KEGG   PATHWAY: hadh00270
Entry
hadh00270                   Pathway                                
Name
Cysteine and methionine metabolism - Hypericibacter adhaerens
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
Pathway map
hadh00270  Cysteine and methionine metabolism
hadh00270

Module
hadh_M00017  Methionine biosynthesis, aspartate => homoserine => methionine [PATH:hadh00270]
hadh_M00021  Cysteine biosynthesis, serine => cysteine [PATH:hadh00270]
hadh_M00035  Methionine degradation [PATH:hadh00270]
hadh_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:hadh00270]
Other DBs
GO: 0006534 0006555
Organism
Hypericibacter adhaerens [GN:hadh]
Gene
FRZ61_34830  hypothetical protein [KO:K00640] [EC:2.3.1.30]
FRZ61_14560  serine acetyltransferase [KO:K00640] [EC:2.3.1.30]
FRZ61_23820  cysK2; cysteine synthase A [KO:K01738] [EC:2.5.1.47]
FRZ61_31410  cysK; cysteine synthase A [KO:K01738] [EC:2.5.1.47]
FRZ61_52700  cysteine synthase A [KO:K01738] [EC:2.5.1.47]
FRZ61_17370  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
FRZ61_23930  cystathionine beta-lyase [KO:K01760] [EC:4.4.1.13]
FRZ61_17380  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
FRZ61_46420  methyltetrahydrofolate--corrinoid methyltransferase [KO:K00548] [EC:2.1.1.13]
FRZ61_15900  methionine synthase [KO:K00548] [EC:2.1.1.13]
FRZ61_52480  metK2; S-adenosylmethionine synthase 2 [KO:K00789] [EC:2.5.1.6]
FRZ61_33560  phosphorylase [KO:K01243] [EC:3.2.2.9]
FRZ61_15610  mtnN; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase [KO:K01243] [EC:3.2.2.9]
FRZ61_09510  laccase domain protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
FRZ61_46520  mtaD; 5-methylthioadenosine/S-adenosylhomocysteine deaminase [KO:K12960] [EC:3.5.4.31 3.5.4.28]
FRZ61_20550  methionine gamma-lyase [KO:K01761] [EC:4.4.1.11]
FRZ61_43760  histidine kinase [KO:K08968] [EC:1.8.4.14]
FRZ61_01350  cytosine-specific methyltransferase [KO:K00558] [EC:2.1.1.37]
FRZ61_01700  ahcY; adenosylhomocysteinase [KO:K01251] [EC:3.13.2.1]
FRZ61_42270  aspartokinase [KO:K00928] [EC:2.7.2.4]
FRZ61_47270  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
FRZ61_25560  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
FRZ61_42910  metA; homoserine O-succinyltransferase [KO:K00651] [EC:2.3.1.46 2.3.1.31]
FRZ61_16900  metA; homoserine O-succinyltransferase [KO:K00651] [EC:2.3.1.46 2.3.1.31]
FRZ61_39300  homoserine O-acetyltransferase [KO:K00641] [EC:2.3.1.31 2.3.1.46]
FRZ61_44550  metX; homoserine O-acetyltransferase [KO:K00641] [EC:2.3.1.31 2.3.1.46]
FRZ61_30160  cystathionine gamma-synthase [KO:K01739] [EC:2.5.1.48]
FRZ61_26660  O-acetylhomoserine aminocarboxypropyltransferase [KO:K01740] [EC:2.5.1.49]
FRZ61_39730  cysD; O-acetylhomoserine aminocarboxypropyltransferase [KO:K01740] [EC:2.5.1.49]
FRZ61_42920  O-acetylhomoserine aminocarboxypropyltransferase [KO:K01740] [EC:2.5.1.49]
FRZ61_17800  O-acetylhomoserine aminocarboxypropyltransferase [KO:K01740] [EC:2.5.1.49]
FRZ61_44170  metZ; O-succinylhomoserine sulfhydrylase [KO:K10764] [EC:2.5.1.-]
FRZ61_28230  aminotransferase [KO:K00826] [EC:2.6.1.42]
FRZ61_40370  branched chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]
FRZ61_42890  branched chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]
FRZ61_09650  branched-chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]
FRZ61_07670  gsh1; glutamate--cysteine ligase [KO:K01919] [EC:6.3.2.2]
FRZ61_49860  gshB; glutathione synthetase [KO:K01920] [EC:6.3.2.3]
FRZ61_48780  aminotransferase [KO:K00812] [EC:2.6.1.1]
FRZ61_10050  aatA; aspartate aminotransferase [KO:K00812] [EC:2.6.1.1]
FRZ61_23850  sulfurtransferase [KO:K01011] [EC:2.8.1.1 2.8.1.2]
FRZ61_47940  dcyD; D-cysteine desulfhydrase [KO:K05396] [EC:4.4.1.15]
FRZ61_43700  mdh; malate dehydrogenase [KO:K00024] [EC:1.1.1.37]
FRZ61_47080  mdh; malate dehydrogenase [KO:K00024] [EC:1.1.1.37]
FRZ61_29530  D-isomer specific 2-hydroxyacid dehydrogenase family protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
FRZ61_50200  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
FRZ61_50210  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03431  S-Inosyl-L-homocysteine
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05324  Nicotianamine
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11437  1-Deoxy-D-xylulose 5-phosphate
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
C22359  S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
PMID:15102328
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
PMID:14551435
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
PMID:12022921
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
PMID:12670965
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
PMID:17169919
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
PMID:17030798
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
PMID:18625006
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
PMID:18391471
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
PMID:10613873
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
PMID:12644499
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
PMID:18520135
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:19270684
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
hadh00010  Glycolysis / Gluconeogenesis
hadh00250  Alanine, aspartate and glutamate metabolism
hadh00260  Glycine, serine and threonine metabolism
hadh00290  Valine, leucine and isoleucine biosynthesis
hadh00430  Taurine and hypotaurine metabolism
hadh00480  Glutathione metabolism
hadh00620  Pyruvate metabolism
hadh00640  Propanoate metabolism
hadh00770  Pantothenate and CoA biosynthesis
hadh00900  Terpenoid backbone biosynthesis
hadh00920  Sulfur metabolism
KO pathway
ko00270   
LinkDB

DBGET integrated database retrieval system