]
ECRM13516_0700  Methylaspartate mutase S chain [KO:K01846] [EC:5.4.99.1]
ECRM13516_0697  Methylaspartate ammonia-lyase [KO:K04835] [EC:4.3.1.2]
ECRM13516_3743  glcD; Glycolate dehydrogenase, subunit GlcD [KO:K00104] [EC:1.1.99.14]
ECRM13516_3742  Glycolate dehydrogenase, FAD-binding subunit GlcE [KO:K11472] [EC:1.1.99.14]
ECRM13516_3741  glcF; Glycolate dehydrogenase, iron-sulfur subunit GlcF [KO:K11473] [EC:1.1.99.14]
ECRM13516_2134  katE; Catalase [KO:K03781] [EC:1.11.1.6]
ECRM13516_1274  ycdW; Putative 2-hydroxyacid dehydrogenase YcdW [KO:K12972] [EC:1.1.1.79 1.1.1.81]
ECRM13516_4349  yiaE; 2-ketoaldonate reductase, broad specificity [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
ECRM13516_4125  gph; Phosphoglycolate phosphatase [KO:K01091] [EC:3.1.3.18]
ECRM13516_4723  glnA; Glutamine synthetase type I [KO:K01915] [EC:6.3.1.2]
ECRM13516_3233  glyA; Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
ECRM13516_3622  gcvP; Glycine dehydrogenase [decarboxylating] (glycine cleavage system P protein) [KO:K00281] [EC:1.4.4.2]
ECRM13516_3624  gcvT; Aminomethyltransferase (glycine cleavage system T protein) [KO:K00605] [EC:2.1.2.10]
ECRM13516_0121  lpdA; Dihydrolipoamide dehydrogenase of pyruvate dehydrogenase complex / Dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
ECRM13516_3623  gcvH; Glycine cleavage system H protein [KO:K02437]
ECRM13516_0496  gcl; Glyoxylate carboligase [KO:K01608] [EC:4.1.1.47]
ECRM13516_0497  glp; Hydroxypyruvate isomerase [KO:K01816] [EC:5.3.1.22]
ECRM13516_3889  garR; 2-hydroxy-3-oxopropionate reductase [KO:K00042] [EC:1.1.1.60]
ECRM13516_0498  ybbQ; 2-hydroxy-3-oxopropionate reductase [KO:K00042] [EC:1.1.1.60]
ECRM13516_3888  yhaD; Glycerate kinase [KO:K00865] [EC:2.7.1.165]
ECRM13516_0502  ybbZ; Glycerate kinase [KO:K00865] [EC:2.7.1.165]
ECRM13516_1777  aldA; Aldehyde dehydrogenase A / Glycolaldehyde dehydrogenase [KO:K07248] [EC:1.2.1.22 1.2.1.21]
ECRM13516_3526  fucO; Lactaldehyde reductase [KO:K00048] [EC:1.1.1.77]
ECRM13516_3823  ttdA; L(+)-tartrate dehydratase alpha subunit [KO:K03779] [EC:4.2.1.32]
ECRM13516_3824  ttdB; L(+)-tartrate dehydratase beta subunit [KO:K03780] [EC:4.2.1.32]
ECRM13516_2205  yeaU; Tartrate dehydrogenase / Tartrate decarboxylase / D-malic enzyme [KO:K07246] [EC:1.1.1.93 4.1.1.73 1.1.1.83]
ECRM13516_2261  eda; 4-Hydroxy-2-oxoglutarate aldolase [KO:K01625] [EC:4.1.2.14 4.1.3.42]
ECRM13516_4740  fdoG; Formate dehydrogenase O alpha subunit / selenocysteine-containing [KO:K00123] [EC:1.17.1.9]
ECRM13516_4739  fdoH; Formate dehydrogenase O beta subunit [KO:K00124]
ECRM13516_4738  fdoI; Formate dehydrogenase O gamma subunit [KO:K00127]
ECRM13516_1559  purU; Formyltetrahydrofolate deformylase [KO:K01433] [EC:3.5.1.10]
ECRM13516_3060  putative oxalyl-CoA decarboxylase [KO:K01577] [EC:4.1.1.8]
ECRM13516_3061  Formyl-coenzyme A transferase [KO:K07749] [EC:2.8.3.16]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00111  Glycerone phosphate
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C20238  (2R)-Ethylmalonyl-CoA
C22337  D-Ribulose 1-phosphate
Reference
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
ecoh00010  Glycolysis / Gluconeogenesis
ecoh00020  Citrate cycle (TCA cycle)
ecoh00030  Pentose phosphate pathway
ecoh00053  Ascorbate and aldarate metabolism
ecoh00071  Fatty acid degradation
ecoh00230  Purine metabolism
ecoh00250  Alanine, aspartate and glutamate metabolism
ecoh00260  Glycine, serine and threonine metabolism
ecoh00620  Pyruvate metabolism
ecoh00710  Carbon fixation by Calvin cycle
ecoh00750  Vitamin B6 metabolism
ecoh00910  Nitrogen metabolism
KO pathway
ko00630   
LinkDB

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