KEGG   PATHWAY: lpic04146
Entry
lpic04146                   Pathway                                
Name
Peroxisome - Lytechinus pictus (painted urchin)
Description
Peroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification. The biogenesis of peroxisomes starts with the early peroxins PEX3, PEX16 and PEX19 and proceeds via several steps. The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. Peroxisomes' deficiencies lead to severe and often fatal inherited peroxisomal disorders (PD). PDs are usually classified in two groups. The first group is disorders of peroxisome biogenesis which include Zellweger syndrome, and the second group is single peroxisomal enzyme deficiencies.
Class
Cellular Processes; Transport and catabolism
Pathway map
lpic04146  Peroxisome
lpic04146

Other DBs
GO: 0005777
Organism
Lytechinus pictus (painted urchin) [GN:lpic]
Gene
129267669  peroxisomal membrane protein PEX16-like [KO:K13335]
129268223  peroxisomal membrane protein PEX16-like [KO:K13335]
129279945  peroxisomal biogenesis factor 3-like [KO:K13336]
129281074  peroxisomal biogenesis factor 3-like [KO:K13336]
129266354  peroxisomal biogenesis factor 19-like [KO:K13337]
129266357  peroxisomal biogenesis factor 19-like [KO:K13337]
129270750  ATP-binding cassette sub-family D member 3-like isoform X1 [KO:K05677] [EC:7.6.2.4]
129278626  peroxisomal ATPase PEX1-like [KO:K13338]
129278866  LOW QUALITY PROTEIN: peroxisomal ATPase PEX1-like [KO:K13338]
129264096  LOW QUALITY PROTEIN: peroxisomal ATPase PEX6-like [KO:K13339]
129264280  peroxisomal ATPase PEX6-like [KO:K13339]
129257234  peroxisome assembly protein 26-like [KO:K13340]
129257235  peroxisome assembly protein 26-like [KO:K13340]
129259631  LOW QUALITY PROTEIN: peroxisomal targeting signal 2 receptor-like [KO:K13341]
129276728  peroxisomal targeting signal 1 receptor-like isoform X1 [KO:K13342]
129276729  peroxisomal targeting signal 1 receptor-like [KO:K13342]
129275916  peroxisomal membrane protein PEX14-like [KO:K13343]
129280434  peroxisomal membrane protein PEX13-like [KO:K13344]
129253577  peroxisome assembly protein 12-like [KO:K13345]
129254846  peroxisome assembly protein 12-A-like [KO:K13345]
129276756  peroxisome assembly protein 10-B-like isoform X1 [KO:K13346]
129276759  peroxisome assembly protein 10-B-like [KO:K13346]
129276358  peroxisome biogenesis factor 2-like isoform X1 [KO:K06664]
129254552  peroxisomal membrane protein 2-like [KO:K13347]
129270951  mpv17-like protein 2 [KO:K13348]
129271944  LOW QUALITY PROTEIN: mpv17-like protein 2 [KO:K13348]
129260324  protein Mpv17-like isoform X1 [KO:K13348]
129260344  protein Mpv17-like [KO:K13348]
129262784  peroxisomal membrane protein 4-like [KO:K13350]
129262259  peroxisomal membrane protein 11B-like [KO:K13351]
129256607  peroxisomal membrane protein 11C-like [KO:K13353]
129269023  peroxisomal membrane protein PMP34-like [KO:K13354]
129269033  LOW QUALITY PROTEIN: peroxisomal membrane protein PMP34-like [KO:K13354]
129274217  2-hydroxyacyl-CoA lyase 1-like [KO:K12261] [EC:4.1.2.63]
129262501  alpha-methylacyl-CoA racemase-like [KO:K01796] [EC:5.1.99.4]
129265386  phytanoyl-CoA dioxygenase, peroxisomal-like [KO:K00477] [EC:1.14.11.18]
129265387  phytanoyl-CoA dioxygenase, peroxisomal-like [KO:K00477] [EC:1.14.11.18]
129253677  peroxisomal acyl-coenzyme A oxidase 3-like [KO:K00232] [EC:1.3.3.6]
129253998  peroxisomal acyl-coenzyme A oxidase 1-like [KO:K00232] [EC:1.3.3.6]
129255014  peroxisomal acyl-coenzyme A oxidase 3-like [KO:K00232] [EC:1.3.3.6]
129255402  peroxisomal acyl-coenzyme A oxidase 1-like [KO:K00232] [EC:1.3.3.6]
129262336  peroxisomal multifunctional enzyme type 2-like [KO:K12405] [EC:1.1.1.- 4.2.1.107 4.2.1.119]
129270999  sterol carrier protein 2-like [KO:K08764] [EC:2.3.1.176]
129271002  sterol carrier protein 2-like [KO:K08764] [EC:2.3.1.176]
129274156  peroxisomal bifunctional enzyme-like [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
129275195  3-ketoacyl-CoA thiolase B, peroxisomal-like [KO:K07513] [EC:2.3.1.16]
129269192  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]-like [KO:K13237] [EC:1.3.1.124]
129269917  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]-like [KO:K13237] [EC:1.3.1.124]
129264728  delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial-like [KO:K12663] [EC:5.3.3.21]
129265900  delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial-like [KO:K12663] [EC:5.3.3.21]
129256766  ATP-binding cassette sub-family D member 1-like [KO:K05675] [EC:7.6.2.4]
129262951  LOW QUALITY PROTEIN: lysosomal cobalamin transporter ABCD4-like [KO:K05678] [EC:7.6.2.8]
129262976  lysosomal cobalamin transporter ABCD4-like [KO:K05678] [EC:7.6.2.8]
129262156  long-chain fatty acid transport protein 2-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
129260024  long-chain fatty acid transport protein 2-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
129260025  long-chain fatty acid transport protein 2-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
129278659  LOW QUALITY PROTEIN: long-chain-fatty-acid--CoA ligase 4-like [KO:K01897] [EC:6.2.1.3]
129278660  long-chain-fatty-acid--CoA ligase 4-like [KO:K01897] [EC:6.2.1.3]
129281151  long-chain-fatty-acid--CoA ligase 5-like [KO:K01897] [EC:6.2.1.3]
129281269  long-chain-fatty-acid--CoA ligase 5-like [KO:K01897] [EC:6.2.1.3]
129281327  long-chain-fatty-acid--CoA ligase 5-like [KO:K01897] [EC:6.2.1.3]
129281435  LOW QUALITY PROTEIN: long-chain-fatty-acid--CoA ligase 5-like [KO:K01897] [EC:6.2.1.3]
129281694  long-chain-fatty-acid--CoA ligase 5-like [KO:K01897] [EC:6.2.1.3]
129281766  long-chain-fatty-acid--CoA ligase 5-like [KO:K01897] [EC:6.2.1.3]
129281779  long-chain-fatty-acid--CoA ligase 1-like [KO:K01897] [EC:6.2.1.3]
129281827  long-chain-fatty-acid--CoA ligase 1-like [KO:K01897] [EC:6.2.1.3]
129281868  long-chain-fatty-acid--CoA ligase 6-like [KO:K01897] [EC:6.2.1.3]
129281896  long-chain-fatty-acid--CoA ligase 1-like [KO:K01897] [EC:6.2.1.3]
129281943  long-chain-fatty-acid--CoA ligase 5-like [KO:K01897] [EC:6.2.1.3]
129257141  LOW QUALITY PROTEIN: peroxisomal trans-2-enoyl-CoA reductase-like [KO:K07753] [EC:1.3.1.38]
129257143  peroxisomal trans-2-enoyl-CoA reductase-like [KO:K07753] [EC:1.3.1.38]
129254098  enoyl-CoA delta isomerase 2-like [KO:K13239] [EC:5.3.3.8]
129254103  enoyl-CoA delta isomerase 2-like [KO:K13239] [EC:5.3.3.8]
129271099  enoyl-CoA delta isomerase 2-like [KO:K13239] [EC:5.3.3.8]
129271132  enoyl-CoA delta isomerase 2-like [KO:K13239] [EC:5.3.3.8]
129271209  uncharacterized Nudix hydrolase NudL-like [KO:K17879] [EC:3.6.1.77]
129254124  uncharacterized protein LOC129254124 [KO:K17879] [EC:3.6.1.77]
129262247  NAD-capped RNA hydrolase NUDT12-like [KO:K03426] [EC:3.6.1.22]
129263477  acyl-coenzyme A diphosphatase NUDT19-like [KO:K13355] [EC:3.6.1.77]
129263488  acyl-coenzyme A diphosphatase NUDT19-like [KO:K13355] [EC:3.6.1.77]
129273386  acyl-coenzyme A thioesterase 8-like [KO:K11992] [EC:3.1.2.27]
129277880  carnitine O-acetyltransferase-like [KO:K00624] [EC:2.3.1.7]
129274804  peroxisomal carnitine O-octanoyltransferase-like [KO:K05940] [EC:2.3.1.137]
129281711  peroxisomal carnitine O-octanoyltransferase-like [KO:K05940] [EC:2.3.1.137]
129259091  malonyl-CoA decarboxylase, mitochondrial-like [KO:K01578] [EC:4.1.1.9]
129264496  dihydroxyacetone phosphate acyltransferase-like [KO:K00649] [EC:2.3.1.42]
129255416  alkyldihydroxyacetonephosphate synthase, peroxisomal-like [KO:K00803] [EC:2.5.1.26]
129267719  fatty acyl-CoA reductase 1-like [KO:K13356] [EC:1.2.1.84]
129268092  LOW QUALITY PROTEIN: fatty acyl-CoA reductase 1-like [KO:K13356] [EC:1.2.1.84]
129268093  fatty acyl-CoA reductase 1-like isoform X1 [KO:K13356] [EC:1.2.1.84]
129268260  fatty acyl-CoA reductase 1-like [KO:K13356] [EC:1.2.1.84]
129268544  fatty acyl-CoA reductase 1-like [KO:K13356] [EC:1.2.1.84]
129260951  phosphomevalonate kinase-like [KO:K13273] [EC:2.7.4.2]
129276563  alanine--glyoxylate aminotransferase-like [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
129258018  D-aspartate oxidase-like [KO:K00273] [EC:1.4.3.3]
129264367  D-aspartate oxidase-like [KO:K00272] [EC:1.4.3.1]
129265705  D-aspartate oxidase-like [KO:K00272] [EC:1.4.3.1]
129269893  D-aspartate oxidase-like [KO:K00272] [EC:1.4.3.1]
129263928  LOW QUALITY PROTEIN: isocitrate dehydrogenase [NADP] cytoplasmic-like [KO:K00031] [EC:1.1.1.42]
129257621  isocitrate dehydrogenase [NADP], mitochondrial-like [KO:K00031] [EC:1.1.1.42]
129257627  LOW QUALITY PROTEIN: isocitrate dehydrogenase [NADP], mitochondrial-like [KO:K00031] [EC:1.1.1.42]
129272787  peroxisomal N(1)-acetyl-spermine/spermidine oxidase-like [KO:K00308] [EC:1.5.3.13]
129282961  peroxisomal sarcosine oxidase-like [KO:K00306] [EC:1.5.3.1 1.5.3.7]
129282972  peroxisomal sarcosine oxidase-like [KO:K00306] [EC:1.5.3.1 1.5.3.7]
129263190  hydroxymethylglutaryl-CoA lyase, mitochondrial-like [KO:K01640] [EC:4.1.3.4]
129274913  2-Hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
129274951  2-Hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
129275268  2-Hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
129264434  2-Hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
129264435  2-Hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
129264437  2-Hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
129264438  2-Hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
129253897  uncharacterized protein LOC129253897 [KO:K11517] [EC:1.1.3.15]
129254132  2-Hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
129254153  2-Hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
129254171  2-Hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
129278547  2-Hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
129278636  2-Hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
129278657  2-Hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
129278668  2-Hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
129284238  2-Hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
129284240  uncharacterized protein LOC129284240 [KO:K11517] [EC:1.1.3.15]
129272466  2-Hydroxyacid oxidase 2-like [KO:K11517] [EC:1.1.3.15]
129272477  2-Hydroxyacid oxidase 2-like [KO:K11517] [EC:1.1.3.15]
129274274  2-Hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
129283193  catalase-like [KO:K03781] [EC:1.11.1.6]
129265658  peroxiredoxin-5, mitochondrial-like [KO:K11187] [EC:1.11.1.24]
129256239  uncharacterized protein LOC129256239 isoform X1 [KO:K04565] [EC:1.15.1.1]
129259293  uncharacterized protein LOC129259293 [KO:K04565] [EC:1.15.1.1]
129266688  superoxide dismutase [Mn]-like [KO:K04564] [EC:1.15.1.1]
129258454  superoxide dismutase [Mn], mitochondrial-like [KO:K04564] [EC:1.15.1.1]
129259042  superoxide dismutase [Mn], mitochondrial-like [KO:K04564] [EC:1.15.1.1]
129272080  peroxiredoxin-like [KO:K13279] [EC:1.11.1.24]
129260275  bifunctional epoxide hydrolase 2-like [KO:K08726] [EC:3.3.2.10 3.1.3.76]
129261305  bifunctional epoxide hydrolase 2-like [KO:K08726] [EC:3.3.2.10 3.1.3.76]
129261533  bifunctional epoxide hydrolase 2-like [KO:K08726] [EC:3.3.2.10 3.1.3.76]
129264472  xanthine dehydrogenase/oxidase-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
129264825  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
129254440  LOW QUALITY PROTEIN: xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
129254936  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
129254937  LOW QUALITY PROTEIN: xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
129281843  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
129276969  dehydrogenase/reductase SDR family member 4-like [KO:K11147] [EC:1.1.-.-]
129276985  dehydrogenase/reductase SDR family member 4-like [KO:K11147] [EC:1.1.-.-]
Reference
PMID:17055078
  Authors
Wanders RJ, Waterham HR
  Title
Peroxisomal disorders: the single peroxisomal enzyme deficiencies.
  Journal
Biochim Biophys Acta 1763:1707-20 (2006)
DOI:10.1016/j.bbamcr.2006.08.010
Reference
PMID:17055079
  Authors
Steinberg SJ, Dodt G, Raymond GV, Braverman NE, Moser AB, Moser HW
  Title
Peroxisome biogenesis disorders.
  Journal
Biochim Biophys Acta 1763:1733-48 (2006)
DOI:10.1016/j.bbamcr.2006.09.010
Reference
PMID:17010456
  Authors
Rottensteiner H, Theodoulou FL
  Title
The ins and outs of peroxisomes: co-ordination of membrane transport and peroxisomal metabolism.
  Journal
Biochim Biophys Acta 1763:1527-40 (2006)
DOI:10.1016/j.bbamcr.2006.08.012
Reference
PMID:16631601
  Authors
Iida R, Yasuda T, Tsubota E, Takatsuka H, Matsuki T, Kishi K
  Title
Human Mpv17-like protein is localized in peroxisomes and regulates expression of antioxidant enzymes.
  Journal
Biochem Biophys Res Commun 344:948-54 (2006)
DOI:10.1016/j.bbrc.2006.04.008
Related
pathway
lpic00071  Fatty acid degradation
lpic00230  Purine metabolism
lpic00564  Glycerophospholipid metabolism
lpic00565  Ether lipid metabolism
lpic00830  Retinol metabolism
lpic00900  Terpenoid backbone biosynthesis
KO pathway
ko04146   
LinkDB

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