KEGG   PATHWAY: mamb04114
Entry
mamb04114                   Pathway                                
Name
Oocyte meiosis - Megalobrama amblycephala (Wuchang bream)
Description
During meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segregate to opposite poles, while the sister chromatids segregate from each other at meoisis II. In vertebrates, immature oocytes are arrested at the PI (prophase of meiosis I). The resumption of meiosis is stimulated by progesterone, which carries the oocyte through two consecutive M-phases (MI and MII) to a second arrest at MII. The key activity driving meiotic progression is the MPF (maturation-promoting factor), a heterodimer of CDC2 (cell division cycle 2 kinase) and cyclin B. In PI-arrested oocytes, MPF is initially inactive and is activated by the dual-specificity CDC25C phosphatase as the result of new synthesis of Mos induced by progesterone. MPF activation mediates the transition from the PI arrest to MI. The subsequent decrease in MPF levels, required to exit from MI into interkinesis, is induced by a negative feedback loop, where CDC2 brings about the activation of the APC (anaphase-promoting complex), which mediates destruction of cyclin B. Re-activation of MPF for MII requires re-accumulation of high levels of cyclin B as well as the inactivation of the APC by newly synthesized Emi2 and other components of the CSF (cytostatic factor), such as cyclin E or high levels of Mos. CSF antagonizes the ubiquitin ligase activity of the APC, preventing cyclin B destruction and meiotic exit until fertilization occurs. Fertilization triggers a transient increase in cytosolic free Ca2+, which leads to CSF inactivation and cyclin B destruction through the APC. Then eggs are released from MII into the first embryonic cell cycle.
Class
Cellular Processes; Cell growth and death
Pathway map
mamb04114  Oocyte meiosis
mamb04114

Other DBs
GO: 0051321
Organism
Megalobrama amblycephala (Wuchang bream) [GN:mamb]
Gene
125259323  insb; LOW QUALITY PROTEIN: preproinsulin b [KO:K04526]
125266058  ins; insulin [KO:K04526]
125277562  insulin [KO:K04526]
125245042  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
125264449  igf1rb; insulin-like growth factor 1b receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
125253737  igf1ra; insulin-like growth factor 1a receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
125254511  pgr; progesterone receptor [KO:K08556]
125266417  ar; androgen receptor [KO:K08557]
125279119  adcy1a; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
125251308  adcy1b; adenylate cyclase type 1b [KO:K08041] [EC:4.6.1.1]
125242992  adcy2a; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
125274762  adcy2b; adenylate cyclase type 2b isoform X1 [KO:K08042] [EC:4.6.1.1]
125243356  adcy3a; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
125278498  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
125264290  adenylate cyclase type 4-like [KO:K08044] [EC:4.6.1.1]
125270200  adcy5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
125259558  adcy6a; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
125260716  adcy6b; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
125265058  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
125278420  si:dkey-206f10.1; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
125250700  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
125269091  si:ch211-132f19.7; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
125262387  adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
125263713  adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
125278182  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
125255428  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
125256470  prkacba; protein kinase, cAMP-dependent, catalytic, beta a [KO:K04345] [EC:2.7.11.11]
125251891  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b [KO:K04345] [EC:2.7.11.11]
125273378  aurka; aurora kinase A [KO:K11481] [EC:2.7.11.1]
125258803  cpeb4a; cytoplasmic polyadenylation element-binding protein 4 isoform X1 [KO:K02602]
125253001  cpeb4b; cytoplasmic polyadenylation element-binding protein 4b isoform X1 [KO:K02602]
125259689  cpeb2; cytoplasmic polyadenylation element-binding protein 2 isoform X1 [KO:K02602]
125265149  cpeb1b; cytoplasmic polyadenylation element-binding protein 1 isoform X1 [KO:K02602]
125247691  cpeb1a; cytoplasmic polyadenylation element-binding protein 1a isoform X1 [KO:K02602]
125276697  cpeb3; cytoplasmic polyadenylation element-binding protein 3 isoform X1 [KO:K02602]
125248778  mos; LOW QUALITY PROTEIN: proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
125253954  map2k1; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
125267337  mapk1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
125275450  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
125266612  rps6ka3a; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
125269144  rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
125257578  rps6ka3b; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
125261084  rps6kal; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
125277432  rps6ka2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
125251695  pkmyt1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1 [KO:K06633] [EC:2.7.11.1]
125277830  ywhaqa; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a [KO:K16197]
125243195  ywhabl; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like [KO:K16197]
125279455  ywhabb; 14-3-3 protein beta/alpha-B [KO:K16197]
125273594  ywhaba; 14-3-3 protein beta/alpha-A [KO:K16197]
125275185  ywhaz; 14-3-3 protein zeta/delta [KO:K16197]
125269071  ywhaqb; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b [KO:K16197]
125265200  ywhae2; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2 [KO:K06630]
125248370  ywhae1; LOW QUALITY PROTEIN: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 [KO:K06630]
125266298  ywhag1; 14-3-3 protein gamma-1 [KO:K16198]
125248810  ywhag2; 14-3-3 protein gamma-B [KO:K16198]
125256773  ywhah; 14-3-3 protein eta [KO:K16198]
125268693  spdya; speedy protein A [KO:K08694]
125268849  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
125256455  cdk2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
125279668  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
125246180  mapk12b; mitogen-activated protein kinase 12b isoform X1 [KO:K04441] [EC:2.7.11.24]
125246181  mapk11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
125279793  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
125254075  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
125257055  mapk14b; LOW QUALITY PROTEIN: mitogen-activated protein kinase 14B [KO:K04441] [EC:2.7.11.24]
125260456  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
125278904  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
125265892  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
125266218  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
125254963  ppp1cab; LOW QUALITY PROTEIN: protein phosphatase 1, catalytic subunit, alpha isozyme b [KO:K06269] [EC:3.1.3.16]
125268817  ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
125276563  ppp1caa; protein phosphatase 1, catalytic subunit, alpha isozyme a [KO:K06269] [EC:3.1.3.16]
125271922  slkb; STE20-like kinase b [KO:K08836] [EC:2.7.11.1]
125276903  slka; STE20-like serine/threonine-protein kinase isoform X1 [KO:K08836] [EC:2.7.11.1]
125259305  si:dkey-81j8.6; serine/threonine-protein kinase 10 [KO:K08836] [EC:2.7.11.1]
125272726  plk1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
125264722  ccnb2; G2/mitotic-specific cyclin-B2 [KO:K21770]
125265451  cth1; cysteine three histidine 1 [KO:K13056]
125273687  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
125258299  cul1b; cullin-1b [KO:K03347]
125250170  cul1a; cullin-1a isoform X1 [KO:K03347]
125253090  skp1; S-phase kinase-associated protein 1 [KO:K03094]
125259455  fbxw11b; F-box and WD repeat domain-containing 11-B isoform X1 [KO:K03362]
125275627  fbxw11a; F-box and WD repeat domain-containing 11-A isoform X1 [KO:K03362]
125276429  fbxo5; F-box only protein 5 [KO:K10292]
125276431  anapc1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
125268015  anapc2; anaphase-promoting complex subunit 2 [KO:K03349]
125272511  cdc27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
125278024  anapc4; anaphase-promoting complex subunit 4 [KO:K03351]
125280083  anapc5; anaphase-promoting complex subunit 5 [KO:K03352]
125268418  anaphase-promoting complex subunit 5-like [KO:K03352]
125270163  cdc16; cell division cycle protein 16 homolog [KO:K03353]
125280729  anapc7; anaphase-promoting complex subunit 7 [KO:K03354]
125252273  LOW QUALITY PROTEIN: cell division cycle protein 23 homolog [KO:K03355]
125253210  cell division cycle protein 23 homolog [KO:K03355]
125260765  LOW QUALITY PROTEIN: anaphase-promoting complex subunit 10-like [KO:K03357]
125272937  anapc11; anaphase-promoting complex subunit 11 isoform X1 [KO:K03358]
125267926  cdc26; anaphase-promoting complex subunit CDC26 [KO:K03359]
125252774  anapc13; anaphase-promoting complex subunit 13 [KO:K12456]
125248112  anapc15; anaphase-promoting complex subunit 15 [KO:K25228]
125255278  anapc16; anaphase-promoting complex subunit 16 [KO:K25229]
125251665  cdc20; cell division cycle protein 20 homolog [KO:K03363]
125243562  fbxo43; F-box only protein 43 isoform X1 [KO:K10318]
125246067  F-box only protein 43-like [KO:K10318]
125259275  pttg1; securin [KO:K06635]
125273720  espl1; LOW QUALITY PROTEIN: separin [KO:K02365] [EC:3.4.22.49]
125251772  meiotic recombination protein REC8 homolog isoform X1 [KO:K13054]
125257658  rec8b; REC8 meiotic recombination protein b [KO:K13054]
125279594  smc1al; structural maintenance of chromosomes 1A, like [KO:K06636]
125247549  smc1b; structural maintenance of chromosomes protein 1B [KO:K06636]
125260674  smc1a; structural maintenance of chromosomes protein 1A [KO:K06636]
125253501  smc3; structural maintenance of chromosomes protein 3 [KO:K06669]
125254637  G2/mitotic-specific cyclin-B1-like isoform X1 [KO:K05868]
125267878  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
125278877  bub1; LOW QUALITY PROTEIN: mitotic checkpoint serine/threonine-protein kinase BUB1 [KO:K02178] [EC:2.7.11.1]
125265888  mad2l1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
125272741  mad1l1; mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679]
125244042  ccne2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
125265166  ccne1; G1/S-specific cyclin-E1 [KO:K06626]
125274667  sgo1; shugoshin 1 isoform X1 [KO:K11580]
125277759  ppp2r5ea; protein phosphatase 2, regulatory subunit B', epsilon [KO:K11584]
125278606  ppp2r5cb; protein phosphatase 2, regulatory subunit B', gamma b isoform X1 [KO:K11584]
125278981  ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
125264571  ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
125269203  ppp2r5ca; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
125277321  ppp2r5eb; protein phosphatase 2, regulatory subunit B', epsilon isoform X1 [KO:K11584]
125248530  ppp2r1bb; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
125267946  ppp2r1ba; protein phosphatase 2, regulatory subunit A, beta a [KO:K03456]
125258755  ppp2caa; protein phosphatase 2 catalytic subunit alpha a [KO:K04382] [EC:3.1.3.16]
125253086  ppp2cab; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
125256296  ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
125273734  itpr1a; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
125256994  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
125254454  itpr2; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
125279368  itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
125279053  calm1b; calmodulin-1b [KO:K02183]
125264806  calml4a; calmodulin-like protein 4a [KO:K02183]
125253545  calm3b; calmodulin 3b (phosphorylase kinase, delta) [KO:K02183]
125247787  calml4b; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
125248338  calm3a; calmodulin 3a (phosphorylase kinase, delta) isoform X1 [KO:K02183]
125255503  calm2b; calmodulin 2b, (phosphorylase kinase, delta) [KO:K02183]
125268828  calm1a; calmodulin-1a [KO:K02183]
125277263  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
125259177  ppp3ccb; protein phosphatase 3, catalytic subunit, gamma isozyme, b isoform X1 [KO:K04348] [EC:3.1.3.16]
125259186  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
125252654  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
125265608  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
125266516  ppp3cca; protein phosphatase 3, catalytic subunit, gamma isozyme, a isoform X1 [KO:K04348] [EC:3.1.3.16]
125271895  ppp3r1b; calcineurin subunit B type 1b [KO:K06268]
125277514  ppp3r1a; calcineurin subunit B type 1 [KO:K06268]
125252343  camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
125262414  LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
125272496  camk2d2; calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
125265885  camk2d1; calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
125266459  camk2b1; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
125255303  camk2g1; calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
125276818  camk2g2; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
Compound
C00076  Calcium cation
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:16760654
  Authors
Haccard O, Jessus C
  Title
Oocyte maturation, Mos and cyclins--a matter of synthesis: two functionally redundant ways to induce meiotic maturation.
  Journal
Cell Cycle 5:1152-9 (2006)
DOI:10.4161/cc.5.11.2800
Reference
PMID:15182704
  Authors
Crane R, Gadea B, Littlepage L, Wu H, Ruderman JV
  Title
Aurora A, meiosis and mitosis.
  Journal
Biol Cell 96:215-29 (2004)
DOI:10.1016/j.biolcel.2003.09.008
Reference
PMID:15136768
  Authors
Perdiguero E, Nebreda AR
  Title
Regulation of Cdc25C activity during the meiotic G2/M transition.
  Journal
Cell Cycle 3:733-7 (2004)
DOI:10.4161/cc.3.6.906
Reference
PMID:17480229
  Authors
Perry JA, Kornbluth S
  Title
Cdc25 and Wee1: analogous opposites?
  Journal
Cell Div 2:12 (2007)
DOI:10.1186/1747-1028-2-12
Reference
PMID:15182701
  Authors
Jessus C, Ozon R
  Title
How does Xenopus oocyte acquire its competence to undergo meiotic maturation?
  Journal
Biol Cell 96:187-92 (2004)
DOI:10.1016/j.biolcel.2003.12.007
Reference
PMID:16518630
  Authors
Revenkova E, Jessberger R
  Title
Shaping meiotic prophase chromosomes: cohesins and synaptonemal complex proteins.
  Journal
Chromosoma 115:235-40 (2006)
DOI:10.1007/s00412-006-0060-x
Reference
PMID:18631137
  Authors
Belloc E, Pique M, Mendez R
  Title
Sequential waves of polyadenylation and deadenylation define a translation circuit that drives meiotic progression.
  Journal
Biochem Soc Trans 36:665-70 (2008)
DOI:10.1042/BST0360665
Reference
PMID:18598214
  Authors
Pesin JA, Orr-Weaver TL
  Title
Regulation of APC/C activators in mitosis and meiosis.
  Journal
Annu Rev Cell Dev Biol 24:475-99 (2008)
DOI:10.1146/annurev.cellbio.041408.115949
Reference
PMID:18550795
  Authors
Tang W, Wu JQ, Guo Y, Hansen DV, Perry JA, Freel CD, Nutt L, Jackson PK, Kornbluth S
  Title
Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition.
  Journal
Mol Biol Cell 19:3536-43 (2008)
DOI:10.1091/mbc.E08-04-0417
Reference
PMID:18946022
  Authors
Wu JQ, Kornbluth S
  Title
Across the meiotic divide - CSF activity in the post-Emi2/XErp1 era.
  Journal
J Cell Sci 121:3509-14 (2008)
DOI:10.1242/jcs.036855
Reference
PMID:16554437
  Authors
Schmidt A, Rauh NR, Nigg EA, Mayer TU
  Title
Cytostatic factor: an activity that puts the cell cycle on hold.
  Journal
J Cell Sci 119:1213-8 (2006)
DOI:10.1242/jcs.02919
Reference
PMID:18096427
  Authors
Vogt E, Kirsch-Volders M, Parry J, Eichenlaub-Ritter U
  Title
Spindle formation, chromosome segregation and the spindle checkpoint in mammalian oocytes and susceptibility to meiotic error.
  Journal
Mutat Res 651:14-29 (2008)
DOI:10.1016/j.mrgentox.2007.10.015
Reference
PMID:18311174
  Authors
Perry AC, Verlhac MH
  Title
Second meiotic arrest and exit in frogs and mice.
  Journal
EMBO Rep 9:246-51 (2008)
DOI:10.1038/embor.2008.22
Reference
PMID:14691134
  Authors
Tunquist BJ, Eyers PA, Chen LG, Lewellyn AL, Maller JL
  Title
Spindle checkpoint proteins Mad1 and Mad2 are required for cytostatic factor-mediated metaphase arrest.
  Journal
J Cell Biol 163:1231-42 (2003)
DOI:10.1083/jcb.200306153
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Related
pathway
mamb04010  MAPK signaling pathway
mamb04120  Ubiquitin mediated proteolysis
mamb04914  Progesterone-mediated oocyte maturation
KO pathway
ko04114   
LinkDB

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