KEGG   PATHWAY: gaf00350
Entry
gaf00350                    Pathway                                
Name
Tyrosine metabolism - Gambusia affinis (western mosquitofish)
Class
Metabolism; Amino acid metabolism
Pathway map
gaf00350  Tyrosine metabolism
gaf00350

Module
gaf_M00042  Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline [PATH:gaf00350]
gaf_M00043  Thyroid hormone biosynthesis, tyrosine => triiodothyronine/thyroxine [PATH:gaf00350]
gaf_M00044  Tyrosine degradation, tyrosine => homogentisate [PATH:gaf00350]
Other DBs
GO: 0006570
Organism
Gambusia affinis (western mosquitofish) [GN:gaf]
Gene
122830292  aspartate aminotransferase, cytoplasmic-like [KO:K14454] [EC:2.6.1.1]
122842394  got1; aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
122843286  got2b; glutamic-oxaloacetic transaminase 2b, mitochondrial [KO:K14455] [EC:2.6.1.1]
122833314  il4i1; L-amino-acid oxidase isoform X1 [KO:K03334] [EC:1.4.3.2]
122820715  L-amino-acid oxidase-like [KO:K03334] [EC:1.4.3.2]
122820716  L-amino-acid oxidase-like [KO:K03334] [EC:1.4.3.2]
122820989  L-amino-acid oxidase-like [KO:K03334] [EC:1.4.3.2]
122820990  L-amino-acid oxidase-like [KO:K03334] [EC:1.4.3.2]
122845229  hpda; 4-hydroxyphenylpyruvate dioxygenase [KO:K00457] [EC:1.13.11.27]
122827890  hpdb; 4-hydroxyphenylpyruvate dioxygenase [KO:K00457] [EC:1.13.11.27]
122823902  hgd; homogentisate 1,2-dioxygenase [KO:K00451] [EC:1.13.11.5]
122846385  gstz1; maleylacetoacetate isomerase isoform X1 [KO:K01800] [EC:5.2.1.2]
122842224  fah; fumarylacetoacetase isoform X1 [KO:K01555] [EC:3.7.1.2]
122844839  tyrosinase-like [KO:K00505] [EC:1.14.18.1]
122833005  tyr; tyrosinase [KO:K00505] [EC:1.14.18.1]
122826240  th2; tyrosine hydroxylase 2 [KO:K00501] [EC:1.14.16.2]
122834999  th; tyrosine 3-monooxygenase [KO:K00501] [EC:1.14.16.2]
122840051  dct; L-dopachrome tautomerase [KO:K01827] [EC:5.3.3.12]
122830117  tyrp1b; tyrosinase-related protein 1b [KO:K00506] [EC:1.14.18.-]
122820169  5,6-dihydroxyindole-2-carboxylic acid oxidase-like [KO:K00506] [EC:1.14.18.-]
122831291  ddc; aromatic-L-amino-acid decarboxylase [KO:K01593] [EC:4.1.1.28 4.1.1.105]
122847123  dbh; dopamine beta-hydroxylase [KO:K00503] [EC:1.14.17.1]
122822990  phenylethanolamine N-methyltransferase [KO:K00553] [EC:2.1.1.28]
122833324  tomt; transmembrane O-methyltransferase homolog [KO:K00545] [EC:2.1.1.6]
122833751  comtb; catechol O-methyltransferase B isoform X1 [KO:K00545] [EC:2.1.1.6]
122847269  si:ch211-127i16.2; probable flavin-containing monoamine oxidase A isoform X1 [KO:K00274] [EC:1.4.3.4]
122840321  mao; amine oxidase [flavin-containing] [KO:K00274] [EC:1.4.3.4]
122821259  aoc2; retina-specific copper amine oxidase [KO:K00276] [EC:1.4.3.21]
122821295  aldh3b1; aldehyde dehydrogenase family 3 member B1 [KO:K00129] [EC:1.2.1.5]
122828176  aldh3b2; aldehyde dehydrogenase family 3 member B1 [KO:K00129] [EC:1.2.1.5]
122846667  alcohol dehydrogenase 1-like [KO:K00121] [EC:1.1.1.284 1.1.1.1]
122846668  alcohol dehydrogenase 1-like [KO:K00121] [EC:1.1.1.284 1.1.1.1]
122846671  alcohol dehydrogenase 1-like [KO:K00121] [EC:1.1.1.284 1.1.1.1]
122836534  alcohol dehydrogenase class-3-like [KO:K00121] [EC:1.1.1.284 1.1.1.1]
122836535  alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
122845674  tpo; thyroid peroxidase isoform X1 [KO:K00431] [EC:1.11.1.8]
122835368  epx; eosinophil peroxidase [KO:K00431] [EC:1.11.1.8]
122827269  aox6; aldehyde oxidase 6 isoform X1 [KO:K00157] [EC:1.2.3.1]
122822496  fahd1; acylpyruvase FAHD1, mitochondrial [KO:K01557] [EC:3.7.1.5]
122836659  mif; macrophage migration inhibitory factor [KO:K07253] [EC:5.3.2.1]
Compound
C00022  Pyruvate
C00042  Succinate
C00082  L-Tyrosine
C00122  Fumarate
C00146  Phenol
C00164  Acetoacetate
C00232  Succinate semialdehyde
C00355  3,4-Dihydroxy-L-phenylalanine
C00483  Tyramine
C00530  Hydroquinone
C00544  Homogentisate
C00547  L-Noradrenaline
C00628  2,5-Dihydroxybenzoate
C00642  4-Hydroxyphenylacetate
C00788  L-Adrenaline
C00811  4-Coumarate
C00822  Dopaquinone
C01036  4-Maleylacetoacetate
C01060  3,5-Diiodo-L-tyrosine
C01061  4-Fumarylacetoacetate
C01161  3,4-Dihydroxyphenylacetate
C01179  3-(4-Hydroxyphenyl)pyruvate
C01384  Maleic acid
C01693  L-Dopachrome
C01829  Thyroxine
C01850  Rosmarinate
C02167  Maleylpyruvate
C02442  N-Methyltyramine
C02465  Triiodothyronine
C02514  3-Fumarylpyruvate
C02515  3-Iodo-L-tyrosine
C03063  2-Oxohept-3-enedioate
C03077  4-Chlorophenylacetate
C03758  Dopamine
C03765  4-Hydroxyphenylacetaldehyde
C03964  (R)-3-(4-Hydroxyphenyl)lactate
C04043  3,4-Dihydroxyphenylacetaldehyde
C04045  3-(3,4-Dihydroxyphenyl)pyruvate
C04052  5-Carboxy-2-oxohept-3-enedioate
C04185  5,6-Dihydroxyindole-2-carboxylate
C04186  5-Carboxymethyl-2-hydroxymuconate
C04368  3-Amino-3-(4-hydroxyphenyl)propanoate
C04642  2-Hydroxy-5-carboxymethylmuconate semialdehyde
C04796  4-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
C04797  5-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
C05338  4-Hydroxyphenylacetyl-CoA
C05350  2-Hydroxy-3-(4-hydroxyphenyl)propenoate
C05576  3,4-Dihydroxyphenylethyleneglycol
C05577  3,4-Dihydroxymandelaldehyde
C05578  5,6-Dihydroxyindole
C05579  Indole-5,6-quinone
C05580  3,4-Dihydroxymandelate
C05581  3-Methoxy-4-hydroxyphenylacetaldehyde
C05582  Homovanillate
C05583  3-Methoxy-4-hydroxyphenylglycolaldehyde
C05584  3-Methoxy-4-hydroxymandelate
C05585  Gentisate aldehyde
C05587  3-Methoxytyramine
C05588  L-Metanephrine
C05589  L-Normetanephrine
C05593  3-Hydroxyphenylacetate
C05594  3-Methoxy-4-hydroxyphenylethyleneglycol
C05595  4-Hydroxyphenylacetylglutamic acid
C05596  p-Hydroxyphenylacetylglycine
C05600  2-Hydroxyhepta-2,4-dienedioate
C05604  2-Carboxy-2,3-dihydro-5,6-dihydroxyindole
C06044  4-Hydroxyphenylethanol
C06046  Salidroside
C06047  Stizolobate
C06048  Stizolobinate
C06199  Hordenine
C06201  2,4-Dihydroxyhept-2-enedioate
C10447  3,4-Dihydroxyphenylpropanoate
C17935  Cysteinyldopa
C17936  Phaeomelanin
C17937  Eumelanin
C17938  5,6-Indolequinone-2-carboxylic acid
C22038  (R)-3-(3,4-Dihydroxyphenyl)lactate
Reference
PMID:8550403
  Authors
Prieto MA, Diaz E, Garcia JL.
  Title
Molecular characterization of the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli W: engineering a mobile aromatic degradative cluster.
  Journal
J Bacteriol 178:111-20 (1996)
DOI:10.1128/JB.178.1.111-120.1996
Reference
PMID:1194238
  Authors
Sparnins VL, Dagley S.
  Title
Alternative routes of aromatic catabolism in Pseudomonas acidovorans and Pseudomonas putida: gallic acid as a substrate and inhibitor of dioxygenases.
  Journal
J Bacteriol 124:1374-81 (1975)
DOI:10.1128/JB.124.3.1374-1381.1975
Reference
PMID:18435614
  Authors
Ito S, Wakamatsu K
  Title
Chemistry of mixed melanogenesis--pivotal roles of dopaquinone.
  Journal
Photochem Photobiol 84:582-92 (2008)
DOI:10.1111/j.1751-1097.2007.00238.x
Reference
PMID:11171088
  Authors
Olivares C, Jimenez-Cervantes C, Lozano JA, Solano F, Garcia-Borron JC
  Title
The 5,6-dihydroxyindole-2-carboxylic acid (DHICA) oxidase activity of human tyrosinase.
  Journal
Biochem J 354:131-9 (2001)
DOI:10.1042/bj3540131
Related
pathway
gaf00020  Citrate cycle (TCA cycle)
gaf00360  Phenylalanine metabolism
gaf00400  Phenylalanine, tyrosine and tryptophan biosynthesis
gaf00620  Pyruvate metabolism
gaf00650  Butanoate metabolism
KO pathway
ko00350   
LinkDB

DBGET integrated database retrieval system