KEGG   PATHWAY: gvr03040
Entry
gvr03040                    Pathway                                
Name
Spliceosome - Galeopterus variegatus (Sunda flying lemur)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
gvr03040  Spliceosome
gvr03040

Other DBs
GO: 0005681
Organism
Galeopterus variegatus (Sunda flying lemur) [GN:gvr]
Gene
103591159  DDX46; probable ATP-dependent RNA helicase DDX46 isoform X1 [KO:K12811] [EC:5.6.2.7]
103606062  DDX39B; spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
103592546  DHX16; putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 [KO:K12813] [EC:5.6.2.6]
103603462  DHX38; pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 isoform X1 [KO:K12815] [EC:5.6.2.6]
103589522  CDC40; pre-mRNA-processing factor 17 [KO:K12816]
103582437  PRPF18; LOW QUALITY PROTEIN: pre-mRNA-splicing factor 18 [KO:K12817]
103604404  DHX8; ATP-dependent RNA helicase DHX8 [KO:K12818] [EC:5.6.2.6]
103602649  SLU7; pre-mRNA-splicing factor SLU7 isoform X1 [KO:K12819]
103598229  DHX15; putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 [KO:K12820] [EC:5.6.2.6]
103610529  SNRPB; small nuclear ribonucleoprotein-associated proteins B and B' isoform X1 [KO:K11086]
103595028  LOW QUALITY PROTEIN: small nuclear ribonucleoprotein Sm D1-like [KO:K11087]
103603927  SNRPD1; small nuclear ribonucleoprotein Sm D1 [KO:K11087]
103595246  SNRPD2; small nuclear ribonucleoprotein Sm D2 [KO:K11096]
103609772  SNRPD3; small nuclear ribonucleoprotein Sm D3 [KO:K11088]
103607790  SNRPE; small nuclear ribonucleoprotein E [KO:K11097]
103593289  small nuclear ribonucleoprotein F-like [KO:K11098]
103593751  SNRPF; small nuclear ribonucleoprotein F [KO:K11098]
103593229  SNRPG; small nuclear ribonucleoprotein G [KO:K11099]
103587767  SNRNP70; U1 small nuclear ribonucleoprotein 70 kDa isoform X1 [KO:K11093]
103603549  SNRPA; U1 small nuclear ribonucleoprotein A [KO:K11091]
103610479  LOW QUALITY PROTEIN: U1 small nuclear ribonucleoprotein C-like [KO:K11095]
103598713  PRPF40B; pre-mRNA-processing factor 40 homolog B isoform X1 [KO:K12821]
103593263  PRPF40A; pre-mRNA-processing factor 40 homolog A isoform X1 [KO:K12821]
103599713  RBM25; RNA-binding protein 25 [KO:K12822]
103593819  DDX5; probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
103587572  TCERG1; transcription elongation regulator 1 isoform X1 [KO:K12824]
103610076  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
103589157  SNRPA1; U2 small nuclear ribonucleoprotein A' [KO:K11092]
103591996  SNRPB2; U2 small nuclear ribonucleoprotein B'' [KO:K11094]
103589400  SF3A1; splicing factor 3A subunit 1 [KO:K12825]
103601163  SF3A2; splicing factor 3A subunit 2 [KO:K12826]
103587874  SF3A3; splicing factor 3A subunit 3 [KO:K12827]
103587113  SF3B1; splicing factor 3B subunit 1 isoform X1 [KO:K12828]
103608191  SF3B2; splicing factor 3B subunit 2 [KO:K12829]
103598315  SF3B3; splicing factor 3B subunit 3 [KO:K12830]
103601195  SF3B4; splicing factor 3B subunit 4 [KO:K12831]
103600556  SF3B5; splicing factor 3B subunit 5 [KO:K12832]
103604536  SF3B6; splicing factor 3B subunit 6 [KO:K12833]
103591644  PHF5A; PHD finger-like domain-containing protein 5A [KO:K12834]
103595640  DDX42; ATP-dependent RNA helicase DDX42 isoform X1 [KO:K12835] [EC:5.6.2.7]
103581265  splicing factor U2AF 35 kDa subunit [KO:K12836]
103592825  U2AF1L4; splicing factor U2AF 26 kDa subunit isoform X1 [KO:K12836]
103598233  U2AF2; splicing factor U2AF 65 kDa subunit isoform X1 [KO:K12837]
103589640  PUF60; poly(U)-binding-splicing factor PUF60 isoform X1 [KO:K12838]
103588289  SMNDC1; survival of motor neuron-related-splicing factor 30 isoform X1 [KO:K12839]
103606506  RBM17; splicing factor 45 [KO:K12840]
103598938  CHERP; calcium homeostasis endoplasmic reticulum protein isoform X1 [KO:K12841]
103602528  U2SURP; U2 snRNP-associated SURP motif-containing protein isoform X1 [KO:K12842]
103582555  LOW QUALITY PROTEIN: retinitis pigmentosa 9 protein-like [KO:K19604]
103592386  LSM2; U6 snRNA-associated Sm-like protein LSm2 [KO:K12621]
103604629  LSM3; U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
103608690  LSM4; U6 snRNA-associated Sm-like protein LSm4 isoform X1 [KO:K12623]
103590244  LSM5; U6 snRNA-associated Sm-like protein LSm5 isoform X1 [KO:K12624]
103604676  LSM6; U6 snRNA-associated Sm-like protein LSm6 isoform X1 [KO:K12625]
103586886  LSM8; LSM8 homolog, U6 small nuclear RNA associated [KO:K12627]
103600430  PRPF3; U4/U6 small nuclear ribonucleoprotein Prp3 [KO:K12843]
103587276  PRPF4; U4/U6 small nuclear ribonucleoprotein Prp4 [KO:K12662]
103590830  PPIH; peptidyl-prolyl cis-trans isomerase H [KO:K09567] [EC:5.2.1.8]
103606872  PRPF31; U4/U6 small nuclear ribonucleoprotein Prp31 [KO:K12844]
103584091  NHP2L1; NHP2-like protein 1 [KO:K12845]
103593221  SNRNP27; U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [KO:K12846]
103594520  USP39; U4/U6.U5 tri-snRNP-associated protein 2 [KO:K12847]
103605624  SART1; U4/U6.U5 tri-snRNP-associated protein 1 [KO:K11984]
103601360  ZMAT2; zinc finger matrin-type protein 2 [KO:K12848]
103594887  PRPF38A; pre-mRNA-splicing factor 38A [KO:K12849]
103585330  PRPF38B; pre-mRNA-splicing factor 38B [KO:K12850]
103595006  EFTUD2; 116 kDa U5 small nuclear ribonucleoprotein component [KO:K12852]
103586607  SNRNP200; U5 small nuclear ribonucleoprotein 200 kDa helicase [KO:K12854] [EC:5.6.2.6]
103593792  PRPF6; pre-mRNA-processing factor 6 isoform X1 [KO:K12855]
103584891  PRPF8; pre-mRNA-processing-splicing factor 8 [KO:K12856]
103597089  SNRNP40; U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857]
103588861  DDX23; probable ATP-dependent RNA helicase DDX23 [KO:K12858] [EC:5.6.2.7]
103599486  TXNL4A; thioredoxin-like protein 4A [KO:K12859]
103601223  PRPF19; pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
103590421  CDC5L; cell division cycle 5-like protein [KO:K12860]
103589333  BCAS2; pre-mRNA-splicing factor SPF27 [KO:K12861]
103592059  PLRG1; pleiotropic regulator 1 isoform X1 [KO:K12862]
103592757  CWC15; spliceosome-associated protein CWC15 homolog [KO:K12863]
103592710  CTNNBL1; beta-catenin-like protein 1 [KO:K12864]
103582623  LOW QUALITY PROTEIN: heat shock 70 kDa protein 6-like [KO:K03283]
103592355  HSPA1A; heat shock 70 kDa protein 1A/1B isoform X1 [KO:K03283]
103592356  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
103587696  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
103589444  PQBP1; polyglutamine-binding protein 1 isoform X1 [KO:K12865]
103598379  WBP11; WW domain-binding protein 11 isoform X1 [KO:K12866]
103589475  SNW domain-containing protein 1-like [KO:K06063]
103589478  LOW QUALITY PROTEIN: SNW domain-containing protein 1-like [KO:K06063]
103605611  SNW1; SNW domain-containing protein 1 [KO:K06063]
103596857  XAB2; pre-mRNA-splicing factor SYF1 isoform X1 [KO:K12867]
103608482  SYF2; pre-mRNA-splicing factor SYF2 [KO:K12868]
103603684  CRNKL1; LOW QUALITY PROTEIN: crooked neck-like protein 1 [KO:K12869]
103599464  crooked neck-like protein 1 [KO:K12869]
103584093  pre-mRNA-splicing factor ISY1 homolog [KO:K12870]
103604585  peptidyl-prolyl cis-trans isomerase-like 1 [KO:K12733] [EC:5.2.1.8]
103610017  PPIE; peptidyl-prolyl cis-trans isomerase E isoform X1 [KO:K09564] [EC:5.2.1.8]
103591232  CCDC12; coiled-coil domain-containing protein 12 isoform X1 [KO:K12871]
103602777  RBM22; pre-mRNA-splicing factor RBM22 [KO:K12872]
103602066  BUD31; protein BUD31 homolog [KO:K12873]
103589393  AQR; intron-binding protein aquarius [KO:K12874]
103585567  ACIN1; LOW QUALITY PROTEIN: apoptotic chromatin condensation inducer in the nucleus [KO:K12875]
103595228  EIF4A3; eukaryotic initiation factor 4A-III isoform X1 [KO:K13025] [EC:5.6.2.7]
103595865  RBM8A; RNA-binding protein 8A isoform X1 [KO:K12876]
103602732  MAGOH; protein mago nashi homolog [KO:K12877]
103603396  protein mago nashi homolog 2 isoform X1 [KO:K12877]
103592849  THOC1; THO complex subunit 1 [KO:K12878]
103602048  THOC2; THO complex subunit 2 isoform X1 [KO:K12879]
103593473  THOC3; THO complex subunit 3 [KO:K12880]
103593346  ALYREF; THO complex subunit 4 [KO:K12881]
103608446  NCBP2; nuclear cap-binding protein subunit 2 [KO:K12883]
103604000  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
103583940  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
103584695  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A3-like [KO:K12741]
103604411  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
103591062  HNRNPA3; heterogeneous nuclear ribonucleoprotein A3 isoform X1 [KO:K12741]
103606742  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
103593247  HNRNPA1; heterogeneous nuclear ribonucleoprotein A1 isoform X1 [KO:K12741]
103599759  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
103603442  heterogeneous nuclear ribonucleoprotein C [KO:K12884]
103591594  HNRNPC; heterogeneous nuclear ribonucleoproteins C1/C2 [KO:K12884]
103601066  RBMX; RNA-binding motif protein, X chromosome [KO:K12885]
103587550  HNRNPK; heterogeneous nuclear ribonucleoprotein K [KO:K12886]
103599765  HNRNPM; heterogeneous nuclear ribonucleoprotein M isoform X1 [KO:K12887]
103605516  HNRNPU; heterogeneous nuclear ribonucleoprotein U isoform X1 [KO:K12888]
103583217  poly(rC)-binding protein 1-like isoform X1 [KO:K12889]
103606271  poly(rC)-binding protein 1-like [KO:K12889]
103593226  PCBP1; poly(rC)-binding protein 1 [KO:K12889]
103600889  LOW QUALITY PROTEIN: poly(rC)-binding protein 1-like [KO:K12889]
103604343  SRSF1; serine/arginine-rich splicing factor 1 [KO:K12890]
103584271  serine/arginine-rich splicing factor 2-like [KO:K12891]
103605220  SRSF2; serine/arginine-rich splicing factor 2 [KO:K12891]
103607324  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
103601016  SRSF5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893]
103607382  SRSF6; serine/arginine-rich splicing factor 6 [KO:K12893]
103587223  SRSF4; serine/arginine-rich splicing factor 4 [KO:K12893]
103592531  SRSF7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
103587797  SRSF9; serine/arginine-rich splicing factor 9 [KO:K21123]
103594637  TRA2B; transformer-2 protein homolog beta isoform X1 [KO:K12897]
103585538  transformer-2 protein homolog alpha isoform X1 [KO:K12897]
103590796  SRSF10; serine/arginine-rich splicing factor 10 isoform X1 [KO:K12900]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

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