KEGG   PATHWAY: gacu04310
Entry
gacu04310                   Pathway                                
Name
Wnt signaling pathway - Gymnodraco acuticeps
Description
Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Class
Environmental Information Processing; Signal transduction
Pathway map
gacu04310  Wnt signaling pathway
gacu04310

Other DBs
GO: 0016055
Organism
Gymnodraco acuticeps [GN:gacu]
Gene
117546296  protein-serine O-palmitoleoyltransferase porcupine-like isoform X1 [KO:K00181] [EC:2.3.1.250]
117535475  protein-serine O-palmitoleoyltransferase porcupine-like isoform X1 [KO:K00181] [EC:2.3.1.250]
117541847  wnt1; protein Wnt-1 [KO:K03209]
117537802  wnt2; protein Wnt-2 [KO:K00182]
117534176  protein Wnt-2b-A-like [KO:K00182]
117541885  protein Wnt-2b-A isoform X1 [KO:K00182]
117547058  wnt3; proto-oncogene Wnt-3 [KO:K00312]
117558461  wnt3a; protein Wnt-3a [KO:K00312]
117551813  wnt4b; wingless-type MMTV integration site family, member 4b [KO:K00408]
117559501  wnt4; protein Wnt-4a [KO:K00408]
117557912  protein Wnt-5a-like [KO:K00444]
117542864  wnt5b; protein Wnt-5b [KO:K00444]
117553349  wnt6b; protein Wnt-6 [KO:K00445]
117547875  wnt7bb; protein Wnt-7b isoform X1 [KO:K00572]
117543124  protein Wnt-7a [KO:K00572]
117558278  wnt7ba; protein Wnt-7b [KO:K00572]
117538184  wnt8b; protein Wnt-8b isoform X1 [KO:K00714]
117545203  protein Wnt-8a-like [KO:K00714]
117545223  protein Wnt-8a-like isoform X1 [KO:K00714]
117548440  wnt9b; protein Wnt-9b [KO:K01064]
117558341  wnt9a; protein Wnt-9a [KO:K01064]
117553358  wnt10a; protein Wnt-10a isoform X1 [KO:K01357]
117541846  wnt10b; protein Wnt-10b [KO:K01357]
117553025  wnt11; protein Wnt-11 [KO:K01384]
117537178  wnt16; protein Wnt-16 isoform X1 [KO:K01558]
117538016  dand5; DAN domain family member 5 [KO:K01645]
117537296  notum2; carboxylesterase notum2 [KO:K19882] [EC:3.1.1.98]
117548308  notum1a; palmitoleoyl-protein carboxylesterase notum1a [KO:K19882] [EC:3.1.1.98]
117561710  notum1b; inactive palmitoleoyl-protein carboxylesterase notum1b isoform X1 [KO:K19882] [EC:3.1.1.98]
117547341  sost; sclerostin [KO:K16834]
117535038  uncharacterized protein LOC117535038 [KO:K02165]
117555326  dkk2; dickkopf-related protein 2 isoform X1 [KO:K02165]
117560780  dickkopf-related protein 1-like isoform X1 [KO:K02165]
117548924  secreted frizzled-related protein 1-like [KO:K02166]
117534906  sfrp2l; secreted frizzled-related protein 2 [KO:K02176]
117556095  sfrp2; secreted frizzled-related protein 2 [KO:K02176]
117554487  frzb; secreted frizzled-related protein 3 [KO:K25481]
117538234  sfrp5; secreted frizzled-related protein 5 [KO:K02222]
117557094  rspo1; R-spondin-1 isoform X1 [KO:K19471]
117555356  rspo2; R-spondin-2 isoform X1 [KO:K23097]
117537435  rspo3; R-spondin-3 [KO:K23098]
117546792  lgr4; leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1 [KO:K04309]
117553105  leucine-rich repeat-containing G-protein coupled receptor 5A-like [KO:K04308]
117542090  leucine-rich repeat-containing G-protein coupled receptor 6 [KO:K08399]
117557276  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase RNF43 [KO:K15694] [EC:2.3.2.27]
117552050  znrf3; E3 ubiquitin-protein ligase znrf3 isoform X1 [KO:K16273] [EC:2.3.2.27]
117546857  fzd1; frizzled-1 [KO:K02432]
117560088  frizzled-7-like [KO:K02432]
117548478  fzd2; frizzled-2 [KO:K02235]
117551420  frizzled-3-like [KO:K02329]
117554245  fzd3a; LOW QUALITY PROTEIN: frizzled-3a [KO:K02329]
117552261  fzd4; frizzled-4 [KO:K02354]
117550223  fzd8a; frizzled-8a [KO:K02375]
117544463  fzd5; frizzled-5 [KO:K02375]
117541282  LOW QUALITY PROTEIN: frizzled-8-like [KO:K02375]
117555452  frizzled-6-like [KO:K02376]
117543990  fzd10; LOW QUALITY PROTEIN: frizzled-10 [KO:K02842]
117557400  fzd9b; frizzled-9b [KO:K02842]
117532762  lrp5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
117550242  bambia; BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a [KO:K10162]
117539550  apcdd1l; protein APCDD1-like [KO:K25812]
117541240  protein APCDD1-like [KO:K25812]
117536873  casein kinase I [KO:K08960] [EC:2.7.11.1]
117535821  csnk1e; LOW QUALITY PROTEIN: casein kinase I [KO:K08960] [EC:2.7.11.1]
117563100  LOW QUALITY PROTEIN: protein Daple-like [KO:K25811]
117563103  ccdc88c; protein Daple [KO:K25811]
117532687  LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
117552717  dvl2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
117543067  dvl1a; putative segment polarity protein dishevelled homolog DVL1P1 isoform X1 [KO:K02353]
117552636  gbp; glycogen synthase kinase binding protein [KO:K03096]
117533638  casein kinase II subunit alpha'-like isoform X1 [KO:K03097] [EC:2.7.11.1]
117539669  csnk2a2b; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
117554015  casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
117535610  casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
117553928  casein kinase II subunit beta isoform X1 [KO:K03115]
117542595  csnk2b; casein kinase II subunit beta [KO:K03115]
117554105  nkd2b; protein naked cuticle homolog 2-like isoform X1 [KO:K03213]
117549141  nkd1; protein naked cuticle homolog 1 isoform X1 [KO:K03213]
117555341  cxxc4; CXXC-type zinc finger protein 4 [KO:K03344]
117540619  senp2; sentrin-specific protease 2 isoform X1 [KO:K03345] [EC:3.4.22.68]
117535811  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
117540803  ctnnb1; catenin beta-1 [KO:K02105]
117562919  catenin beta-1-like [KO:K02105]
117533835  axin-1-like [KO:K02157]
117548757  axin1; axin-1 isoform X1 [KO:K02157]
117562527  axin2; axin-2 [KO:K04385]
117559047  apc2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
117562199  csnk1a1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
117540208  tcf7; transcription factor 7 isoform X1 [KO:K02620]
117556347  transcription factor 7-like 1-A [KO:K04490]
117561075  tcf7l1b; transcription factor 7-like 1-B isoform X1 [KO:K04490]
117543165  tcf7l2; LOW QUALITY PROTEIN: transcription factor 7-like 2 [KO:K04491]
117538196  lzts2a; leucine zipper putative tumor suppressor 2a [KO:K26471]
117547394  leucine zipper putative tumor suppressor 2 homolog [KO:K26471]
117541699  beta-catenin-interacting protein 1 [KO:K04493]
117541748  beta-catenin-interacting protein 1 [KO:K04493]
117533423  cby1; protein chibby homolog 1 isoform X1 [KO:K23402]
117556621  chd8; chromodomain-helicase-DNA-binding protein 8 isoform X1 [KO:K04494] [EC:5.6.2.-]
117552426  sirt1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
117544675  sox17; transcription factor SOX-17 [KO:K04495]
117543847  uncharacterized protein LOC117543847 isoform X1 [KO:K04496] [EC:1.1.1.428]
117540567  C-terminal-binding protein 1 isoform X1 [KO:K04496] [EC:1.1.1.428]
117555995  ctbp1; C-terminal-binding protein 1 isoform X1 [KO:K04496] [EC:1.1.1.428]
117560772  LOW QUALITY PROTEIN: ataxin-2 homolog [KO:K04496] [EC:1.1.1.428]
117550908  tle2a; transducin-like enhancer protein 2a isoform X1 [KO:K04497]
117550923  tle2b; LOW QUALITY PROTEIN: transducin-like enhancer protein 4 [KO:K04497]
117538878  tle3a; transducin-like enhancer protein 3-A isoform X1 [KO:K04497]
117549338  transducin-like enhancer protein 3-B isoform X1 [KO:K04497]
117558621  transducin-like enhancer protein 1 isoform X1 [KO:K04497]
117560927  transducin-like enhancer protein 4 isoform X1 [KO:K04497]
117543628  ctnnd2a; catenin delta-2 isoform X1 [KO:K23491]
117557307  ctnnd2b; catenin delta-2b isoform X1 [KO:K23491]
117534559  ep300b; LOW QUALITY PROTEIN: histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
117548406  crebbpb; CREB binding protein b isoform X1 [KO:K04498] [EC:2.3.1.48]
117536236  ep300a; LOW QUALITY PROTEIN: histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
117561595  crebbpa; LOW QUALITY PROTEIN: CREB-binding protein [KO:K04498] [EC:2.3.1.48]
117551063  ruvbl1; ruvB-like 1 [KO:K04499] [EC:5.6.2.4]
117538269  smad4a; mothers against decapentaplegic homolog 4a [KO:K04501]
117540958  si:dkey-222b8.1; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
117534919  mothers against decapentaplegic homolog 4-like [KO:K04501]
117558648  mothers against decapentaplegic homolog 4-like [KO:K04501]
117538911  smad3b; mothers against decapentaplegic homolog 3b [KO:K23605]
117549346  smad3a; mothers against decapentaplegic homolog 3a isoform X1 [KO:K23605]
117538648  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
117536277  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
117539816  nlk1; nemo-like kinase, type 1 [KO:K04468] [EC:2.7.11.24]
117555593  nlk2; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
117544662  myca; transcriptional regulator Myc-A [KO:K04377]
117534628  transcriptional regulator Myc-like [KO:K04377]
117557427  june; LOW QUALITY PROTEIN: junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
117545557  transcription factor AP-1-like [KO:K04448]
117555214  jun; transcription factor AP-1 [KO:K04448]
117557335  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
117532640  G1/S-specific cyclin-D1-like isoform X1 [KO:K04503]
117548459  ccndx; cyclin Dx [KO:K10151]
117542821  ccnd2a; G1/S-specific cyclin-D2a [KO:K10151]
117559178  G1/S-specific cyclin-D2-like [KO:K10151]
117551118  ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
117562941  ccn4a; cellular communication network factor 4a [KO:K22471]
117541740  ppardb; peroxisome proliferator-activated receptor delta b [KO:K04504]
117556760  presenilin-1-like [KO:K04505] [EC:3.4.23.-]
117548428  cAMP-dependent protein kinase catalytic subunit alpha-like isoform X1 [KO:K04345] [EC:2.7.11.11]
117555105  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
117558377  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b [KO:K04345] [EC:2.7.11.11]
117561581  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
117552767  tp53; cellular tumor antigen p53 [KO:K04451]
117559471  siah1; E3 ubiquitin-protein ligase Siah1 isoform X1 [KO:K04506] [EC:2.3.2.27]
117558323  cacybp; calcyclin-binding protein [KO:K04507]
117540209  skp1; S-phase kinase-associated protein 1 isoform X1 [KO:K03094]
117544334  tbl1x; F-box-like/WD repeat-containing protein TBL1X [KO:K04508]
117545466  F-box-like/WD repeat-containing protein TBL1XR1 [KO:K04508]
117545965  F-box-like/WD repeat-containing protein TBL1XR1 isoform X1 [KO:K04508]
117555793  fbxw11a; F-box/WD repeat-containing protein 11a isoform X1 [KO:K03362]
117539163  cullin-1 [KO:K03347]
117534788  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
117550712  gpc4; glypican-4 [KO:K08110]
117542689  ror1; inactive tyrosine-protein kinase transmembrane receptor ROR1 [KO:K05122] [EC:2.7.10.1]
117562098  ror2; LOW QUALITY PROTEIN: tyrosine-protein kinase transmembrane receptor ROR2 [KO:K05123] [EC:2.7.10.1]
117559018  ryk; LOW QUALITY PROTEIN: tyrosine-protein kinase RYK [KO:K05128] [EC:2.7.10.1]
117544407  vang-like protein 1 [KO:K04510]
117546706  vang-like protein 1 isoform X1 [KO:K04510]
117540862  vang-like protein 2 [KO:K04510]
117555530  vang-like protein 2 [KO:K04510]
117547835  prickle1a; prickle-like protein 1a [KO:K04511]
117534938  LOW QUALITY PROTEIN: prickle-like protein 2 [KO:K04511]
117543130  prickle-like protein 2 isoform X1 [KO:K04511]
117558252  prickle1b; prickle-like protein 1b isoform X1 [KO:K04511]
117563158  prickle3; LOW QUALITY PROTEIN: prickle planar cell polarity protein 3 [KO:K04511]
117553982  invs; inversin isoform X1 [KO:K19626]
117533821  LOW QUALITY PROTEIN: disheveled-associated activator of morphogenesis 1-like [KO:K04512]
117536280  disheveled-associated activator of morphogenesis 1-like isoform X1 [KO:K04512]
117549906  daam2; disheveled-associated activator of morphogenesis 2 isoform X1 [KO:K04512]
117551071  rho-related GTP-binding protein RhoA-B [KO:K04513]
117545976  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
117547686  rho-related GTP-binding protein RhoA-C [KO:K04513]
117541780  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
117542099  rho-related GTP-binding protein RhoA-D [KO:K04513]
117539718  rock2a; LOW QUALITY PROTEIN: rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
117556533  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.39]
117544903  rac1a; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
117548381  rac1b; ras-related C3 botulinum toxin substrate 1b [KO:K04392]
117542525  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
117537676  rac3b; ras-related C3 botulinum toxin substrate 3b [KO:K07861]
117536791  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
117532364  mapk8b; LOW QUALITY PROTEIN: mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
117551262  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
117555963  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
117550444  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
117545410  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858] [EC:3.1.4.11]
117554181  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
117554205  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like isoform X1 [KO:K05858] [EC:3.1.4.11]
117549938  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
117544304  LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II subunit gamma-like [KO:K04515] [EC:2.7.11.17]
117551247  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
117547272  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
117543393  camk2d2; calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
117560739  camk2g2; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
117552299  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
117534701  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform-like [KO:K04348] [EC:3.1.3.16]
117534709  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
117536359  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
117551945  ppp3r1b; calcineurin subunit B type 1b [KO:K06268]
117542348  ppp3r1a; calcineurin subunit B type 1 [KO:K06268]
117548684  si:ch73-374l24.1; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
117561994  prkcaa; protein kinase C, alpha, a [KO:K02677] [EC:2.7.11.13]
117551971  protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
117556109  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
117543213  prkcg; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
117553822  nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1 [KO:K04446]
117559326  nfatc1; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
117537338  nfatc2a; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
117539593  nuclear factor of activated T-cells, cytoplasmic 2-like [KO:K17332]
117556701  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
117540835  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
Compound
C00076  Calcium cation
Reference
PMID:14635791
  Authors
Hatsell S, Rowlands T, Hiremath M, Cowin P.
  Title
Beta-catenin and Tcfs in mammary development and cancer.
  Journal
J Mammary Gland Biol Neoplasia 8:145-58 (2003)
DOI:10.1023/A:1025944723047
Reference
PMID:14745971
  Authors
Yang Y.
  Title
Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
  Journal
Birth Defects Res Part C Embryo Today 69:305-17 (2003)
DOI:10.1002/bdrc.10026
Reference
PMID:12446114
  Authors
Kalderon D.
  Title
Similarities between the Hedgehog and Wnt signaling pathways.
  Journal
Trends Cell Biol 12:523-31 (2002)
DOI:10.1016/S0962-8924(02)02388-7
Reference
PMID:14530294
  Authors
Nusse R.
  Title
Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
  Journal
Development 130:5297-305 (2003)
DOI:10.1242/dev.00821
Reference
PMID:15102436
  Authors
Jope RS, Johnson GV.
  Title
The glamour and gloom of glycogen synthase kinase-3.
  Journal
Trends Biochem Sci 29:95-102 (2004)
DOI:10.1016/j.tibs.2003.12.004
Reference
PMID:12967557
  Authors
Veeman MT, Axelrod JD, Moon RT.
  Title
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
  Journal
Dev Cell 5:367-77 (2003)
DOI:10.1016/S1534-5807(03)00266-1
Reference
PMID:11433294
  Authors
Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
  Title
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
  Journal
Nat Cell Biol 3:628-36 (2001)
DOI:10.1038/35083016
Reference
PMID:23256519
  Authors
Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
  Title
The way Wnt works: Components and mechanism.
  Journal
Growth Factors 31:1-31 (2013)
DOI:10.3109/08977194.2012.752737
Reference
PMID:19482104
  Authors
Carethers JM
  Title
Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
  Journal
Gastroenterology 137:33-6 (2009)
DOI:10.1053/j.gastro.2009.05.011
Reference
PMID:18838381
  Authors
Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
  Title
The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.
  Journal
J Biol Chem 283:33053-8 (2008)
DOI:10.1074/jbc.M804039200
Reference
PMID:23151663
  Authors
Niehrs C
  Title
The complex world of WNT receptor signalling.
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Nat Rev Mol Cell Biol 13:767-79 (2012)
DOI:10.1038/nrm3470
Reference
PMID:28522145
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Abou Ziki MD, Mani A
  Title
Wnt signaling, a novel pathway regulating blood pressure? State of the art review.
  Journal
Atherosclerosis 262:171-178 (2017)
DOI:10.1016/j.atherosclerosis.2017.05.001
Reference
PMID:25808920
  Authors
He Y, Ki H, Kim H, Kim K
  Title
delta-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.
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Cell Biol Int 39:954-61 (2015)
DOI:10.1002/cbin.10465
Reference
PMID:32888647
  Authors
Esaki N, Enomoto A, Takagishi M, Mizutani Y, Iida T, Ushida K, Shiraki Y, Mii S, Takahashi M
  Title
The Daple-CK1epsilon complex regulates Dvl2 phosphorylation and canonical Wnt signaling.
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Biochem Biophys Res Commun 532:406-413 (2020)
DOI:10.1016/j.bbrc.2020.08.066
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PMID:28242765
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Yiew NKH, Chatterjee TK, Tang YL, Pellenberg R, Stansfield BK, Bagi Z, Fulton DJ, Stepp DW, Chen W, Patel V, Kamath VM, Litwin SE, Hui DY, Rudich SM, Kim HW, Weintraub NL
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A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.
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J Biol Chem 292:6312-6324 (2017)
DOI:10.1074/jbc.M116.758078
Related
pathway
gacu04010  MAPK signaling pathway
gacu04110  Cell cycle
gacu04115  p53 signaling pathway
gacu04120  Ubiquitin mediated proteolysis
gacu04350  TGF-beta signaling pathway
gacu04510  Focal adhesion
gacu04520  Adherens junction
KO pathway
ko04310   
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