KEGG   PATHWAY: leri04914
Entry
leri04914                   Pathway                                
Name
Progesterone-mediated oocyte maturation - Leucoraja erinacea (little skate)
Description
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Class
Organismal Systems; Endocrine system
Pathway map
leri04914  Progesterone-mediated oocyte maturation
leri04914

Other DBs
GO: 0001556
Organism
Leucoraja erinacea (little skate) [GN:leri]
Gene
129698283  progesterone receptor-like [KO:K08556]
129695104  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
129700904  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
129703732  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
129711734  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
129712993  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
129701740  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
129699899  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
129707782  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
129707783  mapk11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
129704781  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
129708685  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
129708686  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
129708880  guanine nucleotide-binding protein G(i) subunit alpha-3-like [KO:K04630]
129707792  gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
129693758  guanine nucleotide-binding protein G(i) subunit alpha-1-like [KO:K04630]
129704748  guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
129710284  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
129705029  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08042] [EC:4.6.1.1]
129711549  LOW QUALITY PROTEIN: adenylate cyclase type 2-like [KO:K08042] [EC:4.6.1.1]
129699833  LOW QUALITY PROTEIN: adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
129699122  adcy5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
129696342  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
129699829  adenylate cyclase type 8-like [KO:K08048] [EC:4.6.1.1]
129706900  adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
129700701  LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit beta-like [KO:K04345] [EC:2.7.11.11]
129714364  LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
129707417  aurora kinase C-like isoform X1 [KO:K11481] [EC:2.7.11.1]
129713298  cytoplasmic polyadenylation element-binding protein 2-like isoform X1 [KO:K02602]
129701635  cpeb4b; cytoplasmic polyadenylation element-binding protein 4b isoform X1 [KO:K02602]
129713534  cpeb1a; cytoplasmic polyadenylation element-binding protein 1a isoform X1 [KO:K02602]
129699167  cpeb2; cytoplasmic polyadenylation element-binding protein 2 isoform X1 [KO:K02602]
129703915  cpeb3; cytoplasmic polyadenylation element-binding protein 3 [KO:K02602]
129697618  spdya; speedy protein A isoform X1 [KO:K08694]
129715394  speedy protein 1-A-like [KO:K08694]
129698561  cyclin-dependent kinase 2-like isoform X1 [KO:K02206] [EC:2.7.11.22]
129714694  cdk2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
129704234  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
129698012  ccna1; cyclin-A1 [KO:K06627]
129704173  ccna2; cyclin-A2 [KO:K06627]
129696282  mos; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
129697595  hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
129700542  heat shock protein HSP 90-alpha [KO:K04079]
129712705  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
129709053  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
129702007  rps6kal; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
129709814  rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
129702861  ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
129699863  rps6ka2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
129693452  ribosomal protein S6 kinase alpha-2-like [KO:K04373] [EC:2.7.11.1]
129695062  G2/mitotic-specific cyclin-B1-like isoform X1 [KO:K05868]
129695077  ccnb1; G2/mitotic-specific cyclin-B1 isoform X1 [KO:K05868]
129712632  ccnb2; G2/mitotic-specific cyclin-B2 isoform X1 [KO:K21770]
129694007  G2/mitotic-specific cyclin-B3-like isoform X1 [KO:K21771]
129701668  stk10; serine/threonine-protein kinase 10 isoform X1 [KO:K08837] [EC:2.7.11.1]
129706803  plk1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
129702058  cdc25b; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
129701462  M-phase inducer phosphatase 1-B-like isoform X1 [KO:K05867] [EC:3.1.3.48]
129705839  insulin-like isoform X1 [KO:K04526]
129708784  insulin-like growth factor I [KO:K05459]
129706324  igf1; insulin-like growth factor I [KO:K05459]
129713499  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
129699479  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
129714205  LOW QUALITY PROTEIN: RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
129705951  pde3b; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform X1 [KO:K13296] [EC:3.1.4.17]
129694991  GTPase HRas-like [KO:K07827]
129707662  GTPase KRas isoform X1 [KO:K07827]
129706249  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
129704842  raf1b; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
129693871  bub1; mitotic checkpoint serine/threonine-protein kinase BUB1 [KO:K02178] [EC:2.7.11.1]
129706834  mad1l1; mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679]
129700213  mad2l1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
129711551  mad2l2; mitotic spindle assembly checkpoint protein MAD2B isoform X1 [KO:K13728]
129711164  fzr1a; fizzy/cell division cycle 20 related 1a isoform X1 [KO:K03364]
129700913  fizzy-related protein homolog isoform X1 [KO:K03364]
129697538  anapc1; LOW QUALITY PROTEIN: anaphase-promoting complex subunit 1 [KO:K03348]
129712174  anapc2; anaphase-promoting complex subunit 2 [KO:K03349]
129710250  cdc27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
129698771  anapc4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
129709403  anapc5; anaphase-promoting complex subunit 5 [KO:K03352]
129697905  cdc16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
129709410  anapc7; anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
129701390  cdc23; cell division cycle protein 23 homolog [KO:K03355]
129703596  anapc10; anaphase-promoting complex subunit 10 [KO:K03357]
129708285  anapc11; anaphase-promoting complex subunit 11 [KO:K03358]
129712152  cdc26; anaphase-promoting complex subunit CDC26 isoform X1 [KO:K03359]
129712312  anapc13; anaphase-promoting complex subunit 13 [KO:K12456]
129694774  anapc15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
129712949  anapc16; anaphase-promoting complex subunit 16 [KO:K25229]
Compound
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:12045215
  Authors
Schmitt A, Nebreda AR.
  Title
Signalling pathways in oocyte meiotic maturation.
  Journal
J Cell Sci 115:2457-9 (2002)
Reference
PMID:12084906
  Authors
Cato AC, Nestl A, Mink S.
  Title
Rapid actions of steroid receptors in cellular signaling pathways.
  Journal
Sci STKE 2002:RE9 (2002)
DOI:10.1126/stke.2002.138.re9
Reference
PMID:11730319
  Authors
Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
  Title
The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
  Journal
Biol Cell 93:27-33 (2001)
DOI:10.1016/S0248-4900(01)01127-3
Reference
PMID:11063930
  Authors
Nebreda AR, Ferby I.
  Title
Regulation of the meiotic cell cycle in oocytes.
  Journal
Curr Opin Cell Biol 12:666-75 (2000)
DOI:10.1016/S0955-0674(00)00150-2
Reference
PMID:10497333
  Authors
Ferrell JE Jr.
  Title
Xenopus oocyte maturation: new lessons from a good egg.
  Journal
Bioessays 21:833-42 (1999)
DOI:10.1002/(SICI)1521-1878(199910)21:10<833::AID-BIES5>3.0.CO;2-P
Reference
PMID:12374568
  Authors
Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
  Title
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
  Journal
Biochem J 369:227-38 (2003)
DOI:10.1042/BJ20021243
Reference
PMID:12477927
  Authors
Duckworth BC, Weaver JS, Ruderman JV.
  Title
G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
  Journal
Proc Natl Acad Sci U S A 99:16794-9 (2002)
DOI:10.1073/pnas.222661299
Reference
PMID:11148128
  Authors
Abrieu A, Doree M, Fisher D.
  Title
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
  Journal
J Cell Sci 114:257-67 (2001)
Related
pathway
leri04010  MAPK signaling pathway
leri04110  Cell cycle
KO pathway
ko04914   
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