KEGG   PATHWAY: leri04010
Entry
leri04010                   Pathway                                
Name
MAPK signaling pathway - Leucoraja erinaceus (little skate)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
leri04010  MAPK signaling pathway
leri04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Leucoraja erinaceus (little skate) [GN:leri]
Gene
129693452  [KO:K04373] [EC:2.7.11.1]
129693903  [KO:K03173] [EC:2.3.2.27]
129694094  [KO:K04358]
129694103  [KO:K07830]
129694202  [KO:K03173] [EC:2.3.2.27]
129694318  vegfc; vascular endothelial growth factor C [KO:K05449]
129694413  rasgrf2b; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
129694443  [KO:K20216] [EC:3.1.3.16 3.1.3.48]
129694513  [KO:K03176] [EC:2.7.10.1]
129694559  [KO:K12361]
129694573  [KO:K04419] [EC:2.7.11.25]
129694589  [KO:K03156]
129694591  [KO:K03156]
129694871  [KO:K04464] [EC:2.7.11.24]
129694991  [KO:K07827]
129695189  map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
129695204  [KO:K03283]
129695205  [KO:K03283]
129695206  [KO:K03283]
129695207  [KO:K03283]
129695208  [KO:K03283]
129695210  [KO:K03283]
129695247  casp3b; caspase-3b [KO:K02187] [EC:3.4.22.56]
129695591  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
129695693  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
129695733  ntrk2a; neurotrophic tyrosine kinase, receptor, type 2a [KO:K04360] [EC:2.7.10.1]
129695851  efna5b; ephrin-A5b isoform X1 [KO:K05462]
129695914  [KO:K04454]
129695918  rasa1a; LOW QUALITY PROTEIN: ras GTPase-activating protein 1 [KO:K04352]
129696052  stk3; LOW QUALITY PROTEIN: serine/threonine-protein kinase 3 [KO:K04412]
129696171  fgf10a; fibroblast growth factor 10a [KO:K04358]
129696539  map3k1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
129696581  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
129696623  [KO:K05465]
129696667  nfatc1; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
129696705  [KO:K04377]
129697210  [KO:K04358]
129697362  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
129697414  [KO:K04426] [EC:2.7.11.25]
129697451  kita; mast/stem cell growth factor receptor kita isoform X1 [KO:K05091] [EC:2.7.10.1]
129697462  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
129697505  srfb; serum response factor b isoform X1 [KO:K04378]
129697528  [KO:K05466]
129697560  [KO:K05448]
129698054  flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
129698058  flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
129698093  [KO:K04358]
129698144  pdgfd; platelet-derived growth factor D [KO:K05450]
129698190  [KO:K04386]
129698191  [KO:K04386]
129698193  [KO:K04407] [EC:2.7.11.1]
129698608  tgfbr2l; LOW QUALITY PROTEIN: TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
129698729  atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
129698743  [KO:K04424] [EC:2.7.11.25]
129698871  [KO:K04422] [EC:2.7.11.25]
129698887  [KO:K05085] [EC:2.7.10.1]
129699085  cacnb4a; voltage-dependent L-type calcium channel subunit beta-4a isoform X1 [KO:K04865]
129699105  [KO:K07831]
129699240  [KO:K06268]
129699346  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
129699438  map3k21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
129699479  [KO:K04456] [EC:2.7.11.1]
129699489  rasgrp3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
129699513  [KO:K03099]
129699516  map4k3a; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
129699539  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
129699648  ppm1ba; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
129699713  tgfb2; LOW QUALITY PROTEIN: transforming growth factor beta-2 proprotein [KO:K13376]
129699758  dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
129699782  [KO:K04445] [EC:2.7.11.1]
129699863  rps6ka2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
129699899  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
129700030  fgf5; fibroblast growth factor 5 [KO:K04358]
129700049  rps6ka5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
129700076  [KO:K03283]
129700089  tgfb3; LOW QUALITY PROTEIN: transforming growth factor beta-3 proprotein [KO:K13377]
129700096  [KO:K04379]
129700122  ppm1aa; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
129700327  [KO:K04350]
129700357  max; protein max isoform X1 [KO:K04453]
129700386  map3k9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
129700513  [KO:K16342] [EC:3.1.1.4]
129700521  sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
129700550  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
129700701  [KO:K04345] [EC:2.7.11.11]
129700817  [KO:K25415]
129700825  [KO:K04372] [EC:2.7.11.1]
129700980  jun; transcription factor AP-1 [KO:K04448]
129701014  [KO:K04347]
129701016  [KO:K04402]
129701081  [KO:K04852]
129701123  [KO:K16342] [EC:3.1.1.4]
129701294  [KO:K04389]
129701295  [KO:K04389]
129701416  [KO:K04358]
129701474  [KO:K04449]
129701476  [KO:K18496]
129701573  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
129701585  [KO:K05097] [EC:2.7.10.1]
129701586  [KO:K05090] [EC:2.7.10.1]
129701606  [KO:K05095] [EC:2.7.10.1]
129701673  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
129701716  [KO:K04348] [EC:3.1.3.16]
129701740  [KO:K04440] [EC:2.7.11.24]
129701854  [KO:K05449]
129702007  rps6kal; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
129702058  cdc25b; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
129702259  [KO:K02580]
129702294  si:zfos-2326c3.2; mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
129702339  [KO:K04348] [EC:3.1.3.16]
129702370  fgf16; fibroblast growth factor 16 isoform X1 [KO:K04358]
129702861  [KO:K04373] [EC:2.7.11.1]
129702893  ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
129703083  fgf9; fibroblast growth factor 4A [KO:K04358]
129703176  egf; pro-epidermal growth factor [KO:K04357]
129703274  [KO:K04462] [EC:2.1.1.367]
129703297  rasa2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
129703349  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
129703403  [KO:K04723]
129703470  rapgef2b; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
129703482  [KO:K04410] [EC:2.7.11.1]
129703547  [KO:K04439]
129704011  [KO:K05093] [EC:2.7.10.1]
129704083  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
129704176  [KO:K04358]
129704265  [KO:K04390]
129704302  fgf2; fibroblast growth factor 2 [KO:K18497]
129704437  [KO:K04851]
129704444  cacna2d3a; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
129704564  [KO:K04730] [EC:2.7.11.1]
129704584  [KO:K04444] [EC:2.7.11.1]
129704613  cacna2d2a; voltage-dependent calcium channel subunit alpha-2/delta-2a isoform X1 [KO:K04859]
129704714  [KO:K04375]
129704717  kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
129704781  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
129704842  raf1b; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
129704864  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
129705063  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
129705160  tradd; LOW QUALITY PROTEIN: tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
129705559  bdnf; brain-derived neurotrophic factor [KO:K04355]
129705592  fgf19; fibroblast growth factor 19 [KO:K22603]
129705594  fgf4; fibroblast growth factor 4 [KO:K04358]
129705595  fgf3; fibroblast growth factor 3 [KO:K04358]
129705628  mapk8ip1b; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
129705671  kras; GTPase KRas [KO:K02833]
129705827  ptpn5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
129705838  [KO:K13769]
129705839  [KO:K04526]
129705859  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
129705871  traf6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
129705954  rras2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
129706038  met; LOW QUALITY PROTEIN: hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
129706041  [KO:K12361]
129706068  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
129706126  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
129706249  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
129706324  igf1; insulin-like growth factor I [KO:K05459]
129706351  kitlga; kit ligand a isoform X1 [KO:K05461]
129706363  [KO:K21946] [EC:3.1.3.16 3.1.3.48]
129706431  [KO:K04388] [EC:2.7.11.30]
129706489  [KO:K07836]
129706494  irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
129706539  cacna2d4a; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
129706564  [KO:K04458] [EC:3.1.3.48]
129706639  gna12a; guanine nucleotide-binding protein subunit alpha-12a [KO:K04346]
129706817  [KO:K04432] [EC:2.7.12.2]
129706860  [KO:K19662] [EC:2.7.11.13]
129706861  [KO:K04868]
129706939  [KO:K04392]
129706951  [KO:K04359]
129706984  cacna1ha; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
129707051  mapk8ip3; LOW QUALITY PROTEIN: C-Jun-amino-terminal kinase-interacting protein 3 [KO:K04436]
129707322  [KO:K04411]
129707345  angpt4; angiopoietin-1 [KO:K05465]
129707610  [KO:K04863]
129707662  [KO:K07827]
129707715  [KO:K04356]
129707752  [KO:K22428]
129707757  [KO:K05094] [EC:2.7.10.1]
129707782  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
129707783  mapk11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
129707784  [KO:K04858]
129707785  [KO:K05460]
129707854  mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
129708125  [KO:K04430] [EC:2.7.12.2]
129708162  [KO:K02677] [EC:2.7.11.13]
129708163  [KO:K04870]
129708164  cacng4b; calcium channel, voltage-dependent, gamma subunit 4b [KO:K04869]
129708165  [KO:K04866]
129708248  [KO:K04433] [EC:2.7.12.2]
129708296  [KO:K04359]
129708324  [KO:K04364]
129708385  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
129708424  [KO:K07861]
129708658  [KO:K04458] [EC:3.1.3.48]
129708685  [KO:K04441] [EC:2.7.11.24]
129708686  [KO:K04441] [EC:2.7.11.24]
129708776  [KO:K04857]
129708784  [KO:K05459]
129708834  nras; GTPase NRas [KO:K07828]
129708836  rap1aa; RAP1A, member of RAS oncogene family a [KO:K04353]
129708845  elk4; ETS domain-containing protein Elk-4 [KO:K04376]
129708900  [KO:K04358]
129708974  [KO:K04443] [EC:2.7.11.1]
129709053  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
129709153  mapkapk5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
129709296  si:dkey-1k23.3; LOW QUALITY PROTEIN: heat shock protein beta-1 [KO:K04455]
129709302  taok3a; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
129709507  crkl; crk-like protein [KO:K04438]
129709593  [KO:K05466]
129709625  si:ch211-1i11.3; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
129709814  rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
129709844  [KO:K04381]
129709845  [KO:K04381]
129710062  erbb2; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
129710085  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
129710134  egfra; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
129710205  map3k14a; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
129710233  map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
129710248  maptb; microtubule-associated protein tau isoform X1 [KO:K04380]
129710300  dusp3a; dual specificity protein phosphatase 3 isoform X1 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
129710372  [KO:K02583]
129710539  nlk2; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
129710546  nf1a; neurofibromin [KO:K08052]
129710622  crk; adapter molecule crk [KO:K04438]
129710634  si:ch211-167j9.5; tyrosine kinase receptor Cad96Ca isoform X1 [KO:K05093] [EC:2.7.10.1]
129710695  hspb1; heat shock protein beta-1 [KO:K04455]
129710879  [KO:K04429] [EC:2.7.11.1]
129711001  [KO:K25414]
129711038  [KO:K04449]
129711102  [KO:K04527] [EC:2.7.10.1]
129711109  [KO:K04402]
129711161  [KO:K04372] [EC:2.7.11.1]
129711196  mef2b; myocyte-specific enhancer factor 2B [KO:K04454]
129711246  [KO:K04369] [EC:2.7.12.2]
129711320  fgf22; fibroblast growth factor 22 [KO:K04358]
129711361  [KO:K05462]
129711436  cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
129711496  epha2b; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
129711925  cacna1ba; calcium channel, voltage-dependent, N type, alpha 1B subunit, a [KO:K04849]
129711946  [KO:K03173] [EC:2.3.2.27]
129712322  [KO:K03283]
129712323  [KO:K03283]
129712566  fgf7; fibroblast growth factor 7 isoform X1 [KO:K04358]
129712705  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
129712710  rasgrf1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
129712735  map2k5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
129712925  chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
129712934  ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
129712993  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
129713055  [KO:K04348] [EC:3.1.3.16]
129713066  [KO:K04469]
129713207  [KO:K04362] [EC:2.7.10.1]
129713287  [KO:K04358]
129713340  [KO:K08774]
129713347  [KO:K04358]
129713358  [KO:K04348] [EC:3.1.3.16]
129713371  ikbkb; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
129713374  [KO:K03158]
129713422  [KO:K04519]
129713499  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
129713705  cacna1ia; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
129713738  [KO:K17386]
129713740  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
129713780  [KO:K13769]
129713811  [KO:K04867]
129713924  [KO:K04374]
129713948  [KO:K04392]
129713949  [KO:K04392]
129713961  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
129714006  [KO:K12457]
129714105  ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
129714108  [KO:K09253]
129714134  map3k10; mitogen-activated protein kinase kinase kinase 10 isoform X1 [KO:K04418] [EC:2.7.11.25]
129714196  [KO:K13377]
129714205  [KO:K04456] [EC:2.7.11.1]
129714208  [KO:K16859]
129714274  rasgrp4; RAS guanyl-releasing protein 4 [KO:K04350]
129714364  [KO:K04345] [EC:2.7.11.11]
129714404  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
129714421  [KO:K04344]
129714424  [KO:K25415]
129714627  [KO:K04465]
129714732  [KO:K05085] [EC:2.7.10.1]
129714868  [KO:K02583]
129714999  pak1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
129715107  [KO:K04439]
129715114  map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
129715132  [KO:K04421] [EC:2.7.11.25]
129715134  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
129715159  [KO:K04358]
129715263  daxx; death domain-associated protein 6 isoform X1 [KO:K02308]
129715694  [KO:K04389]
129715850  [KO:K04414] [EC:2.7.11.1]
129715888  [KO:K03156]
129715978  [KO:K04439]
129716210  irak1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
leri04070  Phosphatidylinositol signaling system
leri04110  Cell cycle
leri04115  p53 signaling pathway
leri04210  Apoptosis
leri04310  Wnt signaling pathway
KO pathway
ko04010   

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