KEGG   PATHWAY: ming04141
Entry
ming04141                   Pathway                                
Name
Protein processing in endoplasmic reticulum - Macadamia integrifolia (macadamia nut)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
ming04141  Protein processing in endoplasmic reticulum
ming04141

Other DBs
GO: 0030433 0034976
Organism
Macadamia integrifolia (macadamia nut) [GN:ming]
Gene
122064497  protein transport protein Sec61 subunit alpha-like [KO:K10956]
122066983  preprotein translocase subunit SCY1, chloroplastic isoform X1 [KO:K10956]
122059256  protein transport protein Sec61 subunit alpha-like [KO:K10956]
122079545  protein transport protein Sec61 subunit beta-like [KO:K09481]
122093851  protein transport protein Sec61 subunit beta-like [KO:K09481]
122068989  protein transport protein Sec61 subunit beta-like [KO:K09481]
122081806  protein transport protein Sec61 subunit beta-like [KO:K09481]
122072701  protein transport protein Sec61 subunit beta-like [KO:K09481]
122057659  protein transport protein Sec61 subunit beta-like [KO:K09481]
122079324  protein transport protein Sec61 subunit gamma-like [KO:K07342]
122073064  protein transport protein Sec61 subunit gamma [KO:K07342]
122075291  protein transport protein Sec61 subunit gamma-like [KO:K07342]
122088364  translocation protein SEC62-like [KO:K12275]
122079924  uncharacterized protein LOC122079924 [KO:K12275]
122061875  dnaJ protein ERDJ2-like [KO:K09540]
122082452  dnaJ protein ERDJ2-like [KO:K09540]
122058062  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1B [KO:K12666]
122074826  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1A [KO:K12666]
122081954  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [KO:K12667]
122088288  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
122076692  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
122088983  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit-like isoform X1 [KO:K12670]
122074812  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit-like [KO:K12670]
122063062  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
122086356  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151] [EC:2.4.99.18]
122082026  probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3B [KO:K19478]
122083666  probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3B [KO:K19478]
122093282  oligosaccharyltransferase complex subunit ostc-like [KO:K26501]
122076722  transmembrane protein 258 [KO:K26502]
122061253  transmembrane protein 258-like [KO:K26502]
122074570  mannosyl-oligosaccharide glucosidase GCS1-like [KO:K01228] [EC:3.2.1.106]
122059990  heat shock 70 kDa protein 17-like [KO:K09486]
122093651  heat shock 70 kDa protein 17-like [KO:K09486]
122061867  luminal-binding protein 5-like [KO:K09490] [EC:3.6.4.10]
122081014  luminal-binding protein 5 [KO:K09490] [EC:3.6.4.10]
122084362  luminal-binding protein 5-like [KO:K09490] [EC:3.6.4.10]
122063949  dnaJ protein ERDJ3B-like [KO:K09517]
122057183  dnaJ protein ERDJ3B-like [KO:K09517]
122080755  dnaJ protein P58IPK homolog [KO:K09523]
122058050  dnaJ protein P58IPK homolog [KO:K09523]
122089459  heat shock protein 90-5, chloroplastic-like [KO:K09487]
122080403  heat shock protein 90-6, mitochondrial isoform X1 [KO:K09487]
122069373  endoplasmin homolog [KO:K09487]
122070748  heat shock protein 90-5, chloroplastic-like [KO:K09487]
122084410  endoplasmin homolog [KO:K09487]
122071614  probable glucan 1,3-alpha-glucosidase [KO:K05546] [EC:3.2.1.207]
122072856  probable glucan 1,3-alpha-glucosidase [KO:K05546] [EC:3.2.1.207]
122076538  calnexin homolog isoform X1 [KO:K08054]
122079115  calnexin homolog [KO:K08054]
122079543  calreticulin-3 isoform X1 [KO:K08057]
122091995  calreticulin-like [KO:K08057]
122058013  calreticulin [KO:K08057]
122076596  mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS1-like [KO:K01230] [EC:3.2.1.113]
122059792  mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS3 [KO:K23741] [EC:3.2.1.209]
122062438  SEC12-like protein 1 [KO:K14003]
122080212  SEC12-like protein 2 [KO:K14003]
122075577  GTP-binding protein SAR1A-like [KO:K07953] [EC:3.6.5.-]
122091899  GTP-binding protein SAR1A-like [KO:K07953] [EC:3.6.5.-]
122085551  GTP-binding protein SAR1A-like [KO:K07953] [EC:3.6.5.-]
122057957  GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
122064502  protein transport protein SEC13 homolog A-like isoform X1 [KO:K14004]
122082813  protein transport protein SEC13 homolog B-like [KO:K14004]
122087559  protein transport protein SEC13 homolog A [KO:K14004]
122089016  protein transport protein SEC31 homolog B-like [KO:K14005]
122070549  protein transport protein SEC31 homolog B-like [KO:K14005]
122089306  protein transport protein SEC23-like [KO:K14006]
122090818  protein transport protein SEC23-like [KO:K14006]
122091994  protein transport protein SEC23-like [KO:K14006]
122067061  protein transport protein SEC23-like isoform X1 [KO:K14006]
122081924  protein transport protein SEC23-like [KO:K14006]
122070737  protein transport protein SEC23 isoform X1 [KO:K14006]
122089107  protein transport protein Sec24-like At3g07100 [KO:K14007]
122061620  protein transport protein Sec24-like At4g32640 [KO:K14007]
122070813  protein transport protein Sec24-like At3g07100 [KO:K14007]
122073905  protein transport protein Sec24-like At4g32640 isoform X1 [KO:K14007]
122084299  UDP-glucose:glycoprotein glucosyltransferase [KO:K11718] [EC:2.4.1.-]
122076231  alpha-mannosidase I MNS5-like isoform X1 [KO:K10084]
122064752  alpha-mannosidase I MNS5-like [KO:K10084]
122088226  alpha-mannosidase I MNS4 [KO:K10085]
122076763  protein disulfide isomerase-like 1-6 isoform X1 [KO:K09580] [EC:5.3.4.1]
122093955  protein disulfide-isomerase-like [KO:K09580] [EC:5.3.4.1]
122082716  protein disulfide-isomerase-like [KO:K09580] [EC:5.3.4.1]
122085141  protein disulfide-isomerase 5-2 [KO:K09580] [EC:5.3.4.1]
122085958  protein disulfide isomerase-like 1-4 [KO:K09580] [EC:5.3.4.1]
122058056  protein disulfide isomerase-like 1-4 [KO:K09580] [EC:5.3.4.1]
122090519  protein disulfide-isomerase like 2-1-like [KO:K09584] [EC:5.3.4.1]
122062824  protein disulfide isomerase-like 2-3 [KO:K09584] [EC:5.3.4.1]
122069646  protein disulfide isomerase-like 2-3 [KO:K09584] [EC:5.3.4.1]
122057120  probable protein disulfide-isomerase A6 [KO:K09584] [EC:5.3.4.1]
122084657  endoplasmic reticulum oxidoreductin-1-like [KO:K10950] [EC:1.8.4.-]
122062720  protein OS-9 homolog [KO:K10088]
122077146  translocon-associated protein subunit alpha-like isoform X1 [KO:K13249]
122074052  translocon-associated protein subunit alpha-like [KO:K13249]
122075465  translocon-associated protein subunit beta [KO:K13250]
122078309  translocon-associated protein subunit beta-like [KO:K13250]
122090075  uncharacterized protein LOC122090075 [KO:K14009]
122079686  B-cell receptor-associated protein 31-like [KO:K14009]
122067199  B-cell receptor-associated protein 31-like [KO:K14009]
122094246  B-cell receptor-associated protein 31-like [KO:K14009]
122059991  derlin-2.2 [KO:K13989]
122091561  derlin-1 [KO:K13989]
122094304  derlin-2.2-like isoform X1 [KO:K13989]
122068080  derlin-1-like [KO:K13989]
122090063  chromatin assembly factor 1 subunit A-like [KO:K24348]
122090568  stress response protein NST1-like isoform X1 [KO:K24348]
122091405  plant UBX domain-containing protein 11 [KO:K24348]
122070291  vicilin-like seed storage protein At2g18540 [KO:K24348]
122082557  plant UBX domain-containing protein 2-like [KO:K14011]
122083473  plant UBX domain-containing protein 2-like [KO:K14011]
122060123  plant UBX domain-containing protein 4-like [KO:K14012]
122092728  plant UBX domain-containing protein 4 [KO:K14012]
122076718  cell division cycle protein 48 homolog [KO:K13525]
122061848  cell division cycle protein 48 homolog [KO:K13525]
122067211  cell division control protein 48 homolog E-like [KO:K13525]
122091055  NPL4-like protein 1 [KO:K14015]
122071174  NPL4-like protein 1 [KO:K14015]
122089979  ubiquitin fusion degradation protein 1 homolog [KO:K14016]
122077843  ubiquitin fusion degradation protein 1 homolog [KO:K14016]
122085178  ubiquitin recognition factor in ER-associated degradation protein 1-like isoform X1 [KO:K14016]
122060606  heat shock cognate 70 kDa protein-like [KO:K03283]
122064300  heat shock 70 kDa protein-like [KO:K03283]
122064301  heat shock 70 kDa protein-like [KO:K03283]
122081562  stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283]
122093972  stromal 70 kDa heat shock-related protein, chloroplastic-like [KO:K03283]
122083546  heat shock 70 kDa protein-like [KO:K03283]
122084689  heat shock 70 kDa protein [KO:K03283]
122086297  heat shock cognate 70 kDa protein 2-like [KO:K03283]
122057814  heat shock 70 kDa protein 1 [KO:K03283]
122057868  heat shock cognate 70 kDa protein 2-like [KO:K03283]
122086494  heat shock cognate 70 kDa protein 2 [KO:K03283]
122082587  chaperone protein dnaJ A6-like [KO:K09503]
122085733  dnaJ protein homolog [KO:K09503]
122087107  chaperone protein dnaJ A6-like [KO:K09503]
122058480  dnaJ protein homolog [KO:K09503]
122077574  chaperone protein dnaJ 49-like [KO:K09518]
122091436  chaperone protein dnaJ 49-like [KO:K09518]
122071461  chaperone protein dnaJ 49-like [KO:K09518]
122057387  chaperone protein dnaJ 49-like [KO:K09518]
122061505  heat shock protein 83-like [KO:K04079]
122089222  heat shock protein 83 [KO:K04079]
122069654  heat shock protein 83-like [KO:K04079]
122065767  uncharacterized protein LOC122065767 [KO:K09562]
122058417  hsp70-binding protein 1-like [KO:K09562]
122074653  hsp70 nucleotide exchange factor FES1-like [KO:K09562]
122060011  15.4 kDa class V heat shock protein-like [KO:K13993]
122060073  17.8 kDa class I heat shock protein-like [KO:K13993]
122061192  18.1 kDa class I heat shock protein-like [KO:K13993]
122061371  class I heat shock protein-like [KO:K13993]
122061421  18.1 kDa class I heat shock protein-like [KO:K13993]
122061843  17.4 kDa class III heat shock protein [KO:K13993]
122061969  17.8 kDa class I heat shock protein-like [KO:K13993]
122061973  17.8 kDa class I heat shock protein-like [KO:K13993]
122078651  18.1 kDa class I heat shock protein-like [KO:K13993]
122079097  small heat shock protein, chloroplastic-like [KO:K13993]
122065010  17.1 kDa class II heat shock protein-like [KO:K13993]
122065508  small heat shock protein, chloroplastic-like [KO:K13993]
122066342  17.8 kDa class I heat shock protein-like [KO:K13993]
122066343  18.1 kDa class I heat shock protein-like [KO:K13993]
122066347  17.8 kDa class I heat shock protein-like [KO:K13993]
122066348  18.1 kDa class I heat shock protein-like [KO:K13993]
122066717  17.8 kDa class I heat shock protein-like [KO:K13993]
122066718  17.8 kDa class I heat shock protein-like [KO:K13993]
122093586  small heat shock protein, chloroplastic [KO:K13993]
122066977  class I heat shock protein-like [KO:K13993]
122067144  class I heat shock protein-like [KO:K13993]
122067289  18.1 kDa class I heat shock protein-like [KO:K13993]
122067290  17.8 kDa class I heat shock protein-like [KO:K13993]
122081267  small heat shock protein, chloroplastic-like isoform X1 [KO:K13993]
122081499  15.7 kDa heat shock protein, peroxisomal [KO:K13993]
122094305  15.4 kDa class V heat shock protein [KO:K13993]
122094418  18.2 kDa class I heat shock protein-like [KO:K13993]
122068987  26.5 kDa heat shock protein, mitochondrial [KO:K13993]
122069293  class I heat shock protein-like [KO:K13993]
122083495  16.9 kDa class I heat shock protein 1-like [KO:K13993]
122083723  17.9 kDa class II heat shock protein-like [KO:K13993]
122083773  18.1 kDa class I heat shock protein-like [KO:K13993]
122083777  17.1 kDa class II heat shock protein-like [KO:K13993]
122083778  17.9 kDa class II heat shock protein-like [KO:K13993]
122083872  17.3 kDa class II heat shock protein-like [KO:K13993]
122084291  17.8 kDa class I heat shock protein-like [KO:K13993]
122085028  22.0 kDa class IV heat shock protein-like [KO:K13993]
122073436  18.1 kDa class I heat shock protein-like [KO:K13993]
122073520  18.1 kDa class I heat shock protein-like [KO:K13993]
122086644  18.1 kDa class I heat shock protein-like [KO:K13993]
122058692  16.9 kDa class I heat shock protein 3-like [KO:K13993]
122058783  18.2 kDa class I heat shock protein-like [KO:K13993]
122075142  18.5 kDa class I heat shock protein-like [KO:K13993]
122088110  18.1 kDa class I heat shock protein-like [KO:K13993]
122059029  17.3 kDa class I heat shock protein-like [KO:K13993]
122059703  18.0 kDa class I heat shock protein-like [KO:K13993]
122066072  OVARIAN TUMOR DOMAIN-containing deubiquitinating enzyme 2 isoform X1 [KO:K13719] [EC:3.1.2.-]
122074144  phospholipase A-2-activating protein [KO:K14018]
122076959  ubiquitin receptor RAD23b-like isoform X1 [KO:K10839]
122063193  ubiquitin receptor RAD23c-like [KO:K10839]
122068698  ubiquitin receptor RAD23b-like isoform X1 [KO:K10839]
122084371  ubiquitin domain-containing protein DSK2a-like [KO:K04523]
122074073  ubiquitin domain-containing protein DSK2a-like isoform X1 [KO:K04523]
122058761  peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase [KO:K01456] [EC:3.5.1.52]
122062524  ataxin-3 homolog isoform X1 [KO:K11863] [EC:3.4.22.-]
122087197  ataxin-3 homolog [KO:K11863] [EC:3.4.22.-]
122091381  probable ubiquitin conjugation factor E4 [KO:K10597] [EC:2.3.2.27]
122083299  eukaryotic translation initiation factor 2 subunit alpha homolog [KO:K03237]
122086743  eukaryotic translation initiation factor 2 subunit alpha homolog [KO:K03237]
122077037  subtilisin-like protease SBT6.1 [KO:K08653] [EC:3.4.21.112]
122089854  membrane-bound transcription factor site-2 protease homolog isoform X1 [KO:K07765] [EC:3.4.24.85]
122083784  serine/threonine-protein kinase/endoribonuclease IRE1a isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
122076607  probable E3 ubiquitin ligase SUD1 [KO:K10661] [EC:2.3.2.27]
122065853  probable E3 ubiquitin ligase SUD1 [KO:K10661] [EC:2.3.2.27]
122090581  ubiquitin-conjugating enzyme E2 32-like [KO:K10578] [EC:2.3.2.23]
122085736  ubiquitin-conjugating enzyme E2 32-like [KO:K10578] [EC:2.3.2.23]
122063582  ubiquitin-conjugating enzyme E2 34-like [KO:K04554] [EC:2.3.2.23]
122066709  ubiquitin-conjugating enzyme E2 34-like isoform X1 [KO:K04554] [EC:2.3.2.23]
122067171  ubiquitin-conjugating enzyme E2 34-like [KO:K04554] [EC:2.3.2.23]
122091643  ubiquitin-conjugating enzyme E2 7-like [KO:K10575] [EC:2.3.2.23]
122066446  ubiquitin-conjugating enzyme E2 7-like [KO:K10575] [EC:2.3.2.23]
122070517  ubiquitin-conjugating enzyme E2 7-like [KO:K10575] [EC:2.3.2.23]
122087171  ubiquitin-conjugating enzyme E2 7 [KO:K10575] [EC:2.3.2.23]
122092714  ERAD-associated E3 ubiquitin-protein ligase HRD1A-like [KO:K10601] [EC:2.3.2.27]
122064578  uncharacterized protein LOC122064578 [KO:K10666] [EC:2.3.2.27]
122067210  uncharacterized protein LOC122067210 [KO:K10666] [EC:2.3.2.27]
122087984  uncharacterized protein LOC122087984 [KO:K10666] [EC:2.3.2.27]
122094110  E3 ubiquitin-protein ligase RMA1H1-like [KO:K10666] [EC:2.3.2.27]
122073101  E3 ubiquitin-protein ligase RNF185-like [KO:K10666] [EC:2.3.2.27]
122083598  E3 ubiquitin-protein ligase RNF185-like [KO:K10666] [EC:2.3.2.27]
122080080  ERAD-associated E3 ubiquitin-protein ligase component HRD3A-like [KO:K14026]
122087122  ERAD-associated E3 ubiquitin-protein ligase component HRD3A-like [KO:K14026]
122081608  E3 ubiquitin protein ligase RIN2-like [KO:K10636] [EC:2.3.2.36]
122074129  E3 ubiquitin protein ligase RIN2-like [KO:K10636] [EC:2.3.2.36]
122071695  E3 ubiquitin-protein ligase CHIP isoform X1 [KO:K09561] [EC:2.3.2.27]
122061337  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
122081132  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
122088715  ubiquitin-conjugating enzyme E2 D1-like [KO:K06689] [EC:2.3.2.23]
122089193  ubiquitin-conjugating enzyme E2 11-like [KO:K06689] [EC:2.3.2.23]
122094172  ubiquitin-conjugating enzyme E2 5A-like [KO:K06689] [EC:2.3.2.23]
122069919  ubiquitin-conjugating enzyme E2 D4-like [KO:K06689] [EC:2.3.2.23]
122059594  ubiquitin-conjugating enzyme E2 28-like [KO:K06689] [EC:2.3.2.23]
122073409  ubiquitin-conjugating enzyme E2 28-like [KO:K06689] [EC:2.3.2.23]
122059276  ubiquitin-conjugating enzyme E2 28-like [KO:K06689] [EC:2.3.2.23]
122070160  ubiquitin-conjugating enzyme E2 28-like [KO:K06689] [EC:2.3.2.23]
122087193  ubiquitin-conjugating enzyme E2-17 kDa-like [KO:K06689] [EC:2.3.2.23]
122057906  ubiquitin-conjugating enzyme E2-17 kDa-like [KO:K06689] [EC:2.3.2.23]
122076653  RING-box protein 1a [KO:K03868] [EC:2.3.2.32]
122083431  RING-box protein 1a-like [KO:K03868] [EC:2.3.2.32]
122090770  cullin-1 isoform X1 [KO:K03347]
122091125  cullin-1-like isoform X1 [KO:K03347]
122058019  cullin-1-like [KO:K03347]
122061103  SKP1-like protein 1A [KO:K03094]
122091592  SKP1-like protein 1A [KO:K03094]
122080642  SKP1-like protein 1A [KO:K03094]
122080717  SKP1-like protein 1A [KO:K03094]
122069264  SKP1-like protein 14 [KO:K03094]
122084411  SKP1-like protein 1B [KO:K03094]
122071936  SKP1-like protein 1A [KO:K03094]
122072092  SKP1-like protein 1B [KO:K03094]
122072704  SKP1-like protein 1A [KO:K03094]
122073705  SKP1-like protein 1B [KO:K03094]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
ming00510  N-Glycan biosynthesis
ming03050  Proteasome
ming03060  Protein export
KO pathway
ko04141   
LinkDB

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