KEGG   PATHWAY: hhv04814
Entry
hhv04814                    Pathway                                
Name
Motor proteins - Hyaena hyaena (striped hyena)
Class
Cellular Processes; Cell motility
Pathway map
hhv04814  Motor proteins
hhv04814

Organism
Hyaena hyaena (striped hyena) [GN:hhv]
Gene
120244592  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
120223082  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414]
120234434  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
120236414  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
120223967  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]
120243614  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
120232013  DYNC2LI1; cytoplasmic dynein 2 light intermediate chain 1 [KO:K10417]
120237744  DYNLL2; dynein light chain 2, cytoplasmic [KO:K10418]
120222618  DYNLL1; dynein light chain 1, cytoplasmic [KO:K10418]
120228570  DYNLRB2; LOW QUALITY PROTEIN: dynein light chain roadblock-type 2 [KO:K10419]
120242798  DYNLRB1; dynein light chain roadblock-type 1 [KO:K10419]
120245174  DYNLT1; dynein light chain Tctex-type 1 [KO:K10420]
120248395  DYNLT3; dynein light chain Tctex-type 3 [KO:K10420]
120222979  DYNLT2; dynein light chain Tctex-type protein 2 isoform X1 [KO:K25419]
120236052  DYNLT4; tctex1 domain-containing protein 4 [KO:K25420]
120232599  DYNLT5; tctex1 domain-containing protein 1 [KO:K25421]
120242973  DNAH7; dynein heavy chain 7, axonemal [KO:K10408]
120232775  DNAH3; dynein heavy chain 3, axonemal [KO:K10408]
120238644  DNAH12; dynein heavy chain 12, axonemal [KO:K10408]
120233844  DNAH8; dynein heavy chain 8, axonemal [KO:K10408]
120234132  DNAH14; dynein heavy chain 14, axonemal [KO:K10408]
120228213  DNAH17; dynein heavy chain 17, axonemal [KO:K10408]
120220495  DNAH6; dynein heavy chain 6, axonemal [KO:K10408]
120239428  DNAH1; dynein heavy chain 1, axonemal [KO:K10408]
120220637  DNAH5; dynein heavy chain 5, axonemal [KO:K10408]
120221270  DNAH10; dynein heavy chain 10, axonemal [KO:K10408]
120236208  DNAH11; dynein heavy chain 11, axonemal [KO:K10408]
120231458  DNAH9; dynein heavy chain 9, axonemal [KO:K10408]
120231468  DNAH2; dynein heavy chain 2, axonemal [KO:K10408]
120241756  DNAI1; dynein intermediate chain 1, axonemal [KO:K10409]
120230233  DNAI2; dynein intermediate chain 2, axonemal isoform X1 [KO:K11143]
120241634  DNAI3; dynein intermediate chain 3, axonemal [KO:K24722]
120232602  DNAI4; dynein intermediate chain 4, axonemal [KO:K24723]
120239911  DNALI1; axonemal dynein light intermediate polypeptide 1 [KO:K10410]
120231971  DNAL1; dynein light chain 1, axonemal [KO:K10411]
120241140  DNAL4; dynein light chain 4, axonemal [KO:K10412]
120236996  DCTN1; dynactin subunit 1 isoform X1 [KO:K04648]
120248001  DCTN2; dynactin subunit 2 isoform X1 [KO:K10424]
120241712  DCTN3; dynactin subunit 3 [KO:K10425]
120236591  DCTN4; dynactin subunit 4 [KO:K10426]
120233293  DCTN5; dynactin subunit 5 [KO:K10427]
120221753  dynactin subunit 6-like [KO:K10428]
120222606  DCTN6; dynactin subunit 6 [KO:K10428]
120232040  ACTR1B; beta-centractin [KO:K16575]
120239604  ACTR1A; alpha-centractin isoform X1 [KO:K16575]
120221344  ACTR10; actin-related protein 10 [KO:K16576]
120243008  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
120223827  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
120247132  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
120229791  CAPZB; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
120231972  BICDL1; BICD family-like cargo adapter 1 isoform X1 [KO:K16756]
120241577  BICDL2; BICD family-like cargo adapter 2 [KO:K16756]
120233994  HOOK3; protein Hook homolog 3 isoform X1 [KO:K16536]
120237180  TUBAL3; tubulin alpha chain-like 3 isoform X1 [KO:K07374]
120237885  tubulin alpha-1B chain [KO:K07374]
120237886  tubulin alpha-1C chain [KO:K07374]
120243772  TUBA8; tubulin alpha-8 chain [KO:K07374]
120238803  tubulin alpha-3 chain-like [KO:K07374]
120238829  tubulin alpha-3 chain [KO:K07374]
120227184  tubulin alpha-1C chain-like [KO:K07374]
120227526  tubulin alpha-4A chain [KO:K07374]
120227529  tubulin alpha chain [KO:K07374]
120228924  tubulin alpha-8 chain [KO:K07374]
120223012  tubulin alpha-1B chain-like isoform X1 [KO:K07374]
120220197  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
120229069  TUBB3; tubulin beta-3 chain [KO:K07375]
120234871  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
120241436  TUBB2A; tubulin beta-2A chain isoform X1 [KO:K07375]
120222655  TUBB; tubulin beta chain [KO:K07375]
120222766  TUBB4B; tubulin beta-4B chain [KO:K07375]
120223296  TUBB4A; tubulin beta-4A chain [KO:K07375]
120248428  tubulin gamma-2 chain isoform X1 [KO:K10389]
120248452  TUBG1; tubulin gamma-1 chain [KO:K10389]
120241913  TUBD1; tubulin delta chain isoform X1 [KO:K10390]
120245252  TUBE1; tubulin epsilon chain isoform X1 [KO:K10391]
120240008  KIF5C; kinesin heavy chain [KO:K10396]
120242748  KIF5B; kinesin-1 heavy chain [KO:K10396]
120248003  KIF5A; kinesin heavy chain isoform X1 [KO:K10396]
120243542  KLC3; kinesin light chain 3 isoform X1 [KO:K10407]
120240204  KLC2; kinesin light chain 2 isoform X1 [KO:K10407]
120231184  KLC4; kinesin light chain 4 [KO:K10407]
120247769  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
120223318  KIF3A; kinesin-like protein KIF3A isoform X1 [KO:K10394]
120235429  KIF3B; kinesin-like protein KIF3B [KO:K20196]
120234155  KIFAP3; kinesin-associated protein 3 isoform X1 [KO:K25388]
120235813  KIF3C; kinesin-like protein KIF3C [KO:K20197]
120229830  KIF17; kinesin-like protein KIF17 isoform X1 [KO:K20198]
120233643  KIF1B; kinesin-like protein KIF1B isoform X1 [KO:K10392]
120229515  KIF1A; kinesin-like protein KIF1A isoform X1 [KO:K10392]
120246888  KIF1C; kinesin-like protein KIF1C [KO:K10392]
120220151  KIF13B; kinesin-like protein KIF13B [KO:K17914]
120242676  KIF13A; kinesin-like protein KIF13A isoform X1 [KO:K17914]
120228834  KIF14; kinesin-like protein KIF14 [KO:K17915]
120245184  KIF16B; kinesin-like protein KIF16B [KO:K17916]
120232249  STARD9; stAR-related lipid transfer protein 9 [KO:K16491]
120246065  KIF4A; chromosome-associated kinesin KIF4A isoform X1 [KO:K10395]
120219786  KIF7; LOW QUALITY PROTEIN: kinesin-like protein KIF7 [KO:K18806]
120220526  KIF21A; kinesin-like protein KIF21A isoform X1 [KO:K24185]
120228857  KIF21B; kinesin-like protein KIF21B isoform X1 [KO:K24185]
120244068  KIF27; kinesin-like protein KIF27 isoform X1 [KO:K24186]
120230629  KIF11; kinesin-like protein KIF11 isoform X1 [KO:K10398]
120226572  KIF20B; kinesin-like protein KIF20B isoform X1 [KO:K10402]
120220764  KIF20A; kinesin-like protein KIF20A [KO:K10402]
120221825  KIF23; kinesin-like protein KIF23 isoform X1 [KO:K17387]
120222820  CENPE; centromere-associated protein E [KO:K11498]
120220095  KIF18A; kinesin-like protein KIF18A [KO:K10401]
120222266  KIF18B; kinesin-like protein KIF18B isoform X1 [KO:K26156]
120230257  KIF19; kinesin-like protein KIF19 [KO:K26157]
120228001  kinesin-like protein KIF19 [KO:K26157]
120224347  kinesin-like protein KIF6 [KO:K10397]
120229316  KIF9; kinesin-like protein KIF9 isoform X1 [KO:K10397]
120242201  KIF22; kinesin-like protein KIF22 [KO:K10403]
120235280  KIF26B; kinesin-like protein KIF26B [KO:K10404]
120247798  KIF26A; kinesin-like protein KIF26A [KO:K10404]
120237552  KIF12; kinesin-like protein KIF12 [KO:K10399]
120229333  KIF15; kinesin-like protein KIF15 [KO:K10400]
120225721  KIF2B; kinesin-like protein KIF2B [KO:K10393]
120236067  KIF2C; kinesin-like protein KIF2C isoform X1 [KO:K10393]
120241722  KIF24; kinesin-like protein KIF24 isoform X1 [KO:K10393]
120247591  KIF2A; kinesin-like protein KIF2A isoform X1 [KO:K10393]
120238215  KIFC1; kinesin-like protein KIFC1 isoform X1 [KO:K10405]
120232131  KIFC3; kinesin-like protein KIFC3 isoform X1 [KO:K10406]
120246552  KIFC2; kinesin-like protein KIFC2 isoform X1 [KO:K10406]
120248689  KIF25; LOW QUALITY PROTEIN: kinesin-like protein KIF25 [KO:K18627]
120224875  MYO1A; unconventional myosin-Ia [KO:K10356]
120237709  MYO1H; unconventional myosin-Ih [KO:K10356]
120233451  MYO1B; unconventional myosin-Ib isoform X1 [KO:K10356]
120238915  MYO1G; unconventional myosin-Ig [KO:K10356]
120230880  MYO1E; unconventional myosin-Ie [KO:K10356]
120244832  MYO1F; unconventional myosin-If isoform X1 [KO:K10356]
120245062  MYO1D; unconventional myosin-Id [KO:K10356]
120245500  MYO1C; unconventional myosin-Ic isoform X1 [KO:K10356]
120223569  MYO3A; myosin-IIIa [KO:K08834] [EC:2.7.11.1]
120242836  myosin-IIIb [KO:K08834] [EC:2.7.11.1]
120229675  MYO5B; unconventional myosin-Vb isoform X1 [KO:K10357]
120235010  MYO5A; unconventional myosin-Va isoform X1 [KO:K10357]
120235049  MYO5C; unconventional myosin-Vc [KO:K10357]
120240915  MYO6; LOW QUALITY PROTEIN: unconventional myosin-VI [KO:K10358]
120229601  MYO7A; unconventional myosin-VIIa [KO:K10359]
120245942  MYO7B; unconventional myosin-VIIb [KO:K21868]
120239176  MYO9B; unconventional myosin-IXb isoform X1 [KO:K10360]
120235488  MYO9A; unconventional myosin-IXa isoform X1 [KO:K10360]
120236190  MYO10; unconventional myosin-X isoform X1 [KO:K12559]
120228113  MYO15B; myosin XVB [KO:K10361]
120228715  MYO15A; unconventional myosin-XV [KO:K10361]
120228340  MYO16; unconventional myosin-XVI [KO:K17481]
120227904  MYO18B; unconventional myosin-XVIIIb [KO:K10362]
120244860  MYO18A; unconventional myosin-XVIIIa isoform X1 [KO:K10362]
120248110  MYO19; unconventional myosin-XIX isoform X1 [KO:K25838]
120240268  MYH15; myosin-15 [KO:K24220]
120231448  LOW QUALITY PROTEIN: myosin-8-like [KO:K24220]
120231449  myosin-2 isoform X1 [KO:K24220]
120231450  myosin-1 isoform X1 [KO:K24220]
120231451  LOW QUALITY PROTEIN: myosin-4-like [KO:K24220]
120231456  myosin-3 [KO:K24220]
120231459  LOW QUALITY PROTEIN: myosin-13-like [KO:K24220]
120242770  MYH7B; myosin-7B isoform X1 [KO:K24220]
120247001  myosin-7 [KO:K17751]
120247013  myosin-6 [KO:K17751]
120232697  MYH11; myosin-11 [KO:K10352]
120241162  MYH9; myosin-9 [KO:K10352]
120241792  MYH14; myosin-14 [KO:K10352]
120231384  MYH10; myosin-10 isoform X1 [KO:K10352]
120243750  MYL1; myosin light chain 1/3, skeletal muscle isoform isoform X1 [KO:K05738]
120229352  MYL3; myosin light chain 3 [KO:K12749]
120244252  MYL4; myosin light chain 4 isoform X1 [KO:K12750]
120219927  MYL6B; myosin light chain 6B [KO:K12751]
120219928  MYL6; myosin light polypeptide 6 isoform X1 [KO:K12751]
120247408  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
120222517  MYL5; myosin light chain 5 [KO:K12753]
120238920  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
120228602  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
120239322  MYL10; myosin regulatory light chain 10 [KO:K12756]
120239085  myosin regulatory light polypeptide 9-like [KO:K12757]
120239090  myosin regulatory light chain 12B [KO:K12757]
120234698  myosin regulatory light polypeptide 9-like [KO:K12757]
120242286  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
120237834  ACTA1; actin, alpha skeletal muscle [KO:K10354]
120223794  ACTA2; actin, aortic smooth muscle [KO:K12313]
120241888  ACTC1; actin, alpha cardiac muscle 1 [KO:K12314]
120237006  ACTG2; actin, gamma-enteric smooth muscle [KO:K12315]
120228024  ACTB; actin, cytoplasmic 1 [KO:K05692]
120228303  ACTG1; actin, cytoplasmic 2 [KO:K05692]
120239441  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
120228897  TNNI1; LOW QUALITY PROTEIN: troponin I, slow skeletal muscle [KO:K10371]
120239770  TNNT1; troponin T, slow skeletal muscle [KO:K10372]
120243296  TNNC2; troponin C, skeletal muscle [KO:K12042]
120225509  TNNI2; troponin I, fast skeletal muscle isoform X1 [KO:K12043]
120225515  TNNT3; troponin T, fast skeletal muscle isoform X1 [KO:K12046]
120239760  TNNI3; troponin I, cardiac muscle [KO:K12044]
120228936  TNNT2; troponin T, cardiac muscle isoform X1 [KO:K12045]
120222174  TPM1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
120221291  TPM2; tropomyosin beta chain isoform X1 [KO:K10374]
120221531  TPM3; tropomyosin alpha-3 chain isoform X1 [KO:K09290]
120239171  TPM4; tropomyosin alpha-4 chain isoform X1 [KO:K10375]
Reference
PMID:21092854
  Authors
Hirokawa N, Niwa S, Tanaka Y
  Title
Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease.
  Journal
Neuron 68:610-38 (2010)
DOI:10.1016/j.neuron.2010.09.039
Reference
PMID:25470043 (PDB:4RH7)
  Authors
Schmidt H, Zalyte R, Urnavicius L, Carter AP
  Title
Structure of human cytoplasmic dynein-2 primed for its power stroke.
  Journal
Nature 518:435-438 (2015)
DOI:10.1038/nature14023
Reference
PMID:22398446 (PDB:3VKG 3VKH)
  Authors
Kon T, Oyama T, Shimo-Kon R, Imamula K, Shima T, Sutoh K, Kurisu G
  Title
The 2.8 A crystal structure of the dynein motor domain.
  Journal
Nature 484:345-50 (2012)
DOI:10.1038/nature10955
Reference
PMID:22997337 (PDB:3J1T 3J1U)
  Authors
Redwine WB, Hernandez-Lopez R, Zou S, Huang J, Reck-Peterson SL, Leschziner AE
  Title
Structural basis for microtubule binding and release by dynein.
  Journal
Science 337:1532-1536 (2012)
DOI:10.1126/science.1224151
Reference
PMID:26410600
  Authors
Gibbs KL, Greensmith L, Schiavo G
  Title
Regulation of Axonal Transport by Protein Kinases.
  Journal
Trends Biochem Sci 40:597-610 (2015)
DOI:10.1016/j.tibs.2015.08.003
Reference
PMID:28602352 (PDB:5NUG 5NVS 5NVU 5NW4)
  Authors
Zhang K, Foster HE, Rondelet A, Lacey SE, Bahi-Buisson N, Bird AW, Carter AP
  Title
Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated.
  Journal
Cell 169:1303-1314.e18 (2017)
DOI:10.1016/j.cell.2017.05.025
Reference
PMID:25814576 (PDB:5ADX 5AFR 5AFU)
  Authors
Urnavicius L, Zhang K, Diamant AG, Motz C, Schlager MA, Yu M, Patel NA, Robinson CV, Carter AP
  Title
The structure of the dynactin complex and its interaction with dynein.
  Journal
Science 347:1441-1446 (2015)
DOI:10.1126/science.aaa4080
Reference
PMID:29420470 (PDB:5OWO 6F1T 6F1U 6F1V 6F1Y 6F1Z 6F38 6F3A)
  Authors
Urnavicius L, Lau CK, Elshenawy MM, Morales-Rios E, Motz C, Yildiz A, Carter AP
  Title
Cryo-EM shows how dynactin recruits two dyneins for faster movement.
  Journal
Nature 554:202-206 (2018)
DOI:10.1038/nature25462
Reference
PMID:29662141
  Authors
Reck-Peterson SL, Redwine WB, Vale RD, Carter AP
  Title
The cytoplasmic dynein transport machinery and its many cargoes.
  Journal
Nat Rev Mol Cell Biol 19:382-398 (2018)
DOI:10.1038/s41580-018-0004-3
Reference
PMID:23434508 (PDB:3J2U)
  Authors
Asenjo AB, Chatterjee C, Tan D, DePaoli V, Rice WJ, Diaz-Avalos R, Silvestry M, Sosa H
  Title
Structural model for tubulin recognition and deformation by kinesin-13 microtubule depolymerases.
  Journal
Cell Rep 3:759-68 (2013)
DOI:10.1016/j.celrep.2013.01.030
Reference
PMID:10338210 (PDB:1B7T)
  Authors
Houdusse A, Kalabokis VN, Himmel D, Szent-Gyorgyi AG, Cohen C
  Title
Atomic structure of scallop myosin subfragment S1 complexed with MgADP: a novel conformation of the myosin head.
  Journal
Cell 97:459-70 (1999)
DOI:10.1016/s0092-8674(00)80756-4
Reference
PMID:9428521 (PDB:3KIN)
  Authors
Kozielski F, Sack S, Marx A, Thormahlen M, Schonbrunn E, Biou V, Thompson A, Mandelkow EM, Mandelkow E
  Title
The crystal structure of dimeric kinesin and implications for microtubule-dependent motility.
  Journal
Cell 91:985-94 (1997)
DOI:10.1016/s0092-8674(00)80489-4
Reference
PMID:8316857 (PDB:2MYS)
  Authors
Rayment I, Rypniewski WR, Schmidt-Base K, Smith R, Tomchick DR, Benning MM, Winkelmann DA, Wesenberg G, Holden HM
  Title
Three-dimensional structure of myosin subfragment-1: a molecular motor.
  Journal
Science 261:50-8 (1993)
DOI:10.1126/science.8316857
Reference
PMID:20428469
  Authors
Parker D, Bryant Z, Delp SL
  Title
Coarse-Grained Structural Modeling of Molecular Motors Using Multibody Dynamics.
  Journal
Cell Mol Bioeng 2:366-374 (2009)
DOI:10.1007/s12195-009-0084-4
Reference
PMID:21314430
  Authors
Dominguez R, Holmes KC
  Title
Actin structure and function.
  Journal
Annu Rev Biophys 40:169-86 (2011)
DOI:10.1146/annurev-biophys-042910-155359
Reference
PMID:31919429 (PDB:6KN7 6KN8)
  Authors
Yamada Y, Namba K, Fujii T
  Title
Cardiac muscle thin filament structures reveal calcium regulatory mechanism.
  Journal
Nat Commun 11:153 (2020)
DOI:10.1038/s41467-019-14008-1
Reference
PMID:33912943
  Authors
Kruppa AJ, Buss F
  Title
Motor proteins at the mitochondria-cytoskeleton interface.
  Journal
J Cell Sci 134:239092 (2021)
DOI:10.1242/jcs.226084
KO pathway
ko04814   
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