KEGG   PATHWAY: mleu04142
Entry
mleu04142                   Pathway                                
Name
Lysosome - Mandrillus leucophaeus (drill)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
mleu04142  Lysosome
mleu04142

Other DBs
GO: 0005764
Organism
Mandrillus leucophaeus (drill) [GN:mleu]
Gene
105545849  ATP6V0A2; V-type proton ATPase 116 kDa subunit a isoform 2 [KO:K02154]
105553079  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform 1 [KO:K02154]
105544488  TCIRG1; V-type proton ATPase 116 kDa subunit a isoform 3 [KO:K02154]
105550558  ATP6V0A4; V-type proton ATPase 116 kDa subunit a isoform 4 [KO:K02154]
105551462  ATP6V0D1; V-type proton ATPase subunit d 1 isoform X1 [KO:K02146]
105530486  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
105552436  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
105534270  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
105529763  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
105555070  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit isoform X1 [KO:K03661]
105534167  DMXL1; dmX-like protein 1 isoform X1 [KO:K24155]
105543950  dmX-like protein 2 [KO:K24155]
105533307  WDR7; WD repeat-containing protein 7 [KO:K24738]
105543206  NCOA7; nuclear receptor coactivator 7 isoform X1 [KO:K25442]
105542300  CTSA; lysosomal protective protein isoform X1 [KO:K13289] [EC:3.4.16.5]
105532586  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
105543127  CTSC; dipeptidyl peptidase 1 isoform X1 [KO:K01275] [EC:3.4.14.1]
105545336  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
105547028  CTSE; cathepsin E [KO:K01382] [EC:3.4.23.34]
105544442  CTSF; cathepsin F [KO:K01373] [EC:3.4.22.41]
105532751  CTSG; cathepsin G [KO:K01319] [EC:3.4.21.20]
105542261  CTSH; pro-cathepsin H [KO:K01366] [EC:3.4.22.16]
105534753  CTSK; cathepsin K [KO:K01371] [EC:3.4.22.38]
105534459  LOW QUALITY PROTEIN: putative cathepsin L-like protein 6 [KO:K01365] [EC:3.4.22.15]
105535951  LOW QUALITY PROTEIN: putative inactive cathepsin L-like protein CTSL3P [KO:K01365] [EC:3.4.22.15]
105535952  cathepsin L1 isoform X1 [KO:K01365] [EC:3.4.22.15]
105534752  CTSS; cathepsin S isoform X1 [KO:K01368] [EC:3.4.22.27]
105536595  CTSV; cathepsin L2 [KO:K01375] [EC:3.4.22.43]
105528459  CTSW; cathepsin W isoform X1 [KO:K08569] [EC:3.4.22.-]
105548398  CTSZ; cathepsin Z [KO:K08568] [EC:3.4.18.1]
105528960  NAPSA; napsin-A [KO:K08565] [EC:3.4.23.-]
105528961  napsin-A-like [KO:K08565] [EC:3.4.23.-]
105547952  LGMN; legumain [KO:K01369] [EC:3.4.22.34]
105533898  TPP1; tripeptidyl-peptidase 1 isoform X1 [KO:K01279] [EC:3.4.14.9]
105528161  GLA; alpha-galactosidase A isoform X1 [KO:K01189] [EC:3.2.1.22]
105554504  GLB1; LOW QUALITY PROTEIN: beta-galactosidase [KO:K12309] [EC:3.2.1.23]
105548011  GAA; lysosomal alpha-glucosidase [KO:K12316] [EC:3.2.1.20]
105544841  glucosylceramidase isoform X1 [KO:K01201] [EC:3.2.1.45]
105532697  IDUA; alpha-L-iduronidase [KO:K01217] [EC:3.2.1.76]
105538807  NAGA; alpha-N-acetylgalactosaminidase [KO:K01204] [EC:3.2.1.49]
105553078  NAGLU; alpha-N-acetylglucosaminidase [KO:K01205] [EC:3.2.1.50]
105535270  GALC; galactocerebrosidase isoform X1 [KO:K01202] [EC:3.2.1.46]
105548735  GUSB; beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
105551766  FUCA2; plasma alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
105538120  FUCA1; tissue alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
105538684  HEXA; beta-hexosaminidase subunit alpha isoform X1 [KO:K12373] [EC:3.2.1.52]
105551379  HEXB; beta-hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
105548317  MANBA; beta-mannosidase isoform X1 [KO:K01192] [EC:3.2.1.25]
105550088  MAN2B1; lysosomal alpha-mannosidase [KO:K12311] [EC:3.2.1.24]
105554190  NEU1; sialidase-1 [KO:K01186] [EC:3.2.1.18]
105548980  HYAL2; hyaluronidase-2 [KO:K01197] [EC:3.2.1.35]
105548981  HYAL1; hyaluronidase-1 isoform X1 [KO:K01197] [EC:3.2.1.35]
105548985  HYAL3; hyaluronidase-3 isoform X1 [KO:K01197] [EC:3.2.1.35]
105550877  SPAM1; hyaluronidase PH-20 isoform X1 [KO:K01197] [EC:3.2.1.35]
105550878  HYAL4; hyaluronidase-4 [KO:K01197] [EC:3.2.1.35]
105550925  hyaluronidase-4-like [KO:K01197] [EC:3.2.1.35]
105543591  ARSA; arylsulfatase A [KO:K01134] [EC:3.1.6.8]
105548285  ARSB; arylsulfatase B [KO:K01135] [EC:3.1.6.12]
105535633  ARSG; arylsulfatase G [KO:K12381] [EC:3.1.6.-]
105533415  GALNS; N-acetylgalactosamine-6-sulfatase [KO:K01132] [EC:3.1.6.4]
105534248  GNS; N-acetylglucosamine-6-sulfatase [KO:K01137] [EC:3.1.6.14]
105532912  IDS; iduronate 2-sulfatase isoform X1 [KO:K01136] [EC:3.1.6.13]
105548154  SGSH; N-sulphoglucosamine sulphohydrolase [KO:K01565] [EC:3.10.1.1]
105528565  LIPA; lysosomal acid lipase/cholesteryl ester hydrolase isoform X1 [KO:K01052] [EC:3.1.1.13]
105552356  PLA2G15; group XV phospholipase A2 isoform X1 [KO:K06129] [EC:3.1.1.5]
105550066  DNASE2; deoxyribonuclease-2-alpha isoform X1 [KO:K01158] [EC:3.1.22.1]
105554816  ACP2; lysosomal acid phosphatase isoform X1 [KO:K14410] [EC:3.1.3.2]
105549479  ACP5; tartrate-resistant acid phosphatase type 5 [KO:K14379] [EC:3.1.3.2]
105531251  sphingomyelin phosphodiesterase isoform X1 [KO:K12350] [EC:3.1.4.12]
105539387  ASAH1; acid ceramidase [KO:K12348] [EC:3.5.1.23]
105543584  AGA; N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase isoform X1 [KO:K01444] [EC:3.5.1.26]
105547469  PSAP; prosaposin isoform X1 [KO:K12382]
105555296  PSAPL1; proactivator polypeptide-like 1 [KO:K12382]
105532631  LOW QUALITY PROTEIN: ganglioside GM2 activator-like [KO:K12383]
105543411  GM2A; ganglioside GM2 activator [KO:K12383]
105531499  PPT2; lysosomal thioesterase PPT2 [KO:K01074] [EC:3.1.2.22]
105536838  palmitoyl-protein thioesterase 1-like [KO:K01074] [EC:3.1.2.22]
105537948  PPT1; palmitoyl-protein thioesterase 1 isoform X1 [KO:K01074] [EC:3.1.2.22]
105539242  LAMP1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
105537540  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
105543953  LAMP3; lysosome-associated membrane glycoprotein 3 [KO:K06562]
105549876  CD68; macrosialin isoform X1 [KO:K06501]
105532013  CD63; CD63 antigen isoform X1 [KO:K06497]
105529117  SCARB2; lysosome membrane protein 2 isoform X1 [KO:K12384]
105545236  NPC1; Niemann-Pick C1 protein [KO:K12385]
105540790  NPC2; epididymal secretory protein E1 isoform X1 [KO:K13443]
105539972  CTNS; cystinosin [KO:K12386]
105544555  SLC17A5; sialin [KO:K12301]
105528036  SLC11A1; natural resistance-associated macrophage protein 1 isoform X1 [KO:K12347]
105555633  SLC11A2; natural resistance-associated macrophage protein 2 isoform X2 [KO:K21398]
105533063  LAPTM4A; lysosomal-associated transmembrane protein 4A isoform X1 [KO:K12387]
105553844  LAPTM4B; LOW QUALITY PROTEIN: lysosomal-associated transmembrane protein 4B [KO:K12387]
105535030  LAPTM5; lysosomal-associated transmembrane protein 5 [KO:K12387]
105543322  ABCA2; ATP-binding cassette sub-family A member 2 [KO:K05642]
105527984  ABCB9; ATP-binding cassette sub-family B member 9 isoform X1 [KO:K05656]
105536561  CD164; sialomucin core protein 24 isoform X1 [KO:K06546]
105531030  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 [KO:K12305] [EC:3.6.1.6]
105530956  SORT1; LOW QUALITY PROTEIN: sortilin [KO:K12388]
105541388  CLN3; LOW QUALITY PROTEIN: battenin [KO:K12389]
105554268  CLN5; ceroid-lipofuscinosis neuronal protein 5 [KO:K12390]
105538386  MFSD8; major facilitator superfamily domain-containing protein 8 isoform X1 [KO:K12307]
105554541  HGSNAT; LOW QUALITY PROTEIN: heparan-alpha-glucosaminide N-acetyltransferase [KO:K10532] [EC:2.3.1.78]
105528645  SUMF1; sulfatase-modifying factor 1 isoform X1 [KO:K13444] [EC:1.8.3.7]
105534470  GNPTAB; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta [KO:K08239] [EC:2.7.8.17]
105529718  GNPTG; N-acetylglucosamine-1-phosphotransferase subunit gamma [KO:K10087]
105538598  NAGPA; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [KO:K01125] [EC:3.1.4.45]
105536571  IGF2R; cation-independent mannose-6-phosphate receptor [KO:K06564]
105541976  M6PR; cation-dependent mannose-6-phosphate receptor isoform X1 [KO:K10089]
105554221  CLTA; clathrin light chain A isoform X1 [KO:K04644]
105546737  CLTB; clathrin light chain B isoform X1 [KO:K04645]
105539069  CLTC; clathrin heavy chain 1 isoform X1 [KO:K04646]
105543884  CLTCL1; clathrin heavy chain 2 [KO:K04646]
105547199  AP1G2; AP-1 complex subunit gamma-like 2 isoform X1 [KO:K12391]
105537202  AP1G1; AP-1 complex subunit gamma-1 isoform X1 [KO:K12391]
105550723  AP1B1; AP-1 complex subunit beta-1 isoform X1 [KO:K12392]
105540109  AP1M1; AP-1 complex subunit mu-1 isoform X1 [KO:K12393]
105550138  AP1M2; AP-1 complex subunit mu-2 [KO:K12393]
105543351  AP1S1; AP-1 complex subunit sigma-1A isoform X1 [KO:K12394]
105550577  AP1S2; AP-1 complex subunit sigma-2 isoform X1 [KO:K12394]
105550183  AP1S3; AP-1 complex subunit sigma-3 isoform X1 [KO:K12395]
105551966  AP3D1; AP-3 complex subunit delta-1 [KO:K12396]
105551055  AP3B1; LOW QUALITY PROTEIN: AP-3 complex subunit beta-1 [KO:K12397]
105554285  AP3B2; AP-3 complex subunit beta-2 [KO:K12397]
105547514  AP3M1; AP-3 complex subunit mu-1 isoform X1 [KO:K12398]
105554918  AP3M2; AP-3 complex subunit mu-2 isoform X1 [KO:K12398]
105534183  AP3S1; AP-3 complex subunit sigma-1 [KO:K12399]
105550748  AP4E1; AP-4 complex subunit epsilon-1 [KO:K12400]
105554344  AP4B1; AP-4 complex subunit beta-1 isoform X1 [KO:K12401]
105543693  AP4M1; AP-4 complex subunit mu-1 isoform X1 [KO:K12402]
105549986  AP4S1; AP-4 complex subunit sigma-1 [KO:K12403]
105538894  GGA1; ADP-ribosylation factor-binding protein GGA1 [KO:K12404]
105538194  GGA3; ADP-ribosylation factor-binding protein GGA3 isoform X1 [KO:K12404]
105545137  GGA2; ADP-ribosylation factor-binding protein GGA2 [KO:K12404]
105541155  MCOLN1; mucolipin-1 [KO:K04992]
105545255  LITAF; lipopolysaccharide-induced tumor necrosis factor-alpha factor [KO:K19363]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 10.1038/s41577-021-00626-8 (2021)
DOI:10.1038/s41577-021-00626-8
Related
pathway
mleu00511  Other glycan degradation
mleu00531  Glycosaminoglycan degradation
mleu04130  SNARE interactions in vesicular transport
mleu04140  Autophagy - animal
mleu04144  Endocytosis
KO pathway
ko04142   
LinkDB

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