KEGG   PATHWAY: ehs04150
Entry
ehs04150                    Pathway                                
Name
mTOR signaling pathway - Eurypyga helias (sunbittern)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
ehs04150  mTOR signaling pathway
ehs04150

Organism
Eurypyga helias (sunbittern) [GN:ehs]
Gene
104513622  SLC7A5; large neutral amino acids transporter small subunit 1 [KO:K13780]
104516945  SLC38A9; putative sodium-coupled neutral amino acid transporter 9 [KO:K14995]
104514022  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
104515706  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
104508221  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
104511124  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
104504574  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
104508518  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
104509806  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
104511440  ATP6V1H; V-type proton ATPase subunit H [KO:K02144]
104517229  LAMTOR2; ragulator complex protein LAMTOR2 [KO:K20398]
104504525  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
104516447  FLCN; folliculin [KO:K09594]
104503131  FNIP1; folliculin-interacting protein 1 [KO:K20400]
104514228  FNIP2; folliculin-interacting protein 2 [KO:K20401]
104513103  ras-related GTP-binding protein A [KO:K16185]
104504152  RRAGC; ras-related GTP-binding protein C [KO:K16186]
104504438  RRAGD; ras-related GTP-binding protein D [KO:K16186]
104516307  GATS-like protein 1 [KO:K23081]
104514855  MIOS; WD repeat-containing protein mio [KO:K20407]
104503706  SEH1L; nucleoporin SEH1 [KO:K14299]
104516432  WDR24; WD repeat-containing protein 24 [KO:K20408]
104508524  WDR59; WD repeat-containing protein 59 [KO:K20409]
104516552  SEC13; protein SEC13 homolog [KO:K14004]
104513102  DEP domain-containing protein 5-like [KO:K20404]
104506086  NPRL2; nitrogen permease regulator 2-like protein [KO:K20405]
104516156  NPRL3; nitrogen permease regulator 3-like protein [KO:K20406]
104503068  SKP2; S-phase kinase-associated protein 2 [KO:K03875]
104507598  RNF152; E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
104515908  MTOR; LOW QUALITY PROTEIN: serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
104514220  DEP domain-containing mTOR-interacting protein [KO:K20402]
104506068  DEP domain-containing mTOR-interacting protein-like [KO:K20402]
104508332  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
104504165  TELO2; telomere length regulation protein TEL2 homolog [KO:K11137]
104508780  TTI1; TELO2-interacting protein 1 homolog [KO:K20403]
104509756  LOW QUALITY PROTEIN: CAP-Gly domain-containing linker protein 1-like [KO:K10421]
104515989  GRB10; growth factor receptor-bound protein 10 [KO:K20064]
104513005  LPIN2; phosphatidate phosphatase LPIN2 [KO:K15728] [EC:3.1.3.4]
104506402  LPIN3; phosphatidate phosphatase LPIN3 [KO:K15728] [EC:3.1.3.4]
104506501  LPIN1; phosphatidate phosphatase LPIN1 [KO:K15728] [EC:3.1.3.4]
104516957  ULK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
104516912  ULK2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
104508995  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
104505005  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
104504189  EIF4E2; eukaryotic translation initiation factor 4E type 2 [KO:K03259]
104503003  eukaryotic translation initiation factor 4E-like [KO:K03259]
104503620  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
104503763  RPS6; 40S ribosomal protein S6 [KO:K02991]
104514869  STRADA; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
104504222  STRADB; STE20-related kinase adapter protein beta [KO:K17532]
104507901  CAB39; calcium-binding protein 39 [KO:K08272]
104516941  calcium-binding protein 39-like [KO:K08272]
104502550  5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
104504581  5'-AMP-activated protein kinase catalytic subunit alpha-1-like [KO:K07198] [EC:2.7.11.31]
104511266  TSC1; hamartin isoform X1 [KO:K07206]
104507359  TSC2; tuberin [KO:K07207]
104512923  TBC1D7; TBC1 domain family member 7 isoform X1 [KO:K20396]
104512029  RHEB; GTP-binding protein Rheb [KO:K07208]
104511218  WNT2; protein Wnt-2 [KO:K00182]
104507886  protein Wnt-3a [KO:K00312]
104509177  proto-oncogene Wnt-3 [KO:K00312]
104515061  protein Wnt-4-like [KO:K00408]
104505806  WNT4; protein Wnt-4 [KO:K00408]
104515222  LOW QUALITY PROTEIN: protein Wnt-5b-like [KO:K00444]
104516655  protein Wnt-5a [KO:K00444]
104505552  WNT6; LOW QUALITY PROTEIN: protein Wnt-6 [KO:K00445]
104509972  WNT7B; protein Wnt-7b [KO:K00572]
104515149  WNT7A; protein Wnt-7a [KO:K00572]
104508718  WNT8A; protein Wnt-8a [KO:K00714]
104504402  WNT8B; protein Wnt-8b [KO:K00714]
104507859  WNT9A; protein Wnt-9a [KO:K01064]
104517084  WNT9B; protein Wnt-9b [KO:K01064]
104513686  protein Wnt-10a-like [KO:K01357]
104514342  WNT11; protein Wnt-11 [KO:K01384]
104511987  WNT16; protein Wnt-16 [KO:K01558]
104505137  frizzled-7 [KO:K02432]
104508641  frizzled-2 [KO:K02235]
104506981  FZD3; frizzled-3 [KO:K02329]
104513093  FZD4; frizzled-4 [KO:K02354]
104512719  frizzled-5-like [KO:K02375]
104504195  FZD6; frizzled-6 [KO:K02376]
104504306  FZD10; frizzled-10 [KO:K02842]
104513931  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
104506902  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
104507229  DVL1; segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
104516543  DVL3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
104513483  tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
104514410  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
104516693  INS; insulin [KO:K04526]
104507576  insulin-like growth factor I [KO:K05459]
104515844  IGF1; LOW QUALITY PROTEIN: insulin-like growth factor I [KO:K05459]
104512268  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
104510387  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
104506550  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
104503030  SOS1; son of sevenless homolog 1 [KO:K03099]
104507894  HRAS; GTPase HRas [KO:K02833]
104504813  GTPase KRas [KO:K07827]
104504914  GTPase NRas [KO:K07828]
104511841  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
104503923  RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
104504125  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
104509254  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
104516204  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104507004  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
104507490  RPS6KA1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
104506377  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
104511743  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
104502575  IRS1; insulin receptor substrate 1 [KO:K16172]
104512091  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
104508880  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
104504642  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
104508009  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
104515698  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
104514725  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
104509446  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104507608  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
104505714  MAPKAP1; target of rapamycin complex 2 subunit MAPKAP1 [KO:K20410]
104511031  RICTOR; LOW QUALITY PROTEIN: rapamycin-insensitive companion of mTOR [KO:K08267]
104508439  PRR5; proline-rich protein 5 [KO:K20411]
104503529  PRR5L; proline-rich protein 5-like [KO:K20411]
104512733  rho-related GTP-binding protein RhoC-like [KO:K04513]
104511131  RHOA; transforming protein RhoA isoform X1 [KO:K04513]
104512243  protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
104514535  LOW QUALITY PROTEIN: protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
104504021  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
ehs00561  Glycerolipid metabolism
ehs04010  MAPK signaling pathway
ehs04140  Autophagy - animal
ehs04810  Regulation of actin cytoskeleton
ehs04910  Insulin signaling pathway
KO pathway
ko04150   
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