KEGG   PATHWAY: hsp04914
Entry
hsp04914                    Pathway                                
Name
Progesterone-mediated oocyte maturation - Hippoglossus stenolepis (Pacific halibut)
Description
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Class
Organismal Systems; Endocrine system
Pathway map
hsp04914  Progesterone-mediated oocyte maturation
hsp04914

Other DBs
GO: 0001556
Organism
Hippoglossus stenolepis (Pacific halibut) [GN:hsp]
Gene
118105866  pgr; progesterone receptor [KO:K08556]
118114686  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
118117905  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
118117936  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
118120979  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
118125392  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
118120902  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
118106261  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
118117868  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
118111369  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
118121033  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
118102955  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
118100088  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118118847  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118112070  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
118098029  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
118109156  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
118101535  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
118101536  mapk12b; mitogen-activated protein kinase 12b [KO:K04441] [EC:2.7.11.24]
118110753  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
118111319  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
118111462  zgc:171775; STKc_p38 domain-containing protein isoform X1 [KO:K04441] [EC:2.7.11.24]
118104855  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
118109947  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
118110934  gnai3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
118101688  gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
118104566  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
118104649  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
118118137  adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
118120649  adenylate cyclase type 1 isoform X2 [KO:K08041] [EC:4.6.1.1]
118114339  adcy2a; adenylate cyclase type 2 isoform X2 [KO:K08042] [EC:4.6.1.1]
118125234  adcy2b; adenylate cyclase type 2b isoform X1 [KO:K08042] [EC:4.6.1.1]
118113773  adcy3a; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
118099052  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
118119955  adcy5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
118110500  adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
118110721  adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
118106353  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
118099234  si:dkey-206f10.1; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
118118361  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
118103313  si:ch211-132f19.7; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
118123534  adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
118120272  adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
118123348  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
118123233  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
118117870  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b isoform X1 [KO:K04345] [EC:2.7.11.11]
118121305  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
118105446  aurka; aurora kinase A isoform X1 [KO:K11481] [EC:2.7.11.1]
118122651  cpeb4b; cytoplasmic polyadenylation element-binding protein 4b isoform X1 [KO:K02602]
118118740  cpeb3; cytoplasmic polyadenylation element-binding protein 3 isoform X1 [KO:K02602]
118112059  cytoplasmic polyadenylation element-binding protein 4 isoform X1 [KO:K02602]
118120810  cpeb2; cytoplasmic polyadenylation element-binding protein 2 isoform X1 [KO:K02602]
118119165  cpeb1b; cytoplasmic polyadenylation element-binding protein 1 isoform X2 [KO:K02602]
118116904  spdya; speedy protein A isoform X1 [KO:K08694]
118105369  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
118119385  cdk1; cyclin-dependent kinase 1 isoform X1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
118122266  ccna1; cyclin-A1 [KO:K06627]
118112624  ccna2; cyclin-A2 [KO:K06627]
118098468  mos; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
118099068  hsp90aa1.2; heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2 [KO:K04079]
118099069  hsp90aa1.1; heat shock protein HSP 90-alpha 1 [KO:K04079]
118099876  hsp90ab1; heat shock protein HSP 90-beta isoform X1 [KO:K04079]
118109512  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
118114727  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
118122982  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
118098328  rps6ka3b; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
118109459  ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
118116823  rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X2 [KO:K04373] [EC:2.7.11.1]
118112303  rps6kal; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
118100478  pkmyt1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633] [EC:2.7.11.1]
118098128  ccnb1; G2/mitotic-specific cyclin-B1 isoform X2 [KO:K05868]
118106162  ccnb2; G2/mitotic-specific cyclin-B2 [KO:K21770]
118106347  cyclin N-terminal domain-containing protein 2 [KO:K21770]
118121856  stk10; serine/threonine-protein kinase 10 [KO:K08837] [EC:2.7.11.1]
118098020  plk1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
118116821  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
118112388  insulin [KO:K04526]
118122248  ins; insulin [KO:K04526]
118110683  igf3; insulin-like growth factor 3 [KO:K05459]
118101635  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
118109282  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
118122842  igf1rb; insulin-like growth factor 1b receptor [KO:K05087] [EC:2.7.10.1]
118106240  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118098902  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118121900  RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118116209  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118118965  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118105480  pde3b; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
118109259  kras; GTPase KRas isoform X1 [KO:K07827]
118123859  zgc:55558; GTPase KRas isoform X1 [KO:K07827]
118114645  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
118101548  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
118111456  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
118099287  bub1; mitotic checkpoint serine/threonine-protein kinase BUB1 isoform X1 [KO:K02178] [EC:2.7.11.1]
118123565  mad1l1; mitotic spindle assembly checkpoint protein MAD1 [KO:K06679]
118102231  mad2l1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
118110889  mad2l2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
118121447  fizzy-related protein homolog [KO:K03364]
118118079  fzr1b; fizzy-related protein homolog [KO:K03364]
118118155  fizzy-related protein homolog [KO:K03364]
118119216  anapc1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
118123005  anapc2; anaphase-promoting complex subunit 2 [KO:K03349]
118123700  cdc27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
118120821  anapc4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
118115604  anapc5; anaphase-promoting complex subunit 5 [KO:K03352]
118120277  cdc16; cell division cycle protein 16 homolog [KO:K03353]
118114877  anapc7; anaphase-promoting complex subunit 7 [KO:K03354]
118122406  cdc23; cell division cycle protein 23 homolog [KO:K03355]
118102390  anapc10; anaphase-promoting complex subunit 10 [KO:K03357]
118117826  anapc11; anaphase-promoting complex subunit 11 [KO:K03358]
118125586  cdc26; anaphase-promoting complex subunit CDC26 [KO:K03359]
118110062  anapc13; anaphase-promoting complex subunit 13 [KO:K12456]
118105919  anapc15; anaphase-promoting complex subunit 15 [KO:K25228]
118101016  anapc16; anaphase-promoting complex subunit 16 [KO:K25229]
118100477  kif22; kinesin-like protein KIF22 [KO:K10403]
Compound
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:12045215
  Authors
Schmitt A, Nebreda AR.
  Title
Signalling pathways in oocyte meiotic maturation.
  Journal
J Cell Sci 115:2457-9 (2002)
Reference
PMID:12084906
  Authors
Cato AC, Nestl A, Mink S.
  Title
Rapid actions of steroid receptors in cellular signaling pathways.
  Journal
Sci STKE 2002:RE9 (2002)
DOI:10.1126/stke.2002.138.re9
Reference
PMID:11730319
  Authors
Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
  Title
The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
  Journal
Biol Cell 93:27-33 (2001)
DOI:10.1016/S0248-4900(01)01127-3
Reference
PMID:11063930
  Authors
Nebreda AR, Ferby I.
  Title
Regulation of the meiotic cell cycle in oocytes.
  Journal
Curr Opin Cell Biol 12:666-75 (2000)
DOI:10.1016/S0955-0674(00)00150-2
Reference
PMID:10497333
  Authors
Ferrell JE Jr.
  Title
Xenopus oocyte maturation: new lessons from a good egg.
  Journal
Bioessays 21:833-42 (1999)
DOI:10.1002/(SICI)1521-1878(199910)21:10<833::AID-BIES5>3.0.CO;2-P
Reference
PMID:12374568
  Authors
Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
  Title
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
  Journal
Biochem J 369:227-38 (2003)
DOI:10.1042/BJ20021243
Reference
PMID:12477927
  Authors
Duckworth BC, Weaver JS, Ruderman JV.
  Title
G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
  Journal
Proc Natl Acad Sci U S A 99:16794-9 (2002)
DOI:10.1073/pnas.222661299
Reference
PMID:11148128
  Authors
Abrieu A, Doree M, Fisher D.
  Title
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
  Journal
J Cell Sci 114:257-67 (2001)
Related
pathway
hsp04010  MAPK signaling pathway
hsp04110  Cell cycle
KO pathway
ko04914   
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