KEGG   PATHWAY: gacu04510
Entry
gacu04510                   Pathway                                
Name
Focal adhesion - Gymnodraco acuticeps
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
gacu04510  Focal adhesion
gacu04510

Other DBs
GO: 0005925
Organism
Gymnodraco acuticeps [GN:gacu]
Gene
117532364  mapk8b; LOW QUALITY PROTEIN: mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
117532476  arhgap5; rho GTPase-activating protein 5 [KO:K13709]
117532612  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
117532616  [KO:K00889] [EC:2.7.1.68]
117532640  [KO:K04503]
117532743  [KO:K06485]
117532770  bcar1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
117532898  zgc:158296; caveolin-2 [KO:K12958]
117532930  vegfaa; vascular endothelial growth factor A-A [KO:K05448]
117532977  [KO:K06587]
117533028  [KO:K04349]
117533136  itgb4; integrin beta-4 [KO:K06525]
117533152  parvaa; parvin, alpha a [KO:K06275]
117533368  [KO:K04438]
117533412  myl9b; myosin regulatory light polypeptide 9b [KO:K12755]
117533539  elk1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
117533773  actn1; alpha-actinin-1 [KO:K05699]
117533890  sos2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
117534172  col2a1b; collagen, type II, alpha 1b isoform X1 [KO:K19719]
117534181  [KO:K04353]
117534196  itga7; integrin alpha-7 isoform X1 [KO:K06583]
117534275  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
117534517  [KO:K06236]
117534596  [KO:K05692]
117534604  [KO:K05692]
117534613  [KO:K05692]
117534622  [KO:K05692]
117534874  tln1; LOW QUALITY PROTEIN: talin-1 [KO:K06271]
117534965  tnc; tenascin isoform X1 [KO:K06252]
117535004  [KO:K02649]
117535013  [KO:K05692]
117535097  ilk; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
117535453  [KO:K04410] [EC:2.7.11.1]
117535474  [KO:K05733] [EC:2.7.11.1]
117535626  [KO:K03853] [EC:3.4.22.53]
117535720  col9a1a; LOW QUALITY PROTEIN: collagen, type IX, alpha 1a [KO:K08131]
117535811  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
117536004  birc2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
117536040  thbs4a; thrombospondin-4a isoform X1 [KO:K04659]
117536437  [KO:K06238]
117536440  col6a4a; collagen alpha-6(VI) chain isoform X1 [KO:K06238]
117536485  [KO:K06252]
117536702  [KO:K00889] [EC:2.7.1.68]
117536769  [KO:K05700]
117536791  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
117536854  col9a1b; collagen, type IX, alpha 1b isoform X1 [KO:K08131]
117536862  thbs2a; thrombospondin-2 [KO:K04659]
117536998  col6a3; LOW QUALITY PROTEIN: uncharacterized protein col6a3 [KO:K06238]
117537003  emp2; epithelial membrane protein 2 [KO:K26256]
117537320  [KO:K05460]
117537386  src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
117537609  kdrl; vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
117537644  vegfba; vascular endothelial growth factor A [KO:K05448]
117537676  rac3b; ras-related C3 botulinum toxin substrate 3b [KO:K07861]
117537966  emp1; epithelial membrane protein 1 [KO:K26255]
117538090  itgb5; LOW QUALITY PROTEIN: integrin beta-5 [KO:K06588]
117538458  arhgap35b; LOW QUALITY PROTEIN: rho GTPase-activating protein 35 [KO:K05732]
117538550  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
117538695  cav2; caveolin-2 [KO:K12958]
117538696  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
117538697  cav1; caveolin-1 [KO:K06278]
117538744  [KO:K04438]
117538850  zmp:0000001167; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K17457]
117538865  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
117538903  reln; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
117538998  shc3; SHC-transforming protein 3 [KO:K17448]
117539053  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit A isoform X1 [KO:K06269] [EC:3.1.3.16]
117539054  myl2b; myosin, light chain 2b, regulatory, cardiac, slow [KO:K10351]
117539537  [KO:K05704] [EC:2.7.10.2]
117539718  rock2a; LOW QUALITY PROTEIN: rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
117540042  vtnb; vitronectin b [KO:K06251]
117540390  [KO:K06272] [EC:2.7.11.1]
117540611  fyna; tyrosine-protein kinase fyna [KO:K05703] [EC:2.7.10.2]
117540803  ctnnb1; catenin beta-1 [KO:K02105]
117541013  itga10; integrin alpha-10 [KO:K06586]
117541488  flna; filamin-A isoform X1 [KO:K04437]
117541527  [KO:K05087] [EC:2.7.10.1]
117541780  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
117541887  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
117542099  [KO:K04513]
117542172  itga9; integrin alpha-9 [KO:K06585]
117542174  myl12.2; myosin, light chain 12, genome duplicate 2 isoform X1 [KO:K12757]
117542211  [KO:K05730]
117542227  itga5; LOW QUALITY PROTEIN: integrin alpha-5 [KO:K06484]
117542261  [KO:K27392]
117542274  [KO:K02649]
117542378  [KO:K00922] [EC:2.7.1.153]
117542520  [KO:K26255]
117542525  [KO:K07860]
117542579  [KO:K00889] [EC:2.7.1.68]
117542611  ptk2aa; protein tyrosine kinase 2aa isoform X1 [KO:K05725] [EC:2.7.10.2]
117542741  [KO:K06269] [EC:3.1.3.16]
117542821  ccnd2a; G1/S-specific cyclin-D2a [KO:K10151]
117542953  [KO:K12329]
117542978  [KO:K04393]
117542983  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
117543001  col2a1a; collagen, type II, alpha 1a isoform X1 [KO:K19719]
117543083  col9a3; collagen alpha-3(IX) chain [KO:K08131]
117543213  prkcg; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
117543219  [KO:K00907] [EC:2.7.11.18]
117543268  [KO:K05700]
117543597  [KO:K05730]
117543837  lama4; laminin subunit alpha-4 [KO:K06241]
117543876  [KO:K05760]
117543936  dock1; dedicator of cytokinesis protein 1 [KO:K13708]
117544024  [KO:K04659]
117544100  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
117544212  comp; cartilage oligomeric matrix protein [KO:K04659]
117544430  itga6a; integrin alpha-6 [KO:K06485]
117544493  itga4; LOW QUALITY PROTEIN: integrin alpha-4 [KO:K06483]
117544558  [KO:K04456] [EC:2.7.11.1]
117544682  myl12.1; myosin, light chain 12, genome duplicate 1 [KO:K12757]
117544903  rac1a; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
117544911  itgb3b; integrin beta-3b isoform X1 [KO:K06493]
117544977  erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
117545022  ppp1cab; protein phosphatase 1, catalytic subunit, alpha isozyme b [KO:K06269] [EC:3.1.3.16]
117545032  mylpfb; myosin light chain, phosphorylatable, fast skeletal muscle b [KO:K12758]
117545078  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
117545138  itga3b; integrin alpha-3b [KO:K06482]
117545363  [KO:K04393]
117545508  [KO:K00922] [EC:2.7.1.153]
117545557  [KO:K04448]
117545568  [KO:K02649]
117545684  [KO:K05460]
117545900  [KO:K02833]
117545976  [KO:K04513]
117546028  [KO:K06237]
117546029  [KO:K06237]
117546060  [KO:K04659]
117546425  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117546691  [KO:K05449]
117547064  chad; chondroadherin [KO:K06248]
117547129  braf; LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
117547364  col1a1b; LOW QUALITY PROTEIN: collagen, type I, alpha 1b [KO:K06236]
117547679  lamb2l; laminin subunit beta-2 [KO:K06243]
117547681  [KO:K05459]
117547686  [KO:K04513]
117547712  lamb2; laminin subunit beta-2 [KO:K06243]
117547813  parvb; beta-parvin isoform X1 [KO:K06275]
117547814  parvg; gamma-parvin isoform X1 [KO:K06275]
117547995  zyx; zyxin [KO:K06273]
117548116  zgc:172270; LOW QUALITY PROTEIN: caveolin-3 [KO:K12958]
117548336  mylpfa; myosin light chain, phosphorylatable, fast skeletal muscle a [KO:K12758]
117548381  rac1b; ras-related C3 botulinum toxin substrate 1b [KO:K04392]
117548389  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
117548445  mylk5; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
117548459  ccndx; cyclin Dx [KO:K10151]
117548627  itgb3a; integrin beta-3a [KO:K06493]
117548665  pdgfab; platelet-derived growth factor alpha polypeptide b [KO:K04359]
117548669  ppp1caa; protein phosphatase 1, catalytic subunit, alpha isozyme a [KO:K06269] [EC:3.1.3.16]
117548684  si:ch73-374l24.1; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
117548768  [KO:K05637]
117548936  [KO:K06269] [EC:3.1.3.16]
117549247  [KO:K17449]
117549253  thbs1b; thrombospondin-1 [KO:K16857]
117549308  itgb6; integrin beta-6 [KO:K06589]
117549382  itga11a; integrin alpha-11a [KO:K06587]
117549398  vegfd; vascular endothelial growth factor D [KO:K05449]
117550034  akt1; LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117550083  [KO:K05735] [EC:2.7.11.1]
117550137  [KO:K16857]
117550215  pgfb; placenta growth factor [KO:K16859]
117550231  itgb1a; integrin beta-1a isoform X1 [KO:K05719]
117550293  vegfc; vascular endothelial growth factor C [KO:K05449]
117550753  xiap; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
117550979  shc2; SHC-transforming protein 2 isoform X1 [KO:K17447]
117551012  [KO:K12958]
117551013  cav3; caveolin-3 [KO:K12959]
117551071  [KO:K04513]
117551118  ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
117551245  itga1; integrin alpha-1 [KO:K06480]
117551262  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
117551344  si:ch1073-15f12.3; laminin subunit beta-3 [KO:K06244]
117551507  badb; BCL2 associated agonist of cell death b [KO:K02158]
117551692  vaspb; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
117551707  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117551817  cdc42l; cell division cycle 42, like [KO:K04393]
117551971  [KO:K19662] [EC:2.7.11.13]
117552195  arhgap35a; rho GTPase-activating protein 35 [KO:K05732]
117552219  vtna; vitronectin a [KO:K06251]
117552268  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
117552449  ppp1r12a; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
117552473  lamb1b; laminin subunit beta-1b [KO:K05636]
117552476  igf1; insulin-like growth factor I [KO:K05459]
117552564  [KO:K06237]
117553009  [KO:K03853] [EC:3.4.22.53]
117553016  [KO:K03853] [EC:3.4.22.53]
117553312  [KO:K00889] [EC:2.7.1.68]
117553351  fn1a; fibronectin 1a isoform X1 [KO:K05717]
117553610  egf; pro-epidermal growth factor [KO:K04357]
117553616  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
117553681  [KO:K05725] [EC:2.7.10.2]
117553685  [KO:K05719]
117553868  shc1; SHC-transforming protein 1 isoform X1 [KO:K06279]
117553913  tnxba; tenascin [KO:K06252]
117553916  [KO:K06269] [EC:3.1.3.16]
117553935  [KO:K00889] [EC:2.7.1.68]
117554091  itga8; integrin alpha-8 [KO:K06584]
117554287  pak7; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
117554322  [KO:K16859]
117554776  crkl; crk-like protein [KO:K04438]
117554896  vav2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
117555006  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
117555062  pak2b; serine/threonine-protein kinase PAK 2b [KO:K04410] [EC:2.7.11.1]
117555073  pdgfra; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
117555130  pip5k1ca; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
117555200  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
117555214  jun; transcription factor AP-1 [KO:K04448]
117555318  [KO:K05730]
117555963  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
117556048  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
117556109  [KO:K19662] [EC:2.7.11.13]
117556245  actb1; actin, cytoplasmic 1 [KO:K05692]
117556528  pak4; LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
117556533  [KO:K17388] [EC:2.7.11.1]
117556620  col6a1; collagen alpha-1(VI) chain [KO:K06238]
117556630  col6a2; collagen alpha-2(VI) chain [KO:K06238]
117556692  tln2a; talin-2a isoform X1 [KO:K06271]
117556831  [KO:K06238]
117556853  col4a2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
117556854  col4a1; collagen alpha-1(IV) chain [KO:K06237]
117556978  flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
117557093  actn4; alpha-actinin-4 isoform X1 [KO:K05699]
117557151  [KO:K05703] [EC:2.7.10.2]
117557335  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
117557422  [KO:K06484]
117557427  june; LOW QUALITY PROTEIN: junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
117557458  [KO:K05636]
117557655  igf1ra; LOW QUALITY PROTEIN: insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
117557675  tln2b; talin-2 isoform X1 [KO:K06271]
117557700  vwf; von Willebrand factor [KO:K03900]
117557725  rasgrf1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
117558203  [KO:K06245]
117558349  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
117558363  tnr; tenascin-R isoform X1 [KO:K06252]
117558402  tnn; tenascin-N isoform X1 [KO:K06252]
117558410  mylk4a; LOW QUALITY PROTEIN: myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
117558413  [KO:K06240]
117558492  rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
117558498  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
117558744  [KO:K06240]
117559178  [KO:K10151]
117559500  [KO:K04393]
117559967  col9a2; collagen alpha-2(IX) chain [KO:K08131]
117560203  rapgef1b; rap guanine nucleotide exchange factor 1b isoform X1 [KO:K06277]
117560275  myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
117560397  [KO:K04456] [EC:2.7.11.1]
117560513  mylk4b; LOW QUALITY PROTEIN: myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
117560597  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
117560688  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
117560747  akt3a; LOW QUALITY PROTEIN: RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117560847  ptena; phosphatase and tensin homolog A isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
117561281  itga2.2; integrin alpha-2 [KO:K06481]
117561436  zmp:0000000846; tenascin isoform X1 [KO:K06252]
117561441  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
117561488  lamc3; laminin subunit gamma-3 [KO:K06247]
117561861  pxna; paxillin a isoform X1 [KO:K05760]
117561898  myl2a; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
117561994  prkcaa; protein kinase C, alpha, a [KO:K02677] [EC:2.7.11.13]
117562420  [KO:K06237]
117562514  ppp1r12c; LOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 12C [KO:K17457]
117562857  itgb8; LOW QUALITY PROTEIN: integrin beta-8 [KO:K06591]
117562871  col1a2; collagen alpha-2(I) chain [KO:K06236]
117562919  [KO:K02105]
117563188  [KO:K04364]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
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Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
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Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
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Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
gacu04010  MAPK signaling pathway
gacu04060  Cytokine-cytokine receptor interaction
gacu04070  Phosphatidylinositol signaling system
gacu04110  Cell cycle
gacu04310  Wnt signaling pathway
gacu04512  ECM-receptor interaction
gacu04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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