KEGG   PATHWAY: hrf04142
Entry
hrf04142                    Pathway                                
Name
Lysosome - Haliotis rufescens (red abalone)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
hrf04142  Lysosome
hrf04142

Other DBs
GO: 0005764
Organism
Haliotis rufescens (red abalone) [GN:hrf]
Gene
124132743  V-type proton ATPase 116 kDa subunit a 4-like isoform X1 [KO:K02154]
124135842  V-type proton ATPase 116 kDa subunit a 1-like isoform X1 [KO:K02154]
124143252  V-type proton ATPase subunit d 1-like [KO:K02146]
124139765  V-type proton ATPase subunit H-like isoform X1 [KO:K02144]
124145890  V-type proton ATPase subunit S1-like [KO:K03662]
124110464  V-type proton ATPase 16 kDa proteolipid subunit c-like [KO:K02155]
124143017  V-type proton ATPase 21 kDa proteolipid subunit c''-like [KO:K03661]
124131479  dmX-like protein 2 isoform X1 [KO:K24155]
124142531  WD repeat-containing protein 7-like isoform X1 [KO:K24738]
124110953  oxidation resistance protein 1-like isoform X1 [KO:K25442]
124131380  lysosomal protective protein-like [KO:K13289] [EC:3.4.16.5]
124131632  lysosomal protective protein-like [KO:K13289] [EC:3.4.16.5]
124131700  lysosomal protective protein-like [KO:K13289] [EC:3.4.16.5]
124131581  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
124131582  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
124122018  dipeptidyl peptidase 1-like [KO:K01275] [EC:3.4.14.1]
124112264  lysosomal aspartic protease-like isoform X1 [KO:K01379] [EC:3.4.23.5]
124129105  cysteine proteinase 1-like [KO:K01373] [EC:3.4.22.41]
124131860  uncharacterized protein LOC124131860 isoform X1 [KO:K01373] [EC:3.4.22.41]
124135182  procathepsin L-like [KO:K01371] [EC:3.4.22.38]
124135263  procathepsin L-like [KO:K01371] [EC:3.4.22.38]
124135264  procathepsin L-like [KO:K01371] [EC:3.4.22.38]
124118401  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
124118415  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
124118416  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
124118418  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
124143959  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
124143965  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
124143966  procathepsin L-like isoform X1 [KO:K01365] [EC:3.4.22.15]
124135999  cathepsin L-like [KO:K01365] [EC:3.4.22.15]
124113683  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
124126643  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
124126647  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
124127629  digestive cysteine proteinase 1-like isoform X1 [KO:K01365] [EC:3.4.22.15]
124116881  procathepsin L-like isoform X1 [KO:K01365] [EC:3.4.22.15]
124144467  cathepsin O-like [KO:K01374] [EC:3.4.22.42]
124126641  procathepsin L-like [KO:K01368] [EC:3.4.22.27]
124126648  procathepsin L-like [KO:K01368] [EC:3.4.22.27]
124112862  cathepsin Z-like [KO:K08568] [EC:3.4.18.1]
124112863  cathepsin Z-like [KO:K08568] [EC:3.4.18.1]
124139827  cathepsin Z-like [KO:K08568] [EC:3.4.18.1]
124117809  legumain-like [KO:K01369] [EC:3.4.22.34]
124118633  beta-galactosidase-like [KO:K12309] [EC:3.2.1.23]
124123086  beta-galactosidase-like [KO:K12309] [EC:3.2.1.23]
124132550  lysosomal alpha-glucosidase-like [KO:K12316] [EC:3.2.1.20]
124132741  lysosomal alpha-glucosidase-like isoform X1 [KO:K12316] [EC:3.2.1.20]
124142695  lysosomal alpha-glucosidase-like [KO:K12316] [EC:3.2.1.20]
124122602  lysosomal alpha-glucosidase-like [KO:K12316] [EC:3.2.1.20]
124111659  lysosomal alpha-glucosidase-like [KO:K12316] [EC:3.2.1.20]
124146098  lysosomal alpha-glucosidase-like [KO:K12316] [EC:3.2.1.20]
124146099  lysosomal alpha-glucosidase-like [KO:K12316] [EC:3.2.1.20]
124135701  lysosomal acid glucosylceramidase-like isoform X1 [KO:K01201] [EC:3.2.1.45]
124143040  alpha-L-iduronidase-like [KO:K01217] [EC:3.2.1.76]
124143041  alpha-L-iduronidase-like [KO:K01217] [EC:3.2.1.76]
124114669  alpha-L-iduronidase-like [KO:K01217] [EC:3.2.1.76]
124148132  alpha-N-acetylgalactosaminidase-like [KO:K01204] [EC:3.2.1.49]
124143661  alpha-N-acetylgalactosaminidase-like [KO:K01204] [EC:3.2.1.49]
124119945  alpha-N-acetylgalactosaminidase-like [KO:K01204] [EC:3.2.1.49]
124148129  alpha-N-acetylgalactosaminidase-like isoform X1 [KO:K01204] [EC:3.2.1.49]
124139615  alpha-N-acetylgalactosaminidase-like isoform X2 [KO:K01204] [EC:3.2.1.49]
124148942  alpha-N-acetylgalactosaminidase-like [KO:K01204] [EC:3.2.1.49]
124148995  alpha-N-acetylgalactosaminidase-like [KO:K01204] [EC:3.2.1.49]
124148997  alpha-N-acetylgalactosaminidase-like isoform X2 [KO:K01204] [EC:3.2.1.49]
124148998  alpha-N-acetylgalactosaminidase-like [KO:K01204] [EC:3.2.1.49]
124129757  alpha-N-acetylgalactosaminidase-like [KO:K01204] [EC:3.2.1.49]
125371717  alpha-N-acetylgalactosaminidase-like [KO:K01204] [EC:3.2.1.49]
124139616  alpha-N-acetylgalactosaminidase-like [KO:K01204] [EC:3.2.1.49]
124139617  alpha-galactosidase A-like [KO:K01204] [EC:3.2.1.49]
124135580  alpha-N-acetylglucosaminidase-like isoform X1 [KO:K01205] [EC:3.2.1.50]
124135581  alpha-N-acetylglucosaminidase-like [KO:K01205] [EC:3.2.1.50]
124116671  galactocerebrosidase-like isoform X1 [KO:K01202] [EC:3.2.1.46]
124116721  galactocerebrosidase-like [KO:K01202] [EC:3.2.1.46]
124116725  galactocerebrosidase-like [KO:K01202] [EC:3.2.1.46]
124116741  galactocerebrosidase-like [KO:K01202] [EC:3.2.1.46]
124116744  galactocerebrosidase-like isoform X1 [KO:K01202] [EC:3.2.1.46]
124116758  galactocerebrosidase-like [KO:K01202] [EC:3.2.1.46]
124116768  galactocerebrosidase-like isoform X1 [KO:K01202] [EC:3.2.1.46]
124131421  galactocerebrosidase-like isoform X1 [KO:K01202] [EC:3.2.1.46]
124117044  galactocerebrosidase-like [KO:K01202] [EC:3.2.1.46]
124117049  galactocerebrosidase-like [KO:K01202] [EC:3.2.1.46]
124117386  galactocerebrosidase-like isoform X2 [KO:K01202] [EC:3.2.1.46]
124117806  galactocerebrosidase-like [KO:K01202] [EC:3.2.1.46]
124118021  galactocerebrosidase-like [KO:K01202] [EC:3.2.1.46]
124118031  galactocerebrosidase-like isoform X1 [KO:K01202] [EC:3.2.1.46]
124116698  galactocerebrosidase-like [KO:K01202] [EC:3.2.1.46]
124128514  beta-glucuronidase-like [KO:K01195] [EC:3.2.1.31]
124140231  beta-glucuronidase-like isoform X2 [KO:K01195] [EC:3.2.1.31]
124151875  alpha-L-fucosidase-like [KO:K01206] [EC:3.2.1.51]
124122573  alpha-L-fucosidase-like [KO:K01206] [EC:3.2.1.51]
124136075  alpha-L-fucosidase-like [KO:K01206] [EC:3.2.1.51]
124138379  alpha-L-fucosidase-like [KO:K01206] [EC:3.2.1.51]
124138388  alpha-L-fucosidase-like [KO:K01206] [EC:3.2.1.51]
124138396  alpha-L-fucosidase-like [KO:K01206] [EC:3.2.1.51]
124138404  alpha-L-fucosidase-like [KO:K01206] [EC:3.2.1.51]
124138440  alpha-L-fucosidase-like [KO:K01206] [EC:3.2.1.51]
124126742  alpha-L-fucosidase-like [KO:K01206] [EC:3.2.1.51]
124149080  alpha-L-fucosidase-like [KO:K01206] [EC:3.2.1.51]
124149081  alpha-L-fucosidase-like [KO:K01206] [EC:3.2.1.51]
124149112  alpha-L-fucosidase-like isoform X2 [KO:K01206] [EC:3.2.1.51]
124149113  alpha-L-fucosidase-like [KO:K01206] [EC:3.2.1.51]
124149115  alpha-L-fucosidase-like [KO:K01206] [EC:3.2.1.51]
124149116  alpha-L-fucosidase-like [KO:K01206] [EC:3.2.1.51]
124149117  alpha-L-fucosidase-like [KO:K01206] [EC:3.2.1.51]
124149118  alpha-L-fucosidase-like [KO:K01206] [EC:3.2.1.51]
124149120  alpha-L-fucosidase-like [KO:K01206] [EC:3.2.1.51]
124149121  alpha-L-fucosidase-like [KO:K01206] [EC:3.2.1.51]
124149122  alpha-L-fucosidase-like [KO:K01206] [EC:3.2.1.51]
124149123  alpha-L-fucosidase-like [KO:K01206] [EC:3.2.1.51]
124140147  tissue alpha-L-fucosidase-like [KO:K01206] [EC:3.2.1.51]
124140150  alpha-L-fucosidase-like isoform X2 [KO:K01206] [EC:3.2.1.51]
125371578  alpha-L-fucosidase-like [KO:K01206] [EC:3.2.1.51]
124133827  beta-hexosaminidase-like [KO:K12373] [EC:3.2.1.52]
124133952  uncharacterized protein LOC124133952 isoform X3 [KO:K12373] [EC:3.2.1.52]
124145608  beta-hexosaminidase subunit beta-like [KO:K12373] [EC:3.2.1.52]
124113383  beta-hexosaminidase-like isoform X1 [KO:K12373] [EC:3.2.1.52]
124113430  beta-hexosaminidase subunit beta-like [KO:K12373] [EC:3.2.1.52]
124113514  beta-hexosaminidase subunit beta-like isoform X1 [KO:K12373] [EC:3.2.1.52]
124150097  beta-hexosaminidase subunit beta-like isoform X1 [KO:K12373] [EC:3.2.1.52]
124152326  beta-mannosidase-like [KO:K01192] [EC:3.2.1.25]
124152335  beta-mannosidase-like isoform X2 [KO:K01192] [EC:3.2.1.25]
124152357  beta-mannosidase-like [KO:K01192] [EC:3.2.1.25]
124132515  lysosomal alpha-mannosidase-like isoform X1 [KO:K12311] [EC:3.2.1.24]
124132531  lysosomal alpha-mannosidase-like [KO:K12311] [EC:3.2.1.24]
124150398  lysosomal alpha-mannosidase-like isoform X1 [KO:K12311] [EC:3.2.1.24]
124132471  lysosomal alpha-mannosidase-like [KO:K12311] [EC:3.2.1.24]
124132488  lysosomal alpha-mannosidase-like isoform X2 [KO:K12311] [EC:3.2.1.24]
124129470  hyaluronidase B-like isoform X4 [KO:K01197] [EC:3.2.1.35]
124118160  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
124118166  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
124118167  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
124118182  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
124142654  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
124142661  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
124142672  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
124142691  arylsulfatase J-like [KO:K01135] [EC:3.1.6.12]
124142705  arylsulfatase J-like [KO:K01135] [EC:3.1.6.12]
124142712  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
124143421  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
124143696  arylsulfatase B-like isoform X1 [KO:K01135] [EC:3.1.6.12]
124143795  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
124143802  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
124143811  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
124143822  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
124143839  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
124143844  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
124143845  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
124143851  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
124143862  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
124143874  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
124121090  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
124121861  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
124121947  arylsulfatase B-like isoform X1 [KO:K01135] [EC:3.1.6.12]
124134912  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
124134913  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
124134914  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
124122502  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
124145690  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
124145792  arylsulfatase I-like [KO:K01135] [EC:3.1.6.12]
124145805  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
124112822  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
124124486  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
124113120  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
124113136  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
124113181  arylsulfatase B-like isoform X2 [KO:K01135] [EC:3.1.6.12]
124113216  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
124137818  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
124126041  arylsulfatase B-like isoform X1 [KO:K01135] [EC:3.1.6.12]
124126043  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
124126044  arylsulfatase B-like isoform X1 [KO:K01135] [EC:3.1.6.12]
124147767  arylsulfatase B-like isoform X1 [KO:K01135] [EC:3.1.6.12]
124147768  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
124127423  arylsulfatase B-like isoform X2 [KO:K01135] [EC:3.1.6.12]
124128298  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
124129229  arylsulfatase B-like isoform X1 [KO:K01135] [EC:3.1.6.12]
124117736  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
124117737  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
124117738  arylsulfatase B-like isoform X1 [KO:K01135] [EC:3.1.6.12]
124117739  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
124117740  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
124151544  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
124151545  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
124151555  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
124151556  arylsulfatase B-like isoform X1 [KO:K01135] [EC:3.1.6.12]
124112853  N-acetylgalactosamine-6-sulfatase-like isoform X1 [KO:K01132] [EC:3.1.6.4]
124116039  N-acetylglucosamine-6-sulfatase-like [KO:K01137] [EC:3.1.6.14]
124116040  N-acetylglucosamine-6-sulfatase-like [KO:K01137] [EC:3.1.6.14]
124116042  N-acetylglucosamine-6-sulfatase-like isoform X2 [KO:K01137] [EC:3.1.6.14]
124117774  N-acetylglucosamine-6-sulfatase-like [KO:K01137] [EC:3.1.6.14]
124117782  N-acetylglucosamine-6-sulfatase-like [KO:K01137] [EC:3.1.6.14]
124118457  iduronate 2-sulfatase-like [KO:K01136] [EC:3.1.6.13]
124132900  iduronate 2-sulfatase-like [KO:K01136] [EC:3.1.6.13]
124118983  iduronate 2-sulfatase-like [KO:K01136] [EC:3.1.6.13]
124118984  iduronate 2-sulfatase-like [KO:K01136] [EC:3.1.6.13]
124152520  iduronate 2-sulfatase-like [KO:K01136] [EC:3.1.6.13]
124152521  iduronate 2-sulfatase-like [KO:K01136] [EC:3.1.6.13]
124152523  iduronate 2-sulfatase-like [KO:K01136] [EC:3.1.6.13]
124152524  iduronate 2-sulfatase-like [KO:K01136] [EC:3.1.6.13]
124152526  iduronate 2-sulfatase-like [KO:K01136] [EC:3.1.6.13]
124152528  iduronate 2-sulfatase-like [KO:K01136] [EC:3.1.6.13]
124152530  iduronate 2-sulfatase-like [KO:K01136] [EC:3.1.6.13]
124152531  iduronate 2-sulfatase-like [KO:K01136] [EC:3.1.6.13]
124152532  iduronate 2-sulfatase-like [KO:K01136] [EC:3.1.6.13]
124152533  iduronate 2-sulfatase-like [KO:K01136] [EC:3.1.6.13]
124152534  iduronate 2-sulfatase-like [KO:K01136] [EC:3.1.6.13]
124152535  iduronate 2-sulfatase-like [KO:K01136] [EC:3.1.6.13]
124152538  iduronate 2-sulfatase-like [KO:K01136] [EC:3.1.6.13]
124122656  iduronate 2-sulfatase-like [KO:K01136] [EC:3.1.6.13]
124122661  iduronate 2-sulfatase-like [KO:K01136] [EC:3.1.6.13]
124112807  iduronate 2-sulfatase-like [KO:K01136] [EC:3.1.6.13]
124112980  iduronate 2-sulfatase-like [KO:K01136] [EC:3.1.6.13]
124113001  iduronate 2-sulfatase-like [KO:K01136] [EC:3.1.6.13]
124149615  iduronate 2-sulfatase-like [KO:K01136] [EC:3.1.6.13]
124119286  N-sulphoglucosamine sulphohydrolase-like [KO:K01565] [EC:3.10.1.1]
124152992  N-sulphoglucosamine sulphohydrolase-like [KO:K01565] [EC:3.10.1.1]
124134918  N-sulphoglucosamine sulphohydrolase-like [KO:K01565] [EC:3.10.1.1]
124113807  N-sulphoglucosamine sulphohydrolase-like [KO:K01565] [EC:3.10.1.1]
124151766  N-sulphoglucosamine sulphohydrolase-like [KO:K01565] [EC:3.10.1.1]
124140297  lysosomal acid lipase/cholesteryl ester hydrolase-like [KO:K01052] [EC:3.1.1.13]
124150406  lysosomal acid lipase/cholesteryl ester hydrolase-like [KO:K01052] [EC:3.1.1.13]
124150419  lysosomal acid lipase/cholesteryl ester hydrolase-like [KO:K01052] [EC:3.1.1.13]
124150420  lysosomal acid lipase/cholesteryl ester hydrolase-like [KO:K01052] [EC:3.1.1.13]
124150422  lysosomal acid lipase/cholesteryl ester hydrolase-like [KO:K01052] [EC:3.1.1.13]
124150423  lysosomal acid lipase/cholesteryl ester hydrolase-like [KO:K01052] [EC:3.1.1.13]
125371623  lysosomal acid lipase/cholesteryl ester hydrolase-like [KO:K01052] [EC:3.1.1.13]
124141807  phospholipase A2 group XV-like isoform X1 [KO:K06129] [EC:3.1.1.5]
124121284  plancitoxin-1-like isoform X1 [KO:K01158] [EC:3.1.22.1]
124144633  plancitoxin-1-like [KO:K01158] [EC:3.1.22.1]
124135074  prostatic acid phosphatase-like isoform X1 [KO:K14410] [EC:3.1.3.2]
124112085  prostatic acid phosphatase-like [KO:K14410] [EC:3.1.3.2]
124112086  lysosomal acid phosphatase-like [KO:K14410] [EC:3.1.3.2]
124112092  prostatic acid phosphatase-like [KO:K14410] [EC:3.1.3.2]
124112093  prostatic acid phosphatase-like [KO:K14410] [EC:3.1.3.2]
124125395  prostatic acid phosphatase-like [KO:K14410] [EC:3.1.3.2]
124115880  prostatic acid phosphatase-like [KO:K14410] [EC:3.1.3.2]
124115899  prostatic acid phosphatase-like [KO:K14410] [EC:3.1.3.2]
124119629  tartrate-resistant acid phosphatase type 5-like [KO:K14379] [EC:3.1.3.2]
124146238  tartrate-resistant acid phosphatase type 5-like [KO:K14379] [EC:3.1.3.2]
124118071  sphingomyelin phosphodiesterase-like [KO:K12350] [EC:3.1.4.12]
124120575  sphingomyelin phosphodiesterase-like [KO:K12350] [EC:3.1.4.12]
124147336  sphingomyelin phosphodiesterase A-like [KO:K12350] [EC:3.1.4.12]
124118067  sphingomyelin phosphodiesterase-like [KO:K12350] [EC:3.1.4.12]
124118068  sphingomyelin phosphodiesterase-like [KO:K12350] [EC:3.1.4.12]
124134466  acid ceramidase-like [KO:K12348] [EC:3.5.1.23]
124134467  acid ceramidase-like [KO:K12348] [EC:3.5.1.23]
124133712  N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase- like [KO:K01444] [EC:3.5.1.26]
124147035  N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase- like [KO:K01444] [EC:3.5.1.26]
124131255  prosaposin-like [KO:K12382]
124133656  ganglioside GM2 activator-like [KO:K12383]
124135124  ganglioside GM2 activator-like [KO:K12383]
124122167  ganglioside GM2 activator-like [KO:K12383]
124122983  ganglioside GM2 activator-like [KO:K12383]
124145334  ganglioside GM2 activator-like [KO:K12383]
124112546  ganglioside GM2 activator-like [KO:K12383]
124124671  uncharacterized protein LOC124124671 isoform X1 [KO:K12383]
124137335  ganglioside GM2 activator-like [KO:K12383]
124137336  ganglioside GM2 activator-like [KO:K12383]
124137337  ganglioside GM2 activator-like [KO:K12383]
124137414  ganglioside GM2 activator-like [KO:K12383]
124126409  ganglioside GM2 activator-like [KO:K12383]
124126411  ganglioside GM2 activator-like [KO:K12383]
124149100  ganglioside GM2 activator-like [KO:K12383]
124139837  ganglioside GM2 activator-like [KO:K12383]
124139855  ganglioside GM2 activator-like [KO:K12383]
124144804  lysosomal thioesterase PPT2-A-like [KO:K01074] [EC:3.1.2.22]
124144805  lysosomal thioesterase PPT2-like [KO:K01074] [EC:3.1.2.22]
124115379  palmitoyl-protein thioesterase 1-like [KO:K01074] [EC:3.1.2.22]
125382135  palmitoyl-protein thioesterase 1-like [KO:K01074] [EC:3.1.2.22]
124110388  lysosome-associated membrane glycoprotein 2-like [KO:K06528]
124142416  leukocyte surface antigen CD53-like [KO:K06497]
124146302  CD63 antigen-like [KO:K06497]
124146303  tetraspanin-8-like [KO:K06497]
124140514  CD63 antigen-like [KO:K06497]
124133986  lysosome membrane protein 2-like isoform X2 [KO:K12384]
124139596  lysosome membrane protein 2-like [KO:K12384]
124133275  protein patched homolog 1-like isoform X1 [KO:K12385]
124112759  protein patched homolog 1-like isoform X1 [KO:K12385]
124139428  NPC intracellular cholesterol transporter 1-like [KO:K12385]
124145097  NPC intracellular cholesterol transporter 2-like [KO:K13443]
124145108  NPC intracellular cholesterol transporter 2-like [KO:K13443]
124145119  NPC intracellular cholesterol transporter 2-like isoform X1 [KO:K13443]
124145142  NPC intracellular cholesterol transporter 2-like [KO:K13443]
124113741  cystinosin-like isoform X1 [KO:K12386]
124113742  cystinosin-like [KO:K12386]
124144450  uncharacterized transporter slc-17.2-like [KO:K12301]
124135137  sialin-like [KO:K12301]
124111172  sialin-like [KO:K12301]
124111173  uncharacterized transporter slc-17.2-like [KO:K12301]
124111191  sialin-like [KO:K12301]
124111192  sialin-like [KO:K12301]
124111209  sialin-like [KO:K12301]
124111716  sialin-like [KO:K12301]
124136115  sialin-like [KO:K12301]
124112812  uncharacterized transporter slc-17.2-like [KO:K12301]
124124327  uncharacterized transporter slc-17.2-like isoform X1 [KO:K12301]
124124331  uncharacterized transporter slc-17.2-like [KO:K12301]
124113427  sialin-like [KO:K12301]
124114079  sialin-like isoform X1 [KO:K12301]
124114189  uncharacterized transporter slc-17.2-like [KO:K12301]
124114325  sialin-like isoform X1 [KO:K12301]
124114499  sialin-like [KO:K12301]
124139080  uncharacterized transporter slc-17.2-like [KO:K12301]
124148230  sialin-like [KO:K12301]
124129048  sodium-dependent phosphate transport protein 3-like [KO:K12301]
124149493  sialin-like isoform X1 [KO:K12301]
124149494  sialin-like [KO:K12301]
124149495  sialin-like [KO:K12301]
124149496  sialin-like isoform X1 [KO:K12301]
124149590  sialin-like [KO:K12301]
124115493  uncharacterized transporter slc-17.2-like [KO:K12301]
124121570  uncharacterized transporter slc-17.2-like isoform X1 [KO:K12301]
124124330  uncharacterized transporter slc-17.2-like [KO:K12301]
125378591  uncharacterized transporter slc-17.2-like [KO:K12301]
125378855  uncharacterized transporter slc-17.2-like [KO:K12301]
124124328  uncharacterized transporter slc-17.2-like isoform X1 [KO:K12301]
124124329  uncharacterized transporter slc-17.2-like [KO:K12301]
124142632  natural resistance-associated macrophage protein 2-like [KO:K21398]
124135877  metal transporter nramp1 homolog isoform X1 [KO:K21398]
124125949  lysosomal-associated transmembrane protein 4A-like isoform X1 [KO:K12387]
124142830  ATP-binding cassette sub-family A member 2-like isoform X1 [KO:K05642]
124135219  ABC-type oligopeptide transporter ABCB9-like [KO:K05656]
124117433  ectonucleoside triphosphate diphosphohydrolase 4-like [KO:K12305] [EC:3.6.1.6]
124133822  sortilin-like [KO:K12388]
124146868  battenin-like [KO:K12389]
124113936  battenin-like isoform X2 [KO:K12389]
124132726  ceroid-lipofuscinosis neuronal protein 5-like [KO:K12390]
124115632  ceroid-lipofuscinosis neuronal protein 5-like [KO:K12390]
124115645  ceroid-lipofuscinosis neuronal protein 5 homolog isoform X1 [KO:K12390]
124115646  ceroid-lipofuscinosis neuronal protein 5-like [KO:K12390]
124115648  ceroid-lipofuscinosis neuronal protein 5-like [KO:K12390]
124143672  major facilitator superfamily domain-containing protein 8-like isoform X1 [KO:K12307]
124132561  heparan-alpha-glucosaminide N-acetyltransferase-like isoform X1 [KO:K10532] [EC:2.3.1.78]
124115624  heparan-alpha-glucosaminide N-acetyltransferase-like [KO:K10532] [EC:2.3.1.78]
124145873  formylglycine-generating enzyme-like [KO:K13444] [EC:1.8.3.7]
124141048  N-acetylglucosamine-1-phosphotransferase subunits alpha/beta-like [KO:K08239] [EC:2.7.8.17]
124151059  N-acetylglucosamine-1-phosphotransferase subunit gamma-like isoform X1 [KO:K10087]
124134411  uncharacterized protein LOC124134411 isoform X1 [KO:K01125] [EC:3.1.4.45]
124110850  multiple epidermal growth factor-like domains protein 10 isoform X1 [KO:K01125] [EC:3.1.4.45]
124137939  N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase-like [KO:K01125] [EC:3.1.4.45]
124140047  N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase-like [KO:K01125] [EC:3.1.4.45]
124140048  N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase-like [KO:K01125] [EC:3.1.4.45]
124112441  cation-independent mannose-6-phosphate receptor-like isoform X1 [KO:K06564]
124152746  cation-dependent mannose-6-phosphate receptor-like [KO:K10089]
124121819  cation-dependent mannose-6-phosphate receptor-like [KO:K10089]
124131017  uncharacterized protein LOC124131017 isoform X1 [KO:K10089]
124140441  cation-dependent mannose-6-phosphate receptor-like isoform X1 [KO:K10089]
124117794  cation-dependent mannose-6-phosphate receptor-like [KO:K10089]
124147654  clathrin light chain B-like isoform X2 [KO:K04645]
124137795  clathrin heavy chain 1 isoform X1 [KO:K04646]
124112224  AP-1 complex subunit gamma-1-like isoform X1 [KO:K12391]
124138723  AP-1 complex subunit beta-1-like [KO:K12392]
124135620  AP-1 complex subunit mu-1 isoform X1 [KO:K12393]
124120884  AP-1 complex subunit sigma-2 isoform X1 [KO:K12394]
124153051  AP-3 complex subunit delta-1-like isoform X1 [KO:K12396]
124119492  AP-3 complex subunit beta-2-like isoform X1 [KO:K12397]
124152780  AP-3 complex subunit mu-2-like isoform X1 [KO:K12398]
124115425  AP-3 complex subunit sigma-1-like [KO:K12399]
124127093  AP-4 complex subunit epsilon-1-like isoform X1 [KO:K12400]
124116335  AP-4 complex subunit beta-1-like [KO:K12401]
124134878  AP-4 complex subunit mu-1-like [KO:K12402]
124137064  AP-4 complex subunit sigma-1-like [KO:K12403]
124139547  ADP-ribosylation factor-binding protein GGA1-like isoform X1 [KO:K12404]
124119164  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
124120398  cell death-inducing p53-target protein 1-like isoform X1 [KO:K19363]
124145839  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
124145840  cell death-inducing p53-target protein 1 homolog [KO:K19363]
124145841  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
124113658  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
124113698  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
124113700  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 10.1038/s41577-021-00626-8 (2021)
DOI:10.1038/s41577-021-00626-8
Related
pathway
hrf00511  Other glycan degradation
hrf00531  Glycosaminoglycan degradation
hrf04130  SNARE interactions in vesicular transport
hrf04140  Autophagy - animal
hrf04144  Endocytosis
KO pathway
ko04142   
LinkDB

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