Entry Name Wnt signaling pathway - Gymnodraco acuticeps
Description Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Other DBs Organism Gymnodraco acuticeps [GN:
gacu ]
Gene 117532762 lrp5; low-density lipoprotein receptor-related protein 5 [KO:K03068 ]
117534709 ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
117537338 nfatc2a; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332 ]
117538672 ankrd6b; ankyrin repeat domain-containing protein 6b isoform X1 [KO:K21435 ]
117538878 tle3a; transducin-like enhancer protein 3-A isoform X1 [KO:K04497 ]
117540835 nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334 ]
117540958 si:dkey-222b8.1; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501 ]
117541740 ppardb; peroxisome proliferator-activated receptor delta b [KO:K04504 ]
117541870 celsr3; LOW QUALITY PROTEIN: cadherin EGF LAG seven-pass G-type receptor 3 [KO:K04602 ]
117543067 dvl1a; putative segment polarity protein dishevelled homolog DVL1P1 isoform X1 [KO:K02353 ]
117543165 tcf7l2; LOW QUALITY PROTEIN: transcription factor 7-like 2 [KO:K04491 ]
117543393 camk2d2; calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
117544903 rac1a; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
117546792 lgr4; leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1 [KO:K04309 ]
117549346 smad3a; mothers against decapentaplegic homolog 3a isoform X1 [KO:K23605 ]
117549906 daam2; disheveled-associated activator of morphogenesis 2 isoform X1 [KO:K04512 ]
117549938 plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
117550242 bambia; BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a [KO:K10162 ]
117550444 plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
117550908 tle2a; transducin-like enhancer protein 2a isoform X1 [KO:K04497 ]
117550923 tle2b; LOW QUALITY PROTEIN: transducin-like enhancer protein 4 [KO:K04497 ]
117551080 celsr2; cadherin EGF LAG seven-pass G-type receptor 2 isoform X1 [KO:K04601 ]
117551813 wnt4b; wingless-type MMTV integration site family, member 4b [KO:K00408 ]
117552717 dvl2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353 ]
117554105 nkd2b; protein naked cuticle homolog 2-like isoform X1 [KO:K03213 ]
117555793 fbxw11a; F-box/WD repeat-containing protein 11a isoform X1 [KO:K03362 ]
117556621 chd8; chromodomain-helicase-DNA-binding protein 8 isoform X1 [KO:K04494 ] [EC:5.6.2.-]
117556701 nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333 ]
117557427 june; LOW QUALITY PROTEIN: junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448 ]
117558297 celsr1a; LOW QUALITY PROTEIN: cadherin EGF LAG seven-pass G-type receptor 1 [KO:K04600 ]
117559047 apc2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085 ]
117559326 nfatc1; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446 ]
117560739 camk2g2; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
117563158 prickle3; LOW QUALITY PROTEIN: prickle planar cell polarity protein 3 [KO:K04511 ]
Compound Reference Authors Hatsell S, Rowlands T, Hiremath M, Cowin P.
Title Beta-catenin and Tcfs in mammary development and cancer.
Journal Reference Authors Yang Y.
Title Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
Journal Reference Authors Kalderon D.
Title Similarities between the Hedgehog and Wnt signaling pathways.
Journal Reference Authors Nusse R.
Title Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
Journal Reference Authors Jope RS, Johnson GV.
Title The glamour and gloom of glycogen synthase kinase-3.
Journal Reference Authors Veeman MT, Axelrod JD, Moon RT.
Title A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
Journal Reference Authors Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
Title PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
Journal Reference Authors Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
Title The way Wnt works: Components and mechanism.
Journal Reference Authors Carethers JM
Title Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
Journal Reference Authors Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
Title The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.
Journal Reference Authors Niehrs C
Title The complex world of WNT receptor signalling.
Journal Reference Authors Abou Ziki MD, Mani A
Title Wnt signaling, a novel pathway regulating blood pressure? State of the art review.
Journal Reference Authors He Y, Ki H, Kim H, Kim K
Title delta-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.
Journal Reference Authors Esaki N, Enomoto A, Takagishi M, Mizutani Y, Iida T, Ushida K, Shiraki Y, Mii S, Takahashi M
Title The Daple-CK1epsilon complex regulates Dvl2 phosphorylation and canonical Wnt signaling.
Journal Reference Authors Yiew NKH, Chatterjee TK, Tang YL, Pellenberg R, Stansfield BK, Bagi Z, Fulton DJ, Stepp DW, Chen W, Patel V, Kamath VM, Litwin SE, Hui DY, Rudich SM, Kim HW, Weintraub NL
Title A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.
Journal Related KO pathway
