KEGG   PATHWAY: egz04914
Entry
egz04914                    Pathway                                
Name
Progesterone-mediated oocyte maturation - Egretta garzetta (little egret)
Description
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Class
Organismal Systems; Endocrine system
Pathway map
egz04914  Progesterone-mediated oocyte maturation
egz04914

Other DBs
GO: 0001556
Organism
Egretta garzetta (little egret) [GN:egz]
Gene
104135784  PGR; progesterone receptor [KO:K08556]
104135641  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
104124880  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
104126253  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
104133065  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
104135481  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
104129991  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
104129145  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
104128427  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
104133994  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
104125693  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
104125710  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
104125751  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
104125670  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
104126738  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
104132374  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
104127759  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
104125965  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
104126191  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
104132021  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
104128107  ADCY5; LOW QUALITY PROTEIN: adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
104125176  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
104134444  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
104121973  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
104122904  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
104132188  AURKA; LOW QUALITY PROTEIN: aurora kinase A [KO:K11481] [EC:2.7.11.1]
104134455  CPEB2; cytoplasmic polyadenylation element-binding protein 2 [KO:K02602]
104129166  CPEB3; cytoplasmic polyadenylation element-binding protein 3 [KO:K02602]
104130820  CPEB1; cytoplasmic polyadenylation element-binding protein 1 isoform X1 [KO:K02602]
104133665  CPEB4; cytoplasmic polyadenylation element-binding protein 4 [KO:K02602]
104134623  SPDYA; speedy protein A [KO:K08694]
104124647  CDK1; cyclin-dependent kinase 1 isoform X1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
104129322  CCNA2; cyclin-A2 [KO:K06627]
104131327  CCNA1; cyclin-A1 [KO:K06627]
104127703  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
104124512  HSP90AA1; heat shock protein HSP 90-alpha isoform X1 [KO:K04079]
104132720  HSP90AB1; heat shock protein HSP 90-beta isoform X1 [KO:K04079]
104133527  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
104127223  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104135178  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
104130387  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
104128301  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
104134886  RPS6KA1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
104124904  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
104130767  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
104133018  CCNB3; G2/mitotic-specific cyclin-B3 [KO:K21771]
104133633  STK10; LOW QUALITY PROTEIN: serine/threonine-protein kinase 10 [KO:K08837] [EC:2.7.11.1]
104134547  PLK1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
104121808  CDC25A; M-phase inducer phosphatase 1 [KO:K06645] [EC:3.1.3.48]
104124907  insulin [KO:K04526]
104135582  IGF1; insulin-like growth factor I [KO:K05459]
104122851  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
104131524  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104125648  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
104123195  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
104135137  KRAS; GTPase KRas isoform X1 [KO:K07827]
104135588  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
104124306  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
104128133  BUB1; mitotic checkpoint serine/threonine-protein kinase BUB1 [KO:K02178] [EC:2.7.11.1]
104132612  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 [KO:K06679]
104121946  MAD2L1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
104133082  MAD2L2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
104125040  FZR1; fizzy-related protein homolog isoform X1 [KO:K03364]
104133573  ANAPC1; anaphase-promoting complex subunit 1 [KO:K03348]
104124010  ANAPC2; anaphase-promoting complex subunit 2 [KO:K03349]
104127027  CDC27; LOW QUALITY PROTEIN: cell division cycle protein 27 homolog [KO:K03350]
104134493  ANAPC4; anaphase-promoting complex subunit 4 [KO:K03351]
104130106  ANAPC5; anaphase-promoting complex subunit 5 [KO:K03352]
104126388  CDC16; cell division cycle protein 16 homolog [KO:K03353]
104130109  ANAPC7; LOW QUALITY PROTEIN: anaphase-promoting complex subunit 7 [KO:K03354]
104123634  CDC23; cell division cycle protein 23 homolog [KO:K03355]
104130579  ANAPC10; anaphase-promoting complex subunit 10 [KO:K03357]
104131268  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
104128399  ANAPC16; anaphase-promoting complex subunit 16 isoform X1 [KO:K25229]
Compound
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:12045215
  Authors
Schmitt A, Nebreda AR.
  Title
Signalling pathways in oocyte meiotic maturation.
  Journal
J Cell Sci 115:2457-9 (2002)
Reference
PMID:12084906
  Authors
Cato AC, Nestl A, Mink S.
  Title
Rapid actions of steroid receptors in cellular signaling pathways.
  Journal
Sci STKE 2002:RE9 (2002)
DOI:10.1126/stke.2002.138.re9
Reference
PMID:11730319
  Authors
Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
  Title
The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
  Journal
Biol Cell 93:27-33 (2001)
DOI:10.1016/S0248-4900(01)01127-3
Reference
PMID:11063930
  Authors
Nebreda AR, Ferby I.
  Title
Regulation of the meiotic cell cycle in oocytes.
  Journal
Curr Opin Cell Biol 12:666-75 (2000)
DOI:10.1016/S0955-0674(00)00150-2
Reference
PMID:10497333
  Authors
Ferrell JE Jr.
  Title
Xenopus oocyte maturation: new lessons from a good egg.
  Journal
Bioessays 21:833-42 (1999)
DOI:10.1002/(SICI)1521-1878(199910)21:10<833::AID-BIES5>3.0.CO;2-P
Reference
PMID:12374568
  Authors
Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
  Title
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
  Journal
Biochem J 369:227-38 (2003)
DOI:10.1042/BJ20021243
Reference
PMID:12477927
  Authors
Duckworth BC, Weaver JS, Ruderman JV.
  Title
G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
  Journal
Proc Natl Acad Sci U S A 99:16794-9 (2002)
DOI:10.1073/pnas.222661299
Reference
PMID:11148128
  Authors
Abrieu A, Doree M, Fisher D.
  Title
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
  Journal
J Cell Sci 114:257-67 (2001)
Related
pathway
egz04010  MAPK signaling pathway
egz04110  Cell cycle
KO pathway
ko04914   
LinkDB

DBGET integrated database retrieval system