KEGG ORTHOLOGY: K14381

ORTHOLOGY: K14381

Entry

K14381                      KO

Symbol

SQSTM1

Name

sequestosome 1

Pathway

map04137

Mitophagy - animal

map04140

Autophagy - animal

map04217

Necroptosis

map04218

Cellular senescence

map04380

Osteoclast differentiation

map05014

Amyotrophic lateral sclerosis

map05022

Pathways of neurodegeneration - multiple diseases

map05131

Shigellosis

map05418

Fluid shear stress and atherosclerosis

Disease

H00437

Paget disease of bone

H00594

Distal myopathy

H02342

Frontotemporal dementia and amyotrophic lateral sclerosis

H02586

Distal myopathy with rimmed vacuoles

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K14381  SQSTM1; sequestosome 1
   04137 Mitophagy - animal
    K14381  SQSTM1; sequestosome 1
  09143 Cell growth and death
   04217 Necroptosis
    K14381  SQSTM1; sequestosome 1
   04218 Cellular senescence
    K14381  SQSTM1; sequestosome 1
09150 Organismal Systems
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K14381  SQSTM1; sequestosome 1
09160 Human Diseases
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K14381  SQSTM1; sequestosome 1
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    K14381  SQSTM1; sequestosome 1
   05022 Pathways of neurodegeneration - multiple diseases
    K14381  SQSTM1; sequestosome 1
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K14381  SQSTM1; sequestosome 1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K14381  SQSTM1; sequestosome 1
   03029 Mitochondrial biogenesis
    K14381  SQSTM1; sequestosome 1
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K14381  SQSTM1; sequestosome 1
Membrane trafficking [BR:ko04131]
Autophagy
  Mitophagy
   Cargo receptors
    K14381  SQSTM1; sequestosome 1
  Pexophagy
   Cargo receptors
    K14381  SQSTM1; sequestosome 1
  Aggrephagy
   Cargo receptors
    K14381  SQSTM1; sequestosome 1
  Xenophagy
   Cargo receptors
    K14381  SQSTM1; sequestosome 1
  Other autophagy associated proteins
   Midbophagy
    K14381  SQSTM1; sequestosome 1
Mitochondrial biogenesis [BR:ko03029]
Mitochondrial quality control factors
  Mitophagy factors
   Parkin-dependent mechanism factors
    K14381  SQSTM1; sequestosome 1
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K14381  SQSTM1; sequestosome 1

Genes

HSA:	8878(SQSTM1)

PTR:	462333(SQSTM1)

PPS:	100981358(SQSTM1)

GGO:	101147113(SQSTM1)

PON:	100172461(SQSTM1)

PPYG:

129037504(SQSTM1)

NLE:	100591280(SQSTM1)

HMH:	116471948(SQSTM1)

SSYN:

129485911(SQSTM1)

MCC:	705481(SQSTM1)

MCF:	102144942(SQSTM1)

MTHB:

126956915

MNI:	105483997(SQSTM1)

CSAB:

103245112(SQSTM1)

CATY:

105590410(SQSTM1)

PANU:

101018581(SQSTM1)

TGE:	112626197(SQSTM1)

MLEU:

105537279(SQSTM1)

RRO:	104676201(SQSTM1)

RBB:	108523366(SQSTM1)

TFN:	117064347(SQSTM1)

PTEH:

111527434(SQSTM1)

CANG:

105521683(SQSTM1)

CJC:	100385650(SQSTM1)

SBQ:	101029448(SQSTM1)

CIMI:

108295214(SQSTM1)

ANAN:

105716721(SQSTM1)

CSYR:

103252077(SQSTM1)

MMUR:

105885196(SQSTM1)

LCAT:

123621805(SQSTM1)

PCOQ:

105823270(SQSTM1)

OGA:	100956223(SQSTM1)

MMU:	18412(Sqstm1)

MCAL:

110302322 110304268(Sqstm1)

MPAH:

110331598(Sqstm1)

RNO:	113894(Sqstm1)

MCOC:

116077040(Sqstm1)

ANU:	117710045(Sqstm1)

MUN:	110557385(Sqstm1)

CGE:	100768352(Sqstm1)

MAUA:

101829794(Sqstm1)

PROB:

127219353(Sqstm1)

PLEU:

114681486(Sqstm1)

MORG:

121456180(Sqstm1)

MFOT:

126511461

AAMP:

119812500(Sqstm1)

NGI:	103749374(Sqstm1)

HGL:	101724587(Sqstm1)

CPOC:

100725155(Sqstm1)

CCAN:

109686732(Sqstm1)

DORD:

105996783(Sqstm1)

DSP:	122115407(Sqstm1)

PLOP:

125341940(Sqstm1)

NCAR:

124986635

MMMA:

107159781(Sqstm1)

OCU:

100342157

OPI:	101524376(SQSTM1)

TUP:	102498598(SQSTM1)

GVR:	103600669(SQSTM1)

CFA:	481459(SQSTM1)

CLUD:

112659685(SQSTM1)

VVP:	112932446(SQSTM1)

VLG:	121494449(SQSTM1)

NPO:	129494502(SQSTM1)

AML:	100469252(SQSTM1)

UMR:	103680014(SQSTM1)

UAH:	113261555(SQSTM1)

UAR:	123790491(SQSTM1)

ELK:

111158853

LLV:

125100227

MPUF:

101680892(SQSTM1)

MNP:	132027425(SQSTM1)

MLK:	131832651(SQSTM1)

NVS:	122915724(SQSTM1)

ORO:	101378511(SQSTM1)

EJU:	114201195(SQSTM1)

ZCA:	113929395(SQSTM1)

MLX:	118026511(SQSTM1)

NSU:	110580261(SQSTM1)

FCA:	101085431(SQSTM1)

PYU:	121010520(SQSTM1)

PCOO:

112861403(SQSTM1)

PBG:	122485963(SQSTM1)

PVIV:

125169829(SQSTM1)

LRUF:

124514696

PTG:	102964239(SQSTM1)

PPAD:

109278963(SQSTM1)

PUC:

125935355

AJU:

106969863

HHV:	120245681(SQSTM1)

BTA:	338045(SQSTM1)

BOM:	102279447(SQSTM1)

BIU:	109561336(SQSTM1)

BBUB:

102407430(SQSTM1)

BBIS:

104981529(SQSTM1)

CHX:	102172251(SQSTM1)

OAS:	100135450(SQSTM1)

BTAX:

128051656(SQSTM1)

ODA:	120864357(SQSTM1)

CCAD:

122440582(SQSTM1)

MBEZ:

129552589 129559451(SQSTM1)

SSC:	100518718(SQSTM1)

CFR:	102519914(SQSTM1)

CBAI:

105062004(SQSTM1)

CDK:	105100630(SQSTM1)

VPC:	102545164(SQSTM1)

BACU:

103009745(SQSTM1)

BMUS:

118892049(SQSTM1)

LVE:	103086579(SQSTM1)

OOR:	101286416(SQSTM1)

DLE:	111169258(SQSTM1)

PCAD:

102992889(SQSTM1)

PSIU:

116750832(SQSTM1)

NASI:

112412921(SQSTM1)

ECB:	100067231(SQSTM1)

EPZ:	103560007(SQSTM1)

EAI:	106843726(SQSTM1)

MYB:	102258898(SQSTM1)

MYD:	102770732(SQSTM1)

MMYO:

118658615(SQSTM1)

MLF:	102417337(SQSTM1)

MDT:	132234600(SQSTM1)

PKL:	118725939(SQSTM1)

EFUS:

103301663(SQSTM1)

MNA:	107528430(SQSTM1)

DRO:	112296377(SQSTM1)

SHON:

118995097(SQSTM1)

AJM:	119042610(SQSTM1)

PDIC:

114509393(SQSTM1)

PHAS:

123811856(SQSTM1)

MMF:	118615289(SQSTM1)

PPAM:

129065002(SQSTM1)

HAI:

109392766

RFQ:	117016671(SQSTM1)

PALE:

102891735(SQSTM1)

PGIG:

120616619(SQSTM1)

PVP:	105299974(SQSTM1)

RAY:	107512321(SQSTM1)

MJV:	108401193(SQSTM1)

TOD:	119237206(SQSTM1)

SARA:

101556281(SQSTM1)

SETR:

126015660(SQSTM1)

LAV:	100675905(SQSTM1)

TMU:

101351010

ETF:	101655693(SQSTM1)

DNM:	101413958(SQSTM1)

MDO:	100032104(SQSTM1)

GAS:	123237461(SQSTM1)

SHR:	100924705(SQSTM1)

AFZ:

127550315

PCW:	110216726(SQSTM1)

TVP:	118841303(SQSTM1) 118846849

OAA:	100074478(SQSTM1)

GGA:	770805(SQSTM1)

PCOC:

116232161(SQSTM1)

MGP:	100543577(SQSTM1)

CJO:	107320123(SQSTM1)

TPAI:

128081505(SQSTM1)

LMUT:

125700294(SQSTM1)

NMEL:

110405331(SQSTM1)

APLA:

101790932(SQSTM1)

ACYG:

106032814(SQSTM1)

CATA:

118260565(SQSTM1)

AFUL:

116495008(SQSTM1)

TGU:	100222311(SQSTM1)

LSR:	110482713(SQSTM1)

SCAN:

103817294(SQSTM1)

PMOA:

120498536(SQSTM1)

OTC:	121332260(SQSTM1)

PRUF:

121361307(SQSTM1)

GFR:	102039289(SQSTM1)

FAB:	101807092(SQSTM1)

OMA:	130258592(SQSTM1)

PHI:	102110080(SQSTM1)

PMAJ:

107210859(SQSTM1)

CCAE:

111935553(SQSTM1)

CCW:	104689698(SQSTM1)

CBRC:

103611516(SQSTM1)

ETL:	114063188(SQSTM1)

ZAB:	102072059(SQSTM1)

ZLE:	135453574(SQSTM1)

ACHL:

103806038(SQSTM1)

SVG:	106859588(SQSTM1)

MMEA:

130579341(SQSTM1)

HRT:	120759243(SQSTM1)

SATI:

136367483(SQSTM1)

FPG:	101919269(SQSTM1)

FCH:	102053934(SQSTM1)

CCRI:

104169211(SQSTM1)

NNT:	104403602(SQSTM1)

SHAB:

115616168(SQSTM1)

ACUN:

113485050(SQSTM1)

TALA:

104359955(SQSTM1)

ACHC:

115334198(SQSTM1)

HALD:

104320159(SQSTM1)

AGEN:

126051095

GCL:

127021934

CSTI:

104557922(SQSTM1)

LDI:	104340748(SQSTM1)

MNB:	103772067(SQSTM1)

DPUB:

104309961(SQSTM1)

AVIT:

104274219(SQSTM1)

BRHI:

104500790(SQSTM1)

EGZ:	104123354(SQSTM1)

NNI:	104014189(SQSTM1)

PCRI:

104025153(SQSTM1)

PCAO:

104046671(SQSTM1)

PADL:

103915750(SQSTM1)

AFOR:

103904394(SQSTM1)

FGA:	104070525(SQSTM1)

GSTE:

104259429(SQSTM1)

CLV:	102097516(SQSTM1)

MUI:	104536546(SQSTM1)

PGUU:

104462667(SQSTM1)

PLET:

104625978(SQSTM1)

EHS:	104503880(SQSTM1)

CMAC:

104474385(SQSTM1)

CUCA:

104059415(SQSTM1)

TEO:	104375436(SQSTM1)

BREG:

104630258(SQSTM1)

OHA:	104326918(SQSTM1)

ACAR:

104526623(SQSTM1)

CPEA:

104386491(SQSTM1)

CVF:	104293110(SQSTM1)

RTD:	128915970(SQSTM1)

AAM:	106493464(SQSTM1)

AROW:

112964806(SQSTM1)

NPD:	112954301(SQSTM1)

TGT:	104564505(SQSTM1)

DNE:	112996941(SQSTM1)

SCAM:

104142261(SQSTM1)

ASN:	102373404(SQSTM1)

AMJ:	102571004(SQSTM1)

CPOO:

109310153(SQSTM1)

GGN:	109289899(SQSTM1)

PSS:	102457855(SQSTM1)

CMY:	102936852(SQSTM1)

CCAY:

125641938(SQSTM1)

DCC:	119859881(SQSTM1)

CPIC:

101944118(SQSTM1)

TST:	117881390(SQSTM1)

CABI:

116820054(SQSTM1)

MRV:	120370131(SQSTM1)

ACS:	100556955(sqstm1)

ASAO:

132768938(SQSTM1)

PVT:	110073484(SQSTM1)

SUND:

121921080(SQSTM1)

PBI:	103067573(SQSTM1)

PMUR:

107296620(SQSTM1)

CTIG:

120306858(SQSTM1)

TSR:	106538650(SQSTM1)

PGUT:

117655348(SQSTM1)

APRI:

131191507(SQSTM1)

PTEX:

113433801(SQSTM1)

NSS:	113424605(SQSTM1)

VKO:	123035814(SQSTM1)

PMUA:

114591333(SQSTM1)

PRAF:

128407939(SQSTM1)

ZVI:	118080412(SQSTM1)

HCG:	128344808(SQSTM1)

GJA:	107110311(SQSTM1)

STOW:

125429071(SQSTM1)

EMC:	129327356(SQSTM1)

XLA:	379610(sqstm1.L)

XTR:	493277(sqstm1)

NPR:	108785381(SQSTM1)

RTEM:

120932534(SQSTM1)

BBUF:

121008368(SQSTM1)

BGAR:

122928351(SQSTM1)

MUO:	115458800 115476938(SQSTM1)

GSH:	117351576(SQSTM1)

DRE:	406452(sqstm1)

SRX:	107733435 107743275

SANH:

107663095 107676448(sqstm1)

SGH:	107554668 107575345 107578690

CCAR:

109082293

CAUA:

113113360 113113483

CGIB:

127971599 128026935

PTET:

122357675(sqstm1)

LROH:

127161705(sqstm1)

OMC:	131553635(sqstm1)

PPRM:

120464333(sqstm1)

RKG:	130076446(sqstm1)

MAMB:

125259046(sqstm1)

CIDE:

127494206

CERY:

137019265(sqstm1)

MASI:

127412849 127417868

TROS:

130564073(sqstm1)

TDW:	130437809(sqstm1)

MANU:

129422228 129422521(sqstm1)

IPU:

108268580

IFU:	128611050(sqstm1)

PHYP:

113542895(sqstm1)

SMEO:

124386282(sqstm1)

TFD:	113647769(sqstm1)

TVC:	132855514(sqstm1)

TRN:	134319595(sqstm1)

AMEX:

103026459(sqstm1)

CMAO:

118807315(sqstm1)

EEE:	113584814(sqstm1)

CHAR:

105903806(sqstm1)

TRU:	101074386 115248426

TFS:	130531589(sqstm1)

TNG:	GSTEN00004418G001

LCO:	104938308(sqstm1)

TBEN:

117476129(sqstm1)

CGOB:

115005426(sqstm1)

PGEO:

117444735(sqstm1)

EMAC:

134863208(sqstm1)

ELY:	117258640(sqstm1)

EFO:	125894093(sqstm1)

PLEP:

121947899(sqstm1)

SLUC:

116060255(sqstm1) 116060829

ECRA:

117941469

PFLV:

114552016(sqstm1)

GAT:	120817322(sqstm1)

PPUG:

119211452(sqstm1)

AFB:	129090130(sqstm1)

CLUM:

117737603(sqstm1)

MSAM:

119888137(sqstm1)

SCHU:

122880178(sqstm1)

CUD:	121516454(sqstm1)

ALAT:

119007148(sqstm1)

ASTR:

137602576(sqstm1)

MZE:	101468330(sqstm1)

ONL:	100710448(sqstm1)

OAU:	116335506(sqstm1)

OLA:	101165790 101166287(sqstm1)

OML:	112141461 112141467

CSAI:

133447744(sqstm1)

XMA:	102235769(sqstm1)

XCO:	114139605(sqstm1)

XHE:	116714597(sqstm1)

PRET:

103471795(sqstm1)

PFOR:

103131220(sqstm1)

PLAI:

106958560(sqstm1)

PMEI:

106922883(sqstm1)

GAF:	122836756(sqstm1)

PPRL:

129354325

CVG:	107082716(sqstm1)

CTUL:

119784554(sqstm1)

GMU:	124860827(sqstm1)

NFU:	107381143(sqstm1)

KMR:	108248956(sqstm1)

ALIM:

106533286(sqstm1)

NWH:	119408812(sqstm1)

AOCE:

111585345(sqstm1)

MCEP:

125007811(sqstm1)

CSEM:

103390783

POV:	109641427(sqstm1)

SSEN:

122762899 122762911

HHIP:

117769074(sqstm1)

HSP:	118111928(sqstm1)

PPLT:

128445466(sqstm1)

SMAU:

118319139(sqstm1)

LCF:

108891804

SDU:	111233501(sqstm1)

SLAL:

111665615

XGL:	120785228(sqstm1)

HCQ:	109508331(sqstm1)

SSCV:

125974820

SBIA:

133508436(sqstm1)

PEE:	133407353(sqstm1)

PTAO:

133485159(sqstm1)

BPEC:

110153110(sqstm1)

MALB:

109951117(sqstm1)

BSPL:

114864285(sqstm1)

SJO:	128362915(sqstm1)

SASA:

100195312(sqstm)

STRU:

115171017 115205128(sqstm1)

OTW:	112221034 112256318(sqstm1)

OMY:	110488911 110505107(sqstm1)

OGO:	123993489 124011061(sqstm1)

ONE:	115129536 115130793

OKI:	109864825 109905265

OKE:	118363578(sqstm1) 118379271

SALP:

111965816 111967567

SNH:	120048046 120062254(sqstm1)

CCLU:

121534351(sqstm1) 121541633

ELS:	105028384(sqstm1)

SFM:	108925413(sqstm1)

PKI:	111859867(sqstm1)

AANG:

118223874(sqstm1)

LOC:	102691605(sqstm1)

PSPA:

121297301(sqstm1) 121324864

ARUT:

117431815 117964626

PSEX:

120541986(sqstm1)

LCM:	102359142(SQSTM1)

CMK:	103188227(sqstm1)

RTP:	109927682(sqstm1)

CPLA:

122556464(sqstm1)

HOC:	132823481(sqstm1)

LERI:

129701581(sqstm1)

PMRN:

116955013(SQSTM1)

LRJ:	133347781(SQSTM1)

BFO:

118419585

BBEL:

109487701

CIN:	100176775 100184598

SCLV:

SPU:

LPIC:

APLC:

ARUN:

SKO:	100375829 100376279

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

105838304 105838655 114255138

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:	105679873(ref(2)P)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

TPRE:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

CSET:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_201470

BANY:

PMAC:

PPOT:

PXU:

PRAP:

ZCE:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

PXY:

LGLY:

CLEC:

HHAL:

HVI:

PHU:	Phum_PHUM372150

FOC:

TPAL:

ZNE:

CSEC:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_306849

DMK:

116927915

DPZ:

124327508

PVM:

113821749

PJA:	122248040 122248098

PCHN:

PMOO:

HAME:

PCLA:

PTRU:

HAZT:

EAF:	111695328 111696442 111702089 111714555

LSM:	121114103 121124134

PPOI:

119093523 119093524 119113181

DSV:

RSAN:

RMP:

CSCU:

CVS:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

129585700 129597638 129598866

BMY:	BM_BM2024(Bm2024)

LOA:	LOAG_01401

HRO:	HELRODRAFT_174776

PVUL:

126829276

PCAN:

112559605

BGT:	106054637 106054638

GAE:	121374896 121374981

HRF:	124146022 124149571 124149577 124149595 124149601

HRJ:	124262859 124262860 124277412 124277413 124277414 124291392 124291393

CRG:	105345618 105345634

CANU:

CVN:

MYI:

PMAX:

MMER:

RPHI:

MAEA:

128227622 128227623 128228938

OBI:

106873472

OSN:	115211761 115214023

LJP:

135473582

LAK:	106158993 106166208 112042683

LLON:

NVE:

EPA:

ATEN:

AMIL:

PDAM:

SPIS:

DGT:	114521360 114543298

XEN:

124446409

HMG:

100211305

RES:

135690665

TAD:	TRIADDRAFT_64162

AQU:

100637508

TGB:	HG536_0G02220

PTM:	GSPATT00018159001 GSPATT00029038001 GSPATT00031144001

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Reference

PMID:16877352

Authors

Yip KH, Feng H, Pavlos NJ, Zheng MH, Xu J

Title

p62 ubiquitin binding-associated domain mediated the receptor activator of nuclear factor-kappaB ligand-induced osteoclast formation: a new insight into the pathogenesis of Paget's disease of bone.

Journal

Am J Pathol 169:503-14 (2006)
DOI:10.2353/ajpath.2006.050960

Reference

PMID:8551575

Authors

Devergne O, Hummel M, Koeppen H, Le Beau MM, Nathanson EC, Kieff E, Birkenbach M

Title

A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes.

Journal

J Virol 70:1143-53 (1996)
DOI:10.1128/JVI.70.2.1143-1153.1996

Sequence

[hsa:8878]

LinkDB

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