KEGG   PATHWAY: hhal04140
Entry
hhal04140                   Pathway                                
Name
Autophagy - animal - Halyomorpha halys (brown marmorated stink bug)
Description
Autophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily conserved among eukaryotes and exquisitely regulated. This progress initiates with production of the autophagosome, a double-membrane intracellular structure of reticular origin that engulfs cytoplasmic contents and ultimately fuses with lysosomes for cargo degradation. Autophagy is regulated in response to extra- or intracellular stress and signals such as starvation, growth factor deprivation and ER stress. Constitutive level of autophagy plays an important role in cellular homeostasis and maintains quality control of essential cellular components.
Class
Cellular Processes; Transport and catabolism
Pathway map
hhal04140  Autophagy - animal
hhal04140

Other DBs
GO: 0006914
Organism
Halyomorpha halys (brown marmorated stink bug) [GN:hhal]
Gene
106683319  LIRP isoform X1 [KO:K04526]
106681977  insulin receptor substrate 1 isoform X2 [KO:K16172]
106689392  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
106692677  phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
106690061  3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
106686263  RAC serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
106685077  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
106677601  GTPase HRas [KO:K07827]
106692565  ras-related protein M-Ras-like isoform X1 [KO:K07831]
106678481  ras-like protein 2 [KO:K07830]
106686382  dual specificity mitogen-activated protein kinase kinase dSOR1 [KO:K04368] [EC:2.7.12.2]
106681503  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
106683313  hypoxia-inducible factor 1-alpha [KO:K08268]
106692653  tuberin isoform X1 [KO:K07207]
106680840  hamartin isoform X1 [KO:K07206]
106679326  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform X3 [KO:K15464]
106682155  GTP-binding protein Rheb homolog [KO:K07208]
106680843  regulatory-associated protein of mTOR isoform X1 [KO:K07204]
106678881  serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
106682702  target of rapamycin complex subunit lst8 [KO:K08266]
106691622  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
106687993  immunoglobulin-binding protein 1b [KO:K17606]
106687861  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
106677115  serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
106682084  autophagy-related protein 13 isoform X1 [KO:K08331]
106682677  RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
106684884  autophagy-related protein 2 homolog B [KO:K17906]
106681546  WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
106681879  WD repeat domain phosphoinositide-interacting protein 3 [KO:K22991]
106683098  WD repeat domain phosphoinositide-interacting protein 4-like isoform X1 [KO:K22991]
106685278  autophagy-related protein 9A isoform X1 [KO:K17907]
106688743  transcription factor SPT20 homolog isoform X1 [KO:K21245]
106686463  ras-related protein Rab-8A isoform X1 [KO:K07901]
106680253  ras-related protein Rab-39B [KO:K07925]
106679724  mucin-2-like isoform X1 [KO:K14381]
106682065  uncharacterized protein LOC106682065 isoform X1 [KO:K14381]
106688729  serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
106685324  ras-related protein Rab-1A [KO:K07874]
106685701  ras-related protein Rab-1B-like [KO:K07874]
106678336  ras-related GTP-binding protein A [KO:K16185]
106686983  ras-related GTP-binding protein C [KO:K16186]
106677060  serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
106679444  5'-AMP-activated protein kinase catalytic subunit alpha-2-like isoform X1 [KO:K07198] [EC:2.7.11.31]
106689748  5'-AMP-activated protein kinase catalytic subunit alpha-2-like [KO:K07198] [EC:2.7.11.31]
106678700  cAMP-dependent protein kinase catalytic subunit [KO:K04345] [EC:2.7.11.11]
106688150  cAMP-dependent protein kinase catalytic subunit [KO:K04345] [EC:2.7.11.11]
106682178  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
106683818  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
112209999  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
106687088  cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
106687089  cAMP-dependent protein kinase catalytic subunit-like [KO:K04345] [EC:2.7.11.11]
106692631  serine/threonine-protein kinase STE20 [KO:K06068] [EC:2.7.11.13]
106685067  stress-activated protein kinase JNK [KO:K04440] [EC:2.7.11.24]
106685068  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
106679143  beclin-1-like protein isoform X1 [KO:K08334]
106680198  beclin-1-like protein [KO:K08334]
106680210  beclin-1-like protein [KO:K08334]
106680220  beclin-1-like protein [KO:K08334]
106680226  beclin-1-like protein isoform X1 [KO:K08334]
106677358  beclin-1-like protein isoform X1 [KO:K08334]
106688949  nuclear receptor-binding factor 2 [KO:K21246]
106679374  phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
106683533  phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
106677020  phosphatidylinositol 3-kinase catalytic subunit type 3-like [KO:K00914] [EC:2.7.1.137]
106692331  beclin 1-associated autophagy-related key regulator [KO:K17889]
106691791  uncharacterized protein LOC106691791 isoform X1 [KO:K17985]
106683518  TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
106680891  tumor protein p53-inducible nuclear protein 2 isoform X1 [KO:K21247]
106687545  UV radiation resistance associated protein [KO:K21249]
106687544  endophilin-B1 isoform X1 [KO:K11248]
106683220  run domain Beclin-1-interacting and cysteine-rich domain-containing protein isoform X1 [KO:K19330]
106679439  calcium/calmodulin-dependent protein kinase kinase 2 isoform X1 [KO:K07359] [EC:2.7.11.17]
106679784  mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
106680133  serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
106689508  inositol 1,4,5-trisphosphate receptor [KO:K04958]
106684306  death-associated protein kinase 1 isoform X1 [KO:K08803] [EC:2.7.11.1]
106683408  eIF-2-alpha kinase GCN2 [KO:K16196] [EC:2.7.11.1]
106681723  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
106685372  myotubularin-related protein 14 [KO:K18086] [EC:3.1.3.64 3.1.3.95]
106682986  zinc finger FYVE domain-containing protein 1-like [KO:K17603]
106690529  autophagy protein 12-like isoform X1 [KO:K08336]
106692107  autophagy protein 5 [KO:K08339]
106678717  autophagy-related protein 16-1 [KO:K17890]
112210050  autophagy-related protein 16-1-like [KO:K17890]
106678091  ubiquitin-like modifier-activating enzyme ATG7 [KO:K08337]
106683222  ubiquitin-like-conjugating enzyme ATG3 isoform X1 [KO:K08343]
106692489  gamma-aminobutyric acid receptor-associated protein [KO:K08341]
106683692  cysteine protease ATG4B-like [KO:K08342] [EC:3.4.22.-]
106688609  uncharacterized protein LOC106688609 isoform X1 [KO:K21348]
106679159  WD repeat and FYVE domain-containing protein 3 isoform X1 [KO:K22262]
106690258  ubiquitin-60S ribosomal protein L40 [KO:K02927]
106682530  ubiquitin-40S ribosomal protein S27a [KO:K02977]
106689152  polyubiquitin-C [KO:K08770]
106688418  synaptosomal-associated protein 29 [KO:K08509]
106679746  synaptobrevin homolog YKT6 [KO:K08516]
106677971  ectopic P granules protein 5 homolog isoform X1 [KO:K23883]
106687385  vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
106680907  vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
106684601  vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
106689232  vacuolar protein sorting-associated protein 33A isoform X1 [KO:K20182]
106681914  vam6/Vps39-like protein [KO:K20183]
106685691  vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
106683664  Golgi reassembly-stacking protein 2 [KO:K26797]
106687218  ras-related protein rab7 [KO:K07897]
106683689  lysosome-associated membrane glycoprotein 2-like [KO:K06528]
106679806  aspartic proteinase A3-like [KO:K01379] [EC:3.4.23.5]
106679810  aspartic proteinase-like isoform X1 [KO:K01379] [EC:3.4.23.5]
106689815  aspartic proteinase oryzasin-1-like isoform X1 [KO:K01379] [EC:3.4.23.5]
106690232  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
106681111  pepsin-2B-like isoform X1 [KO:K01379] [EC:3.4.23.5]
106690635  cathepsin D [KO:K01379] [EC:3.4.23.5]
106682325  cathepsin D-like [KO:K01379] [EC:3.4.23.5]
106682496  aspartic proteinase A3 isoform X1 [KO:K01379] [EC:3.4.23.5]
112210518  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
106677813  procardosin-A [KO:K01379] [EC:3.4.23.5]
106677349  lysosomal aspartic protease [KO:K01379] [EC:3.4.23.5]
106684832  lysosomal aspartic protease [KO:K01379] [EC:3.4.23.5]
106677347  uncharacterized protein LOC106677347 [KO:K01379] [EC:3.4.23.5]
106678424  cathepsin L1 [KO:K01365] [EC:3.4.22.15]
106679110  cathepsin L1-like isoform X1 [KO:K01365] [EC:3.4.22.15]
106679112  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
106679113  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
106689926  cathepsin L1 [KO:K01365] [EC:3.4.22.15]
106690107  cathepsin L1-like isoform X1 [KO:K01365] [EC:3.4.22.15]
106690564  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
106691003  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
106691004  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
106691005  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
106691006  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
106691516  cathepsin L1 isoform X1 [KO:K01365] [EC:3.4.22.15]
106682597  cathepsin L1 [KO:K01365] [EC:3.4.22.15]
106684490  LOW QUALITY PROTEIN: cathepsin L-like [KO:K01365] [EC:3.4.22.15]
106690550  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
106684312  cathepsin L1 [KO:K01365] [EC:3.4.22.15]
106684321  cathepsin L1 [KO:K01365] [EC:3.4.22.15]
106684498  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
106684499  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
106684501  cathepsin L1-like isoform X1 [KO:K01365] [EC:3.4.22.15]
106684502  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
106684503  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
106684523  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
106684521  cathepsin L1 [KO:K01365] [EC:3.4.22.15]
106679805  cathepsin L1 isoform X1 [KO:K01365] [EC:3.4.22.15]
106691202  digestive cysteine proteinase 1-like [KO:K01365] [EC:3.4.22.15]
106687112  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
106687113  cathepsin L1-like isoform X1 [KO:K01365] [EC:3.4.22.15]
106689018  cathepsin B-like isoform X1 [KO:K01363] [EC:3.4.22.1]
106689147  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
106689154  cathepsin B [KO:K01363] [EC:3.4.22.1]
106689155  cathepsin B-like cysteine proteinase 4 [KO:K01363] [EC:3.4.22.1]
106690036  cathepsin B [KO:K01363] [EC:3.4.22.1]
106685198  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
Compound
C00035  GDP
C00044  GTP
C00350  Phosphatidylethanolamine
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15325584
  Authors
Meijer AJ, Codogno P.
  Title
Regulation and role of autophagy in mammalian cells.
  Journal
Int J Biochem Cell Biol 36:2445-62 (2004)
DOI:10.1016/j.biocel.2004.02.002
Reference
PMID:16099218
  Authors
Deretic V.
  Title
Autophagy in innate and adaptive immunity.
  Journal
Trends Immunol 26:523-8 (2005)
DOI:10.1016/j.it.2005.08.003
Reference
PMID:16200202
  Authors
Levine B, Yuan J.
  Title
Autophagy in cell death: an innocent convict?
  Journal
J Clin Invest 115:2679-88 (2005)
DOI:10.1172/JCI26390
Reference
PMID:15325588
  Authors
Tanida I, Ueno T, Kominami E.
  Title
LC3 conjugation system in mammalian autophagy.
  Journal
Int J Biochem Cell Biol 36:2503-18 (2004)
DOI:10.1016/j.biocel.2004.05.009
Reference
PMID:15928708
  Authors
Lum JJ, DeBerardinis RJ, Thompson CB.
  Title
Autophagy in metazoans: cell survival in the land of plenty.
  Journal
Nat Rev Mol Cell Biol 6:439-48 (2005)
DOI:10.1038/nrm1660
Reference
PMID:15978794
  Authors
Reggiori F, Klionsky DJ.
  Title
Autophagosomes: biogenesis from scratch?
  Journal
Curr Opin Cell Biol 17:415-22 (2005)
DOI:10.1016/j.ceb.2005.06.007
Reference
PMID:11099404
  Authors
Klionsky DJ, Emr SD.
  Title
Autophagy as a regulated pathway of cellular degradation.
  Journal
Science 290:1717-21 (2000)
DOI:10.1126/science.290.5497.1717
Reference
PMID:16125113
  Authors
Bechet D, Tassa A, Taillandier D, Combaret L, Attaix D.
  Title
Lysosomal proteolysis in skeletal muscle.
  Journal
Int J Biochem Cell Biol 37:2098-114 (2005)
DOI:10.1016/j.biocel.2005.02.029
Reference
PMID:19653858
  Authors
He C, Klionsky DJ
  Title
Regulation mechanisms and signaling pathways of autophagy.
  Journal
Annu Rev Genet 43:67-93 (2009)
DOI:10.1146/annurev-genet-102808-114910
Reference
PMID:19802558
  Authors
Yang Z, Klionsky DJ
  Title
An overview of the molecular mechanism of autophagy.
  Journal
Curr Top Microbiol Immunol 335:1-32 (2009)
DOI:10.1007/978-3-642-00302-8_1
Reference
PMID:20034776
  Authors
Yang Z, Klionsky DJ
  Title
Mammalian autophagy: core molecular machinery and signaling regulation.
  Journal
Curr Opin Cell Biol 22:124-31 (2010)
DOI:10.1016/j.ceb.2009.11.014
Reference
PMID:21187343
  Authors
Chen Y, Klionsky DJ
  Title
The regulation of autophagy - unanswered questions.
  Journal
J Cell Sci 124:161-70 (2011)
DOI:10.1242/jcs.064576
Reference
PMID:21801009
  Authors
Mizushima N, Yoshimori T, Ohsumi Y
  Title
The role of Atg proteins in autophagosome formation.
  Journal
Annu Rev Cell Dev Biol 27:107-32 (2011)
DOI:10.1146/annurev-cellbio-092910-154005
Reference
PMID:24343578
  Authors
Russell RC, Yuan HX, Guan KL
  Title
Autophagy regulation by nutrient signaling.
  Journal
Cell Res 24:42-57 (2014)
DOI:10.1038/cr.2013.166
Reference
PMID:25948417
  Authors
Noda NN, Fujioka Y
  Title
Atg1 family kinases in autophagy initiation.
  Journal
Cell Mol Life Sci 72:3083-96 (2015)
DOI:10.1007/s00018-015-1917-z
Related
pathway
hhal04141  Protein processing in endoplasmic reticulum
hhal04142  Lysosome
hhal04150  mTOR signaling pathway
KO pathway
ko04140   
LinkDB

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