KEGG   PATHWAY: mmur00983
Entry
mmur00983                   Pathway                                
Name
Drug metabolism - other enzymes - Microcebus murinus (gray mouse lemur)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
mmur00983  Drug metabolism - other enzymes
mmur00983

Organism
Microcebus murinus (gray mouse lemur) [GN:mmur]
Gene
105871446  HPRT1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
105874948  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 isoform X2 [KO:K00088] [EC:1.1.1.205]
105884839  IMPDH1; inosine-5'-monophosphate dehydrogenase 1 isoform X1 [KO:K00088] [EC:1.1.1.205]
105856841  GMPS; GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
105865217  TPMT; thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
105884462  XDH; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
105865878  ITPA; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
105875531  liver carboxylesterase 1-like [KO:K01044] [EC:3.1.1.1]
105871709  liver carboxylesterase 1-like isoform X1 [KO:K01044] [EC:3.1.1.1]
105866535  liver carboxylesterase 1-like [KO:K01044] [EC:3.1.1.1]
105866541  liver carboxylesterase 1-like [KO:K01044] [EC:3.1.1.1]
105866547  liver carboxylesterase 1-like isoform X1 [KO:K01044] [EC:3.1.1.1]
105858918  CES2; LOW QUALITY PROTEIN: cocaine esterase [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
105883051  UDP-glucuronosyltransferase 2B4-like [KO:K00699] [EC:2.4.1.17]
105883080  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
105883081  UDP-glucuronosyltransferase 2B7-like isoform X1 [KO:K00699] [EC:2.4.1.17]
105883083  UDP-glucuronosyltransferase 2B31-like isoform X1 [KO:K00699] [EC:2.4.1.17]
105883084  UDP-glucuronosyltransferase 2B4-like isoform X1 [KO:K00699] [EC:2.4.1.17]
105883085  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
105883086  UDP-glucuronosyltransferase 2B4-like [KO:K00699] [EC:2.4.1.17]
105869279  UDP-glucuronosyltransferase 2B7-like isoform X1 [KO:K00699] [EC:2.4.1.17]
105869299  UDP-glucuronosyltransferase 2B4-like isoform X3 [KO:K00699] [EC:2.4.1.17]
105869304  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
105886128  UDP-glucuronosyltransferase 1-1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
105886138  UDP-glucuronosyltransferase 1-8-like [KO:K00699] [EC:2.4.1.17]
105886140  UDP-glucuronosyltransferase 1-8-like [KO:K00699] [EC:2.4.1.17]
105886142  UDP-glucuronosyltransferase 1-3-like [KO:K00699] [EC:2.4.1.17]
105886143  UDP-glucuronosyltransferase 1-8-like [KO:K00699] [EC:2.4.1.17]
105886144  UDP-glucuronosyltransferase 1-8-like [KO:K00699] [EC:2.4.1.17]
109729189  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
109729208  UDP-glucuronosyltransferase 2B4-like [KO:K00699] [EC:2.4.1.17]
109730987  UDP-glucuronosyltransferase 1-8-like [KO:K00699] [EC:2.4.1.17]
105864507  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
105864508  UDP-glucuronosyltransferase 2A1 isoform X10 [KO:K00699] [EC:2.4.1.17]
105871011  GUSB; beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
105868328  cytochrome P450 3A4-like [KO:K17689] [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]
105868331  cytochrome P450 3A4 [KO:K17689] [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]
105883992  CDA; cytidine deaminase [KO:K01489] [EC:3.5.4.5]
105885000  TYMP; thymidine phosphorylase [KO:K00758] [EC:2.4.2.4]
105885769  DPYD; dihydropyrimidine dehydrogenase [NADP(+)] [KO:K00207] [EC:1.3.1.2]
105882140  DPYS; dihydropyrimidinase [KO:K01464] [EC:3.5.2.2]
105862769  UPB1; beta-ureidopropionase [KO:K01431] [EC:3.5.1.6]
105860479  UPP2; LOW QUALITY PROTEIN: uridine phosphorylase 2 [KO:K00757] [EC:2.4.2.3]
105855178  UPP1; uridine phosphorylase 1 isoform X1 [KO:K00757] [EC:2.4.2.3]
105859861  UCK1; uridine-cytidine kinase 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
105860493  UCK2; uridine-cytidine kinase 2 [KO:K00876] [EC:2.7.1.48]
105875761  UCKL1; uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
105866710  TK1; thymidine kinase, cytosolic isoform X1 [KO:K00857] [EC:2.7.1.21]
105859028  TK2; thymidine kinase 2, mitochondrial [KO:K00857] [EC:2.7.1.21]
105879859  UMPS; uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
105877517  CMPK1; UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
105860311  RRM1; ribonucleoside-diphosphate reductase large subunit isoform X1 [KO:K10807] [EC:1.17.4.1]
105882174  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
105879016  RRM2; LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
105880916  LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase subunit M2-like [KO:K10808] [EC:1.17.4.1]
105859619  NME3; nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
105881916  NME7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
105874916  NME6; nucleoside diphosphate kinase 6 isoform X1 [KO:K00940] [EC:2.7.4.6]
105885136  nucleoside diphosphate kinase A isoform X1 [KO:K00940] [EC:2.7.4.6]
105856270  NME4; nucleoside diphosphate kinase, mitochondrial isoform X1 [KO:K00940] [EC:2.7.4.6]
105879535  nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
105870734  DUT; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 [KO:K01520] [EC:3.6.1.23]
105870807  MPO; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
105882540  arylamine N-acetyltransferase 1-like [KO:K00622] [EC:2.3.1.5]
105882541  arylamine N-acetyltransferase 1-like [KO:K00622] [EC:2.3.1.5]
105882543  arylamine N-acetyltransferase 1-like [KO:K00622] [EC:2.3.1.5]
105861495  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
105874655  GSTO2; glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
105874660  GSTO1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
105860497  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
105869168  glutathione S-transferase-like isoform X1 [KO:K00799] [EC:2.5.1.18]
105869170  LOW QUALITY PROTEIN: glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
105869190  glutathione S-transferase A1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
105869191  glutathione S-transferase A3-like [KO:K00799] [EC:2.5.1.18]
105869211  glutathione S-transferase A4 isoform X1 [KO:K00799] [EC:2.5.1.18]
105869212  LOW QUALITY PROTEIN: glutathione S-transferase A3-like [KO:K00799] [EC:2.5.1.18]
105862780  LOW QUALITY PROTEIN: glutathione S-transferase theta-2B-like [KO:K00799] [EC:2.5.1.18]
105862781  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
105862782  glutathione S-transferase theta-3 [KO:K00799] [EC:2.5.1.18]
105862783  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
105877389  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
105863995  GSTM4; glutathione S-transferase Mu 4 isoform X1 [KO:K00799] [EC:2.5.1.18]
105863998  glutathione S-transferase Mu 2 [KO:K00799] [EC:2.5.1.18]
105864000  GSTM3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
109729221  glutathione S-transferase Mu 2-like [KO:K00799] [EC:2.5.1.18]
105872351  MGST2; microsomal glutathione S-transferase 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
105867418  glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
105867419  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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