KEGG   PATHWAY: masy00260
Entry
masy00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Massilia sp. YMA4
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
masy00260  Glycine, serine and threonine metabolism
masy00260

Module
masy_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:masy00260]
masy_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:masy00260]
masy_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:masy00260]
masy_M00621  Glycine cleavage system [PATH:masy00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Massilia sp. YMA4 [GN:masy]
Gene
DPH57_09650  aspartate kinase [KO:K00928] [EC:2.7.2.4]
DPH57_00270  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
DPH57_00505  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
DPH57_15410  homoserine kinase [KO:K02204] [EC:2.7.1.39]
DPH57_04875  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
DPH57_06020  threonine synthase [KO:K01733] [EC:4.2.3.1]
DPH57_01345  low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
DPH57_04855  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
DPH57_11480  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
DPH57_10870  alanine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
DPH57_08730  glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]
DPH57_20640  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
DPH57_27045  glycerate kinase [KO:K11529] [EC:2.7.1.165]
DPH57_22100  2,3-diphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
DPH57_15555  histidine phosphatase family protein [KO:K15634] [EC:5.4.2.11]
DPH57_21255  D-2-hydroxyacid dehydrogenase family protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
DPH57_12730  3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
DPH57_07445  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
DPH57_11485  NADP-dependent 3-hydroxy acid dehydrogenase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
DPH57_06005  kbl; glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
DPH57_23690  monoamine oxidase [KO:K00274] [EC:1.4.3.4]
DPH57_04240  gcvP; glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
DPH57_04250  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
DPH57_21085  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
DPH57_00865  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
DPH57_04245  gcvH; glycine cleavage system protein GcvH [KO:K02437]
DPH57_21705  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
DPH57_01425  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
DPH57_04980  cysteine synthase family protein [KO:K01697] [EC:4.2.1.22]
DPH57_07910  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
DPH57_07915  cystathionine beta-lyase [KO:K01758] [EC:4.4.1.1]
DPH57_06015  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
DPH57_23320  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
DPH57_19430  amino acid deaminase [KO:K01753] [EC:4.3.1.18]
DPH57_12065  aspartate racemase [KO:K25316] [EC:5.1.1.10]
DPH57_00300  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
DPH57_00295  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
DPH57_09155  hypothetical protein [KO:K00836] [EC:2.6.1.76]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
masy00010  Glycolysis / Gluconeogenesis
masy00020  Citrate cycle (TCA cycle)
masy00230  Purine metabolism
masy00250  Alanine, aspartate and glutamate metabolism
masy00270  Cysteine and methionine metabolism
masy00290  Valine, leucine and isoleucine biosynthesis
masy00300  Lysine biosynthesis
masy00330  Arginine and proline metabolism
masy00460  Cyanoamino acid metabolism
masy00470  D-Amino acid metabolism
masy00564  Glycerophospholipid metabolism
masy00600  Sphingolipid metabolism
masy00620  Pyruvate metabolism
masy00630  Glyoxylate and dicarboxylate metabolism
masy00640  Propanoate metabolism
masy00680  Methane metabolism
masy00860  Porphyrin metabolism
masy00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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