KEGG   PATHWAY: ecok00230
Entry
ecok00230                   Pathway                                
Name
Purine metabolism - Escherichia coli K-12 MDS42
Class
Metabolism; Nucleotide metabolism
Pathway map
ecok00230  Purine metabolism
ecok00230

Module
ecok_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:ecok00230]
ecok_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:ecok00230]
ecok_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:ecok00230]
ecok_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:ecok00230]
ecok_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:ecok00230]
ecok_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:ecok00230]
ecok_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:ecok00230]
Other DBs
GO: 0006163 0042278
Organism
Escherichia coli K-12 MDS42 [GN:ecok]
Gene
ECMDS42_2509  nudF; ADP-ribose pyrophosphatase [KO:K01515] [EC:3.6.1.13 3.6.1.-]
ECMDS42_2843  nudE; ADP-ribose diphosphatase [KO:K08312] [EC:3.6.1.-]
ECMDS42_3740  deoB; phosphopentomutase [KO:K01839] [EC:5.4.2.7]
ECMDS42_2826  yhfW; predicted mutase [KO:K01839] [EC:5.4.2.7]
ECMDS42_0544  pgm; phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
ECMDS42_0994  prsA; phosphoribosylpyrophosphate synthase [KO:K00948] [EC:2.7.6.1]
ECMDS42_1883  purF; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
ECMDS42_3443  purD; phosphoribosylglycinamide synthetase phosphoribosylamine-glycine ligase [KO:K01945] [EC:6.3.4.13]
ECMDS42_2043  purN; phosphoribosylglycinamide formyltransferase 1 [KO:K11175] [EC:2.1.2.2]
ECMDS42_1526  purT; phosphoribosylglycinamide formyltransferase 2 [KO:K08289] [EC:6.3.1.21]
ECMDS42_2102  purL; phosphoribosylformyl-glycineamide synthetase [KO:K01952] [EC:6.3.5.3]
ECMDS42_2042  purM; phosphoribosylaminoimidazole synthetase [KO:K01933] [EC:6.3.3.1]
ECMDS42_0417  purK; N5-carboxyaminoimidazole ribonucleotide synthase [KO:K01589] [EC:6.3.4.18]
ECMDS42_0418  purE; N5-carboxyaminoimidazole ribonucleotide mutase [KO:K01588] [EC:5.4.99.18]
ECMDS42_2019  purC; phosphoribosylaminoimidazole-succinocarboxamide synthetase [KO:K01923] [EC:6.3.2.6]
ECMDS42_0952  purB; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
ECMDS42_3444  purH; fused IMP cyclohydrolase/phosphoribosylaminoimidazolecarboxamide formyltransferase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
ECMDS42_0368  apt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
ECMDS42_0379  ushA; bifunctional UDP-sugar hydrolase/5'-nucleotidase [KO:K11751] [EC:3.1.3.5 3.6.1.45]
ECMDS42_2249  surE; broad specificity 5'(3')-nucleotidase and polyphosphatase [KO:K03787] [EC:3.1.3.5 3.1.3.6]
ECMDS42_0531  nagD; UMP phosphatase [KO:K02566] [EC:3.1.3.5]
ECMDS42_2845  yrfG; predicted hydrolase [KO:K20881] [EC:3.1.3.-]
ECMDS42_0376  gsk; inosine/guanosine kinase [KO:K00892] [EC:2.7.1.73]
ECMDS42_1957  xapA; purine nucleoside phosphorylase II [KO:K03783] [EC:2.4.2.1]
ECMDS42_3741  deoD; purine-nucleoside phosphorylase [KO:K03784] [EC:2.4.2.1]
ECMDS42_0291  yaiE; conserved protein [KO:K09913] [EC:2.4.2.1 2.4.2.2]
ECMDS42_2138  yfiH; conserved protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
ECMDS42_0116  hpt; hypoxanthine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
ECMDS42_2051  guaB; IMP dehydrogenase [KO:K00088] [EC:1.1.1.205]
ECMDS42_2061  ndk; multifunctional nucleoside diphosphate kinase and apyrimidinic endonuclease and 3'-phosphodiesterase [KO:K00940] [EC:2.7.4.6]
ECMDS42_3751  yjjX; thiamin metabolism associated protein [KO:K01529] [EC:3.6.1.73]
ECMDS42_2452  yggV; dITP/XTP pyrophosphatase [KO:K01519] [EC:3.6.1.66]
ECMDS42_0227  gpt; guanine-hypoxanthine phosphoribosyltransferase [KO:K00769] [EC:2.4.2.22]
ECMDS42_2366  xdhA; xanthine dehydrogenase, molybdenum binding subunit [KO:K00087] [EC:1.17.1.4]
ECMDS42_2367  xdhB; xanthine dehydrogenase, FAD-binding subunit [KO:K13479] [EC:1.17.1.4]
ECMDS42_2368  xdhC; xanthine dehydrogenase, Fe-S binding subunit [KO:K13480]
ECMDS42_2050  guaA; GMP synthetase [KO:K01951] [EC:6.3.5.2]
ECMDS42_0096  guaC; GMP reductase [KO:K00364] [EC:1.7.1.7]
ECMDS42_2383  guaD; guanine deaminase [KO:K01487] [EC:3.5.4.3]
ECMDS42_3082  gmk; guanylate kinase [KO:K00942] [EC:2.7.4.8]
ECMDS42_1803  nrdA; ribonucleoside diphosphate reductase 1, alpha subunit [KO:K00525] [EC:1.17.4.1]
ECMDS42_2179  nrdE; ribonucleoside-diphosphate reductase 2, alpha subunit [KO:K00525] [EC:1.17.4.1]
ECMDS42_1804  nrdB; ribonucleoside diphosphate reductase 1, beta subunit, ferritin-like [KO:K00526] [EC:1.17.4.1]
ECMDS42_2180  nrdF; ribonucleoside-diphosphate reductase 2, beta subunit, ferritin-like [KO:K00526] [EC:1.17.4.1]
ECMDS42_3679  nrdD; anaerobic ribonucleoside-triphosphate reductase [KO:K21636] [EC:1.1.98.6]
ECMDS42_0147  dgt; deoxyguanosine triphosphate triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
ECMDS42_1862  yfbR; deoxyribonucleoside 5'-monophosphatase [KO:K08722] [EC:3.1.3.89]
ECMDS42_3084  spoT; bifunctional (p)ppGpp synthetase II/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase [KO:K01139] [EC:2.7.6.5 3.1.7.2]
ECMDS42_3217  gpp; guanosine pentaphosphatase/exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
ECMDS42_2045  ppx; exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
ECMDS42_2288  relA; (p)ppGpp synthetase I/GTP pyrophosphokinase [KO:K00951] [EC:2.7.6.5]
ECMDS42_3246  cyaA; adenylate cyclase [KO:K05851] [EC:4.6.1.1]
ECMDS42_3619  purA; adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
ECMDS42_1293  add; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
ECMDS42_1610  amn; AMP nucleosidase [KO:K01241] [EC:3.2.2.4]
ECMDS42_2300  ygdH; conserved protein [KO:K06966] [EC:3.2.2.10 3.2.2.-]
ECMDS42_3100  ade; cryptic adenine deaminase [KO:K01486] [EC:3.5.4.2]
ECMDS42_3655  cpdB; 2':3'-cyclic-nucleotide 2'-phosphodiesterase [KO:K01119] [EC:3.1.4.16 3.1.3.6]
ECMDS42_0373  adk; adenylate kinase [KO:K00939] [EC:2.7.4.3]
ECMDS42_2285  mazG; nucleoside triphosphate pyrophosphohydrolase [KO:K04765] [EC:3.6.1.9]
ECMDS42_2507  cpdA; cyclic 3',5'-adenosine monophosphate phosphodiesterase [KO:K03651] [EC:3.1.4.53]
ECMDS42_0042  apaH; diadenosine tetraphosphatase [KO:K01525] [EC:3.6.1.41]
ECMDS42_2255  cysC; adenosine 5'-phosphosulfate kinase [KO:K00860] [EC:2.7.1.25]
ECMDS42_2256  cysN; sulfate adenylyltransferase, subunit 1 [KO:K00956] [EC:2.7.7.4]
ECMDS42_2257  cysD; sulfate adenylyltransferase, subunit 2 [KO:K00957] [EC:2.7.7.4]
ECMDS42_1597  yedX; conserved protein [KO:K07127] [EC:3.5.2.17]
ECMDS42_0405  allB; allantoinase [KO:K01466] [EC:3.5.2.5]
ECMDS42_0409  allC; allantoate amidohydrolase [KO:K02083] [EC:3.5.3.9]
ECMDS42_0408  ylbA; conserved protein [KO:K14977] [EC:3.5.3.26]
ECMDS42_0398  allA; ureidoglycolate hydrolase [KO:K01483] [EC:4.3.2.3]
ECMDS42_0410  allD; ureidoglycolate dehydrogenase [KO:K00073] [EC:1.1.1.350]
ECMDS42_0246  yahI; predicted carbamate kinase-like protein [KO:K00926] [EC:2.7.2.2]
ECMDS42_0416  ybcF; predicted carbamate kinase [KO:K00926] [EC:2.7.2.2]
ECMDS42_2374  yqeA; predicted amino acid kinase [KO:K00926] [EC:2.7.2.2]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
ecok00030  Pentose phosphate pathway
ecok00220  Arginine biosynthesis
ecok00250  Alanine, aspartate and glutamate metabolism
ecok00260  Glycine, serine and threonine metabolism
ecok00340  Histidine metabolism
ecok00630  Glyoxylate and dicarboxylate metabolism
ecok00730  Thiamine metabolism
ecok00740  Riboflavin metabolism
ecok00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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