KEGG   PATHWAY: mgp04514
Entry
mgp04514                    Pathway                                
Name
Cell adhesion molecules - Meleagris gallopavo (turkey)
Description
Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
mgp04514  Cell adhesion molecules
mgp04514

Other DBs
GO: 0050839
Organism
Meleagris gallopavo (turkey) [GN:mgp]
Gene
104913823  CD2; T-cell surface antigen CD2 isoform X1 [KO:K06449]
104911932  VSIR; V-type immunoglobulin domain-containing suppressor of T-cell activation [KO:K23268]
100548631  IGSF11; immunoglobulin superfamily member 11 [KO:K06791]
100540827  CD80; T-lymphocyte activation antigen CD80 isoform X1 [KO:K05412]
100549187  LOW QUALITY PROTEIN: programmed cell death 1 ligand 1 [KO:K06745]
100126555  CD28; T-cell-specific surface glycoprotein CD28 [KO:K06470]
100544635  CD86; T-lymphocyte activation antigen CD86 [KO:K05413]
100542850  CTLA4; cytotoxic T-lymphocyte protein 4 [KO:K06538]
100539282  ICOS ligand [KO:K06710]
100542536  ICOS; inducible T-cell costimulator [KO:K06713]
100547088  class II histocompatibility antigen, B-L beta chain-like [KO:K06752]
100549648  DMA; class II histocompatibility antigen, M alpha chain [KO:K06752]
100550217  DMB2; LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
104916737  class II histocompatibility antigen, B-L beta chain-like [KO:K06752]
104916784  class II histocompatibility antigen, B-L beta chain [KO:K06752]
104913632  class II histocompatibility antigen, B-L beta chain [KO:K06752]
104916321  HLA class II histocompatibility antigen, DM beta chain-like [KO:K06752]
104912840  M1-specific T cell receptor beta chain-like [KO:K10785]
100126554  CD4; CD4 molecule precursor [KO:K06454]
100545817  class I histocompatibility antigen, F10 alpha chain isoform X1 [KO:K06751]
100546931  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
104916485  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
100126556  T-cell surface glycoprotein CD8 alpha chain precursor [KO:K06458]
100550587  T-cell surface glycoprotein CD8 alpha chain-like isoform X1 [KO:K06458]
100550742  T-cell surface glycoprotein CD8 alpha chain-like [KO:K06458]
104910899  T-cell surface glycoprotein CD8 alpha chain-like isoform X2 [KO:K06458]
104910915  T-cell surface glycoprotein CD8 alpha chain-like [KO:K06458]
104916555  T-cell surface glycoprotein CD8 alpha chain-like isoform X1 [KO:K06458]
104916556  T-cell surface glycoprotein CD8 alpha chain-like isoform X1 [KO:K06458]
100550897  CD8B; T-cell surface glycoprotein CD8 beta chain [KO:K06459]
104915010  LOW QUALITY PROTEIN: programmed cell death 1 ligand 1 [KO:K06708]
100545124  CD276; CD276 antigen [KO:K06746]
100543751  VTCN1; V-set domain-containing T-cell activation inhibitor 1 isoform X2 [KO:K06747]
104912661  PDCD1; programmed cell death protein 1 [KO:K06744]
104914080  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
100546658  CD40LG; CD40 ligand [KO:K03161]
100546741  ALCAM; CD166 antigen [KO:K06547]
104910943  CD6; T-cell differentiation antigen CD6 [KO:K06456]
104910239  CD226; CD226 antigen [KO:K06567]
100543565  ITGB2; integrin beta-2 [KO:K06464]
100546661  PTPRC; receptor-type tyrosine-protein phosphatase C [KO:K06478] [EC:3.1.3.48]
104915916  LOW QUALITY PROTEIN: sialoadhesin-like [KO:K06548]
100549194  NECTIN3; nectin-3 [KO:K06592]
104915733  CLDN34; claudin-34 [KO:K06087]
100544952  CLDN20; claudin-20 [KO:K06087]
100543398  CLDN10; claudin-10 [KO:K06087]
100550942  claudin-8-like [KO:K06087]
100547701  CLDN19; claudin-19 [KO:K06087]
100540364  CLDN8; claudin-8 [KO:K06087]
100548564  CLDN3; claudin-3 [KO:K06087]
100547722  claudin-22-like [KO:K06087]
100550435  CLDN23; claudin-23 [KO:K06087]
100549221  CLDN1; claudin-1 [KO:K06087]
100549680  CLDN16; claudin-16 [KO:K06087]
100544404  CLDN2; claudin-2 [KO:K06087]
100544298  LOW QUALITY PROTEIN: claudin-15-like [KO:K06087]
100548297  CLDN18; claudin-18 isoform X1 [KO:K06087]
100540028  CLDN11; claudin-11 [KO:K06087]
100549555  CLDN14; claudin-14 [KO:K06087]
104916873  CLDN5; LOW QUALITY PROTEIN: claudin-5 [KO:K06087]
100541271  CLDN25; putative claudin-25 [KO:K06087]
100547855  claudin-16-like [KO:K06087]
104913875  claudin-3-like [KO:K06087]
100547877  claudin-22-like [KO:K06087]
100550187  CLDN12; LOW QUALITY PROTEIN: claudin-12 [KO:K06087]
104917096  junctional adhesion molecule A [KO:K06089]
100548325  JAM2; junctional adhesion molecule B isoform X1 [KO:K06735]
100539731  JAM3; junctional adhesion molecule C [KO:K06785]
100543543  ESAM; endothelial cell-selective adhesion molecule [KO:K06787]
100544769  CDH5; cadherin-5 [KO:K06533]
100543427  PECAM1; platelet endothelial cell adhesion molecule isoform X6 [KO:K06471]
100546939  CD99; CD99 antigen [KO:K06520]
104916250  XG; glycoprotein Xg [KO:K06520]
104912225  CD99L2; CD99 antigen-like protein 2 [KO:K06520]
104913545  SELPLG; P-selectin glycoprotein ligand 1 [KO:K06544]
100545334  P-selectin isoform X1 [KO:K06496]
100545328  ITGA4; integrin alpha-4 [KO:K06483]
100551464  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
100538631  ITGA9; integrin alpha-9 [KO:K06585]
104912281  VCAM1; vascular cell adhesion protein 1 [KO:K06527]
104914694  MADCAM1; mucosal addressin cell adhesion molecule 1 [KO:K06779]
100549596  CD34; hematopoietic progenitor cell antigen CD34 isoform X1 [KO:K06474]
100545747  GLG1; Golgi apparatus protein 1 [KO:K06816]
104909321  E-selectin [KO:K06494]
100549644  NECTIN1; nectin-1 isoform X1 [KO:K06081]
100542837  CDH2; cadherin-2 [KO:K06736]
100547250  NCAM2; neural cell adhesion molecule 2 [KO:K06491]
100547600  NCAM1; neural cell adhesion molecule 1 [KO:K06491]
100542193  CADM1; cell adhesion molecule 1 [KO:K06781]
104912371  netrin-G1 [KO:K07522]
100544960  LRRC4C; leucine-rich repeat-containing protein 4C [KO:K07523]
100542294  NTNG2; netrin-G2 isoform X6 [KO:K16359]
104915929  LRRC4; leucine-rich repeat-containing protein 4 [KO:K16351]
100542855  receptor-type tyrosine-protein phosphatase F [KO:K05695] [EC:3.1.3.48]
100539692  leucine-rich repeat-containing protein 4B [KO:K16360]
100541597  SDC1; syndecan-1 [KO:K06257]
100190902  SDC2; syndecan-2 precursor [KO:K16336]
100303706  SDC3; syndecan-3 precursor [KO:K16337]
100126249  SDC4; syndecan-4 precursor [KO:K16338]
100541922  ITGAV; integrin alpha-V [KO:K06487]
100540683  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
100546503  integrin alpha-8 [KO:K06584]
100547882  NRXN3; neurexin 3 isoform X8 [KO:K07377]
100551203  NLGN3; neuroligin-3 isoform X1 [KO:K07378]
100549681  NLGN1; neuroligin-1 isoform X1 [KO:K07378]
100545716  NLGN4X; neuroligin-4, X-linked isoform X3 [KO:K07378]
100551029  PTPRS; LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase S [KO:K06778] [EC:3.1.3.48]
100545098  SLITRK1; SLIT and NTRK-like protein 1 [KO:K25832]
100549014  SLITRK2; SLIT and NTRK-like protein 2 [KO:K25833]
100542697  SLITRK4; SLIT and NTRK-like protein 4 [KO:K25835]
104917448  SLITRK5; SLIT and NTRK-like protein 5 [KO:K25836]
100544796  SLITRK6; LOW QUALITY PROTEIN: SLIT and NTRK-like protein 6 [KO:K25837]
100550569  receptor-type tyrosine-protein phosphatase delta-like [KO:K06777] [EC:3.1.3.48]
100541874  SLITRK3; SLIT and NTRK-like protein 3 [KO:K25834]
100543342  CADM3; cell adhesion molecule 3 [KO:K06780]
100548728  NRCAM; LOW QUALITY PROTEIN: neuronal cell adhesion molecule [KO:K06756]
100548882  CNTN1; contactin-1 [KO:K06759]
100550127  receptor-type tyrosine-protein phosphatase mu [KO:K05693] [EC:3.1.3.48]
100541945  CNTN2; contactin-2 [KO:K06760]
100545191  neurofascin [KO:K06757]
100544839  CNTNAP1; LOW QUALITY PROTEIN: contactin-associated protein 1 [KO:K07379]
104910079  CNTNAP2; contactin-associated protein-like 2 isoform X2 [KO:K07380]
104916922  myelin protein P0 [KO:K06770]
104913062  cadherin-1 [KO:K05689]
100550062  VCAN; versican core protein [KO:K06793]
100538428  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
100547026  B-cadherin [KO:K06796]
100544203  cadherin-4 [KO:K06797]
100544665  NEO1; neogenin [KO:K06766]
Reference
PMID:14690046
  Authors
Barclay AN.
  Title
Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
  Journal
Semin Immunol 15:215-23 (2003)
DOI:10.1016/S1044-5323(03)00047-2
Reference
PMID:11910893
  Authors
Sharpe AH, Freeman GJ.
  Title
The B7-CD28 superfamily.
  Journal
Nat Rev Immunol 2:116-26 (2002)
DOI:10.1038/nri727
Reference
PMID:9597126
  Authors
Grewal IS, Flavell RA.
  Title
CD40 and CD154 in cell-mediated immunity.
  Journal
Annu Rev Immunol 16:111-35 (1998)
DOI:10.1146/annurev.immunol.16.1.111
Reference
PMID:16034094
  Authors
Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
  Title
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
  Journal
J Immunol 175:1558-65 (2005)
DOI:10.4049/jimmunol.175.3.1558
Reference
PMID:12234363
  Authors
Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
  Title
Cell adhesion and polarity during immune interactions.
  Journal
Immunol Rev 186:68-82 (2002)
DOI:10.1034/j.1600-065X.2002.18607.x
Reference
PMID:15071551
  Authors
Dejana E.
  Title
Endothelial cell-cell junctions: happy together.
  Journal
Nat Rev Mol Cell Biol 5:261-70 (2004)
DOI:10.1038/nrm1357
Reference
PMID:14519386
  Authors
Bazzoni G.
  Title
The JAM family of junctional adhesion molecules.
  Journal
Curr Opin Cell Biol 15:525-30 (2003)
DOI:10.1016/S0955-0674(03)00104-2
Reference
PMID:10798271
  Authors
Becker BF, Heindl B, Kupatt C, Zahler S.
  Title
Endothelial function and hemostasis.
  Journal
Z Kardiol 89:160-7 (2000)
DOI:10.1007/PL00007320
Reference
PMID:9150551
  Authors
Elangbam CS, Qualls CW Jr, Dahlgren RR.
  Title
Cell adhesion molecules--update.
  Journal
Vet Pathol 34:61-73 (1997)
DOI:10.1177/030098589703400113
Reference
PMID:12810109
  Authors
Muller WA.
  Title
Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
  Journal
Trends Immunol 24:327-34 (2003)
DOI:10.1016/S1471-4906(03)00117-0
Reference
PMID:14519398
  Authors
Yamagata M, Sanes JR, Weiner JA.
  Title
Synaptic adhesion molecules.
  Journal
Curr Opin Cell Biol 15:621-32 (2003)
DOI:10.1016/S0955-0674(03)00107-8
Reference
PMID:15882774
  Authors
Ethell IM, Pasquale EB.
  Title
Molecular mechanisms of dendritic spine development and remodeling.
  Journal
Prog Neurobiol 75:161-205 (2005)
DOI:10.1016/j.pneurobio.2005.02.003
Reference
PMID:11050419
  Authors
Benson DL, Schnapp LM, Shapiro L, Huntley GW.
  Title
Making memories stick: cell-adhesion molecules in synaptic plasticity.
  Journal
Trends Cell Biol 10:473-82 (2000)
DOI:10.1016/S0962-8924(00)01838-9
Reference
PMID:11860281
  Authors
Rosdahl JA, Mourton TL, Brady-Kalnay SM.
  Title
Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
  Journal
Mol Cell Neurosci 19:292-306 (2002)
DOI:10.1006/mcne.2001.1071
Reference
PMID:10964748
  Authors
Dunican DJ, Doherty P.
  Title
The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
  Journal
Mol Cell Biol Res Commun 3:255-63 (2000)
DOI:10.1006/mcbr.2000.0225
Reference
PMID:12367625
  Authors
Girault JA, Peles E.
  Title
Development of nodes of Ranvier.
  Journal
Curr Opin Neurobiol 12:476-85 (2002)
DOI:10.1016/S0959-4388(02)00370-7
Reference
PMID:10664064
  Authors
Arroyo EJ, Scherer SS.
  Title
On the molecular architecture of myelinated fibers.
  Journal
Histochem Cell Biol 113:1-18 (2000)
DOI:10.1007/s004180050001
Reference
PMID:14556710
  Authors
Salzer JL.
  Title
Polarized domains of myelinated axons.
  Journal
Neuron 40:297-318 (2003)
DOI:10.1016/S0896-6273(03)00628-7
Reference
PMID:15561584
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002
Reference
PMID:15551862
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116
Reference
PMID:15115723
  Authors
Siu MK, Cheng CY.
  Title
Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
  Journal
Biol Reprod 71:375-91 (2004)
DOI:10.1095/biolreprod.104.028225
Reference
PMID:15056568
  Authors
Lee NP, Cheng CY.
  Title
Adaptors, junction dynamics, and spermatogenesis.
  Journal
Biol Reprod 71:392-404 (2004)
DOI:10.1095/biolreprod.104.027268
Reference
PMID:15728677
  Authors
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
  Title
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
  Journal
Development 132:1525-37 (2005)
DOI:10.1242/dev.01697
Reference
PMID:12500939
  Authors
Marthiens V, Gavard J, Lambert M, Mege RM.
  Title
Cadherin-based cell adhesion in neuromuscular development.
  Journal
Biol Cell 94:315-26 (2002)
DOI:10.1016/S0248-4900(02)00005-9
Reference
PMID:15923648
  Authors
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
  Title
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
  Journal
J Cell Sci 118:2355-62 (2005)
DOI:10.1242/jcs.02397
Related
pathway
mgp04520  Adherens junction
mgp04530  Tight junction
KO pathway
ko04514   
LinkDB

DBGET integrated database retrieval system