KEGG   PATHWAY: mfot00983
Entry
mfot00983                   Pathway                                
Name
Drug metabolism - other enzymes - Microtus fortis (reed vole)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
mfot00983  Drug metabolism - other enzymes
mfot00983

Organism
Microtus fortis (reed vole) [GN:mfot]
Gene
126488291  hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
126499821  inosine-5'-monophosphate dehydrogenase 2 [KO:K00088] [EC:1.1.1.205]
126501152  inosine-5'-monophosphate dehydrogenase 1 isoform X1 [KO:K00088] [EC:1.1.1.205]
126504933  GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
126502529  thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
126514218  xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
126496710  inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
126487805  carboxylesterase 1D-like [KO:K01044] [EC:3.1.1.1]
126487863  carboxylesterase 1F-like [KO:K01044] [EC:3.1.1.1]
126502578  carboxylesterase 1D isoform X1 [KO:K01044] [EC:3.1.1.1]
126502579  liver carboxylesterase 1-like isoform X1 [KO:K01044] [EC:3.1.1.1]
126502581  carboxylesterase 1E-like [KO:K01044] [EC:3.1.1.1]
126502582  liver carboxylesterase 1-like [KO:K01044] [EC:3.1.1.1]
126502576  liver carboxylesterase 1 isoform X1 [KO:K01044] [EC:3.1.1.1]
126502580  liver carboxylesterase 1-like isoform X1 [KO:K01044] [EC:3.1.1.1]
126502544  acylcarnitine hydrolase-like isoform X1 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
126502545  acylcarnitine hydrolase-like isoform X1 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
126502547  acylcarnitine hydrolase-like isoform X1 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
126502548  acylcarnitine hydrolase-like isoform X1 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
126502549  pyrethroid hydrolase Ces2e-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
126502550  acylcarnitine hydrolase-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
126502565  acylcarnitine hydrolase-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
126503061  acylcarnitine hydrolase-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
126502552  pyrethroid hydrolase Ces2e-like isoform X1 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
126502454  acylcarnitine hydrolase-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
126506227  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
126506291  UDP-glucuronosyltransferase 2B31-like isoform X1 [KO:K00699] [EC:2.4.1.17]
126506292  UDP-glucuronosyltransferase 2B1 [KO:K00699] [EC:2.4.1.17]
126506293  UDP-glucuronosyltransferase 2B31-like isoform X1 [KO:K00699] [EC:2.4.1.17]
126506294  UDP-glucuronosyltransferase 2A3-like [KO:K00699] [EC:2.4.1.17]
126506295  UDP-glucuronosyltransferase 2B17-like isoform X1 [KO:K00699] [EC:2.4.1.17]
126506298  UDP-glucuronosyltransferase 2B17-like isoform X1 [KO:K00699] [EC:2.4.1.17]
126506606  UDP-glucuronosyltransferase 2A2 isoform X1 [KO:K00699] [EC:2.4.1.17]
126514270  UDP-glucuronosyltransferase 1-6 isoform X1 [KO:K00699] [EC:2.4.1.17]
126489061  UDP-glucuronosyltransferase 1A7-like [KO:K00699] [EC:2.4.1.17]
126489062  UDP-glucuronosyltransferase 1A7-like [KO:K00699] [EC:2.4.1.17]
126489063  UDP-glucuronosyltransferase 1A8-like isoform X1 [KO:K00699] [EC:2.4.1.17]
126489064  UDP-glucuronosyltransferase 1A8-like [KO:K00699] [EC:2.4.1.17]
126489066  UDP-glucuronosyltransferase 1A8-like [KO:K00699] [EC:2.4.1.17]
126489067  UDP-glucuronosyltransferase 1A7-like [KO:K00699] [EC:2.4.1.17]
126489487  UDP-glucuronosyltransferase 1A7-like [KO:K00699] [EC:2.4.1.17]
126504201  beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
126508692  LOW QUALITY PROTEIN: cytidine deaminase [KO:K01489] [EC:3.5.4.5]
126492170  thymidine phosphorylase isoform X1 [KO:K00758] [EC:2.4.2.4]
126512098  dihydropyrimidine dehydrogenase [NADP(+)] [KO:K00207] [EC:1.3.1.2]
126513002  dihydropyrimidinase [KO:K01464] [EC:3.5.2.2]
126500205  beta-ureidopropionase [KO:K01431] [EC:3.5.1.6]
126500993  uridine phosphorylase 1 [KO:K00757] [EC:2.4.2.3]
126488167  uridine phosphorylase 2 isoform X1 [KO:K00757] [EC:2.4.2.3]
126509463  uridine-cytidine kinase 1 [KO:K00876] [EC:2.7.1.48]
126511272  uridine-cytidine kinase 2 [KO:K00876] [EC:2.7.1.48]
126500302  thymidine kinase, cytosolic [KO:K00857] [EC:2.7.1.21]
126502857  thymidine kinase 2, mitochondrial isoform X1 [KO:K00857] [EC:2.7.1.21]
126512224  uridine 5'-monophosphate synthase isoform X1 [KO:K13421] [EC:2.4.2.10 4.1.1.23]
126497945  UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
126488854  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
126501367  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
126508957  ribonucleoside-diphosphate reductase subunit M2-like [KO:K10808] [EC:1.17.4.1]
126513701  ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
126499964  nucleoside diphosphate kinase 6 isoform X1 [KO:K00940] [EC:2.7.4.6]
126507751  nucleoside diphosphate kinase, mitochondrial-like [KO:K00940] [EC:2.7.4.6]
126496036  nucleoside diphosphate kinase B-like [KO:K00940] [EC:2.7.4.6]
126496948  nucleoside diphosphate kinase, mitochondrial isoform X1 [KO:K00940] [EC:2.7.4.6]
126510262  nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
126510264  nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
126511248  nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
126490970  nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
126498386  nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
126496731  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial [KO:K01520] [EC:3.6.1.23]
126510373  myeloperoxidase [KO:K10789] [EC:1.11.2.2]
126513742  arylamine N-acetyltransferase 3-like [KO:K00622] [EC:2.3.1.5]
126513743  arylamine N-acetyltransferase 2 [KO:K00622] [EC:2.3.1.5]
126513749  arylamine N-acetyltransferase 1 [KO:K00622] [EC:2.3.1.5]
126498260  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
126491445  glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
126491866  glutathione S-transferase Mu 3 isoform X1 [KO:K00799] [EC:2.5.1.18]
126491867  glutathione S-transferase Mu 6 isoform X1 [KO:K00799] [EC:2.5.1.18]
126491868  glutathione S-transferase Mu 7 [KO:K00799] [EC:2.5.1.18]
126491869  glutathione S-transferase Mu 2 [KO:K00799] [EC:2.5.1.18]
126491870  glutathione S-transferase Mu 2-like [KO:K00799] [EC:2.5.1.18]
126491889  glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
126499212  glutathione S-transferase theta-3 [KO:K00799] [EC:2.5.1.18]
126499222  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
126499232  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
126499310  microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
126487880  glutathione S-transferase Mu 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
126487881  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
126487883  glutathione S-transferase Mu 4-like [KO:K00799] [EC:2.5.1.18]
126487884  glutathione S-transferase Mu 4 [KO:K00799] [EC:2.5.1.18]
126501513  glutathione S-transferase theta-2-like [KO:K00799] [EC:2.5.1.18]
126495752  glutathione S-transferase alpha-3 [KO:K00799] [EC:2.5.1.18]
126489682  glutathione S-transferase-like isoform X1 [KO:K00799] [EC:2.5.1.18]
126496924  glutathione S-transferase alpha-3-like [KO:K00799] [EC:2.5.1.18]
126496940  glutathione S-transferase A6 isoform X1 [KO:K00799] [EC:2.5.1.18]
126496941  glutathione S-transferase A6-like [KO:K00799] [EC:2.5.1.18]
126503400  glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
126497282  microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
126504036  glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
126511192  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
126511276  microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
126491101  glutathione S-transferase A1 isoform X1 [KO:K00799] [EC:2.5.1.18]
126491187  glutathione S-transferase A2-like isoform X1 [KO:K00799] [EC:2.5.1.18]
126498812  glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
126498898  glutathione S-transferase P-like isoform X1 [KO:K23790] [EC:2.5.1.18]
126500077  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
126515453  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
126488776  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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