KEGG   PATHWAY: hsp04010
Entry
hsp04010                    Pathway                                
Name
MAPK signaling pathway - Hippoglossus stenolepis (Pacific halibut)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
hsp04010  MAPK signaling pathway
hsp04010

Other DBs
GO: 0000165
Organism
Hippoglossus stenolepis (Pacific halibut) [GN:hsp]
Gene
118123248  cacna1aa; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
118098171  cacna1ab; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b [KO:K04344]
118125577  cacna1bb; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
118115325  cacna1ba; calcium channel, voltage-dependent, N type, alpha 1B subunit, a [KO:K04849]
118101730  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
118111329  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
118105190  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a [KO:K04851]
118121388  voltage-dependent R-type calcium channel subunit alpha-1E isoform X2 [KO:K04852]
118118210  voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
118111219  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04853]
118111156  cacna1fb; LOW QUALITY PROTEIN: calcium channel, voltage-dependent, L type, alpha 1F subunit [KO:K04853]
118100800  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
118123622  cacna1ha; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04855]
118123791  LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
118100681  voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
118111041  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1 isoform X1 [KO:K04857]
118102011  cacna2d1a; voltage-dependent calcium channel subunit alpha-2/delta-1a [KO:K04858]
118109924  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
118104804  cacna2d2a; voltage-dependent calcium channel subunit alpha-2/delta-2a isoform X1 [KO:K04859]
118105519  voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
118105527  cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
118110695  cacna2d3a; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
118109202  cacna2d4b; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
118101855  cacna2d4a; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
118122938  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
118098850  cacnb2a; voltage-dependent L-type calcium channel subunit beta-2a isoform X1 [KO:K04863]
118110502  voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
118111577  cacnb3b; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04864]
118103622  voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
118120030  cacnb4a; voltage-dependent L-type calcium channel subunit beta-4a isoform X1 [KO:K04865]
118123296  cacng1b; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
118118121  voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
118115639  voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
118123852  cacng2a; calcium channel, voltage-dependent, gamma subunit 2a [KO:K04867]
118121901  cacng3a; voltage-dependent calcium channel gamma-3 subunit isoform X1 [KO:K04868]
118123259  cacng3b; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
118123295  cacng4b; calcium channel, voltage-dependent, gamma subunit 4b [KO:K04869]
118118112  voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
118115155  cacng5a; calcium channel, voltage-dependent, gamma subunit 5a [KO:K04870]
118123504  cacng5b; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
118113231  cacng6b; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
118124651  voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
118113224  cacng7b; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
118124637  cacng7a; calcium channel, voltage-dependent, gamma subunit 7a [KO:K04872]
118113211  cacng8b; voltage-dependent calcium channel gamma-4 subunit [KO:K04873]
118124621  voltage-dependent calcium channel gamma-4 subunit [KO:K04873]
118123348  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
118123233  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
118117870  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b isoform X1 [KO:K04345] [EC:2.7.11.11]
118121305  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
118117698  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
118123848  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
118121712  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
118123258  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
118113177  prkcg; protein kinase C alpha type [KO:K19663] [EC:2.7.11.13]
118123197  gna12a; guanine nucleotide-binding protein subunit alpha-12a [KO:K04346]
118123551  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04347]
118118268  gng12a; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12a [KO:K04347]
118121005  gng12b; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 isoform X1 [KO:K04347]
118115697  ppp3cca; protein phosphatase 3, catalytic subunit, gamma isozyme, a isoform X1 [KO:K04348] [EC:3.1.3.16]
118121862  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118102577  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118112713  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118125882  ppp3ccb; protein phosphatase 3, catalytic subunit, gamma isozyme, b isoform X1 [KO:K04348] [EC:3.1.3.16]
118122573  ppp3r1b; calcineurin subunit B type 1b [KO:K06268]
118118945  calcineurin subunit B type 1 isoform X1 [KO:K06268]
118108083  ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
118110131  rasgrf1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
118115683  rasgrf2b; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
118125732  rasgrf2a; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
118116799  RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
118105835  rasgrp4; RAS guanyl-releasing protein 4 isoform X1 [KO:K04350]
118102494  RAS guanyl-releasing protein 2 [KO:K12361]
118118849  rasgrp3; LOW QUALITY PROTEIN: ras guanyl-releasing protein 3 [KO:K12362]
118111870  rapgef2b; rap guanine nucleotide exchange factor 2 isoform X2 [KO:K08018]
118105857  neurofibromin isoform X1 [KO:K08052]
118115046  ras GTPase-activating protein 1 isoform X1 [KO:K04352]
118106054  rasa2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
118111396  ras-related protein Rap-1A [KO:K04353]
118104695  ras-related protein Rap-1A [KO:K04353]
118101522  ras-related protein Rap-1b [KO:K07836]
118111983  egf; pro-epidermal growth factor [KO:K04357]
118102353  tgfa; protransforming growth factor alpha isoform X1 [KO:K08774]
118115213  proepiregulin-like [KO:K09784]
118121838  putative fibroblast growth factor 1 isoform X1 [KO:K18496]
118112587  fgf1a; putative fibroblast growth factor 1 [KO:K18496]
118112066  fgf2; fibroblast growth factor 2 [KO:K18497]
118106232  fgf4; fibroblast growth factor 4 [KO:K04358]
118115271  fibroblast growth factor 10 [KO:K04358]
118115524  fgf5; fibroblast growth factor 5 [KO:K04358]
118115888  fibroblast growth factor 20 [KO:K04358]
118109164  fibroblast growth factor 6 isoform X1 [KO:K04358]
118122925  fgf8b; fibroblast growth factor 8b [KO:K04358]
118109980  fgf7; fibroblast growth factor 7 [KO:K04358]
118110450  fgf3; fibroblast growth factor 3 [KO:K04358]
118101428  fibroblast growth factor 6 [KO:K04358]
118111822  fgf24; fibroblast growth factor 24 isoform X1 [KO:K04358]
118111848  fibroblast growth factor 4 [KO:K04358]
118119111  fgf8a; fibroblast growth factor 8 [KO:K04358]
118112347  fgf20b; fibroblast growth factor 20b [KO:K04358]
118112703  fgf18a; fibroblast growth factor 18a [KO:K04358]
118112796  fgf16; fibroblast growth factor 16 [KO:K04358]
118114560  fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
118125424  fgf10a; fibroblast growth factor 10a [KO:K04358]
118120343  fgf9; fibroblast growth factor 4A [KO:K04358]
124854749  fgf22; fibroblast growth factor 22 [KO:K04358]
124851964  fgf19; fibroblast growth factor 19 [KO:K22603]
118100363  fgf21; fibroblast growth factor 21 [KO:K22429]
118109163  fibroblast growth factor 23 [KO:K22428]
118101426  fgf23; fibroblast growth factor 23 [KO:K22428]
118110421  ngfa; neurotrophin-7 [KO:K02582]
118104764  ngfb; nerve growth factor [KO:K02582]
118109813  bdnf; brain-derived neurotrophic factor isoform X1 [KO:K04355]
118101944  ntf3; neurotrophin-3 [KO:K04356]
118112388  insulin [KO:K04526]
118122248  ins; insulin [KO:K04526]
118110683  igf3; insulin-like growth factor 3 [KO:K05459]
118101635  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
118109885  igf2b; insulin-like growth factor 2b isoform X1 [KO:K13769]
118123505  pdgfab; platelet-derived growth factor alpha polypeptide b [KO:K04359]
118115566  platelet-derived growth factor subunit A [KO:K04359]
118124023  si:ch211-79m20.1; uncharacterized protein DDB_G0271670 [KO:K17386]
118112805  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
118106220  pdgfd; platelet-derived growth factor D [KO:K05450]
118109891  kitlga; kit ligand a isoform X1 [KO:K05461]
118101784  uncharacterized protein LOC118101784 [KO:K05461]
118099307  vegfab; LOW QUALITY PROTEIN: vascular endothelial growth factor Ab [KO:K05448]
118111819  vegfba; vascular endothelial growth factor A [KO:K05448]
118099951  pgfa; vascular endothelial growth factor A isoform X1 [KO:K16859]
118116899  pgfb; placenta growth factor [KO:K16859]
118118972  vegfc; vascular endothelial growth factor C [KO:K05449]
118103589  vascular endothelial growth factor C [KO:K05449]
118114054  vegfd; vascular endothelial growth factor D [KO:K05449]
118110071  hepatocyte growth factor [KO:K05460]
118101930  hgfa; hepatocyte growth factor a isoform X1 [KO:K05460]
118101931  angpt4; angiopoietin-4 [KO:K05465]
118124865  angpt1; angiopoietin-1 [KO:K05465]
118119056  angpt2a; angiopoietin-2a [KO:K05466]
118124321  angpt2b; angiopoietin-2b [KO:K05466]
118115131  efna5b; ephrin-A5b isoform X1 [KO:K05462]
118116266  efna2a; ephrin-A2 isoform X1 [KO:K05462]
118114038  efna1b; ephrin-A1b [KO:K05462]
118114174  si:dkey-246i14.3; ephrin-A4 [KO:K05462]
118120639  ephrin-A2 [KO:K05462]
118114319  efna3b; ephrin-A3b [KO:K05462]
118124354  efna3a; ephrin-A3 isoform X1 [KO:K05462]
118125186  efna1a; ephrin-A1a isoform X1 [KO:K05462]
118125671  ephrin-A5b [KO:K05462]
118115291  gdnfb; glial cell line-derived neurotrophic factor [KO:K05452]
118125423  gdnfa; glial cell line-derived neurotrophic factor [KO:K05452]
118117992  neurturin [KO:K25414]
118117987  uncharacterized protein LOC118117987 [KO:K25415]
118121186  neurturin [KO:K25415]
118117797  persephin [KO:K25416]
118098524  melanoma receptor tyrosine-protein kinase isoform X1 [KO:K04361] [EC:2.7.10.1]
118117214  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
118100226  erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
118111348  erbb3b; receptor tyrosine-protein kinase erbB-3b [KO:K05084] [EC:2.7.10.1]
118104849  erbb3a; receptor tyrosine-protein kinase erbB-3a [KO:K05084] [EC:2.7.10.1]
118103181  LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
118120013  receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
118114999  fgfr1a; fibroblast growth factor receptor 1-A isoform X1 [KO:K04362] [EC:2.7.10.1]
118126069  fgfr1b; fibroblast growth factor receptor 1b [KO:K04362] [EC:2.7.10.1]
118118851  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
118105710  si:ch211-167j9.5; tyrosine kinase receptor Cad96Ca isoform X1 [KO:K05093] [EC:2.7.10.1]
118116294  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
118122084  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
118100798  ngfrb; nerve growth factor receptor b [KO:K02583]
118114236  nradd; tumor necrosis factor receptor superfamily member 16 isoform X1 [KO:K02583]
118123890  ngfra; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
118113983  ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
118114803  ntrk2a; neurotrophic tyrosine kinase, receptor, type 2a isoform X1 [KO:K04360] [EC:2.7.10.1]
118125518  ntrk2b; neurotrophic tyrosine kinase, receptor, type 2b [KO:K04360] [EC:2.7.10.1]
118118019  insra; insulin receptor a isoform X1 [KO:K04527] [EC:2.7.10.1]
118120869  insrb; insulin receptor b [KO:K04527] [EC:2.7.10.1]
118109282  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
118122842  igf1rb; insulin-like growth factor 1b receptor [KO:K05087] [EC:2.7.10.1]
118121006  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
118122120  platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
118112689  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
118122375  csf1rb; macrophage colony-stimulating factor 1 receptor 2 [KO:K05090] [EC:2.7.10.1]
118112690  csf1ra; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
118101384  kitb; KIT proto-oncogene, receptor tyrosine kinase b isoform X1 [KO:K05091] [EC:2.7.10.1]
118121339  kita; mast/stem cell growth factor receptor kita isoform X1 [KO:K05091] [EC:2.7.10.1]
118098887  flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
118098302  flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
118112191  kdrl; vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
118111966  flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
118121175  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
118109571  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
118111020  epha2b; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
118105283  epha2a; ephrin type-A receptor 2a [KO:K05103] [EC:2.7.10.1]
118119412  ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X2 [KO:K05126] [EC:2.7.10.1]
118123567  grb2b; growth factor receptor-bound protein 2b isoform X1 [KO:K04364]
118116998  sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
118120279  LOW QUALITY PROTEIN: son of sevenless homolog 1-like [KO:K03099]
118109904  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
118109259  kras; GTPase KRas isoform X1 [KO:K07827]
118123859  zgc:55558; GTPase KRas isoform X1 [KO:K07827]
118104419  rras2; ras-related protein R-Ras2 [KO:K07830]
118119875  mrasa; ras-related protein M-Ras [KO:K07831]
118114645  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
118101548  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
118111456  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
118109512  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
124854736  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
118116275  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
118114727  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
118122982  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
118120705  mknk2b; MAP kinase-interacting serine/threonine-protein kinase 2b [KO:K04372] [EC:2.7.11.1]
124854779  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
118098328  rps6ka3b; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
118109459  ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
118116823  rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X2 [KO:K04373] [EC:2.7.11.1]
118112303  rps6kal; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
118116537  atf4a; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
118124024  atf4b; activating transcription factor 4b [KO:K04374]
118111080  elk1; ETS domain-containing protein Elk-3 isoform X1 [KO:K04375]
118104751  elk4; ETS domain-containing protein Elk-4 isoform X1 [KO:K04376]
118098820  myca; transcriptional regulator Myc-A [KO:K04377]
118104858  mych; myelocytomatosis oncogene homolog [KO:K04377]
118118918  srfb; serum response factor b isoform X1 [KO:K04378]
118119507  serum response factor isoform X1 [KO:K04378]
118099879  protein c-Fos [KO:K04379]
118099880  protein c-Fos [KO:K04379]
118116885  fosaa; protein c-Fos [KO:K04379]
118100853  mapta; microtubule-associated protein tau isoform X1 [KO:K04380]
118114234  stathmin-like [KO:K04381]
118114235  stathmin [KO:K04381]
118125166  stmn1a; stathmin 1a [KO:K04381]
118121107  pla2g4ab; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
118123623  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
124854941  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
124854942  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
118115136  interleukin-1 beta [KO:K04519]
118105944  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
118112176  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
118113442  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
118099356  transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
118116105  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
118113213  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
118119887  interleukin-1 receptor type 1 [KO:K04386]
118106494  LOW QUALITY PROTEIN: interleukin-1 receptor accessory protein [KO:K04723]
118098266  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
118119939  tgfbr2l; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
118113748  TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
118124881  TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
118111865  cd40lg; CD40 ligand [KO:K04389]
118121152  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
118119490  fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
118100454  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
118123944  rac1b; ras-related C3 botulinum toxin substrate 1b [KO:K04392]
118124698  rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
118123199  rac3a; ras-related C3 botulinum toxin substrate 3a [KO:K07861]
118100767  ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
118110581  cell division control protein 42 homolog isoform X1 [KO:K04393]
118104534  cell division control protein 42 homolog isoform X1 [KO:K04393]
118113252  cdc42l; cell division cycle 42, like [KO:K04393]
118124665  cell division control protein 42 homolog [KO:K04393]
118109955  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
118112335  caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
118112812  LOW QUALITY PROTEIN: caspase-3 [KO:K02187] [EC:3.4.22.56]
118125353  casp3a; caspase-3a [KO:K02187] [EC:3.4.22.56]
118115649  traf2a; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
118098034  TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
118125819  traf2b; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
118103786  daxx; death domain-associated protein 6 [KO:K02308]
118098776  myd88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
118111658  irak1; LOW QUALITY PROTEIN: interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
118109649  irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
118106693  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
118098216  gadd45gb.1; growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1 [KO:K04402]
118098217  growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
118115579  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
118115882  growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
118118323  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
118121000  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
118121018  growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
118124569  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
118099163  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
118102986  ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
118119106  map4k3a; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
118112089  si:zfos-2326c3.2; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
118103379  mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
118120436  mitogen-activated protein kinase kinase kinase kinase 4 isoform X2 [KO:K04407] [EC:2.7.11.1]
118106526  pak1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
118115912  serine/threonine-protein kinase PAK 2 isoform X1 [KO:K04410] [EC:2.7.11.1]
118121065  pak2b; serine/threonine-protein kinase PAK 2b [KO:K04410] [EC:2.7.11.1]
118104803  serine/threonine-protein kinase 4 [KO:K04411]
118124989  stk3; serine/threonine-protein kinase 3 [KO:K04412]
118102591  map4k2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
118098891  map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
118102482  mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
118103322  map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
118098509  map3k22; mitogen-activated protein kinase kinase kinase 22 [KO:K04421] [EC:2.7.11.25]
118123588  map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
118116148  map3k9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
118106588  map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
118119529  map3k21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
118110865  map3k12; mitogen-activated protein kinase kinase kinase 12 isoform X2 [KO:K04423] [EC:2.7.11.25]
118105499  mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
118120283  si:ch211-45c16.2; mitogen-activated protein kinase kinase kinase 13 isoform X1 [KO:K04422] [EC:2.7.11.25]
118117617  mitogen-activated protein kinase kinase kinase 21 [KO:K04424] [EC:2.7.11.25]
118120336  zak; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
118099367  map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
118113345  si:ch211-1i11.3; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
118099311  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
118116505  mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
118119073  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
118106094  taok1a; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
118122424  taok1b; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
118114591  taok3a; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
118123961  taok2a; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
118100411  taok2b; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
118125355  taok3b; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
118123140  map2k4a; dual specificity mitogen-activated protein kinase kinase 4a isoform X1 [KO:K04430] [EC:2.7.12.2]
118101068  map2k4b; dual specificity mitogen-activated protein kinase kinase 4b isoform X1 [KO:K04430] [EC:2.7.12.2]
118117141  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
118123527  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
118100279  map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
118109052  mapk8ip1a; C-Jun-amino-terminal kinase-interacting protein 1a [KO:K04434]
118112083  mapk8ip1b; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
118109698  mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
118123771  mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
118110670  flna; filamin-A isoform X1 [KO:K04437]
118106304  crk; adapter molecule crk isoform X1 [KO:K04438]
118121874  adapter molecule crk [KO:K04438]
118125678  crkl; crk-like protein [KO:K04438]
118106000  arrb1; beta-arrestin-1 isoform X1 [KO:K04439]
118122185  arrb2a; arrestin, beta 2a isoform X1 [KO:K04439]
118100088  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118118847  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118112070  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
118098029  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
118109156  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
118101535  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
118101536  mapk12b; mitogen-activated protein kinase 12b [KO:K04441] [EC:2.7.11.24]
118110753  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
118111319  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
118111462  zgc:171775; STKc_p38 domain-containing protein isoform X1 [KO:K04441] [EC:2.7.11.24]
118104855  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
118115562  mapkapk5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
118104584  mapkapk2a; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
118104912  mapkapk3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
118105351  MAP kinase-activated protein kinase 2 [KO:K04444] [EC:2.7.11.1]
118116345  rps6ka5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
118122122  rps6ka4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
118116821  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
118114042  nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
118125071  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
118109638  nfatc3b; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
118110108  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
118121433  jun; transcription factor AP-1 [KO:K04448]
118117519  transcription factor Jun [KO:K04448]
118125425  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
118117913  transcription factor JunD [KO:K04449]
118120614  transcription factor JunD [KO:K04449]
118120014  atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
118102319  tp53; cellular tumor antigen p53 [KO:K04451]
118103780  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
118099471  max; protein max isoform X1 [KO:K04453]
118116721  protein max isoform X1 [KO:K04453]
118115619  mef2cb; myocyte enhancer factor 2cb isoform X1 [KO:K04454]
118125722  myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
118121821  hspb1; heat shock protein beta-1 [KO:K04455]
118125928  heat shock protein beta-1 [KO:K04455]
118106240  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118098902  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118121900  RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118116209  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118118965  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118106398  ppm1na; protein phosphatase, Mg2+/Mn2+ dependent, 1Na (putative) isoform X1 [KO:K04457] [EC:3.1.3.16]
118121841  ppm1nb; protein phosphatase, Mg2+/Mn2+ dependent, 1Nb (putative) [KO:K04457] [EC:3.1.3.16]
118116889  ppm1aa; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
118101596  ptprr; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
118109097  ptpn5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
118110392  tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
118112328  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
118098142  dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
118115695  dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
118109199  dusp8a; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
118102005  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
118111477  dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
118104760  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
118124346  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
118109343  dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
118099270  dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
118123595  dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
118100183  dusp3a; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
118106689  ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
118100190  ppm1bb; protein phosphatase 1bb isoform X1 [KO:K04461] [EC:3.1.3.16]
118118910  ppm1ba; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
118121919  heat shock cognate 71 kDa protein [KO:K03283]
118121978  heat shock cognate 71 kDa protein [KO:K03283]
118110396  LOW QUALITY PROTEIN: heat shock 70 kDa protein [KO:K03283]
118110398  LOW QUALITY PROTEIN: heat shock 70 kDa protein [KO:K03283]
118111103  LOW QUALITY PROTEIN: heat shock 70 kDa protein [KO:K03283]
118113603  heat shock cognate 71 kDa protein [KO:K03283]
118125940  heat shock cognate 70 kDa protein [KO:K03283]
118106548  mecom; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
118107267  map2k5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
118101055  mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
118110808  nr4a1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
118104857  probable nuclear hormone receptor HR38 [KO:K04465]
118100220  mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
118123057  map3k14a; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
118100852  inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
118118677  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
118114623  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
118110546  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
118123470  nlk1; nemo-like kinase, type 1 [KO:K04468] [EC:2.7.11.24]
118111826  nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
118118888  nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
118102445  rela; transcription factor p65 isoform X1 [KO:K04735]
118106191  relb; transcription factor p65 isoform X1 [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
hsp04070  Phosphatidylinositol signaling system
hsp04110  Cell cycle
hsp04115  p53 signaling pathway
hsp04210  Apoptosis
hsp04310  Wnt signaling pathway
KO pathway
ko04010   
LinkDB

DBGET integrated database retrieval system